luteal phase

Drastic reduction in intrusive thoughts, anxiety and fears (and better sleep) with GABA, tryptophan, 5-HTP and the pyroluria protocol

May 6, 2022 By Trudy Scott 33 Comments

It’s not uncommon for an adult woman to have had intrusive thoughts her entire life and not even recognize that they are connected to her anxiety levels. She is often unaware that there is anything she can do to actually ease her anxiety and reduce the bad thoughts (such as fearing horrible things happening to her husband and children). Enter the amino acids: GABA, tryptophan, 5-HTP and the pyroluria protocol (zinc, vitamin B6 and evening primrose oil). They can do all of this and more. Kimberly shared her own experience and success on a blog post about intrusive thoughts and these specific nutrients. Here is her story in her own words:

Oh my goodness, I’m realizing after reading this, that intrusive thoughts are something I’ve had my entire life. As a child, this manifested in thoughts of what might happen to my one stable parent when we were apart. More recently, I feared horrible things happening to my husband or children. Like the author of the original blog wrote, these intrusive thoughts reflect a greater anxiety. But I didn’t realize this until I began experimenting with your protocols.

I first tried GABA when I felt extremely anxious, but not on a regular basis. Next, I added the pyroluria protocol, which did bring some relief to the intrusive thoughts. Fast forward to today, when I also take 5-HTP, tryptophan and GABA regularly and have noticed a drastic reduction in those thoughts/fears. It’s like a miracle.

My fear level is maybe 15% of what it used to be, if that.

I also find that I can use extra GABA at night if I wake up and can’t shut off my mind. It works like a charm to help me get back to sleep. What a blessing to have these amino acids.

I’m a calmer, more serene person than I’ve ever been, without (for the most part) the crippling, irrational fears I used to experience. Thank you, as always, Trudy. You are also a tremendous blessing.

I thanked her for sharing and said how glad I was that she is connecting more and more dots. It’s very common to suddenly realize you’ve had these intrusive thoughts your entire life. With her amazing results, combining all the above nutrients she is a poster child for this approach that I use with my clients. I’m thrilled for her miracle outcome and so very happy for her.

I’m sharing her story here as a new blog so I can provide her with some additional approaches to explore and so you can see how these amino acids and other nutrients have worked for someone else (and get your own insights.) I’m also sharing my feedback on how she approached things.

Additional approaches to her to explore: adjusting what is working for her now

Her fear level is maybe 15% of what it used to be but ideally we want to improve on that by fine-tuning what she is doing and capitalize on what is working. Know this – it’s not unreasonable to expect that to get to zero!

If we were working together this is what I’d suggest (assuming she hasn’t already done this):

Review the low GABA and low serotonin questionnaires and adjust the GABA and/or tryptophan/5-HTP based on any symptoms that remain with a score above zero.
After that, if there are still some troubling low serotonin symptoms experiment with different doses and timings of tryptophan and 5-HTP – some people do better on one vs the other
Also, if there are still some troubling low GABA symptoms, experiment with a few different GABA products. I’ve had folks try up to 5 different products before they find the perfect one for their needs
If she can see the social anxiety and other pyroluria signs remain, we’d adjust zinc, vitamin B6 (and possibly add P5P) and evening primrose oil.

With all of the above, I’d have her do one change at a time and carefully document everything in her food-mood log.

Identifying if the remaining fear/intrusive thoughts are more pronounced in the second half of her cycle

It may simply be a matter of identifying if the remaining fear/intrusive thoughts are more pronounced in the second half of her cycle i.e. after ovulation. As I shared on the blog, one study showed that “women in the ‘early luteal’ phase… had more than three times as many intrusive thoughts.”

She may need to adjust the amino acids up during this period and it may be that over the next 2 months she sees these symptoms resolve with her current approach, as her hormones become balanced. It’s typical to see this in 2-3 months.

