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Are adrenal issues causing your anxiety? Highlights from the book: Adrenal Transformation Protocol by Izabella Wentz PharmD

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adrenal transformation protocol

This is a guest post from my friend and colleague, Dr. Izabella Wentz, who just came out with her latest book, Adrenal Transformation Protocol (my Amazon link). The book is focused on healing your adrenals, and in it she shares specific strategies to support anxiety. Izabella shares a few of the many strategies with you here in this guest post.

You’ll notice that we share many common approaches:

  • Addressing low blood sugar (much more on that below)
  • Caffeine intake: Izabella recommends reducing caffeine but I have found many folks in my community need to quit altogether. I have noticed that those with panic disorders experience increases in symptoms such as nervousness, fear, nausea, heart palpitations, and tremors after consuming caffeine and said the effects were similar to how they felt during a panic attack.
  • Gluten elimination: Interestingly, I have found in my clinical experience and research that there is a connection between gluten and anxiety, social phobia, depression, and even schizophrenia.
  • Using herbal adaptogens, addressing nutrient deficiencies, and even pyroluria which can deplete key nutrients needed for adrenal health (especially when under high amounts of stress).

All of her approaches focus on adrenal health specifically and she has now taken over 3000 people on an adrenal healing journey. And 86% of them reported that their anxiety improved after going through her protocol.

By Dr. Izabella Wentz. PharmD

Stress is at the root cause of many chronic health issues, and very well may be at the root of your anxiety, too. Chronic stress can put a burden on our adrenal glands, resulting in an excess of stress hormones like cortisol. The body’s repeated exposure to cortisol can result in increased blood sugar levels, increased heart rate, and increased blood pressure, all of which can lead to feelings of anxiety.

The adrenals are two small glands, located on top of each kidney, that release hormones such as cortisol and adrenaline. Adrenal dysfunction generally occurs when your hypothalamic-pituitary-adrenal (HPA) axis is unable to effectively manage your stress response. The HPA axis describes the interactive feedback loop that takes place among these three endocrine, or hormone-producing, glands. If the communication among these three breaks down, your adrenals and their ability to produce important essential hormones can be jeopardized.

Overactive adrenals can leave you feeling like you’re constantly in “fight or flight” mode. First, your body releases high levels of stress chemicals like adrenaline and cortisol. To ensure you’re ready to defend yourself or run, these chemicals spike your blood sugar, as well as increase heart rate, blood pressure, and insulin levels – making you feel anxious, stressed and wide awake at night.

Chronic stress is one of the most common causes of adrenal dysfunction. Our bodies are well-equipped to respond to acute stressors (like being chased by a bear or getting out of the way of an oncoming car), where we experience activation of the fight-or-flight response, followed by a return to the rest-and-digest state.

However, many of us today face a never-ending presence of stressful, yet non-life-threatening, situations that can lead to the constant activation of the stress response.

With enough chronic stress, the HPA axis becomes overwhelmed and desensitized to the usual feedback loop, and stops sending messages to the adrenals to produce more hormones or less hormones, no matter what’s happening.[1]

Other common causes of adrenal dysfunction include sleep deprivation, blood sugar dysregulation, and chronic inflammation (which are all forms of stress on the body).

Symptoms of poor adrenal function may include the following:

  • Feeling overwhelmed
  • Feeling anxious
  • Feeling tired despite adequate sleep
  • Trouble falling asleep or trouble staying asleep
  • Difficulty getting up in the morning
  • Dependency on caffeine
  • Cravings for salty foods (a.k.a. the “I just ate a whole bag of chips” syndrome)
  • Cravings for sweet foods
  • Increased effort required for everyday activities
  • Intolerance to exercise
  • Low blood pressure
  • Feeling faint/dizzy when getting up quickly
  • Easily startled
  • Mental fog or trouble concentrating
  • Alternating diarrhea/constipation
  • Low blood sugar (often presenting as feeling angry when hungry or, as I like to call it, “hangry”)
  • Decreased sex drive
  • Decreased ability to handle stress
  • Longer healing time
  • Mild depression
  • Less enjoyment in life
  • Feeling worse after skipping meals
  • Increased premenstrual syndrome (PMS)
  • Reduced ability to make decisions
  • Reduced productivity
  • Poor memory

If you have three or more of these symptoms, and if these symptoms developed after experiencing a period of acute or chronic stress, sleep deprivation, an infection, or toxic exposure, chances are that you have adrenal dysfunction.

The anxiety adrenal connection

Anxiety is a hallmark symptom of adrenal dysfunction. When the adrenals are compromised, your resilience to stress starts to go down, and you might start to feel more anxious.

Of course, anxiety and adrenal dysfunction run on a two-way street. Chronic stress and anxiety can tax the adrenals, and weakened adrenals can contribute to feelings of anxiety.[2]

There’s another connection here that I’d like to highlight, and that is the thyroid. The thyroid is impacted by adrenal function, and anxiety can also be connected to thyroid conditions. In fact, I’ve noticed that up to 50 percent of my clients with anxiety have Hashimoto’s, an autoimmune thyroid condition.

A 2004 study found an association between the presence of a mood or anxiety disorder, and the presence of anti-TPO antibodies (indicating Hashimoto’s).[3] It also noted that a slight reduction in thyroid hormone secretion (such as that found in subclinical hypothyroidism) may affect mood as well. Therefore, it’s also possible that the anxiety you are feeling is related to your thyroid.

Anxiety solutions: Use the ABC’s

One of the first places to start is with the ABCs of adrenal health – adaptogens, B vitamins, and vitamin C.

Adaptogens both tone down overactive systems and boost underactive systems in the body, and are thought to help normalize the HPA axis. Examples of adaptogenic herbs that may increase the body’s ability to resist stress include: ashwagandha, astragalus, reishi mushroom, dang shen, eleuthero, ginseng, jiaogulan, licorice, maca, schisandra, spikenard, and suma.

