Today I’m sharing results from a new study on GABA and theanine and how this combination improves sleep: “GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.”
I shared highlights from this paper with practitioners at the Integrative Medicine for Mental Health Conference, presenting on “GABA for anxiety, insomnia, ADHD, autism and addictions.”
The authors share the sleep and anxiety benefits of both GABA and theanine:
γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter and it is well established that activation of GABAA receptors favours sleep.
l-Theanine, a naturally occurring amino acid first discovered in green tea, is a well-known anti-anxiety supplement with proven relaxation benefits.
The study objective was to investigate the: “potential synergistic sleep enhancement effect of GABA/l-theanine mixture.”
The GABA/l-theanine mixture showed a decrease in sleep latency (length of time to fall asleep) and an increase in sleep duration compared to GABA or theanine alone.
The study authors state:
The increase in GABA receptor and GluN1 (glutamine receptor subunit) expression is attributed to the potential neuromodulatory properties of GABA/l-theanine combination, which seems to affect sleep behaviour.
The dosing of GABA and theanine used in this animal study cannot be extrapolated to humans
Here are the amounts used in the study:
- GABA: 100mg per kg of body weight
- theanine: 20 mg per kg of body weight
This was an animal study and these very high doses based on weight do not extrapolate to humans. I have adult clients start with 125 mg GABA and increase based on their unique needs.
Keep in mind I do not make amino acid recommendations based on weight but instead use the trial method to find the ideal amount.
Using a GABA/theanine combination lessens the rushing feeling and prevents waking multiple times during the night
Anu shares how a combination helps her:
My doctor has recommended I take GABA 500mg with L-Theanine 200mg three times a day to stop the rushing and flushing feeling of extremely high cortisol, high melatonin, and low serotonin. I cannot find much on what the negative effects of high doses of GABA and l-theanine can be on the body so am asking you if you know. I only know that low doses of GABA did not have any effect on me but that the higher doses seem to lessen the rushing feeling and help me to sleep (only waking once not 3-5x/night).
I have clients and those individuals in my program start low and increase based on their response. A dose of 500mg GABA is considered high but is fine to continue with if it’s not the starting dose and not causing any adverse effects.
Using GABA alone improves sleep and mood and ends carb cravings
I have found the combination of GABA and theanine to be extremely helpful for many of my clients but not everyone needs to use both to get results. Some folks do very well on GABA alone and some folks do really well on theanine alone.
Here’s one mom’s experience of using just GABA for her son with autism:
“Got some GABA for our ASD [autism spectrum disorder] child. He has not slept well for years. We had tried all kinds of stuff. I am a healthcare pro and have studied and read and tried so much. But this stuff is a true miracle. For the first time in years my child sleeps. He sang and was all smiles from ear to ear for the first three days.
He has also really noticed a difference in his carb cravings since doing GABA. He went to grandma’s and was not tempted by 6 pies, tons of cookies, sweet rolls etc. We were both shocked. This is a kid who would mow through tons of cookies, rolls and pastries.”
Here are some other blogs on the benefits of using oral GABA
- Sleep improvement: Oral intake of GABA and Apocynum venetum leaf extract
- How GABA eases agonizing rectal pain and spasms in under 2 minutes
- Oral GABA supplementation allows better prioritizing of planned actions
- GABA helps with inhibition of unwanted thoughts
The best way for you to figure out if you will benefit from the combination or either of them alone is to use the trial method. Do the low GABA questionnaire and do a trial of either GABA alone or theanine alone or a combination of both, until you find the right amount to improve your sleep and ease anxiety.
A good quality GABA/theanine product: GABA-T SAP
If you find the combination works well for you, GABA-T SAP by Nutritional Fundamentals, is a really nice combination product that I use with clients who have both anxiety and insomnia issues. I find that opening up the capsule onto the tongue is more effective than swallowing it. You can find this product and other GABA products I recommend on my supplements blog.
Additional resources when you are new to using GABA and other amino acids as supplements
As always, I use the symptoms questionnaire to figure out if low GABA or other neurotransmitter imbalances may be an issue.
If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.
There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control (this is covered in an entire chapter too), sugar cravings, anxiety and mood issues.
The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.
If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support.
If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.
Wrapping up and your feedback
Now I’d love to hear from you – have you found GABA alone to help you with both sleep and anxiety or have you found that the combination of GABA and theanine is more helpful?
Feel free to ask your questions below.