microbiome

Dr. David Perlmutter on The Role of Microbiome Diversity in Health and Disease

March 18, 2016 By Trudy Scott Leave a Comment

I had the distinct pleasure of hearing Dr. David Perlmutter present in person at the recent Integrative Healthcare Symposium. Dr. Perlmutter is a well-known neurologist and author of New York Times Bestsellers Grain Brain – The Surprising Truth About Wheat, Carbs, and Sugar – Your Brain’s Silent Killers and Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain – For Life

David-Perlmutter

As expected, his talk was riveting, and so I’d like to share some of it with you! He opened with this quote from Julian Davies, Professor Emeritus, Microbiology and Immunology, UBC, showing just how much we have yet to learn about the microbiome:

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Once the diversity of the microbial world is catalogued it will make astronomy look like a pitiful science.

There can be no doubt that modern behavior and dietary changes are altering the microbial ecology of humans. While some of these changes could be beneficial, others are disruptive and may be a driving force behind the rapidly increasing rates of chronic inflammatory diseases in developed countries. Common medical interventions, such as antibiotic therapy, have dramatically reduced infectious disease burdens worldwide. However, rather than being targeted strikes against harmful bacteria alone, such therapies can also act as weapons of mass microbial disruption.

You can find the full paper here: Ancient Human Microbiomes

We know how harmful artificial sweeteners are (Mira Dessy writes about these and other harmful ingredients in her book The Pantry Principle)but now we are seeing how they affect the microbiome and contribute to diabetes.

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In summary, our results suggest that NAS [non-caloric artificial sweeteners] consumption in both mice and humans enhances the risk of glucose intolerance and that these adverse metabolic effects are mediated by modulation of the composition and function of the microbiota. Notably, several of the bacterial taxa that changed following NAS consumption were previously associated with type 2 diabetes in humans, including over-representation of Bacteroides and under-representation of Clostridiales.

You can read the entire article in Nature: Artificial sweeteners induce glucose intolerance by altering the gut microbiota

You may have switched to artificial sweeteners because of sugar cravings and the desire to reduce sugar consumption. If this is the case, and you want to quit the artificial sweeteners and not go back to sugar, do check out this recent blog I wrote about diabetes and anxiety/cravings, and how the amino acid GABA was shown to:

increase islet hormonal secretion, suggesting potential therapeutic benefits for diabetes.

The GABA, will of course, also help with the cravings and quitting and not leave you feeling deprived, or needing to use willpower. You can read more on this topic here: GABA for ending sugar cravings (and anxiety and insomnia)

This paper in the Journal of Neuroinflammation shows us how connected the gut and the brain are:

Chronic intestinal inflammation suppresses hippocampal neurogenesis. Increased levels of proinflammatory cytokines have detrimental effects on proliferation of progenitors of neuronal lineage. Deficient hippocampal neurogenesis may underlie increased rate of mood disorder and cognitive impairment observed in IBD [inflammatory bowel disease] patients.

You can read the paper here: Chronic intestinal inflammation alters hippocampal neurogenesis.

This paper: Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance states that :

Celiac disease, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North America and Europe, where an estimated 5% of the population now suffers from it. Symptoms include nausea, diarrhea, skin rashes, macrocytic anemia and depression. It is a multifactorial disease associated with numerous nutritional deficiencies as well as reproductive issues and increased risk to thyroid disease, kidney failure and cancer. Here, we propose that glyphosate, the active ingredient in the herbicide, Roundup®, is the most important causal factor in this epidemic.

Glyphosate residues in wheat and other crops are likely increasing recently due to the growing practice of crop desiccation just prior to the harvest.

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It discusses how glyphosate can cause the following:

Changes in microbiome
Impairment of cytochrome P450 enzymes (detoxification)
Compromises in D3 activation, maintaining bile acid
Chelation of iron, cobalt, molybdenum and copper
Depletion of tryptophan, tyrosine, methionine and selenomethionine

All of these factors can have a direct impact on your anxiety and depression levels. Dr. Perlmutter also discussed how glyphosate affects the shikimate pathway and in turn impacts our microbiome causing mood issues and anxiety.

