NBMI Archives - everywomanover29 blog

Professor Boyd Haley set out to find a safe and non-toxic heavy metal chelator that would cross the blood-brain barrier, get inside the cells and bind mercury. The compound was initially sold as an antioxidant called OSR and is now called NBMI. In 2018 I wrote a blog about this – Mercury detox: NBMI as a safe and non-toxic heavy metal chelator. At the time NBMI was in phase 2 clinical trials. The blog was a popular one then and still gets many comments and requests for updates. Today I’m sharing some updates on progress, new studies and proposed new applications. I still find NBMI intriguing and look forward to it being readily available once the studies are completed.

The recent newsletter from EmeraMed, reports that their projects are all running according to plan (despite coronavirus setbacks) and “producing the anticipated positive results necessary to bring our drug to market. When we complete the studies requested last year by the FDA, EmeraMed will file a new drug application (NDA), which then starts the FDA approval process.”

Studies on metal binding have shown that NBMI is strongly attracted to mercury, arsenic, lead, cadmium, uranium, gadolinium [used as a contrast agent in MRIs] and free iron and copper.

EmeraMed are expanding the clinical trials to look at other disorders that NBMI can potentially improve. These updates were shared in the newsletter:

The Colombian drug regulatory agency INVIMA approved a trial for mercury intoxication in May 2020:

…mercury intoxication and kidney disease are a serious life-threatening intractable condition and prominent in Colombia

…mercury from fish in the Santa Margareta river is one potential source for kidney injury leading to dialysis treatment. It will be a double-blind placebo controlled pivotal study, the participants health and results will be carefully monitored.

The treatment will be much longer than our earlier trials with gold miners and will look at numerous physiological parameters.

There are two pilot studies on iron overload in Europe:

Excess iron causes many devastating disorders, some lethal. Atypical Parkinson, an always fatal disease, is partially finished.

We expect to receive an interim report by July 2020 on a Thalassemia study that shows a highly significant benefit from NBMI. 8 out of 8 improved without any reported drug induce toxic side effects. “Impressive” in the words of one reviewer.

A potential use for COVID-19 based on NBMI increasing glutathione levels:

The mechanism of action is based on the ability of Emeramide to: 1; enter cells and cross the blood brain barrier, 2; scavenge and remove existing hydroxyl free radicals lowering oxidative stress and 3; chelate into non-reactive and non-toxic complexes several toxic metals and most importantly Fe2+ a redox metal that has been proposed to be displaced from hemoglobin by the COVID-19 infection.

We know NBMI would help because viruses need to release free iron to be able to reproduce. That iron causes oxidative stress possibly leading to a cytokine storm.

Another potential application is environmental clean-up of rivers, lakes and streams:

Arsenic (As) in drinking water is a well-recognized problem but since it is very difficult to remove, EPA maximum drinking water standard allows drinking water to have arsenic levels that cause significant amounts of bladder and lung cancers.

And one more potential application is the improved “treatment of waste-water sewer sludge to remove mercury or other toxic metals before it is spread on farms.”

Here is the mercury feasibility trial mentioned in the newsletter: Efficacy of N,N’bis-(2-mercaptoethyl) Isophthalamide on Mercury Intoxication: A Randomized Controlled Trial, where NBMI was given to 36 gold miners with high levels of mercury in their urine:

Although this study was designed with a small sample size to test for feasibility, the gained results with 300 mg NBMI already showed an effect on physical fatigue with statistical significance and there were indications to positive effects on other symptoms, like sleeping problems.

The newsletter link above has information about which countries are allowing early access. Please contact the company directly rather than ask me about how to obtain the product as I am simply sharing what they have shared with me. I also encourage you to sign up for EmeraMed’s newsletter so you can keep up to date with progress and access information.

I find it intriguing and look forward to it being readily available once the studies are completed.

Please share if you used the original OSR product with any success or if you have managed to obtain NBMI and trial it?

And feel free to post your questions for Professor Boyd Haley. I’m hoping to have him speak on Anxiety Summit 6: Toxins/Meds/Infections.