My feedback on her approach

Here is my feedback on how she did things and why I love her approach:

She experimented with GABA some of the time – as needed – based on what she was learning from me from blogs, my book and interviews.
She made one change at a time, adding the pyroluria protocol next
Then she added tryptophan and 5-HTP (hopefully one at a time)
And then her use of the amino acids became regular. This last aspect of consistency is a needle mover for so many of my clients.
She now tweaks things and takes extra GABA at night if needed. This may be needed after a tough day or if you’ve been glutened or exposed to insecticides.

I will add that the sequence could have been varied and still have had a similar successful outcome, for example, amino acid consistency from day 1 and then adding the pyroluria protocol (this is what I typically do with clients).

However, it’s my goal to empower women like Kimberly to take charge, learn, make changes, listen to their bodies, learn some more and adjust to see further improvements. It makes me immensely happy when I hear that she is a calmer, more serene person than she’s ever been. I feel confident that she’ll be able to get to zero intrusive thoughts with the tips I shared above.

She may or may not also need to consider other possible root causes of intrusive thoughts: low magnesium, low iron, diet (a low carb/high fat intrusive thoughts case study) and gluten issues.

Psychiatric medication discontinuation syndrome, Lyme disease, mold toxicity, heavy metals, toxins, infections, TBI and trauma can also be factors with intrusive thoughts and anxiety, but with her huge improvement I’d suspect these root causes are unlikely for her.

Resources if you are new to using the amino acids and pyroluria supplements

If you are new to using GABA or tryptophan/5-HTP as a supplement, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the low GABA and low serotonin symptoms).

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, blood sugar control, sugar cravings, self-medicating with alcohol and more.

My book also has an entire chapter on pyroluria (with the protocol and questionnaire). The questionnaire is on the blog too, together with many other related posts (simply search for pyroluria).

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA Quickstart Program. This is a paid online/virtual group program where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Do you experience intrusive thoughts or did you have them in the past? Feel free to describe them if you feel comfortable doing so.

And did you think you’d be able to reduce the horrible intrusive thoughts with a nutritional approach?

What helped reduce them for you? If you used a similar approach, how did it look for you?

If you’re a practitioner, have you found this approach to help reduce intrusive thoughts and ease anxiety in your clients/patients?

If you have questions please share them here too.

Intrusive thoughts are a thing with anxiety: low GABA, low serotonin, pyroluria (low zinc & vitamin B6) and hormone imbalances as possible causes

February 4, 2022 By Trudy Scott 50 Comments

Intrusive thoughts are a thing with anxiety even though they are not often talked about. It’s for this reason I shared a link to an article on Facebook recently – “The Debilitating Anxiety Symptom No One Ever Talks About” – and the response was overwhelming. I promised to do a blog to do a deeper dive into this topic and share actual real-life examples of uncomfortable and unwanted intrusive thoughts that seemingly appear out of no-where when you have anxiety. And of course, I’m using these real-life examples to highlight some of the many biochemical root causes and nutritional solutions: low GABA, low serotonin, low zinc, low vitamin B6 (and pyroluria) and hormone imbalances. These root cause solutions are all backed by research and clinical results.

You’ll also discover that intrusive thoughts are more common than you’d expect and it’s not just you who experiences them.

Katelyn, author of the above article, shared this about her intrusive thoughts (and this is part of what I shared on Facebook):

As I gained more life experiences, my intrusive thoughts developed into other fears. Now that I was older, these thoughts turned into new scenarios, ones that felt more real. For example, when I started driving, I’d see myself veering off the road, hitting a side rail, flying off a ledge, or running head-on into a semi. I didn’t really want to do any of these things. I just wanted to get to my destination, but these thoughts would keep running through my mind, and I couldn’t stop them.

I did not realize intrusive thoughts were a ‘thing,’ and I thought this was just me

The Facebook post and article quickly resonated with many women with someone saying “I have never identified with an article more…wow.”

One woman said “I did not realize intrusive thoughts were a ‘thing,’ a symptom of something” and someone else said “I thought this was just me.”

