GABA

I have chronic insomnia and I started getting headaches with GABA, 5-HTP and melatonin

February 1, 2019 By Trudy Scott 14 Comments

A combination of GABA (gamma-aminobutyric acid) and 5-HTP (5-hydroxytryptophan) can often improve sleep duration more than the use of either of these two amino acids alone. I blogged about this and the supporting research published in 2016.

Eve asked this question about her chronic sleep problems and headaches that she suspects are being triggered by the supplements:

I have chronic insomnia and I have been using 100mg 5-HTP, 250mg GABA and 1mg melatonin during the night for a week but the second day I used them I started getting a headache. Do you have idea what happened and can you please help me?

I shared this feedback about each person having unique needs and that I trial one amino acid at a time to find the ideal dose and then once we have a good baseline with good results and no adverse effects, we add the next one if needed. With 3 new supplements being started at once, we don’t know which one may be helping and which one (or more) is causing headaches.

A reminder I give all my clients is NOT to push through with the amino acids when you are experiencing any adverse effects. Headaches are more common with tyrosine rather than 5-HTP or GABA but too much of any one of the amino acids may cause a headache and with some folks, even a small amount can cause a headache especially if it’s not needed. At the first sign of a headache my advice is to stop the latest supplement added and see how you do. If 3 where started at one time, as in this situation, stop all 3 and add them back one at a time, watching for headaches and benefits.

Eve didn’t say which GABA product she was using. Source Naturals GABA Calm is the one I most often recommend, and the small amount of tyrosine could be causing her headaches. If this is the case, a switch to a GABA-only product or a GABA-theanine product may be what is needed.

It’s always important to also review the amino acid precautions before use. If you have migraines, tyrosine may make them worse.

But I do want to also add that some folks cannot tolerate 500mg tyrosine at all and yet they do just fine with the 25mg of tyrosine in the GABA Calm product (and sometimes up to 75mg of tyrosine when three GABA Calm lozenges are needed at once).

It’s also good to be aware that some folks do better on tryptophan versus 5-HTP so if it is the 5-HTP that is the problem I’d consider a trial of tryptophan. The best way to do that is to replace the 5-HTP with tryptophan (and I recommend Lidtke 500mg tryptophan).

You want to also look carefully at each of the products in case there are fillers that could be causing the headaches.

If it turns out that none of these are working i.e. the problem with sleep isn’t because of low serotonin and low GABA, then we ask these questions and address them:

is there a gut issue i.e. is there candida, parasites and/or dysbiosis?
is night-time cortisol high?
is gluten or other grains an issue? or was there accidental gluten exposure?
is caffeine or alcohol consumption a problem?
is there EMF and WiFi exposure?
are there medication side-effects?
has there been mold exposure or some other environmental trigger?

Have you had issues when trialing amino acids for sleep or anxiety and then figured out what the problem was?

Anxiety, stress and high cortisol: forest bathing to the rescue

January 25, 2019 By Trudy Scott 16 Comments

On the way home from a snorkelling trip to the beach earlier this week we stopped at Centennial Park in Sydney and were wowed by the magnificent trees. It inspired me to write this blog about forest bathing to inspire you to think about the power of nature as a simple way to give you joy and contribute to a wonderful sense of calm and peace. I was quite giddy with these feelings while there and still feel waves of awe days later when thinking about it and looking at these pictures of the Paperbark Grove and the massive Morton Bay fig trees.

We know being in nature has a psychological impact making us feel calm and relaxed, happy and joyful, and even playful. But what exactly is forest bathing and are there really physiological impacts i.e. does forest bathing simply help you feel good or does it actually lower your cortisol levels or blood pressure?

This paper, The physiological effects of Shinrin-yoku (taking in the forest atmosphere or forest bathing): evidence from field experiments in 24 forests across Japan, defines forest bathing:

The term Shinrin-yoku (taking in the forest atmosphere or forest bathing) was coined by the Japanese Ministry of Agriculture, Forestry, and Fisheries in 1982. It can be defined as making contact with and taking in the atmosphere of the forest: a process intended to improve an individual’s state of mental and physical relaxation

The above study set out to measure and clarify the physiological effects of Shinrin-yoku or forest bathing with 12 young male university students who had no history of physical or psychiatric disorders:

12 subjects walked in and viewed a forest or city area. On the first day, six subjects were sent to a forest area, and the others to a city area. On the second day, each group was sent to the other area as a cross-check.