Mercury toxicity is a big issue when it comes to anxiety. Detoxification of mercury can be a complex process and is often controversial. I recently had the opportunity to hear Professor Boyd Haley’s interview on the Heavy Metals Summit where he addresses all this so well and shares some cutting-edge information. I was really quite blown away with what I learned.

Effective Mercury Detoxification Strategies is covered by Professor Haley, a researcher I have been following for years. He is interviewed by one of the summit hosts, Dr. Dietrich Klinghardt who asks brilliant questions. Be prepared for deep questions and some pretty technical feedback.

Professor Haley shares this about mercury amalgams in the mouth and iron that is displaced:

mercury vapor can penetrate any part of the body it wants. Mercury would rather be in fatty tissues, and that makes the brain a prime target. Plus, you can take it in through the axonal nerves… from the nasal cavity up into the brain. And if you breathe it, it gets into the body and it travels, basically penetrating every cell or any membrane.

When mercury is converted from Hg0 [elemental mercury] to Hg2+ [inorganic mercury] it displaces iron from iron sulfur centers in the brain. And that iron is now free, and iron is a very potent oxidative stress inducer…that’s associated with Alzheimer’s disease and other neurological illnesses [such as anxiety].

He talks about the synergistic effect of aluminum and mercury, and offers that the DMPS challenge test does show mercury body burden but isn’t good enough for reducing body burden, and that both DMPS and DMSA can make some people sicker and affect their kidneys. This has always been one of my concerns with this approach. I shared how I reacted badly to DMPS in my anxiety summit interview with Dr. John Dempster.

Professor Haley then shares how he set out to find a safe and non-toxic heavy metal chelator that would cross the blood-brain barrier, get inside the cells and bind the mercury. The compound was initially sold as an antioxidant (as OSR), is now called NBMI and is in phase 2 clinical trials:

It was sold for a long time, and called OSR, Oxidative Stress Relief. And now, it’s called NBMI…it takes a carboxybenzoate which is found in berries and couples to the carboxyl groups cystamine which is cysteine without the carboxyl group. And when you do that, you neutralize both of the charges, and you make an uncharged compound that has two sulfurs off two arms that can surround a mercury atom or any atom of any size.

And that compound is what we’re working on today. We’re now going into phase two studies. When we gave it to humans in a phase one study, the safety and pharmacokinetics, it was 60-80% absorbed into the blood. And we didn’t have one single adverse effect reported. It is the same thing we had when we sold it as a dietary antioxidant – this compound not only does it bind mercury, it is a very potent oxygen-radical scavenger, just like glutathione.

As of now this compound is only available in Switzerland and chelates any metal that binds sulfur – like mercury, lead, iron, cadmium, copper – all of which can increase anxiety when levels are high.

Dr. Klinghardt has been using it with success and feels Professor Haley deserves the Nobel Prize for his work! This is so promising because as you’ll hear in Dr. Klinghardt’s interview: Biophysics of Heavy Metal Detox (don’t miss this one either) heavy metal toxicity is at the root of most illnesses:

I found over the years that decreasing the body burden off metals, especially aluminum, lead, and mercury – if you can get that down – there is a point when we have been effective where all the vitality comes back.

I am so excited to share more as I learn more.

A good complement to the above two interviews is co-host, Dr. Christine Shaffer’s interview on Metal Allergies and Detoxing the Brain, where she shares much of what makes a detox successful. The discussion on how to get the brain’s glymphatic system working well is fascinating: sleep, melatonin (liposomal) and even GABA (also liposomal), looking at the vagus nerve and much more.

Update 7/10/20:

Here are updates on progress, new studies and proposed new applications – Mercury & gadolinium toxicity, iron overload, COVID-19: NBMI research update and potential applications.

The EmeraMed site has information about which countries are allowing early access. Please contact the company directly rather than ask me about how to obtain the product as I am simply sharing what they have shared with me. I also encourage you to sign up for EmeraMed’s newsletter so you can keep up to date with progress and access information.

I still find NBMI intriguing and look forward to it being readily available once the studies are completed. I’ll share again when I have additional information.