Ashwagandha in particular is helpful for stress and anxiety, and it can also support thyroid health. Research supports that ashwagandha may offer antidepressant, antioxidant, anti-inflammatory and neuroprotective benefits.[4] It also may reduce anxiety, improve sleep, and even help address sexual dysfunction in women.[5]

Rhodiola is another favorite for stress support, mood support, and improved sleep. Sometimes referred to as golden root, rhodiola focuses on our nervous system health. Izabella has found it to be helpful for those with depressed cortisol levels (which can happen in later stages of adrenal dysfunction).

One of the main chemicals in rhodiola is salidroside, found to have neuroprotective effects that reduce the impact of stress on the immune system and the neuro-endocrine system.[6] Studies have found an anti-fatigue effect along with cognitive function improvements, such as memory improvements (during stressful conditions), and it’s also been shown to diminish depressive symptoms.[7]

B vitamins and vitamin C tend to be depleted during times of stress and high cortisol production. In particular, deficiencies in pantothenic acid and biotin (vitamins in the “B” family), have been linked to decreased adrenal function in animals and humans.[8]

Vitamin C is an important antioxidant that helps support the adrenals, mitochondria, collagen production, and immune function.[9] It’s also needed for the production of cortisol.

Supplementing with the ABCs is a really good place to start if you’re experiencing anxiety or adrenal dysfunction.

Balancing blood sugar

One of the most important strategies to reduce your anxiety involves addressing blood sugar issues. Blood sugar swings can put us on an emotional rollercoaster.

After consuming carbohydrate-rich foods, some people find their blood sugar goes up too high, too quickly.

This leads to a rapid, sometimes excessive release of insulin (a hormone that regulates blood sugar levels). These insulin surges can cause low blood sugar, which can cause unpleasant symptoms such as anxiety, nervousness, lightheadedness, fatigue, excessive hunger, and “hanger”.[10]

You can balance your blood sugar by reducing your intake of carbohydrates, and increasing your protein and fat intake. A low-carb or ketogenic diet (a low-carb diet where the body breaks down fats for fuel instead of relying on carbohydrates) could be beneficial for some.

Starting the day off by having a breakfast that is filled with good fats (for example, avocado or coconut milk), as well as a good source of protein, while limiting your intake of sugars (even from fruit). Some options include eggs with avocados, burger patties, or protein and fat-based smoothies. In addition to a good breakfast, eating frequent protein and fat-containing meals and snacks, help to balance your blood sugar throughout the day.

Eat on a schedule to avoid getting “Hangry”

It’s ideal to eat every two to three hours, and avoid high carbohydrate foods, to support balanced blood sugar. This will also help with energy levels, feelings of anxiety, and “hanger”. A typical day would look like this:

  • Start the day with an energizing Adrenal Kick Start (recipe is in the book), followed by a blood-sugar-balancing breakfast smoothie.
  • A mid-morning snack/caffeine-free latte/tea/green juice to help with blood sugar, hunger, hormones, and energy levels.
  • A nourishing and balancing midday lunch.
  • Another snack/caffeine-free latte/tea/green juice two to three hours later.
  • An easy-to-digest dinner is scheduled for the early evening to set up for restful sleep.
  • An optional after dinner snack or tea, to support restful sleep through stable blood sugar levels at night.

Reduce (and ideally eliminate) caffeine

If you’re currently drinking coffee, soda, green tea, or black tea, removing or reducing your intake of caffeine can be helpful for an immediate reduction in anxiety, and is supportive over time to your adrenals.

Some people who are slow metabolizers of caffeine and do not clear it effectively out of their body may not be able to have any caffeine at all – not even chocolate! Others who are fast metabolizers and are able to clear caffeine more quickly from their bodies, may be able to tolerate more daily caffeine without it impacting their anxiety levels.

Regardless of your genes and metabolism of caffeine, the weaker your adrenals and the more unbalanced your blood sugar levels are, the more likely you are to experience anxiety from caffeine. This is because caffeine forces more glucose to be produced by the liver, sending the body on a blood sugar rollercoaster that can trigger anxiety.

If you’re thinking about reducing your caffeine intake, do it gradually over time, instead of quitting cold-turkey, which can cause withdrawal symptoms such as headaches, fatigue and even vomiting.

There are ways to improve energy levels and sleep before trying to get off caffeine, such as supporting your mitochondria and tuning into the circadian rhythm.

[Trudy’s note: be sure to read my comment above about the need to eliminate caffeine altogether in many instances]

Address low magnesium

Research suggests that a magnesium deficiency may be associated with anxiety. Several studies have found that feelings of fear and panic can be greatly reduced with an increased magnesium intake.[11] It has even been shown to have a positive effect on both post-traumatic anxiety and premenstrual anxiety, as well.[12]

Even more interesting, is the understanding that magnesium also controls the hypothalamic-pituitary-adrenocortical (HPA) axis, which is the hub of the body’s stress response system.[13] This could provide some explanation as to why a magnesium deficiency could lead to increased stress and anxiety when the HPA axis is out of balance. Other signs of a magnesium deficiency include headaches, insomnia, constipation, and menstrual cramps.

A magnesium supplement throughout the day may help, or at bedtime if you have insomnia or a racing mind when you’re trying to fall asleep. The citrate version is best if you tend to be constipated (magnesium citrate has stool softening effects), and I recommend the glycinate version if you tend to have normal bowel movements or diarrhea. Keep in mind that, for some people, magnesium glycinate can worsen anxiety symptoms. If you notice that your anxiety increases after taking magnesium glycinate, try switching to magnesium citrate.

Remove reactive foods

The most common food reactions responsible for anxiety symptoms are due to gluten, dairy, soy, grains (especially corn), sugar, caffeine (as discussed above), and surprisingly to some, nuts.[14]

Doing targeted food sensitivity testing, or simply a trial of eliminating the suspect foods for a period of time (with an elimination diet), can help you uncover your food triggers.

If anxiety is not resolved using the strategies above, there are many advanced strategies for anxiety support, and the book provides plenty of information and options for testing.