Jeffrey Smith, non-GMO advocate, founder of Institute for Responsible Technology also talks about this on our Anxiety Summit interview: Anxiety, depression, GMOs and Roundup

Roundup shuts down this pathway called the shikimate pathway. Monsanto bragged up-and-down because Roundup blocks the shikimate pathway in order to kill weeds. And because humans don’t have the shikimate pathway, they said Roundup must be safe for humans. But it’s not safe for a lot of reasons.

It’s an endocrine disruptor. It can promote cancer. It’s linked to heart disease and diabetes. But what they failed to point out was that the shikimate pathway is what our gut bacteria use to produce the vast majority of the l-tryptophan that we assimilate. L-tryptophan is a precursor to melatonin, which is linked to sleep and circadian rhythms, daily cycles, but it’s also a precursor to serotonin and now we land squarely on the world of anxiety. Without sufficient serotonin there can be anxiety and depression.

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And now for a little fun! My book The Antianxiety Food Solution was on sale at the event, as was my colleague Julie Matthews’ book Nourishing Hope for Autism. After purchasing my signed copy of Brain Maker and “staged” it at the book table next to our books!

I have to admit it did give me a little thrill to see our books next to Dr. Perlmutter’s brilliant book and another great brain book Why Isn’t My Brain Working by Datis Kharrazian. The other book in the picture is a brand new book on prostate health by Dr. Geo Espinoza: Thrive Don’t Only Survive.

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The other thrill was actually meeting a hero of mine! I heard his excellent presentation on the first day of the conference and then bumped in to him and his wife in one of the exhibit halls. I thanked him for his brilliance and asked if I could get a photo with him and he kindly obliged.

A bigger thrill and honor would be able to interview him on my next Anxiety Summit, now planned for June, so I can share his brilliance with you!

In the meantime, I encourage you to check out his great blog and get a copy of Brain Maker, so you can learn from this great man and feel your absolute best!

Got questions? Feedback? Please post them in the comments.

Microbiome & your mood! Don’t miss Microbiome Medicine Summit

February 24, 2016 By Trudy Scott 6 Comments

The trillions of organisms (known collectively as the microbiome) that live all over your body have a profound influence on your health. Understanding your microbiome is vitally important if you suffer from chronic diseases of the heart and digestive system, autoimmune disease, diabetes, thyroid disorders, anxiety and depression and more. The Microbiome Medicine Summit runs February 29 – March 7 and the line-up of speakers and topics is stellar!

Learn more and register here: https://qt247.isrefer.com/go/BIOME16reg/trudyscottcn/

Here are just some of the great speakers:

Aviva Romm, MD: “Connecting Women’s Health and Your Microbiome.” Dr. Romm is the author of many wonderful books on natural health for women, one of which is WomanWise. She shares:

And so we know that right now in the United States, 34% of all women are going to have a C-section. And not only that, every mom who gets a C-section also gets an antibiotic. So those babies are getting the double whammy. They’re not getting exposed to the vaginal flora and mom’s breast milk is getting affected by the antibiotic. And baby is getting some of that antibiotic. So they’re getting an antibiotic exposure, and not getting the microbiome exposure. And then a whole other percentage of babies, maybe as much as 30% of babies on top of that, are getting exposure to an antibiotic all during labor or through mom because mom is positive with something called Group B strep. And so we give the mom an antibiotic to prevent her from passing this potentially serious infection on to the baby. So anywhere from 30% to 40% of babies in the United States are being born with an antibiotic exposure or absence of that good healthy immune education.

Natasha Campbell-McBride, MD: “The Relationship Between Gut Health, Mental Disorders and Mental Clarity.” Dr. Campbell-McBride is well-known for her book and program The Gut and Psychology Syndrome and the GAPS diet that benefits so many with anxiety and depression and other mood issues.

And the summit host, Raphael Kellman, MD, who created The Microbiome Medicine Summit to present ground-breaking information and a whole new perspective that could help you improve your emotional and physical wellbeing! His book is The Microbiome Diet and his talk is called “The Microbiome: The Next Revolution in Modern Medicine.”