The participants sat and viewed the landscape for 12-16 minutes and then walked in the landscape for 14-18 minutes (in one of the 24 forests and then in one of the 24 city areas on the second day).

The subjects had the following markers measured before breakfast and both before and after the walking and viewing periods:

salivary cortisol
blood pressure
pulse rate and
heart rate variability

After this surprisingly short period of viewing and walking in the forests the following results were found:

forest bathing promotes lower concentrations of cortisol, lower pulse rate, lower blood pressure, greater parasympathetic nerve activity, and lower sympathetic nerve activity

So, what we have, is more activity of the parasympathetic system i.e. more of the calming “rest and digest” activity and less activity of the sympathetic system i.e. what we term as “fight or flight” or stress activity.

The authors suggest that forest bathing “may be used as a strategy for preventive medicine” and I wholeheartedly agree.

Given that GABA can lower high pressure and calm down the “fight or flight” sympathetic system (see this animal study) I won’t be surprised when we see research showing us that forest bathing boosts GABA levels just in a similar way that yoga boosts GABA.

If you don’t have everyday access to parks, trees or forests be sure to go out of your way to make detours down nearby tree-lined streets to get some of these wonderful health benefits.

And because we know that simply looking at images of greenery and nature can have a calming and stress-reducing effect, here is a bigger version of the photo I took of the Paperbark Grove for you to enjoy looking at!

My picture of the Paperbark Grove in Centennial Park, Sydney

We were so excited to “discover” this gem and got home and googled it only to find out it’s a popular avenue for wedding parties! I’m sure you can see why!

Right next to the Paperbark Grove are three giant Moreton Bay fig trees. These trees are estimated to be older that the park, which was opened in 1888.

Here I am being “hugged” by one of them (doesn’t it take tree-hugging to another level!?)

If you’re local to Sydney or come for a visit one day, I highly recommend a trip to Centennial Park to see these magnificent trees and do your own Australian version of forest bathing. You may just see me there!

Until then, I encourage you to get outside into forests, get “hugged” by trees, hug trees and gaze up and enjoy every calming and joyous moment. It can help to lower your cortisol levels so you can be free of anxiety and it may even help to prevent anxiety!

Please do share your favorite forest bathing locations and how they make you feel.

Mycotoxin illness is real! Is mold the root cause of your mystery symptoms and unresolved anxiety?

January 21, 2019 By Trudy Scott 13 Comments

Do you suffer from mystery symptoms and unresolved anxiety? Toxic mold is one possible unrecognized root cause – it can create hormonal imbalances, brain disrepair and neurotransmitter imbalances, chronic gastrointestinal issues and multiple autoimmune conditions.

Almost 20 years ago, your host, Dr. Margaret Christensen, was a successful OB-Gyn with a booming practice. She began having debilitating fatigue, was unable to think clearly and she ached all over, to such an extent that she had to close her practice.

Her family also showed symptoms: learning difficulties, insomnia, severe mood swings, migraines, ADD, asthma and bronchitis, tremors, sinusitis. After 8 years of sickness, they finally found toxic mold in their water-damaged house.

You should suspect and look into mold toxicity if you are:

Enduring terrible mood swings, anxiety and/or depression
Suffering from sinus infections, bronchitis and migraines
Weakened by gut issues, brain fog, fatigue, neurologic symptoms
Constantly challenged with sleep issues
Reacting to chemicals, smells, foods, medications

You may have told mold toxicity isn’t a real issue or that it is a pseudo condition. I was digging through the recent research and it’s not surprising that many doctors say it’s not real especially with studies like this one: Toxic mold: phantom risk vs science:

Indoor mold growth is variable, and its discovery in a building does not necessarily mean occupants have been exposed. Human response to fungal antigens may induce IgE or IgG antibodies that connote prior exposure but not necessarily a symptomatic state.