Someone else responded: “I thought it was only me as well. I’ve had thoughts like this nearly my entire life.”

(You can read the entire article here: The Debilitating Anxiety Symptom No One Ever Talks About)

The purpose of this blog is to share actual feedback so you can see how varied these intrusive thoughts can be. And recognize that they are a thing and that you are not alone if you experience them.

And then use these cases to illustrate the variety of root causes (and solutions) and show how some of them are very interconnected: like zinc and vitamin B6 for pyroluria, for making GABA and serotonin, and also for hormone balance (more on that below).

A definition from The Anxiety and Depression Association of America

In case you need a definition: “Unwanted intrusive thoughts are stuck thoughts that cause great distress. They seem to come from out of nowhere, arrive with a whoosh, and cause a great deal of anxiety.

The content of unwanted intrusive thoughts often focuses on sexual or violent or socially unacceptable images. People who experience unwanted intrusive thoughts are afraid that they might commit the acts they picture in their mind. They also fear that the thoughts mean something terrible about them….

Unwanted intrusive thoughts can be very explicit, and many people are ashamed and worried about them, and therefore keep them secret.” ~ The Anxiety and Depression Association of America (ADAA).

The ADAA offers an excellent overview that is worth reading, but unfortunately they do not offer any of the nutritional solutions that we know can eliminate these uncomfortable intrusive thoughts.

GABA support with the amino acid GABA

Assessing for and addressing low GABA levels is the first place I start because you get results so quickly if low GABA is one of the root causes.

Jacqueline shared this on the Facebook post about intrusive thoughts: “GABA definitely helped me with this! Also meditation has helped me to learn to stay present. The two combined are helpful.”

Tiffany shares how Source Naturals GABA Calm helps her: “I have definitely noticed that sublingual GABA Calm that you suggest helps calm my overactive brain.”

Elicia offered this input about GABA on the seasonality of GABA blog and needing more in winter:

I use GABA Calm and usually take 1 or 2 a day. The past two days I’ve taken 4 because I suspected that I needed an increase.

I take it for physical anxiety, insomnia and intrusive thoughts. My symptoms had been worsening recently. The increased GABA seems to be helping.

Intrusive thoughts is one of the symptoms on the low GABA section of the Amino Acids Mood Questionnaire: “Have intrusive thoughts, perseverate or have an overactive brain or have unwanted thoughts – thoughts about unpleasant memories, images or worries.”

This is not in my book or on the original questionnaire but was added in 2017 based on new GABA research on intrusive thoughts. I blogged about this here: GABA helps with inhibition of unwanted thoughts (and have added more recent supporting research on the glutamate/GABA balance i.e. increased glutamatergic excitation and reduced GABAergic inhibition.)

Serotonin support with the amino acid 5-HTP (or tryptophan)

Assessing for and addressing low serotonin levels would be the next step for the same reason – you get results so quickly if low serotonin is one of the root causes.

Yosef shared this about his anxiety, panic and intrusive thoughts on the GABA blog on intrusive thoughts hoping low GABA might be his root cause, with GABA as a solution:

I have issues with intrusive thoughts that present daily challenges. On top of that, I have been living with anxiety and panic issues for so long that I have adjusted to the limitations (I work from home, order pretty much everything online and have a very tolerant wife). I’ve been trying mindfulness for the intrusive thoughts, but if GABA might help with that and the panic (and perhaps help me unlearn the agoraphobia) that would be awesome. Imagine being able to go on vacations with my wife!! I’m ordering some and will give it a shot.

About 6 weeks later he shared that he didn’t notice a drastic difference with GABA but that serotonin support did help. He used 5-HTP and shared these wonderful results after using it for only a week:

What did make a difference is 5-HTP (Now – 100mg). I’ve been using it for a week so far. It was recommended by Dr. Amen (the brain doctor) who says it is helpful with OCD, intrusive thoughts, and the like. You take it before going to sleep. It used to be that I had trouble falling asleep because of the “noise” in my head – random anxious thoughts, jumpiness. I would usually need to have something playing (podcast, music, anything) to help me fall asleep. So far, on 5-HTP I find it easier to fall asleep, I don’t have to search for the right podcast, etc. I just feel really tired and fall asleep.

