everywomanover29 blog

Food, Mood and Women's Health – Be your healthiest, look and feel great!

Inflammation

The Anxiety Summit – Psychoneuroimmunology, the new psychiatry

By 9 Comments

Kelly Brogan

Dr. Kelly Brogan, MD. Holistic women’s health psychiatry was interviewed by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

Psychoneuroimmunology, the new psychiatry

  • The role of inflammation in anxiety and depression
  • Hormones and where the endocrine system fits in
  • Where inflammation comes from
  • What a healthy microbiome looks like
  • Natural lifestyle interventions to reverse symptoms and favorite nutraceuticals
  • Why psychiatrists don’t know about this

Here are some snippets from our interview:

What psychoneuroimmunology refers to is essentially the inherent inter-connectedness between multiple systems. So, it’s about no longer looking at psychiatry as a head up phenomenon, which at best can result in limited outcomes and at worst, can be quite dangerous. And what psychoneuroimmunology implies is that there is a relationship between neurology – so, between brain science – and the immune system. It is sometimes called psychoneuroendocrinology – it also sort of ropes in the gut and the endocrine system with the implication being that you cannot treat one without knowledge about the others. So, I think it’s very exciting and really is a term that embodies functional medicine, or naturopathy at its best.

What many are speaking about is something called the cytokine model, which has been around since 1991, the first paper hypothesizing about this model. So, it’s been a growing literature for some time. And what it refers to is essentially it looks at depression or anxiety, for example, as this non-specific sort of fever that tells us actually very little about what’s causing the body to react, but tells us that there’s is an expression of imbalance and that the body is working to recalibrate. So, there’s some sort of stressor or triggers or assault and the compensatory response on the part of the body is what we are seeing as these psychiatric symptoms.

Cytokines in the blood, or inflammatory messengers, such as CRP, IL-1, IL-6, and TNF-alpha are predictive and linearly related to depression and anxiety, especially in women.

Here is Dr. Brogan’s wonderful blog post on the topic of Psychoneuroimmunology, the new Psychiatry

What is driving this inflammation? How does it get kicked off? And how does it induce depression? With the limited clinical applications and revelations that came with the completion of the Human Genome Project in 2002, we have begun to focus on where we have outsourced our physiologic functions.

The microbiome has become an important consideration, and particularly, the gut, which houses at least 10 times as many human cells as there are in our bodies, and 150 times as many genes as are in our genome. These microbes control many vital operations and are responsible for synthesis of neuroactive and nutritional compounds, for immune modulation, and for inflammatory signaling.

Here is one of the studies on how traditional diets can impact the microbiome: Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part II – contemporary contextual research

researchers reported less potentially pathogenic bacteria, yet a far greater degree of biodiversity and microbial richness in rural Africans living a traditional lifestyle and consuming traditional high fiber foods

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here www.theAnxietySummit.com

The Anxiety Summit – Microbes in the gut and psychobiotics as a potential treatment for anxiety and depression

By 20 Comments

Dr_Ted_Dinan_Anxiety2

Dr. Ted Dinan, MD, PhD. Professor of Psychiatry at University College Cork was interviewed  by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

Microbes in the gut and psychobiotics as a potential treatment for anxiety and depression

  • Varied ways in which anxiety presents
  • Anxiety as a co-morbid condition e.g. irritable bowel syndrome
  • Microbes in the gut and the influence on emotional activity
  • Non-pharmacological approaches to treating anxiety
  • Psychobiotics as a potential treatment and the newest research in this area

Here are some snippets from our interview

Now the brain-gut axis is an axis that we learned more about over the decade or 2, how does the brain communicate with the gut, how does the gut communicate with the brain, and the view of irritable bowel syndrome is that it is as I say a brain axis disorder, an exceedingly common disorder, up to at least 50 percent and some studies suggest much higher rates in terms of the presence of psychiatric symptoms in patients with irritable bowel syndrome. The general view is that at least 50 percent of patients with irritable bowel syndrome have a coexistent or comorbid depression or anxiety.

We’re gradually I think learning more about the pathology underlying irritable bowel syndrome and we and others have published a number of studies show that for instance patients with irritable bowel syndrome have high levels of cytokines. Now cytokines are chemicals that are produced by the immune system and there are certain cytokines that are caused pro-inflammatory. They give rise to inflammation or are the product of inflammation. And certainly there is now good evidence that many patients with irritable bowel syndrome do have very high levels of these pro-inflammatory molecules in their blood stream. The molecules would be molecules like interleukin 6 and CNF-alpha.

Here is the quote from Dr. Dinan’s article that was co-written with Dr. John Cryan and called Psychobiotics: How Gut Bacteria Mess with Your Mind

In the 20th century the major focus of microbiological research was on finding ways to kill microbes by antibiotics. This century the focus has changed somewhat with the recognition of the health benefits of bacteria, not just from an immunity perspective but from a mental health one.

Here is some of Dr. Dinan’s research:

Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?

co-morbidity with mood disorders such as depression and anxiety is common in IBS

Psychobiotics: a novel class of psychotropic.

Here, we define a psychobiotic as a live organism that, when ingested in adequate amounts, produces a health benefit in patients suffering from psychiatric illness. As a class of probiotic, these bacteria are capable of producing and delivering neuroactive substances such as gamma-aminobutyric acid and serotonin, which act on the brain-gut axis. Preclinical evaluation in rodents suggests that certain psychobiotics possess antidepressant or anxiolytic activity. Effects may be mediated via the vagus nerve, spinal cord, or neuroendocrine systems. So far, psychobiotics have been most extensively studied in a liaison psychiatric setting in patients with irritable bowel syndrome, where positive benefits have been reported for a number of organisms including Bifidobacterium infantis. Evidence is emerging of benefits in alleviating symptoms of depression and in chronic fatigue syndrome. Such benefits may be related to the anti-inflammatory actions of certain psychobiotics and a capacity to reduce hypothalamic-pituitary-adrenal axis activity. Results from large scale placebo-controlled studies are awaited.