When mold-related symptoms occur, they are likely the result of transient irritation, allergy, or infection. Building-related illness due to mycotoxicosis has never been proved in the medical literature. Prompt remediation of water-damaged material and infrastructure repair should be the primary response to fungal contamination in buildings.

There are a rather large number of studies that reach the same conclusion (it’s not real) but the good news is that there is a 2013 paper – A review of the mechanism of injury and treatment approaches for illness resulting from exposure to water-damaged buildings, mold, and mycotoxins acknowledging that mycotoxins are an issue for many individuals:

Illness results from a combination of factors present in water-damaged indoor environments including, mold spores and hyphal fragments, mycotoxins, bacteria, bacterial endotoxins, and cell wall components as well as other factors. Mechanisms of illness include inflammation, oxidative stress, toxicity, infection, allergy, and irritant effects of exposure.

And ask anyone who has lived through mold toxicity and then healed and thrived, just how real and debilitating it is trying to figure out if it is in fact toxic mold that is the root cause and then what to do about it.

This same paper reviews commonly used treatments

such as glutathione, antioxidants, antifungals, and sequestering agents such as cholestyramine, charcoal, clay and chlorella, antioxidants, probiotics, and induced sweating.

All of the above will be covered in the summit (and much more).

Here are a few highlights and insights from me.

The interview with Dr. Ann Shippy – “Overview of the Journey to Recovery” – is just that, a very useful summary of all the mold connections and it highlights many of the other speakers and topics. She also shares this about Lyme disease, toxic mold and your total toxic load

Patients can have Lyme disease and not be sick but when they are sick it’s often because mold is suppressing the immune system and causing symptoms. It may not even be Lyme but mold instead.

Yuli Horesh covers: “Diffusing Probiotics to Defend Your Environment.” It is a fascinating interview I look forward to seeing some long-term research on the safety aspects. Other than this it makes so much sense and is a very exciting approach together with everything else. I also want to say that we don’t want to be thinking of this as a short-cut/quick-fix and not doing anything else.

Dr. Mary Ackerly’s interview is fabulous and is not to be missed– “Brain on Fire: The Role of Toxic Mold in Triggering Psychiatric Symptoms”. It’s very exciting to hear a psychiatrist who is so knowledgeable and passionate about this topic. I loved that she talked specific testing and about group 1, 2,3 and 3B in terms of how sick folks are and how quickly they respond to treatment and what needs to be done in terms of remediation.

I was also thrilled to learn about the International Society for Environmentally Acquired Illness (ISEAI) and encourage you to check them out as a resource for both your own recovery and if you’re a practitioner, for learning. They are hosting their first conference in May: “Healing Complex patients in a Toxic World”.

I was hoping to learn more about the NeuroQuant Triage Brain Atrophy Report (from Cortech) from her and other speakers. I wanted to know if a contrast agent is needed during the MRI as many folks have issues with gadolinium toxicity when having MRIs and I’d be very concerned about adding to the toxic load. It seems the contrast isn’t needed.

In Dr. Jill Carnahan’s interview – “Metabolic Endotoxemia and the Gut-Brain Connection”, she recommends a provoked or challenged urinary myctoxin test with some glutathione or sauna because you can get false negatives if you don’t do this before testing. She also shares all her favorite binders: charcoal, clay, zeolite, glucommanan and citrus pectin.

They also talk about SIBO (small intestinal bacterial infection) and say that a lot of SIBO is really SIFO (small intestinal fungal infection), how toxic mold can impact gut motility and and how antifungals rather than anti-bacterials are the way to go in this instance.

Jeff Bookout’s interview on “Non-Toxic Remediation for Chemically Sensitive” is wonderful. They cover dry-fogging, using non-toxic citrus based oils, practical tips for travel and hotel rooms, keeping dorm rooms safe from toxic mold and how best to clean the HVAC (heating, ventilation and air-conditioning) system so you’re not dispersing toxic mold throughout the house. This is a very practical and common-sense interview.