He shares this fascinating information:

The microbiome is the community of trillions of bacteria that live in your digestive tract and elsewhere throughout your body. Collectively weighing about three pounds — the same weight as our brain — these bacteria outnumber our human cells by a factor of about 9 to 1. I jokingly tell my patients that I might look like a human, but I am really just “bacteria in a suit.” Each of us is literally more bacteria than human.

Not only do our bacteria outnumber us, their genes outnumber our genes — by a factor of 150 to 1. In many ways, their genes have more of an influence over our day-to-day life than our own genes do.

When your microbiome is balanced, you have a terrific ally that keeps your body healthy, promoting good digestion, clear thinking, balanced mood, and glowing overall health. When your microbiome goes out of balance, however, you risk such symptoms as brain fog, depression, anxiety, bad skin and insomnia — and, down the road, obesity, diabetes, and cancer.

I’m not speaking on this summit but will be listening and learning along with you. Learn more and register here:
https://qt247.isrefer.com/go/BIOME16reg/trudyscottcn/

PS. I’m actually in New York city at the moment and get to hear Dr. Aviva Romm live at the Integrative Health Symposium. But when you sign up for this summit you get to hear her in the comfort of your own home! Enjoy the summit and don’t forget to share with a loved one or friend who may benefit from this too.
https://qt247.isrefer.com/go/BIOME16reg/trudyscottcn/

PPS. It starts Monday next week!

Healing Anxiety through the Gut on the Heal Your Gut Summit

December 28, 2015 By Trudy Scott 8 Comments

Gut dysfunction can be linked to virtually every disease and can cause conditions like autoimmunity, fatigue, depression, anxiety and panic attacks, food sensitivities, chronic pain, allergies and many more. These conditions are by and large preventable.

Gut issues and anxiety often go hand-in hand and my interview addresses Healing Anxiety through the Gut:

Can you relate to the following phrases? “I have butterflies in my stomach,” “I can feel it in my gut,” or “I just have this awful feeling in the pit of my stomach.” These aren’t just figures of speech.

It can be difficult to assess which came first. Is the anxiety affecting your digestion, or did poor digestion lead to anxiety or make anxiety worse? Sometimes it’s a mixture of both, and both need to be addressed.

Digestive disorders are very common in the United States. Over a third of all adults are affected by some kind of digestive disorder, and each year forty-five million people visit the doctor for reflux, constipation, irritable bowel syndrome (IBS), liver disease, and other digestive complaints.

Studies have found that people with digestive complaints such IBS, food allergies and sensitivities, small intestinal bacterial overgrowth and ulcerative colitis frequently suffer from anxiety and also depression too.

One study found that 50 to 90 percent of people with IBS who visited a doctor for treatment also suffered from various anxiety disorders (panic disorder, generalized anxiety disorder, social phobia, and post-traumatic stress disorder) and major depression.

There are many factors that can be considered when it comes to anxiety and gut health: the microbiome and psychobiotics (or good bacteria), low serotonin and an amino acid like tryptophan, low levels of stomach acid, low zinc, food sensitivities and much more.

Join us for this fabulous upcoming online event that is being hosted by 3 of my favorite people: Dr. Josh Axe, who specializes in functional medicine and is on a mission to transform the health of millions all across the world; Donna Gates, the international best-selling author of The Body Ecology Diet and Dr. Eric L. Zielinski, a sought-after natural health educator, motivational speaker and author, and host of the well-known Essential Oils Summit.

I’m honored to have been invited to present with this excellent line-up of speakers that include:

Josh Axe, DNM, DC, CNS: 5 Steps to Heal Leaky Gut
Leo Galland, MD: Why Allergies Could Be Signaling Bigger Problems
David Perlmutter, MD: Heal Your Gut by Going Grain Free
Ty Bollinger: Boost Immunity with Gut-Immune-Cancer Connection

Here are some of the great speakers who I’ll be presenting with on day 5 of the summit:

I hope you can join us! You can register here https://ju127.isrefer.com/go/healyourgutreg/trudyscottcn/

Genome Meets Microbiome by Dr. Robert Rountree at IFM

June 5, 2015 By Trudy Scott 10 Comments

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I’m going to share some gems from one of my favorite talks at the annual IFM conference The Omics Revolution – Nature and Nurture. It was a talk by Dr. Robert Rountree and was called “Genome Meets Microbiome” and he opens with this great slide that paints an incredible picture:

Humans are like mobile warm-blooded coral reefs, home to vast numbers of microbial ecosystems that are rich in biodiversity

Dr. Rountree shared how humans have more than 100 trillion microbiota, outnumbering human cells by 10:1. And he shared this great quote from Dr. Martin J Blaser, MD’s 2014 paper:

It is reasonable to propose that the composition of the microbiome and its activities are involved in most, if not all, of the biological processes that constitute human health and disease

Here are some other gems from the talk:

Disease-specific alterations in the enteric virome in inflammatory bowel disease (such as Crohn’s disease and ulcerative colitis) and how changes in the virome may contribute to intestinal inflammation and dysbiosis
Methanogens in human health and disease Evidence has linked overabundance of methanogens to constipation and IBS, influencing intestinal transit and pH. These methanogens ensure more complete fermentation of carbohydrates, leading to higher production and absorption of SCFAs (short chain fatty acids), which may lead to obesity
The emerging world of the fungal microbiome or the mycobiome “Early-stage studies show interactions between the mycobiome and other microbes, with host physiology, and in pathogenic and mutualistic phenotypes. Current research portends a vital role for the mycobiome in human health and disease.”

So we have the microbiome, the virome, methanogens and the mycobiome! (and so much more)

He closes with this:

Alteration of the microbiome by our modern lifestyle (diet, stress, excessive hygiene and antibiotics) may be responsible for many chronic diseases [my addition: including anxiety and depression]

When I arrived in Austin I headed to the local Whole Foods to stock up on travel food (like I always do) and found some probiotic-rich foods that are made right in Austin. Now I can highly recommend this fabulous sauerkraut and fermented carrots from Hat Creek Pickles. I munched on this yummy food (and sardines, boiled eggs, grass-fed beef jerky, pemmican and fruit) all weekend! I even brought what was left of the the sauerkraut home!

Raw, local, organic, delish!!!! and oh so pretty too.

sauerkraut and fermented carrots — Sauerkraut and fermented carrots

Happy gut means happy Trudy! How are you looking after your gut?

The Anxiety Summit – Sauerkraut for Gut Healing and Reducing Anxiety

May 8, 2015 By Trudy Scott 36 Comments

Summer Bock, Master Fermentationist, was interviewed on the Anxiety Summit by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

Sauerkraut for Gut Healing and Reducing Anxiety

Summer’s journey and recovery from allergies, gut problems, anxiety and panic attacks, and how fermented foods turned things round for her
The good bacteria we get from fermented foods: psychobiotics and anxiety
Sauerkraut: a “promising nutraceutical for the treatment of malnutrition-induced diseases” and how it helps with asthma, IBS and inflammatory bowel disease
The 3 categories of fermented foods: Functional Ferments, Increased Assimilation Ferments and Primarily Preservation Ferments
The history of kefir
How to buy sauerkraut in the store
How to make your own sauerkraut at home and why

Summer discovered that all the symptoms she was having (food and environmental allergies, anxiety and panic attacks, skin problems) were connected to her gut and that she needed probiotics.

With me being a herbalist and purist, I wanted to know how my ancestors did it. If I don’t have probiotics in my diet how do I get them? What is the whole food version of probiotics? It was when I discovered sauerkraut and kefir and all of these fermented foods and started including them in my diet, that’s when I started to see improvements in my health.

Sauerkraut is a whole food version of probiotics. The probiotics are one thing but raw (unpasteurized) sauerkraut also contains lactic acid which serves as a natural antibiotic.

I mentioned my season 2 interview with Dr. Ted Dinan, MD, PhD. Professor of Psychiatry at University College Cork: Microbes in the gut and psychobiotics as a potential treatment for anxiety and depression

we define a psychobiotic as a live organism that, when ingested in adequate amounts, produces a health benefit in patients suffering from psychiatric illness

This is Dr. Dinan’s most recent paper, published April this year: Gut Microbiota: The Conductor in the Orchestra of Immune-Neuroendocrine Communication

We discussed this paper at length: A MINI REVIEW ON THE MICROBIOCHEMICAL PROPERTIES OF SAUERKRAUT.