He did a trial of GABA and then a trial of 5-HTP when GABA didn’t help. This is exactly what I would have done. Tryptophan is also an option when 5-HTP is not tolerated.

You’ll see intrusive thoughts listed as “Obsessive thoughts or behaviors” on the low serotonin section of the Amino Acids Mood Questionnaire

5-HTP and tryptophan are listed in this paper: Nutraceuticals in the treatment of obsessive compulsive disorder (OCD): a review of mechanistic and clinical evidence.

Low zinc and low vitamin B6 (and pyroluria)

Low zinc and low vitamin B6 is common with the social anxiety condition called pyroluria. Kez shared how addressing pyroluria/pyrrole disorder resolved her intrusive or ruminating thoughts:

I noticed after being diagnosed with pyrolle disorder that when I had been taking zinc and vitamin B6 supps for a couple of years, the ruminating thoughts left me and my head was peaceful.

Before starting on the zinc and vitamin B6, she described her intrusive thoughts as follows:

Everything would go around and around in my head, it never stopped. And if my son was a few minutes late home, I would picture him in an accident dead on the side of the road. All really negative stuff. When I realised it had stopped it was such a relief.

She confirmed that she didn’t use 5-HTP/tryptophan or GABA. However the pyroluria protocol helps with the production of GABA and serotonin, and also helps to balance sex hormones (more on that below).

You’ll see “Neurotransmitter imbalances, especially low serotonin” on the Pyroluria Questionnnaire.

In one study, Alterations of serum zinc, copper, manganese, iron, calcium, and magnesium concentrations and the complexity of interelement relations in patients with obsessive-compulsive disorder, patients with obsessive-compulsive disorder had low zinc, iron and magnesium.

In another study, Depressive Symptoms in Middle-Aged and Elderly Women Are Associated with a Low Intake of Vitamin B6: A Cross-Sectional Study, they looked at anxiety symptoms like “feeling tense, restless, or panicky; feeling something awful will happen; having worrying thoughts” and low vitamin B6.

Hormonal imbalances: more than 3 x the intrusive thoughts

In this study summary, Hormone levels may provide key to understanding psychological disorders in women, the authors share that “a common symptom of mood and anxiety problems is the tendency to experience repetitive and unwanted thoughts. These ‘intrusive thoughts’ often occur in the days and weeks after a stressful experience.” In this particular study the women watched a 14-minute stressful film containing death or injury and then salivary hormone levels were measured.

In this study “women in the ‘early luteal’ phase… had more than three times as many intrusive thoughts.” The luteal phase happens after ovulation i.e. about 16 to 20 days after the start of their period.

The authors conclude that “Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences.”

If your intrusive thoughts ramp up in the luteal phase it’s important to consider the role of hormone imbalances.

But keep in mind that the pyroluria protocol also helps to balance sex hormones. And that tryptophan and GABA help to balance hormones too: Tryptophan for PMS: premenstrual dysphoria, mood swings, tension, and irritability.

As I mentioned above, I typically like to start with addressing low serotonin and/or low GABA because the amino acids offer quick relief, and they give you time to dig deeper into other causes like hormonal imbalances. I also always consider pyroluria with anyone who is anxious so that’s high on the list too. We can see results in a week when we figure out the correct doses.

In part 2, I share one woman’s story of how a lifetime of horrible and bizarre intrusive thoughts were eliminated by a low carb/high fat diet (not as strict as keto).

Stay tuned for part 3 of this blog where I’ll address other possible root causes of intrusive thoughts: low magnesium, low iron, gluten issues, discontinuation syndrome, Lyme disease, mold toxicity, heavy metals, toxins, infections, TBI and trauma.