If you didn’t register yet, I’m hoping this inspires you to register and tune in. It’s one of the most popular summits I’ve promoted and I feel it’s a topic we all need to learn about and ideally before it’s a problem because when you’re in the midst of it, it makes it that much more challenging to deal with. You just never know when you may need this information. Take for example all the people affected recently by the dreadful floods in Townsville in Australia, and elsewhere.

If you are in the midst of dealing with your own mold toxicity I know you’re getting great resources for remediation and recovery. Be sure to have a friend or loved one who has not been affected, listen in and read the transcripts so you’re not alone in figuring things out.

Even if you don’t currently have symptoms of mold toxicity, it’s an excellent resource so you can be prepared the next time you have water damage in your home, office or school. It will also allow you to make sure you don’t have a growing mold problem which may affect your health down the road.

The Toxic Mold Summit health experts, air quality experts and mold remediation specialists will help you identify if you have mold exposure and share the latest tools and techniques for dealing with toxic mold.

When you register be sure to check out the ebook, “Got Mold? Now What? Hope for Health and Home: Overview of Toxic Mold and Biotoxin Illness!” It covers why you get the following symptoms and the mechanisms, total toxic load, recommended testing for you and your moldy home (or work place or school etc.), resources to make you more resilient, basic treatment steps and dietary approaches to consider.

Here are symptoms and illnesses caused by toxic mold exposure. Dr. Christensen explains that mold/biotoxin illness may present in many ways, even within the same family who have been exposed to mold, and often with some kind of pain or inflammation, and in almost any area of the body:

Chronic recurrent upper respiratory and sinus infections
Chronic headaches/migraines
Severe chronic fatigue or ongoing flu-like symptoms
Fibromyalgia (tender, sore muscles)
Neurological issues (tremors, neuropathy, brain fog, ADD, learning issues, etc.)
Neuro-degenerative diseases (Parkinson’s, MS, ALS, Alzheimer’s and other dementias)
Severe gut symptoms (IBS, Crohn’s, ulcerative colitis, SIBO/SIFO)
Autoimmune disorders (thyroid, Hashimoto’s, psoriasis, rheumatoid arthritis, eczema, hives)
Multiple chemical sensitivities and histamine intolerance (rashes and hives)
Night sweats (common in men of all ages, as well as women)
Psychiatric symptoms (anxiety, depression, panic attacks, bipolar symptoms, psychosis)
Severe sleep disturbances
Recurrent interstitial cystitis, bladder infections and frequent urination
Hormonal imbalances (adrenal and thyroid hormones)
Infertility, heavy periods and cramps, endometriosis, PMS, PCOS
Cardiovascular disease
Lyme and co-infections, including viral infections like EBV, HHV6
Cancer (especially hormonal, leukemias/lymphomas and bladder/kidney)
Children: chronic ear, throat and upper respiratory infections, asthma, allergies, ADD/ADHD, sleep, irritability, bedwetting

In the testing section she does state that “HLA genetics tests are not necessary but can be interesting” and I was intrigued to hear this because I considered this a gold standard test to have done.

Here are some of the excellent topics and speakers:

Chemical Sensitivity and Detoxing Your Home with Bridgit Danner, LAc, FDNP
Heavy Metals, Fatigue and Detox with Wendy Myers, FDN-P, NC, CHHC
Essentials Oils to Treat and Prevent Mold Toxicity with Jen Broyles, CHC
Mold Inspection and Detection with JW Biava
Mold, Mental Illness and Suicide Prevention with Jill Sheppard Davenport, MS, CNS, LN
Mold, Histamine and Multiple Chemical Sensitivity with Gail Clayton, RPh, MS, CNS
Brain on Fire: Mental Illness and Mold with Mary Beth Ackerley, MD, MD(H), ABIHM
Advanced Therapies for Mold Recovery with Mark Hyman, MD
Finding a Quality Mold Inspector and Remediator with Jason Earle, IEP

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UPDATE: March 28, 2021
This summit is being re-released for a third time on April 26 – May 2, 2021 due to the high demand and excellent content.