Address copper toxicity

A toxic buildup of copper may be at the root of anxiety, racing thoughts, mood swings, fatigue, and insomnia.[15] High-copper foods include shellfish, oysters, nuts, seeds, and chocolate. We can also absorb copper from our water and metal pipes and products. Certain medications (oral contraceptives, antacids, copper-rich multivitamins), excess estrogen, copper IUDs, and zinc deficiency can increase our exposure. Many people with adrenal dysfunction have a congested liver, so that is likely one reason copper toxicity is a common root cause.

Reducing copper containing foods, and increase zinc containing foods (non-organ meats, eggs, poultry).

Balance thyroid hormones

Having an excess amount of thyroid hormone can make us extremely anxious, irritable and on edge. This is commonly attributed to Graves’ disease, but can also occur in Hashimoto’s. The ideal TSH for most people is between 0.5-2 μIU/mL. Levels that are too high or too low indicate an imbalance of thyroid hormone levels and have been associated with various symptoms, including anxiety. Work with your doctor to test your thyroid and adjust medication if needed.

Address female hormone imbalances

Estrogen dominance and/or low progesterone may lead to many symptoms like irritability, mood lability, depression, and mood swings.[16] If tests reveal low progesterone, supplementing with oral or topical bioidentical progesterone might just be the chill pill you need.

Address gut infections

An imbalance of gut bacteria can contribute to mood issues. There are also certain overgrowths and gut infections that can impact anxiety levels. For example, overgrowth of Streptococcus bacteria has been associated with obsessive-compulsive disorder.[17] The book includes recommendations for further testing that can help you determine if you have an overgrowth or infection.

Address iron toxicity/overload

A buildup of too much iron can cause irritability and depression.[18] Ferritin levels above 200 ng/dL in women (300 ng/mL in men) can indicate iron toxicity or overload. The book offers several different options for treatment.

Address mold toxicity

There is a big connection between mood issues and mold exposure.[19] If your symptoms appeared or increased after moving into a new home, there’s a good chance your anxiety may be connected to mold exposure.

Address common nutrient deficiencies

Nutrient deficiencies are common in those with adrenal issues, and could be contributing to feelings of anxiety. Address these important nutrients for mood support: omega-3 fatty acids, folate (vitamin B9), iron, vitamin B12, and vitamin D.

Address the social anxiety condition called pyroluria

Symptoms of social anxiety have been associated with pyroluria, which is a condition where there are too many pyrrole molecules in your body.[20] These molecules can deplete your system of essential nutrients that play an important role in mood and adrenal health.

[Trudy’s note: I’m really pleased to see pyroluria mentioned in this book, because it’s not often acknowledged as a condition. I also appreciate the reference, in the pyroluria section, to my work and book, The Antianxiety Food Solution.]

Adrenal Transformation Protocol – for anxiety

Adrenal Transformation Protocol (my Amazon link) provides comprehensive support for the many potential stressors the body can experience, so that you can heal anxiety using a whole body, root-cause approach.

When we address the root causes of adrenal fatigue and anxiety, like blood sugar imbalances, food sensitivities, and nutrient deficiencies, we can increase our resilience and reduce feelings of anxiety!

Adrenal dysfunction often begins after a stressful period in our lives. When the body puts cortisol front and center, rebuilding and repairing go on the backburner, and we can end up with a host of symptoms including fatigue, brain fog, and anxiety.

While most people can bounce back from small stressors, some of us can get caught up in a stress cycle that ends up affecting our physiology. When we are caught in this stress cycle, it throws our hormonal systems out of balance, and leads to us being stuck in “fight or flight” mode. Prolonged “fight or flight” mode eventually leads to burnout, and often contributes to anxiety.

Through years of research, patient study, and work with thousands of clients, my signature protocol has been shown to reverse symptoms of adrenal fatigue. It provides a foundation for optimal health, and can even be one of the keys to resolving anxiety.

In both my own work and Izabella’s, we have found that addressing the adrenals often results in the complete resolution of chronic stress symptoms!

Izabella has experienced multiple bouts of adrenal fatigue and has struggled with anxiety. She realized that her body was responding to the various stress triggers in her environment, and decided to send it safety signals instead, to put it into a healing and rebuilding state. The protocol worked so well for her that she piloted it as a program with a small group in 2020. Despite all of the things that happened in 2020, people reported that the program helped them rebalance their stress response.

Over 3000 people have now completed this protocol, with incredible results, and it’s all in her new book, Adrenal Transformation Protocol (my Amazon link). The book outlines a simple four-week plan to help you recover your adrenal function and resolve symptoms like fatigue, brain fog, depression, and anxiety. The protocol is designed to help you feel calm, strong, excited about life, and brilliant once more!

In addition to reduced brain fog, reduced fatigue, and better sleep, participants reported incredible results in mood – 86 percent reported reduced anxiety and 80 percent reported reduced feelings of nervousness.

Adrenal dysfunction can be a root cause of anxiety. If you’re still experiencing anxiety symptoms and feel like you’ve tried everything, but haven’t yet addressed your adrenal health, I’d highly recommend Adrenal Transformation Protocol (my Amazon link)!

Feel free to share your feedback once you’ve read the book.

Also, let us know if any of the above approaches have helped you address your adrenal issues?

If you have questions and other feedback please share it here too.

[1] Cook SB. Current Controversy: Does Adrenal Fatigue Exist?. Natural Medicine Journal. 2017;9(10).[2] Faravelli C, Lo Sauro C, Lelli L, et al. The role of life events and HPA axis in anxiety disorders: a review. Curr Pharm Des. 2012;18(35):5663-5674. doi:10.2174/138161212803530907

[3] Carta M, Loviselli A, Hardoy M et al. The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: A field of interest for public health in the future. BMC Psychiatry. 2004;4(1). doi:10.1186/1471-244x-4-25.