This is the recent resistance training anxiety study I mentioned: The anxiolytic effects of resistance exercise

This research has shown that resistance training at a low-to-moderate intensity (<70% 1 repetition maximum) produces the most reliable and robust decreases in anxiety.

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here www.theAnxietySummit.com

The Anxiety Summit – Gluten’s impact on the inflamed brain: reducing anxiety and depression

By 32 Comments

Tom

Dr. Tom O’Bryan, DC host of ‘The Gluten Summit – A Grain of Truth’ is interviewed  by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

Gluten’s impact on the inflamed brain: reducing anxiety and depression

  • Terminology and why it’s not called gluten intolerance but sensitivity
  • Is gluten sensitivity just a fad and the recent FODMAPs research
  • The multitude of diseases and symptoms caused by gluten sensitivity
  • Gluten sensitivity as a contributing factor to psychiatric manifestations/anxiety/depression and new 2014 research from Italy
  • Suicide rates in kids with celiac disease (even when they quit gluten), and kids celiac camps
  • The conundrum with testing
  • Doing an elimination and then challenge?
  • Can anyone eat wheat or should we all be gluten-free

One of my favorite quotes in my anxiety food talks is this one from a 2012 paper by Jackson and Fasano called Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity

gluten sensitivity remains undertreated and underrecognized as a contributing factor to psychiatric and neurologic manifestations.

Here are some snippets from our interview:

73% of kids with celiac disease have social phobia, 63% still have social phobia on a gluten-free diet. You have to also heal the gut and address nutritional deficiencies

No human on the planet can digest gluten! Whether or not it causes symptoms like anxiety or depression or arthritis why eat anything that would cause inflammation!

He shares recent research published in BMC Medicine. The study looking at Italians with non-celiac gluten sensitivity, found that 68% of participants felt “a lack of well-being” and 39% experienced anxiety. In the large majority of patients, the time lapse between gluten ingestion and the appearance of symptoms varied from a few hours to 1 day.

No human on the planet can digest gluten! Whether or not it causes symptoms” like anxiety or depression or arthritis “why eat anything that would cause inflammation”

The gluten-FODMAPs discussion and non-celiac gluten sensitivity is a fad:

Dr. O’Bryan summed it up like this:

it took two studies to do this but it appears to be the FODMAPs in the wheat that cause the GI complaints (the bloating, the gas, the abdominal pain) but it’s the proteins that cause symptoms in the brain and other parts of the body

I write about gluten often. Here are some additional links for you:

Last year Dr. O’Bryan hosted the fantastic Gluten Summit and you can grab a copy of one of the interviews here: Dr. Marsh’s Gluten Summit interview: Why the Early Stages of Celiac Disease Must be Taken Seriously

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here www.theAnxietySummit.com

The Role of Inflammation in Stress, Anxiety and Depression

By 10 Comments

NTA-Conference-2013

“Inflammation: The Fire Within” is the theme of the annual conference of the Nutritional Therapy Association. It will be held in Vancouver, WA on March 15, 16, 17. I’m thrilled to presenting on Friday from 10-11:30am and my topic is “The Role of Inflammation in Stress, Anxiety and Depression.”

This presentation will provide health and nutrition professionals with current, evidence-based information the role of inflammation in stress, and on anxiety and mood disorders. It will explain:

  • the negative impact of pro-inflammatory junk food, trans fats, feed-lot meat, pesticides, gluten, fructose and caffeine on stress, anxiety and depression
  • the recent research supporting the anti-inflammatory benefits of real whole food, the Mediterranean diet (for both reducing inflammation and reducing and preventing depression, fish and fish oils (with some exceptions), dark chocolate (with some caveats), probiotics, zinc and vitamin B6
  • the links between social stress and inflammation
  • the effects of maternal inflammation on anxiety and social behavior of offspring
  • the links between pyroluria (see the pyroluria questionnaire here), social anxiety and oxidative stress
  • how inflammation leads to low serotonin and mood issues

It’s quite incredible how much of an impact inflammation has on mood disorders and how simply taking steps to lower inflammation can have a positive impact. What is equally fascinating is that so many of the foods and nutrients that eliminate anxiety and depression also lower inflammation! The body is quite amazing in its ability to heal when provided with the correct nutrients!

I will also be exhibiting and will have delicious 100% certified Organic Tulsi Teas donated by Organic India and great for stress-relief and you guessed it… inflammation! Do come and try some yummy lemon-ginger or licorice or find some in your local grocery store. We’ll also do zinc status testing because zinc is key for alleviating anxiety, stress and depression. I’ll also have DVD sets and copies of my book The Antianxiety Food Solution for sale. And I’ll also be offering Lidtke samples of the amazing amino acids tryptophan (for low serotonin) and DPA/Endorphigen (for low endorphins and comfort eating). These amino acids also help with inflammation!

And I’m thrilled that my friend and colleague Mira Dessy will be joining me at my booth. She is a Nutrition Educator, Real Food Advocate and author of the fabulous new book The Pantry Principle: How to read the label and understand what’s really in your food (find her here and on facebook here).

The event has many great speakers and will be a content-rich educational three days. You can learn more and register here:
http://nutritionaltherapy.com/events-resources/nta-conferences

The sessions will be recorded and available for purchase from Nutritional Therapy Association if you can’t make it to the live event.