I was thrilled to be invited to speak on this summit AND my interview, Immediate Relief for Anxiety, also happens to be one of the registration gifts so you get access right away!

We initially cover some of the many connections between mold toxicity and anxiety and low mood. I share from this 2018 paper, Effects of Mycotoxins on Neuropsychiatric Symptoms and Immune Processes:

the presence of mold and dampness was associated with the prevalence of depression and emotional distress
it’s unclear whether neuropsychological problems are due to the adverse effects of mycotoxins or the emotional and financial stress of keeping a house clean in the face of recurrent mold [it’s very likely both + the loss of treasured possessions for some folks too]
a low sense of control may lead to an elevated risk for anxiety and depression.

I also share how much I learned from Dr. Neil Nathan’s presentation at one of the IMMH conferences: “Mold Toxicity as an Unrecognized Cause of Mental Health issues.” He shares that “mold toxicity may directly trigger anxiety, panic attacks, depression, depersonalization and hallucinations AND mast cell activation, multiple chemical sensitivities, secondary porphyrias, methylation dysfunction and pyroluria” … all of which plays a role in anxiety/depression.

I go on and cover the solutions for the anxiety and panic attacks (often directly triggered by mold toxicity) and the sense of loss while you are dealing with the mold toxicity and home remediation or move:

mold anxiety and how to use GABA and serotonin support to ease the anxiety, fears, insomnia, worry and panic attacks that are so common with mold toxicity (so there is not the added toxic burden of psychiatric meds)
how certain mycotoxins may actually lead to high serotonin and what to do in this instance
using DPA (an amino acid that boosts endorphins) to help comfort folks who may lose their homes and beloved contents/books/photos due to mycotoxins

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If you or a loved one suffers from mystery symptoms and/or unresolved anxiety I encourage you to tune in to learn more.

I’ll see you online at this educational summit when you register here.

Can you relate to any of this? Have you been ill as a result of toxic mold exposure? Or do you suspect mold is one of your root causes?

Have you remediated a moldy home and healed your self with a functional medicine approach?

Why does chewable GABA make me run to the bathroom and what GABA do I use instead?

January 4, 2019 By Trudy Scott 9 Comments

The amino acid GABA (gamma-amino butyric acid) helps to raise GABA neurotransmitter levels and ease the physical symptoms of anxiety: stiff and tense muscles as well as feelings of stress, overwhelm and often panic attacks and overthinking/unwanted thoughts too. It can also help with the visceral pain of IBS/SIBO and insomnia. GABA eases symptoms very quickly, often within 5 minutes but is most effective when taken sublingually, is chewed or is opened on to the tongue.

I often get feedback from individuals in my community saying GABA doesn’t work for them for one reason or another. Digestive issues are a common problem and one question I often hear is the one about chewable GABA and gas, bloating and/or diarrhea.

Rav asks this question on the blog:

What about individuals with IBS (irritable bowel syndrome) or Colitis who cannot take chewable tablets? I used to take the GABA-Pro by Bioclinic Naturals and it just made me run to the bathroom. Should those with digestive trouble steer clear from chewable forms of GABA?

This is an excellent question and something you always need to consider when having digestive upset: is it due to a new supplement I’ve recently added? You have to find a product that works for you and we’re all different. Just like we need to read labels with food we need to read and understand the labels of supplements too.

There are a number of factors to consider: sugar alcohols, natural flavors and plant-based cellulose ingredients.

Let’s look at sugar alcohols first

Many of the chewable or sublingual forms of GABA contain sugar alcohols which can be problematic and cause digestive upset and often explosive diarrhea. Sugar alcohols include xylitol, sorbitol, mannitol and erythritol. Your reaction will depend on the amount of sugar alcohols used, how many chewable tablets you use and how accustomed you are to sugar alcohols. You may get used to them and eventually be fine with consuming small amounts and yet for others the tiniest amount is an issue.

Many of the chewable forms also contain natural flavors which could potentially be problematic for you.