[4] Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019;98(37):e17186. doi:10.1097/MD.0000000000017186

[5] Dongre S, Langade D, Bhattacharyya S. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. Biomed Res Int. 2015;2015:284154. doi:10.1155/2015/284154

[6]  Lee Y, Jung JC, Jang S, et al. Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated from Rhodiola rosea. Evid Based Complement Alternat Med. 2013;2013:514049. doi:10.1155/2013/514049

[7] Cropley M, Banks AP, Boyle J. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytother Res. 2015;29(12):1934-1939. doi:10.1002/ptr.5486

[8] Pan L, Jaroenporn S, Yamamoto T, et al. Effects of pantothenic acid supplement on secretion of steroids by the adrenal cortex in female rats. Reprod Med Biol. 2011;11(2):101-104. Published 2011 Dec

[9] Valdés F. Vitamina C [Vitamin C]. Actas Dermosifiliogr. 2006;97(9):557-568. doi:10.1016/s0001-7310(06)73466-4

[10] Mathew P, Thoppil D. Hypoglycemia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; July 23, 2022.

[11] Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review. Nutrients. 2017 May; 9(5): 429. doi:10.3390/nu9050429.

[12] Fromm L, Heath DL, Vink R, Nimmo AJ. Magnesium attenuates post-traumatic depression/anxiety following diffuse traumatic brain injury in rats. J Am Coll Nutr. 2004;23(5):529S-533S. doi:10.1080/07315724.2004.10719396

[13] Sartori SB, Whittle N, Hetzenauer A, Singewald N. Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology. 2012;62(1):304-312. doi:10.1016/j.neuropharm.2011.07.027

[14] Vatn MH. Food intolerance and psychosomatic experience. Scand J Work Environ Health. 1997;23 Suppl 3:75-78.

[15] Russo AJ. Decreased zinc and increased copper in individuals with anxiety. Nutr Metab Insights. 2011;4:1-5. Published 2011 Feb 7. doi:10.4137/NMI.S6349

[16] Glick ID, Bennett SE. Psychiatric complications of progesterone and oral contraceptives. J Clin Psychopharmacol. 1981;1(6):350-367. doi:10.1097/00004714-198111000-00003

[17] Mell LK, Davis RL, Owens D. Association between streptococcal infection and obsessive-compulsive disorder, Tourette’s syndrome, and tic disorder. Pediatrics. 2005;116(1):56-60. doi:10.1542/peds.2004-2058

[18] Cutler P. Iron overload and psychiatric illness. Can J Psychiatry. 1994;39(1):8-11. doi:10.1177/070674379403900104

[19] Harding CF, Pytte CL, Page KG, et al. Mold inhalation causes innate immune activation, neural, cognitive and emotional dysfunction. Brain Behav Immun. 2020;87:218-228. doi:10.1016/j.bbi.2019.11.006

[20] Mensah A. Mood instability: Pyrrole disorder underlying cause bipolar, DMDD. Mensah Medical. https://www.mensahmedical.com/pyroluria-pyrrole-disorder/. Published July 12, 2016. Accessed February 8, 2023.

Hashimoto’s Food Pharmacology, a new recipe book by Dr. Izabella Wentz

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The beautiful new recipe book Hashimoto’s Food Pharmacology: Nutrition Protocols and Healing Recipes to Take Charge of Your Thyroid Health (my Amazon link) by Thyroid Pharmacist, Dr. Izabella Wentz, just launched and I want to make sure you know about it and to also share some recipes with you.

I just got my copy and I’m excited to try out some of the yummy nutrient-dense and healing recipes. Flipping through it quickly I know already that I’ll be making the Morrocan Lamb Stew, the Truffled veggies and Cilantro-Lime Guacomole (it looks like a nice spin with some different flavors), the Liver Pate (this recipe has cinnamon!), the Zucchini Bread and the Mango Salsa (yuuummmm – I love mango and adore it in a spicy salsa). I’ll also make the Farinata bread (made with garbanzo beans) and Bacon and Chive Scalloped Potatoes for my family (I have SIBO and will enjoy them soon too I hope). I could go on and on…

Here is the Bacon and Chive Scalloped Potatoes recipe for you to try…

Dr. Izabella recently shared the AI Very Berry Pie recipe on Facebook and gave me permission to share it here too. She wrote that she created it when she was pregnant with their son (and why!) and more about the ingredients and nutrients:

I needed something yummy and nutrient dense! Initially the cookbook wasn’t going to have a dessert section but it ended up with 14 dessert recipes inspired by my sweet boy 😊 You can thank him and my pregnancy cravings.

The pie is filled with berries and the crust is gluten-free, dairy-free, egg-free and nut-free. This was a huge hit at all of our parties. I hope you enjoy it! AI Very Berry Pie has the texture of a crumbly shortcake and even browns like a traditional pie. The secret to the yummy texture is the palm shortening, which can be used in Paleo baking instead of butter, while the maple syrup allows for a nice light brown color. Cassava flour is a fantastic gluten-free substitute for this kind of baking. I chose a mix of berries to include in this pie because of their antioxidant status; however, you can replace the fruit in the filling with apples, cherries, plums, peaches, or any other type of fruit you like.

I do love the blurb that Dr. Izabella includes with each recipe with a bit of the backstory and all the nutrients and health benefits we’ll be getting. The recipe photos are superb too!

Here is the recipe for the AI Very Berry Pie

Ingredients
CRUST
3 cups cassava flour
1 teaspoon sea salt or pink Himalayan sea salt
1 teaspoon baking soda
1 tablespoon vanilla
½ cup maple syrup
1⅓ cup palm shortening

FILLING
5 cups mixed berries (halved strawberries, blueberries, blackberries, and raspberries)
¼ cup maple syrup (optional)

Directions

  1. Preheat the oven to 400°F.
  2. In a stand mixer, mix the cassava flour, salt, baking soda, and vanilla.
  3. Add the maple syrup and mix, until the texture becomes crumbly.
  4. Add the palm shortening, 1⁄3 cup at a time, until the crust reaches a pliable texture.
  5. Divide the dough in thirds; reserve two-thirds for the base, and one-third for the pie top.
  6. Roll out the dough with a rolling pin (used specifically for gf baking)
  7. Gently press 1/3 of the dough into the bottom of a 9-inch round pie pan to create the pie base and another third of the pie dough onto the sides of the pie pan.
  8. Toss the berries with maple syrup, if added sweetness is desired
  9. Roll out the remaining third of the crust and place on top
  10. Bake for 15-20 minutes until fruit is cooked through and crust Browned