Resources if you are new to using GABA and 5-HTP/tryptophan as supplements

If you are new to using the the amino acids GABA or 5-HTP/tryptophan as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see the low GABA and other low neurotransmitter symptoms) and a brief overview here: Anxiety and targeted individual amino acid supplements: a summary.

If you suspect low levels of GABA or low serotonin and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids so you are knowledgeable. And be sure to share it with the team you or your loved one is working with.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the GABA products that I use with my individual clients and those in my group programs.

We appreciate Katelyn for writing the article I shared and everyone for being willing to share their stories so we can all learn and feel better.

Let’s change this and talk about intrusive thoughts so we don’t have to feel alone and so we can find solutions. As Katelyn says: “If you struggle with intrusive thoughts, share them. The more we share these experiences, the better we can understand ourselves and others and the more we can help one another. Know you are not alone.”

I’ll add this: and share your success with nutritional solutions when something works for you. Share it with your friends and your health practitioner.

Did you know intrusive thoughts are a ‘thing,’ or did you think it was just you?

Has any of the above helped you: GABA, 5-HTP or tryptophan, zinc and/or vitamin B6?

And have you observed more intrusive thoughts after ovulation and before your next period?

Feel free to ask your questions here too.

Tryptophan doesn’t work, then it does and then it doesn’t: could it be hormonal shifts, dietary factors and/or parasites?

November 26, 2021 By Trudy Scott 19 Comments

Have you been in a situation where tryptophan doesn’t work, then it does work, and then sometimes it doesn’t work as expected? There is a reasonable explanation as to why it may not work initially – too much or too little was used. The variable results and the need to switch between lower and higher doses on an ongoing basis can happen but it’s not very pronounced unless there is a specific reason. In this blog I cover some of these reasons – hormone shifts, dietary factors and parasites/other digestive issues.

I’m writing this blog in response to a question that was posted on one of my speaker pages on the Anxiety Summit: Gut-Brain Axis. This is the actual question:

I tried to use tryptophan the first time (whole capsule) and got really high. Some time later I tried again, but used 1/4 of a capsule and had a good result. A few weeks later 1/4 of the capsule didn’t work at night. So I went up to half a capsule. And that’s where I am now. But some nights (very rare) I can only get good results from a whole capsule. I use it along with the same amount of GABA. Is that a normal reaction for tryptophan?

I don’t know what brand of tryptophan she was using but assume 500mg was her starting dose and she now shifts between 125 mg (¼ capsule) and 250 mg (½ capsule) with variable results.

It’s not unusual for someone to not feel great on 500 mg if that dose is too much for their unique needs. She did the right thing by lowering her dose. It’s also reasonable that someone may find 500 mg as an initial dose isn’t enough to reduce symptoms.

The variable results and the need to switch between 125 mg and 250 mg can happen but it’s not very pronounced unless there is a specific reason. Some of these reasons include hormone shifts, dietary factors, parasites/other digestive issues, thyroid issues, low lithium, product quality and environmental factors. More on all this below.

Hormone shifts/more serotonin is needed in the luteal phase

I have my clients track when the variability happens, with female clients documenting their cycles. Some women need more serotonin support in the luteal phase i.e. after ovulation and right up to before their periods. Some may even need additional tryptophan for the first few days of their periods too.

Write about tryptophan working well in the luteal phase in this blog – Tryptophan for PMS: premenstrual dysphoria, mood swings, tension, and irritability

In a study published in 1999, A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria, tryptophan was found to reduce symptoms of PMS when used in the luteal phase or second half of the cycle (i.e. after ovulation):

37 patients with premenstrual dysphoric disorder were treated with L-tryptophan 6 g per day, and 34 were given placebo. The treatments were administered under double-blind conditions for 17 days, from the time of ovulation to the third day of menstruation, during three consecutive menstrual cycles.