Let’s now look at cellulose and rice flour

I’m also starting to see more and more folks have digestive distress and gas from products with plant-based cellulose ingredients, especially when someone has IBS or SIBO (small intestinal bacterial overgrowth). For example, you may see hydroxypropylcellulose on the label. This helps the chewable keep its shape and stay intact longer when in the mouth.

With capsules you may see cellulose, methylcellulose or hypromellose on the “Other Ingredients” section on the label, with these vegetable-based ingredients replacing the gelatin capsule. This also often causes bloating and gas when IBS/SIBO is an issue.

The rice flour filler in many products can also be problematic for some folks with IBS/SIBO.

Reading the label

The product Rav mentions – GABA-Pro by Bioclinic Naturals – is not one I’m familiar with but a quick check shows these ingredients in addition to the GABA:

Xylitol, stearic acid, hydroxypropylcellulose, silica, natural tropical fruit flavour (banana, pomegranate, pineapple, mango, passionfruit, orange, tangerine, mandarin), citric acid, vegetable grade magnesium stearate (lubricant).

The xylitol is a sugar alcohol, the hydroxypropylcellulose is plant-based cellulose and there are many natural flavors in this product. Any one or all could be the issue.

Magnesium stearate, a bulking agent and lubricant, is often reported as being problematic but since it’s in so many products, it’s unlikely to be causing digestive distress in this case. If you’d like to learn more, Dr Josh Axe has a great blog addressing some of the hype around magnesium stearate concluding it’s safe to consume.

Interestingly, the product label says GABA (gamma-amino butyric acid) when in actual fact it contains pharma GABA (a fermented form of GABA). It’s unlikely that this is the issue for Rav but I do find it a strange way to label a product.

Finally, it’s always important to check quality and make sure there are no artificial colors, preservatives, or sweeteners, no dairy, no gluten and no GMO ingredients in the supplement. This product passes this test.

What GABA do I use instead?

One option is to switch to another chewable such as GABA Calm. This is one of my favorite GABA products because it works so well, is a nice low dose of GABA, is convenient when you’re out and about and actually tastes good. This one does contain the sugar alcohols sorbitol and mannitol, as well as a natural flavor which may well also be an issue, although I’ve had few complaints from clients and those in my community.

The other option is to use a GABA-only product or a combination GABA and theanine product (such as NFH GABA-T SAP) opened onto the tongue. It’s not as convenient but if it gets you the calming results you’re looking for then it’s a non-issue.

And finally, you could do a trial of using the chewable during the day and the opened GABA capsule at night so you’re consuming less sugar alcohols overall (if that’s your issue).

You can find the GABA Calm, NFH GABA-T SAP and Enzymatic Therapy GABA on the supplements blog here. To be clear, I’m not saying the GABA-Pro product isn’t a good choice in general, rather that it may not be ideal for you, based on your unique needs and what is going on with your gut at any one time.

How do you do with these chewable GABA products (or others like this). Do you do well on them or do you end up running to the toilet or battle with gas and/or bloating?

Or do you prefer a GABA-only or GABA/theanine combination product (opened onto the tongue)?

Gut bacteria, pain and anxiety connections: Klebsiella and ankylosing spondylitis

December 28, 2018 By Trudy Scott 21 Comments

We know about the gut-brain connection where the health of our microbiome impacts how anxious or depressed we feel, but we often forget that there is a gut-pain connection too and how addressing dysbiosis and bad bacteria in the gut can have far-reaching benefits.

An old work friend recently reached out asking for help for her husband who had been diagnosed with ankylosing spondylitis, ulcerative colitis and gluten sensitivity, and was not seeing results with conventional treatment. I did some digging for them and a colleague mentioned that they had addressed Klebsiella when they discovered that her husband had genes predisposing him to ankylosing spondylitis. Read on to see what I’ve learned.

Klebsiella as a precursor to ankylosing spondylitis

The paper shared with me: The relationship between Klebsiella infection and ankylosing spondylitis, discusses the HLA-B27 gene and the Klebsiella connection:

Klebsiella-reactive arthritis is the precursor stage occurring in the early and active phases of ankylosing spondylitis.

