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Using 750 mg GABA in a hard tablet form for anxiety: I do not experience the flush but I am also not sure it is doing much of anything for me

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gaba hard tablet

Today I’m addressing a question from someone in this community about a particular GABA product and her confusion about dosing with 750mg and using a hard tablet (she calls it a pill). When she uses it she doesn’t notice any effect i.e. no calming benefits and no adverse niacin-type tingly flush either. This is what she asked:

Not sure if “Source Naturals GABA Calm Mind” is on your list, but I thought it was one you had recommended at one time? Anyway, these are pills that cannot be opened like a capsule and 1 pill = 750 mg.

Personally, I had the tingly flush when I used a different product that WAS a capsule and opened it on my tongue…unfortunately I do not recall dosage or product name but I purchased at Whole Foods.

With this particular product (Source Naturals GABA Calm Mind) in pill form, although the dosage could be higher, I do not experience the flush…(however, I also am not sure it is doing much of anything for me).

This is my feedback for her: I have never recommended the Source Naturals GABA Calm Mind 750 mg tablet ever (she calls it a pill but I know she is referring to the hard tablets).

These are not a very effective way to use GABA. As you can see, she doesn’t feel it’s doing anything for her in terms of easing her anxiety and being calming. With a high dose of GABA we also often see a niacin-like flush or tingling and yet with this pill/tablet form she didn’t experience this either. GABA is much more effective when used sublingually or opening a capsule (and starting low at 125mg). More on this below.

But I’m not surprised she is confused and asking this question. The Source Naturals GABA Calm Mind has a very similar bottle/name/label to Source Naturals GABA Calm (the sublingual with 125mg GABA) and there is also a Source Naturals GABA Calm Mind 750 mg capsules (which can be opened).

She mentions the tingly flush when using a different product that was a capsule and opened on to her tongue. I’d suspect the tingling happened with a 500 mg GABA or 750 mg GABA product as this is a common dosage found in health stores. Opening the capsule and using less is best when starting out.

If you have to break it it’s a tablet and much less effective

All this logic applies to any brand of hard GABA tablet. Someone just shared on Facebook that she had purchased a GABA product in the Netherlands and broke it in half in order to use a lower dose. If you have to break it it’s a tablet and much less effective and possibly not at all effective. Be sure to read the front and back of the bottle and avoid hard tablets.

From time to time someone will see some benefit with a GABA tablet that is swallowed but it’s usually minimal.

The most effective forms of GABA to use

Here is a quick recap if you’re new to GABA. It’s an amino acid that is used as a supplement to boost GABA levels (a calming neurotransmitter) and ease physical tension type anxiety symptoms. It’s most effective when used sublingually, or as a powder or by using a GABA capsule opened on to the tongue or as a liposomal product.

When using GABA it must ideally be in one of these forms for the best effects:

  • Capsule form so the gelatin or cellulose capsule can be opened and the contents sprinkled onto the tongue, or some of it depending on dosing (NFH GABA-T SAP is a good example of this one – it contains GABA and theanine)
  • Sublingual form which is sucked/held in the mouth (Source Naturals GABA Calm 125mg is a good example of this – this is the GABA product that I have the most success with and it’s easy to use when out and about; PharmaGABA chewables are another option)
  • Powder form which is measured out using special tiny measuring spoon and sprinkled on to the tongue (Healthwise and Bulk Nutrients are good examples of this one)
  • Liposomal form which is sprayed into the mouth and held for a few minutes (Designs for Health Liposomal Neurocalm and Quicksilver Scientific Liposomal GABA with L-Theanine are good examples of this form)

This blog, Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs. You can find a list of selected GABA products.

Here are a few success stories where the above different forms have been used:

Resources if you are new to using the amino acids as supplements

If you are new to using any of the amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the symptoms of neurotransmitter imbalances, including low GABA).

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, self-medicating with alcohol and more.

The book doesn’t include product names (per the publisher’s request) so as mentioned above, this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support. There are many moms in the program who are having much success with their kids.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids with success with their clients/patients.

Did you use a GABA product that didn’t work for you before finding the ideal product and dose?

Please share which product didn’t work (was it a hard tablet?) and what did work for you. And be sure to share how it helps to ease your physical anxiety, insomnia, pain, intrusive thoughts and cravings (for sugar or alcohol).

Have you experienced the niacin-like flush or tingle from using too high a dose of GABA? How much did that and which product?

If you’re a practitioner, which forms of GABA do you find the most success with?

If you have questions please share them here too.