Here is the official book blurb:

When I was in pharmacy school, I discovered that food has a profound impact on our healing and that what we put in our bodies will either heal us or make us sicker. In the same way that we use pharmaceuticals to impact our biology, we can use food as our medicine. I call this concept food pharmacology. Food is one of the most powerful tools in your healing journey.” – Dr. Izabella Wentz

More than 35 million Americans currently suffer from Hashimoto’s—the country’s fastest-growing autoimmune disease, which affects the thyroid gland and causes the body to attack its own cells. Many individuals with or without a formal diagnosis suffer daily symptoms, including chronic cough, acid reflux, irritable bowel syndrome, allergies, persistent pain, hair loss, brain fog, and forgetfulness.

Hashimoto’s Food Pharmacology (my Amazon link) combines Dr. Izabella Wentz’s revolutionary and proven approach to reversing thyroid symptoms with delicious, easy-to-use recipes that delight the taste buds while they heal the body. Inside you will discover:

  • 125 delicious and nutritious recipes for salads, smoothies, bone broths and crockpot and bibimbap-style meals, with thyroid-supporting nutrient details on every page
  • Over 100 stunning food and lifestyle photographs
  • Tips for revamping your kitchen and pantry
  • An FAQ for easy reference and quick answers
  • Easy-to-use, personalized meal plans and food rotation schedules to accommodate any diet

Successfully transforming the lives of thousands, Dr. Izabella Wentz makes it easier than ever before to live a life free from the suffering of autoimmune disease.

I recommend this book if you have hypothyroidism (an underactive thyroid), Hashimoto’s Thyroiditis or another autoimmune condition and want specific autoimmune-friendly recipes. Many of the recipes can be modified to low-FODMAP if you have SIBO (small intestinal bacterial overgrowth). If you do have oxalate issues you’ll need to adjust the recipes that use nut flours, greens like spinach, berries etc.

Even if you don’t have a thyroid or autoimmune condition it’s a lovely recipe book if you are looking for new nutrient-dense and healing recipes and some inspiration to get cooking!

Keep in mind, this book is way more than a recipe book. It’s also a nutrition guide with detailed information about how to improve your digestion and nutrient absorption; assessments and protocols; a discussion about the vegan/vegetarian diet and why a paleo-type diet with grass-fed red meat is beneficial if you have Hashimoto’s; why beets are good for you if you have the MTHFR gene mutation; crucial nutrients for thyroid function; when lab testing says you’re not gluten sensitive and much more.

You can purchase your copy of Hashimoto’s Food Pharmacology here (my Amazon link) or at your favorite bookstore.

Big congratulations to my brilliant friend Izabella Wentz!

If you have your copy already, what recipes are you most excited to try out? Or have you already tried some recipes? Do let us know.

Thyroid disease: anxiety, panic attacks and seizures on The Broken Brain

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There are things that are commonly misdiagnosed as seizure disorders, panic attacks and anxiety attacks. All of these things can stem from thyroid disease and can be reversed when you get proper thyroid treatment.

~ Izabella Wentz, PharmD, author of Hashimoto’s Protocol

Here are some wise words of wisdom from one of the 57 expert speakers – Dr. Izabella Wentz – sharing about the thyroid-brain connection on Dr. Mark Hyman’s 8 -part Broken Brain docuseries.

As well as anxiety and panic attacks, some other issues with the thyroid are fatigue, brain fog, apathy, irritability, depression, bipolar disorder and psychotic disorders.

With Hashimoto’s encephalopathy there can be gait and balance problems, seizures, delusions and even hallucinations.

Izabella shares her own Hashimoto’s story and how she experienced anxiety, panic attacks, social anxiety and bad brain fog. She said she felt her mind slipping away and how scary it was but also that thyroid problems are fairly resolvable.

Some of the solutions she offers:

  • a paleo or autoimmune paleo diet
  • getting rid of reactive foods
  • including bone broth if tolerated
  • 200-400mcg selenium methionine (it reduces an autoimmune attack on the thyroid by half and also improves anxiety and reduces hair loss)
  • 600mg of thiamine (has been shown to reverse thyroid fatigue in 6 days; she has found the benfotiamine form to be the most helpful)

Save the date for the 8 -part Broken Brain docusersies, hosted by Dr. Mark Hyman – and register here. It airs January 17-25th

(I have just found out that if you watched the series during the pre-launch in October and want to watch it again this time around you do NOT need to sign up again under a new email address. My apologies for the confusion!)

Here’s a list of ALL the episodes, to showcase just some of what you will have access to. Each episode will be available for 24 hours, at no-cost!

  1. The Broken Brain Epidemic / Dr. Hyman’s Story (January 17)
  2. Gut Brain Connection: Getting to The Root of a Broken Brain (January 18)
  3. Losing Your Mind (Alzheimer’s, Dementia, MS, and More) (January 19)
  4. ADHD and Autism (January 20)
  5. Depression & Anxiety (January 21)
  6. Traumatic Brain Injury: Accidents, Sports, and More (January 22)
  7. 7 Steps to An UltraMind (Part 1) (January 23)
  8. 7 Steps to An UltraMind (Part 2) (January 24)

See you there!

It’s not just you: More women than men have thyroid disorders

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Guest post by Izabella Wentz, PharmD, FASCP

If you’ve ever wondered why more women than men seem to have autoimmune disorders, you’re not alone—I repeatedly get asked this question by people (mostly women!) who come to me seeking help with a thyroid disorder.

Even if you have had a hunch that more women than men are affected by autoimmune diseases such as lupus, rheumatoid arthritis, and multiple sclerosis, you’ll be surprised by this statistic: women account for a whopping 78% of all cases of autoimmune disease.