Let’s learn more about Klebsiella, ankylosing spondylitis, the anxiety connection and prevalence, the role of neuro-inflammation and genes, the problems of a high carb diet and the role the amino acids GABA, tryptophan and DPA play in pain and anxiety relief and being able to quit the carbs easily, plus provide sleep support.

In case you’re not familiar with Klebsiella, this excellent FX Medicine article describes it as follows:

Klebsiella pneumoniae (KP) is a type of gram-negative rod-shaped bacteria that can cause different types of infections ranging from pneumonia (lung), blood infections (septicaemia), wound or surgical infections, urinary tract infections, small intestinal bowel overgrowth (SIBO), ankylosing spondylitis, Crohn’s disease, ulcerative colitis and meningitis (brain).

Ankylosing spondylitis is an inflammatory disease of the spine

In case you’re not familiar with the condition ankylosing spondylitis (pronounced like this) the Mayo Clinic site provides this summary:

Ankylosing spondylitis is an inflammatory disease that, over time, can cause some of the vertebrae in your spine to fuse. This fusing makes the spine less flexible and can result in a hunched-forward posture. If ribs are affected, it can be difficult to breathe deeply.

Ankylosing spondylitis affects men more often than women. Signs and symptoms typically begin in early adulthood. Inflammation also can occur in other parts of your body – most commonly, your eyes.

They say there is no cure and the treatments include pain medications and physical therapy to ease symptoms (and surgery in some cases).

I’m all for physical therapy but you’ll notice there is no mention of gut health or Klebsiella. This is why we have to keep searching for root causes – and work with a functional medicine practitioner – no matter what the health condition, be it ankylosing spondylitis or anything else.

Prevalence of anxiety in ankylosing spondylitis

As with most physical conditions there is a connection with anxiety. This paper: Prevalence of psychological disorders, sleep disturbance and stressful life events and their relationships with disease parameters in Chinese patients with ankylosing spondylitis reports that

AS [ankylosing spondylitis] patients had more severe psychological disorders, sleep disturbance, and stressful life events.

Prevalence of anxiety, depression, and sleep disturbance was 31.6%, 59.3%, and 31.0% respectively.

We have to ask ourselves if we have anxiety, depression and insomnia because of the pain being experienced or because of one or more of the root causes that contribute to both pain and anxiety.

Microbiota disturbance, neuro-inflammation, and anxiety

Often the research focuses on the former but we know that there is Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice. In this 2018 animal study treatment with lactobacilli suppresses this neuro-inflammation.

Ankylosing spondylitis, Crohn’s disease, genes and a high carb diet

The above FX Medicine article shares the connection between ankylosing spondylitis, Crohn’s disease and ulcerative colitis, as well as the genetic susceptibility, together with the problems of a high carb diet:

Genetically susceptible people, such as those who have the HLA-B27 allelotypes and consume a high starch/carbohydrate diet, can trigger a growth in Klebsiella in the bowel, the starch becoming a main food supply for the Klebsiella.

The amino acids for pain, carb addition, anxiety and insomnia

The amino acids come into the picture again, helping to ease the pain, provide precursors for neurotransmitter production until the microbiome is balanced, and eliminate carbohydrate cravings so they can be given up without willpower.

As always figuring out your own imbalance and doing an amino acid trial is key. Here is a summary of how they may help in this instance, assuming you have low levels of GABA, serotonin and/or endorphins:

GABA helps with stress eating of carbs, eases physical anxiety, eases some pain.
Tryptophan helps with afternoon and evening carb cravings, eases mental worry-type anxiety and depression, and also eases some pain. Both GABA and tryptophan help with insomnia.
DPA boosts endorphins providing acupuncture-like pain relief and provides the emotional comfort that starchy treats often do.

The FX Medicine article has treatment and prevention tips for you to share with your functional medicine doctor, who will be able to run a functional stool test such as the GI-MAP offered by Diagnostic Solutions Lab.