The pill and other hormonal contraception: depression, anxiety and FAM

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homonal-contraception

Women taking the contraceptive pill and other hormonal contraception are more likely to be depressed. These are the findings from a Danish study published in JAMA Psychiatry and reported in an article on PubMed Health.

This was a large prospective cohort study which aimed to investigate whether using hormonal contraception is associated with the future use of antidepressants and a diagnosis of depression.

More than 1 million women aged 15 to 34, with no prior history of depression, were included in the study [and followed for 13 years].

The researchers compared users of hormonal contraception with non-users and found users were more likely to be prescribed antidepressants and diagnosed with depression.

This study found that those women who used the pill were 23% more likely to use antidepressants.

And here are the connections between antidepressant use and these other birth control methods (categorized by estrogen type and dose, progesterone type and the method of contraception):

  • progestogen-only pill – 34% more likely to use antidepressants
  • levonorgestrel intrauterine system (IUS) – 40% more likely to use antidepressants
  • vaginal ring (etonogestrel) – 60% more likely to use antidepressants
  • contraceptive patch (norgestrolmin) – 100% more likely to use antidepressants

The study authors state this:

it’s important to note this study is not able to prove that the contraceptive methods are responsible for the depression, only to find possible links to investigate further.

The researchers don’t advise that women should stop using their contraception, just that further studies are needed. If this association is found to be true, depression may have to be added as a possible side effect of hormonal contraception. 

My fellow nutritionist Karla Maree says this: ‘we’re going to need black box warnings on these medications” and I agree. It’s disappointing that the researchers say further studies are needed.

Dr. Daniel Amen sees the association in his practice and shared this about birth control pills when I interviewed him during season 3 of the Anxiety Summit.

Unfortunately, they drop serotonin levels. You’ve got to ask yourself why are 23 percent of women between the ages of 20 and 60 taking antidepressants. In large part, it’s the birth-control pills that are changing the hormones in their brain, the neurotransmitters in their brain. All of a sudden, they’re more anxious and they’re more depressed.

Birth control pills also can drop magnesium. Magnesium is a natural calmer to nerve cells. They literally can change things. 

We know the pill can also deplete vitamin B6 and folate, and can raise copper levels so these are likely some of the additional reasons we see mood changes in women taking them.

You may have noticed that Dr. Amen mentions 23 percent in our interview – which was actually done in May 2015. He is referring to a 2011 report released by the National Center for Health Statistics:

  • the rate of antidepressant use in this country among teens and adults (people ages 12 and older) increased by almost 400% between 1988–1994 and 2005–2008.
  • 23% of women in their 40s and 50s take antidepressants, a higher percentage than any other group (by age or sex)
  • women are 2½ times more likely to be taking an antidepressant than men

Is this related to hormonal birth control? Very likely! I’m not in favor of any of these hormonal birth control methods and know from experience that they often cause both depression and anxiety in my clients but seeing these percentages is still shocking!

It’s quite strange how many of my clients don’t think of birth control as having side-effects or being as “bad” as other medications. This was certainly the case for me. I’ve very seldom taken medications in my life but I did use the pill and then an IUD for a short while, and initially I didn’t give either a second thought. But I’m sure they were part of the perfect storm that contributed to my anxiety and panic attacks in my late 30s. I was prescribed an antidepressant at this time but chose not to take it, instead searching for nutritional solutions.

During my search for answers, I read tons of books and one book has had a huge impact on me: Taking Charge of Your Fertility by Toni Weschler. It offered a powerful non-hormonal option for birth control: the Fertility Awareness Method or FAM and gave me so much insight about my body and hormones. It’s also something I now share with my clients. It deserves an entire review so stay tuned. For now, you can check out an overview on her website.

My version of the book was published in 1995 and Toni now has a new revised 2015 edition: Taking Charge of Your Fertility, 20th Anniversary Edition: The Definitive Guide to Natural Birth Control, Pregnancy Achievement, and Reproductive Health.

taking-charge-of-your-fertility

What about you? Do you consider birth control more acceptable than other medications? Are you or were you on birth control and an antidepressant? And do you/did you feel that the birth control affected your mood and contributed to your depression or anxiety?

Or did it improve your symptoms (some women do report a better mood)?

Have you considered or used FAM as an alternative method of birth control? (or pregnancy achievement?)

Have you been offered birth control because of heavy periods or PMS? There are better ways to deal with this and one approach would be to address low serotonin levels with tryptophan.

If you’re in menopause and have no need for this information, please pass it on to your daughters and grand-daughters, nieces, sisters and girlfriends.