Hashimoto’s thyroiditis, which I was diagnosed with at 27, is five to eight times more common in women. (I’ve since gotten myself into remission and have dedicated my life to helping others heal from this condition.)

These disproportionate figures have perplexed experts for some time. After years of research and time spent working with people with thyroid disorders, I have formed my own theory, which I call the Izabella Wentz Safety Theory. I can’t wait to share it with you—but first, I’ll tell you a little about some of the other influences autoimmunity.

Searching for an Explanation

When we consider why more women than men have Hashimoto’s and other diseases of autoimmunity, we have to consider two key differences between men and women: hormones and a propensity to use more personal care products.

Regarding the first, there’s no denying that hormones could play a major role in autoimmunity developing. Three of the most likely times for the onset of thyroid disease are during and around puberty, pregnancy, and perimenopause.

Sex hormones such as estrogen and prolactin help regulate the immune system and fluctuations in these could contribute to thyroid disorders especially. Estrogen can alter the requirements for thyroid hormone, which could result in an autoimmune condition, especially if nutrient deficiencies are present. Prolactin, a hormone released by the pituitary gland in women after childbirth, can become elevated in women with Hashimoto’s (even in those not postpartum) and has been linked to increased thyroid antibodies and infertility.

Women do have a higher risk of developing diseases of the thyroid after they’ve given birth. But theories, such as “fetal microchimerism” which suggests that the presence of fetal cells in a woman’s thyroid gland after childbirth could be the spark of an immune system response, haven’t proven to be true.  

All this is to say that at present, there isn’t enough information to support the idea that hormones alone are to blame for the higher rates of autoimmunity in women.

It’s also been considered that because women generally use a greater number of personal care products—makeup, lotions, perfumes, etc.—they are more exposed to a greater number of chemicals, which could alter the immune system.

I haven’t seen enough evidence to convince me of this explanation either.

In truth, I think the answer is much more complicated and requires us to consider some of the underlying vulnerabilities that often occur in people with Hashimoto’s.

Unsafe Conditions Ahead: Go Back to Bed!

After working with thousands of people with Hashimoto’s, I’ve found that there are some common co-occurring factors. Many have nutrient depletions, intestinal permeability, food sensitivities, an impaired stress response, an impaired ability to get rid of toxins, and infections.

The more I thought about these factors, the more I realized that they have something in common: they all send a message to our bodies that the environment isn’t entirely safe and maybe self-preservation mode is what’s best for now. This provided the basis for my Safety Theory.

Let me explain.

Women are responsible for bringing new life into the world. And with this job comes a more finely tuned ability to sense the safety of the environment. We may be more inclined to sense that it’s not be the best time to reproduce—this could be because resources are scarce and we need to focus on our own survival, or for some other protective reason.

In either case, it’s a result of an evolutionary adaptation, or what’s known as adaptive physiology.

When we were cavewomen, one of the main sources of stress was food scarcity—we didn’t always know when we were getting our next meal. When we didn’t eat, consumed things that we weren’t intended to digest, or developed nutrient deficiencies, our bodies would conserve resources and reduce calorie burning.

Strangely enough, even though these scenarios first occurred hundreds of thousands of years ago, there are aspects of modern living that are replicating these signals: we go on calorie-restricted diets (signals food scarcity), eat a highly processed diet (creates nutrient deficiencies), and try to eat foods we’re not intended to digest, such as gluten (leads to digestive difficulties/intestinal permeability).

And when these vulnerabilities are present, they set the stage for an attack on the thyroid to take place and for some of the symptoms of self-preservation to develop. As thyroid function is disrupted, metabolism is slowed and you are sent into a quasi-hibernation mode.

Your body is signaling to you to conserve energy, hold onto weight, making you feel cold and tired all the time so you stay in your cave (or your bed), and lowering your interest in reproduction (low libido) until the environment is safe and fertile once again.

Other Environmental Threats Women Face and How the Thyroid Responds

Did you know that your thyroid gland can sense danger and initiate the autoimmune response? I think in this ability lies another possible clue as to why more women than men develop thyroid disorders.

It’s no secret that the world we live in is not as safe for a woman as it is for a man. Women are more likely to be abused, physically, emotionally, and sexually. And abuse is one of the most undeniable messages to our bodies that we are not safe. The function of the perceptive and sensitive thyroid is put at risk when this is the case.

This is part of my Safety Theory, but it’s not just a theory—multiple studies have confirmed that thyroid hormone imbalances occur in people who have been abused:

The abuse doesn’t have to be physical to trigger a red alert in the body. Many girls and women today experience emotional abuse or trauma that can make us feel isolated and cue up a flight response. This can happen at school or in adult social circles, where if we can’t keep up the appearance of being a Superwoman, we might get edged out of the tribe.

The Key to Healing—Showing (and Telling) Your Body It’s Safe

In working with so many women with Hashimoto’s over the years, I’ve learned so much about the condition and the vulnerabilities that can lead to its development. And I’ve also learned about some of the most effective strategies and approaches to healing.

One of the most moving revelations was that a message of safety is so important to helping women through recovery. I’m referring to comprehensive self-care, which can include internal mantras and the right kind of exercise and pampering that help create a restorative environment.

But it should be more than that.

What I’ve found is vital is addressing the vulnerabilities head-on—the signals your body is sending to conserve need to be shut off. You must repair your internal ability to respond to stress and restore detoxifying and digestive functions, eliminate food sensitivities and infections, and replenish nutrients that are lacking.

I’ve spent years creating and refining protocols that help women (and men) accomplish these goals. And I’ve finally been able to collect and present them together in one place in one program in my new book Hashimoto’s Protocol: A 90-Day Plan for Reversing Thyroid Symptoms and Getting Your Life Back.

When you follow the protocols I outline there, you send safety signals to your body by reducing your toxic burden, supporting your stress response, and supporting your gut with nutrition and targeted supplements. You communicate in a concrete way that the environment is stable and safe, and your thyroid can get back to its important work of helping you feel energized and warm, calm and clear headed.