They looked at dysphoria, which is defined as a state of unease or generalized dissatisfaction with life, plus mood swings, tension (and anxiety), and irritability and they found a 34.5% reduction of symptoms with tryptophan compared to 10.4% with placebo.

The paper concludes: “that these results suggest that increasing serotonin synthesis during the late luteal phase of the menstrual cycle has a beneficial effect in patients with premenstrual dysphoric disorder.”

It’s a small study but the results are powerful and it’s something I see clinically with my clients. The one big difference is that I typically have clients using tryptophan throughout the month.

But if you are seeing tryptophan work and then not work at similar times each month this is something to consider and track. And then if need be, increase and decrease tryptophan accordingly (and track again).

Dietary factors – collagen, gluten, sugar, wine and coffee

There are other factors to consider too and dietary impacts is one. For example, collagen leads to a higher need for tryptophan in susceptible individuals (due to it’s serotonin-lowering effects – I blog about this here)

Another dietary factor is accidental gluten exposure in susceptible individuals or a newly discovered gluten issue

High sugar intake, alcohol and/or caffeine consumption may also be a factor – contributing to added stress for the adrenals and depletions in zinc and the B vitamins. This can contribute to lowered serotonin and a need for a higher dose of tryptophan.

Now imagine if it’s just before her period and she adds collagen to her diet and she also eats out and gets zapped by gluten. Triple whammy for this woman!

And she goes to a party and happens to indulge in cocktails or wine, and then goes on a binge at the dessert table, followed by a few cups of coffee (or even one dessert and one cup of coffee).

A food-mood log really helps you figure things out. And then, if need be, increase and decrease tryptophan accordingly. And track again and address the dietary issues.

Parasites and other gut issues

If she has a very pronounced shift in symptoms for 4-5 days around a full moon each month – more severe insomnia, more anxious, more depressed – I would want to check for parasites.

I would also want to check for other digestion issues like dysbiosis, SIBO (small intestinal bacterial overgrowth), candida and liver health as they may all be factors. With SIBO and candida, dietary slip-ups may make symptoms worse right after the slip-up, for example increased bloating making sleep and anxiety worse.

Using tryptophan sublingually/opened on the tongue may bypass some of the digestive/liver issues until they are resolved.

As mentioned above, if need be, increase and decrease tryptophan accordingly. And track again and address the underlying issues.

Other factors to rule out – thyroid, lithium, environmental factors and the product

Two other underlying root causes we always want to rule out when we see variable results using tryptophan (and any of the amino acids) are Hashimoto’s thyroiditis (because we can have variable thyroid results – sometimes hypo/low and sometimes hyper/high) and low levels of lithium (because this can affect the results we see with all the amino acids).

And we always check environmental factors like mold, EMFs and outside stresses. And look for infections like Lyme disease or EBV. If the basics are not unearthing the solution we continue to dig deeper and do a full functional medicine workup. And adjust the tryptophan as needed.

And finally the quality of the product is key. I find Lidtke Tryptophan to be better than many other brands. I’ve also had many clients switch to Lidtke tryptophan and see better results and often need a lower dose.

Resources if you are new to using tryptophan and the amino acids as supplements

If you are new to using the amino acids tryptophan/5-HTP and the other amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see the low serotonin symptoms here) and a brief overview here, Anxiety and targeted individual amino acid supplements: a summary.

If you suspect low serotonin or low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids so you are knowledgeable. And be sure to share it with the team you or your loved one is working with.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acid products that I use with my individual clients and those in my group programs.

I always appreciate good questions like this and hope this feedback has helped her and you too if you’ve experienced something like this (or if you do in the future). In case you’re wondering, this question was posted after someone tuned into my interview, “GABA & Tryptophan: Gut-Anxiety Connections” on the Anxiety Summit 5: Gut-Brain Axis.

Have you had a variable response to tryptophan (or 5-HTP) and can you relate to any of this?

What did you figure out to be the reason?

Feel free to ask your questions here too.