Healthy colons of humans contain some beneficial bacteria which feed on digestive wastes, thereby producing lactic acid. Without these beneficial bacteria, the digestive tracts become a thriving zone for pathogenic bacteria and yeasts, resulting in candidiasis. However, it is suggested that the consumption of lacto-fermented sauerkraut could help re-establish lactobacilli.

could be a promising nutraceutical for the treatment of malnutrition-induced diseases. Also, it could be suggested that the consumption of lacto-fermented sauerkraut could help reestablish lactobacilli-opportunistic infective agents equilibrium

lacto-fermented sauerkraut provides an array of lactobacilli probiotics, vitamin C, dietary folates, manganese and pyridoxine

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here: www.theAnxietySummit.com

Missed this interview or can’t listen live? Or want this and the other great interviews for your learning library? Purchase the MP3s or MP3s + transcripts and listen when it suits you.

You can find your purchasing options here: Anxiety Summit Season 1, Anxiety Summit Season 2, and Anxiety Summit Season 3.

The Anxiety Summit – New 2015 Food/Nutrient Research on Anxiety and Speaker Highlights

May 6, 2015 By Trudy Scott 107 Comments

The host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution opens up the Anxiety Summit Season 3.

New 2015 Food/Nutrient Research on Anxiety and Speaker Highlights

Nutritional medicine as mainstream in psychiatry
What if nutrients could treat mental illness?
The gut microbiome and diet in psychiatry, and the guts of remote Amazon dwellers
Dietary guidelines from Brazil, exercise, mindfulness, caffeine and social interaction
Preschoolers on Medicaid being prescribed psychotropic drugs and other medication news
Speaker highlights, gems and connections

“Nutritional Medicine as Mainstream in Psychiatry” published in January this year.

Psychiatry is at an important juncture, with the current pharmacologically focused model having achieved modest benefits in addressing the burden of poor mental health worldwide. Although the determinants of mental health are complex, the emerging and compelling evidence for nutrition as a crucial factor in the high prevalence and incidence of mental disorders suggests that diet is as important to psychiatry as it is to cardiology, endocrinology, and gastroenterology. Evidence is steadily growing for the relation between dietary quality (and potential nutritional deficiencies) and mental health, and for the select use of nutrient-based supplements to address deficiencies, or as monotherapies or augmentation therapies.

The abstract concludes as follows:

We present a viewpoint from an international collaboration of academics (members of the International Society for Nutritional Psychiatry Research), in which we provide a context and overview of the current evidence in this emerging field of research, and discuss the future direction. We advocate recognition of diet and nutrition as central determinants of both physical and mental health.

I blogged about this earlier this year and you can read more here

Here is part of “What if nutrients could treat mental illness?”

We are at a tipping point in psychiatry.

The growing body of literature on the effect of nutrients on mental health is compelling enough and consistent enough for us to pay attention. It is time to revisit the role of diet and supplementary nutrients in the treatment of mental illness and to invest in this line of research.

Here are the other studies I mentioned:

“A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood”

“Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis”

Here are 2014 dietary guidelines of Brazil What is your takeaway? who will you teach to cook? Will you take cooking lessons? Will you plan more family sit-down meals?

Here is the information on Preschoolers on Medicaid being prescribed psychotropic drugs – very disturbing and sad!

And here are all the speakers of Season 3 of The Anxiety Summit.

Here are some of the words from Top of the World

A new beginning, a brand new day
All of my fears are gone away
I feel so calm, so free, so whole
Right now, I’m feeling on top of the world

You’ll find the link to download the song on the replay page. Enjoy and share!

A few final words from me –

Please don’t tolerate how you feel
Don’t ever give up hope and keep looking for answers until you have zero anxiety – there may be one root cause, there may be many but you can end your anxiety!
Finally ….“You deserve to feel your absolute best, and can and should feel on top of the world – always!”

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here: www.theAnxietySummit.com

Missed this interview or can’t listen live? Or want this and the other great interviews for your learning library? Purchase the MP3s or MP3s + transcripts and listen when it suits you.

You can find your purchasing options here: Anxiety Summit Season 1, Anxiety Summit Season 2, and Anxiety Summit Season 3.