I have dedicated my life’s work to helping women heal from Hashimoto’s so that they might feel safe, supported, and active in their lives again. I hope you’ll check out Hashimoto’s Protocol to see if might help you or a loved one recover from a thyroid disorder.

Until then, I encourage you to start sending safety signals today. Start by being nice to your body—feed it nutritious foods when it’s hungry and don’t skip meals. Don’t subject it to excessive or unnecessary stress, which means make time for play and rest. Stop forcing it to push through exhaustion by piling on the caffeine—rest! Listen to your digestion; if there are signs that a food is not working for you, don’t double up on antacids, but instead adjust.

Listen to your body and care for it like a child, or any other loved one who you would treat with absolute care. Like someone you’d want to make sure feels safe.

Hashimoto’s Protocol by Dr. Izabella Wentz

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The great new book called Hashimoto’s Protocol by Dr. Izabella Wentz just made #1 on the New York Times bestseller list!

Since I’m in Australia I have a kindle edition of Dr. Izabella’s brilliant new book that just released last week: Hashimoto’s Protocol: A 90-Day Plan for Reversing Thyroid Symptoms and Getting Your Life Back. It’s a must-read if you are dealing with Hashimoto’s or actually any thyroid problems (or if you suspect you may have thyroid issues)!

If you are a practitioner I highly recommend it too!

Here’s the official blurb:

Dr. Izabella Wentz, the author of the phenomenal New York Times bestseller Hashimoto’s Thyroiditis, returns with a long-awaited, groundbreaking prescription to reverse the symptoms of this serious autoimmune condition that is becoming one of the country’s fastest growing diseases.

More than thirty-five million Americans currently suffer from Hashimoto’s—an autoimmune disease that affects the thyroid gland and causes the body to attack its own cells. To alleviate the symptoms of this debilitating condition—including chronic cough, acid reflux, IBS, allergies, chronic pain, hair loss, brain fog, and forgetfulness [plus anxiety and depression] —patients are often prescribed synthetic hormones that have numerous life-altering side effects.

But there is a better way.

Diagnosed with Hashimoto’s at twenty-seven, pharmacist Dr. Izabella Wentz knows first-hand the effects of the disease, as well as the value—and limitations—of medication. The key to improved health, she argues, involves lifestyle interventions. In Hashimoto’s Protocol, she outlines a proven treatment that has helped thousands heal and many others feel better—in as fast as ninety days.

Drawing on her own personal experience as well as her work consulting with thousands of patients, Hashimoto’s Protocol offers a practical pathway for healing and reversing the autoimmune damage at the root of the disease. The first step is a quick-start two-week detox that includes foods to eat and inflammatory foods to avoid, advice on supplements to support the liver, and an adrenal recovery plan. Next, readers create a personalized plan with foods, supplements, and other lifestyle interventions tailored to their body’s own unique Hashimoto’s triggers, which they can identify using self-tests included in the book. Hashimoto’s Protocol also features original recipes.

Grounded in the latest science, Hashimoto’s Protocol is the first book to offer a proven protocol by an acknowledged expert in the field to treat this condition without dangerous hormones—and help sufferers reclaim their lives.

Izabella has done a wonderful job! I love that she covers the basics like liver support, the adrenals and gut health and then goes into advanced protocols for trauma, infections, toxins and nutrient deficiencies! I really LOVE how she dives deep into the newest research and connects ALL the dots in a really smart way!

And even if you don’t have thyroid issues you would benefit from these sections that are applicable for everyone:

  • Root Cause Liver Support Protocol — how to support your liver by clearing detox pathways so that you’re able to release toxins and get your energy back.
  • Adrenal Recovery Protocol — how to reset your response to stress so that you can regenerate your body.
  • The Gut Balancing Protocol — the right nutrients so that your gut starts working at its optimal level.

Here is a snippet from the Liver support section:

Halogens and halogen-containing chemicals: These chemicals include bromide, chloride, and fluoride; are structurally similar to iodine; and may take up receptor sites in the thyroid gland. Unfortunately, their presence in the thyroid gland can

lead to thyroid cell death and inflammation. Individuals exposed to high levels of halogen-containing substances have been found to have higher rates of thyroid antibodies.

Chlorine: When found in polychlorinated biphenyls (PCBs), chlorine has been shown to be toxic to thyroid cells and to promote the onset of Hashimoto’s through increasing TSH, thyroid antibodies, and thyroid size. PCBs are found in industrial products. Chlorine is also found in water systems, pools, cleaning products, and plastics.

Bromide: This can be found in baked goods, plastics, soft drinks, and even our mattresses, which are coated with brominated flame retardants. Studies show bromine-containing substances—polybrominated diphenyl ethers (PBDEs)—are connected to an increased incidence of Hashimoto’s.

Fluoride: This thyroid-suppressing halogen is found in water, toothpaste, and some medications as well as in black, green, and red tea. Using a reverse osmosis filter is the best way to get rid of fluoride.

The gentle two-week Liver support section

will guide you on how to eliminate hidden toxins from your everyday life and how to help your liver process out the toxins you may have in your body. Both are critical steps for anyone who’s had problems with taking supplements or is struggling with current symptoms. Most people see drastic changes just by completing this step alone.

 

Here is the Amazon link or support your local book store if you have one nearby!

Also enjoy the fabulous 2 week recipe plan Dr. Izabella is offering. It has 2 weeks worth of recipes, meal plans and shopping lists based on the autoimmune Paleo diet template. Click here to learn more and signup for the 2 week recipe plan.

Hope you enjoy these great thyroid resources!

If you already have a copy let us know what you think and which sections have helped you?

Anxiety and the thyroid: how to make the amino acids more effective

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Did you know that thyroid disease can be a root cause of anxiety? In fact, most of my anxious clients have thyroid issues.

Having an excess amount of thyroid hormone can make us extremely anxious, irritable and on edge. This is one symptom that is commonly attributed to Graves’ disease but can also happen in Hashimoto’s.

In the early stages of Hashimoto’s, the thyroid is under attack by the immune system. Thyroid cells are broken down, and they release thyroid hormones into the bloodstream. This causes thyroid hormone surges or a transient hyperthyroidism.

I know how awful anxiety can feel, I had anxiety, panic attacks and pyroluria (social anxiety) in my late 30s, together with an underactive thyroid, adrenal issues, gluten sensitivity, heavy metals, low progesterone (I call it my perfect storm!).   

I’m excited to share that there is a way out and that you don’t have to feel this way forever. Everyone is different, but two of the things that worked wonders for me and now work for my clients are nutrition and targeted individual amino acids (like GABA and tryptophan).

But are you aware that the amino acids will be effective for addressing low GABA and low serotonin (in their typical quick manner, often providing relief in 5 to 10 minutes) ONLY when thyroid health is optimal (not many people know this!)

And by optimizing your thyroid health, I don’t just mean taking thyroid medications….

Dr. Izabella Wentz, the Thyroid Pharmacist, is a personal friend of mine – we’re both members of Mindshare, a collaboration of like-minded functional medicine practitioners. 

Magdalena Wzelaki, Niki Gratrix, Izabella Wentz, myself and Julie Matthews

I adore Izabella and love how she is connecting all the dots with the research and the feedback she receives from her community.  She is trailblazing and always focused on the why of how a condition develops.

She has found that thyroid disease is triggered by a combination of food sensitivities, nutrient depletions, intestinal permeability, chronic infections, toxins and also a faulty stress response.

The thing about thyroid disease, just like anxiety, is that it’s a sign of a bigger imbalance in your body – while thyroid medications and glandulars can certainly help, they do not get to the underlying root cause of the condition, and thyroid conditions, which are usually autoimmune in nature, may progress to other types of autoimmune disorders.

Hashimoto’s, a condition that affects up to 27% of the population in the United States has 5 stages to it. Out of the 90 million or so people that have it, close to 80 million don’t know that they have it. Often, they are in the earlier stages that are missed by conventional tests.

Hashimoto’s is the primary cause of hypothyroidism, accounting for 95% of cases of hypothyroid in the United States. This condition occurs when the immune system recognizes the thyroid gland as foreign invader and launches an attack against it, eventually destroying enough of the thyroid to produce hypothyroidism.

The five stages of Hashimoto’s are:

1) In the first stage, for all intents and purposes, you will just have the genetic predisposition

2) In the second stage, you start developing an autoimmune attack on the thyroid gland – at this stage, you will also have thyroid symptoms (the most common one is anxiety), but the TSH test will still be normal. Only the thyroid antibodies will be elevated at that point, and at this stage people are often misdiagnosed with anxiety or depression

3) The third stage is when the thyroid gland starts to have more damage than it can repair, and begins to fail. More symptoms are seen, but doctors often miss this stage as well because the TSH is only “slightly” elevated according to their reference ranges

4) The fourth stage, we see overt hypothyroidism. At this page a person has had a significant amount of thyroid damage, and their thyroid fully loses its ability to compensate and create thyroid hormone

5) The fifth stage is the scariest, this is when a thyroid condition progresses to another autoimmune condition. The immune system finds another target to attack, and person may end up with lupus, rheumatoid arthritis, Sjogren’s or even multiple sclerosis.

The only treatment that is offered by conventional medicine is thyroid hormones, which is prescribed in stage 4. When that can help of course, it doesn’t address most people’s symptoms and doesn’t stop the progression of the condition and autoimmunity. There is no conventional treatment for stopping or reversing the progression, but luckily we have functional medicine and nutrition to the rescue!

A shocking thing that Izabella has shared, is that it takes people on average of 10 years to get diagnosed, and this is also the time it takes to get from stage 2 to stage 4 of Hashimoto’s! Izabella was actually misdiagnosed with anxiety and chronic fatigue for almost a decade before she got the Hashimoto’s diagnosis, and many people are told that they have intractable infertility, lifelong anxiety that they are told they will have to “manage” forever or even told they have treatment-resistant depression, or that they are simply overweight and lazy.

I know that many of my clients with anxiety are likely still in the earliest stages of Hashimoto’s, and there is hope that you can eliminate your symptoms, AND you can actually prevent the damage to the thyroid gland if you intervene at this point.

Izabella created the Thyroid Secret documentary series to help you connect the dots of your own thyroid condition, so that you can rebuild your health and eliminate your symptoms (and potentially your health conditions). She shares her latest research in overcoming thyroid disorders, and interviews the top experts who share their best strategies as well.

I was so excited when Izabella asked me to join the Thyroid Secret as an expert – in fact my interview was the very last thing I did in the United States, before I moved to Australia! This topic is so important to me (and so key for my clients and you to know about) that I did the interview in an empty house, with just a few chairs and our almost-packed suitcases, and just a few hours to spare before we got on the plane!

Here are a few pictures (I was ironing my clothes on a spare table in the mostly empty study!):

The Thyroid Secret covers not just the symptoms of thyroid disease (like anxiety) that can masquerade as mental illness, but also the triggers that can cause both conditions, and the solutions and protocols you need to recover your health.

When your thyroid is working as it should be, the amazing amino acids like GABA and tryptophan are truly effective in 5-10 minutes – so you really can say they are amazing!  You will see incredible results – anxiety relief right away – and a feeling of hope while you dig deeper for root causes that can take longer to address.

I wrote this blog for everyone using amino acids and not seeing results.  And also for everyone with a thyroid condition or if you have unresolved symptoms that could be related to your thyroid.

I do hope you’re already signed up and are enjoying watching, listening and learning as much as I am.

If you haven’t yet signed up you can still join as my guest to view the entire series at no cost (it started March 1). Just use this link to register.

We’ve come together in this Thyroid Secret documentary to give you this information because you deserve to feel on top of the world again!

Got questions or feedback? Your favorite speaker and some takeaways?

Did you find that GABA, tryptophan and other amino acids were more effective once you addressed your thyroid health? If you’re a practitioner do you see this with patients/clients?

Please share in the blog comments below.