Just because there are these gut bacteria, pain, anxiety, Klebsiella and ankylosing spondylitis connections, it doesn’t necessarily mean everyone with ankylosing spondylitis has Klebsiella or that everyone who has Klebsiella will go on to develop ankylosing spondylitis (as stated above) or even that everyone with ankylosing spondylitis will have anxiety. I’m simply connecting some dots so you can start to think outside the box.

I’d love to hear what has worked for you or a loved one with ankylosing spondylitis and/or if you’ve seen elevated Klebsiella on your stool test or have the genetic predisposition?

Have the amino acids and a low-carb diet helped the healing process and eased some of your anxiety while addressing the underlying Klebsiella infection?

The amino acids GABA and tryptophan can help to relieve anxiety in children: an interview with Dr. Nicole Beurkens

December 14, 2018 By Trudy Scott 16 Comments

Using individual amino acids such as GABA and tryptophan can have an incredible impact on children with anxiety, easing anxiety very quickly. I don’t often write or talk about using amino acids with children and since many of you have asked for more resources for children, today I’m sharing an interview I recently did on this topic on The Better Behavior Show. This is a podcast hosted by my colleague and good friend Dr. Nicole Beurkens.

I share specifics on how Amino acids can help to relieve anxiety in children, together with some case studies.

Dr. Nicole sums up the power of the amino acids beautifully – and this is exactly why my clients love them so much – they take the edge off quickly, provide results and help with overwhelm:

I think that the fact that these [amino acids] can work quickly is really helpful. And as you said, it helps to take the edge off, it helps to reduce the symptoms so then we can more effectively address all of the underlying things. Because often, I’ll have parents say, “Oh, you want me to change the diet and do all these things, I just feel so overwhelmed, my kid is having so many issues, I don’t know how we’re going to do any of that.” And then when you can use things like targeted aminos to help take the edge off the symptoms for the parent and the child, it makes all of that other stuff more doable, I think.

Here are some snippets from one of the stories I share – the wonderful results I had with a 11-year old girl who had been adopted, was diagnosed with reactive attachment disorder and had explosive anger issues. This young girl:

….also had insomnia, so she was not sleeping well at all. She was very fatigued in the day, had really bad anxiety about going to school and loved colored candies and she was a big bread eater.

This family didn’t have much money to spend so I really had to find an affordable solution with the biggest benefits. She was anemic so we addressed that with iron supplements and getting her eating quality grass-fed red meat again and we figured out that gluten was an issue so she went gluten-free and this made a big difference with the outbursts.

The other factor was to figure out if low serotonin was a factor and address this. The big clues were the anger, the insomnia, the anxiety and the sugary cravings:

I was talking to her about the fact that she loved candies and she loved bread, and I said — how would you feel about giving it up? She was fuming with me. She was in a swivel chair and she turned her back to me and she didn’t want to talk about it.

I offered her a 100mg chewable tryptophan to see if it would help with her sugar cravings and the fact that she was furious with me:

“How about trying this amino acid, it’s called tryptophan and it’s chewable and it doesn’t taste bad… and then we’ll talk a little bit later. Don’t worry about what I said earlier.” So I gave her 100mg of chewable tryptophan.

She chewed the tryptophan and within 5 minutes, she turned around, smiled at me and said, “I think I can do it, I’m ready to do it.”

She was calm and smiling, and ready to give up the candies and bread and other gluten-containing products. These 3 interventions – addressing her low iron levels, having her go gluten-free and supplementing with tryptophan – completely turned this little girl’s life around.

Here is the link to the entire transcript of our interview: Amino acids can help to relieve anxiety in children. You can also find the audio interview at this same link or by going directly to iTunes – simply search for “The Better Behavior Show.”

Do listen in and/or read the transcript and learn more about:

how I do a trial of the amino acids (this allows for quick results in 5-10 minutes)
how I’ve worked with non-verbal children
a simple trick for using the unpleasant tasting tryptophan sublingually
what low GABA anxiety looks like in a child
why ADHD symptoms in children may actually be anxiety (I share another success story in this section)
why I use GABA Calm with children and adults (Dr. Nicole uses this GABA product too and loves that it’s sublingual and tastes great)
times you may consider using tyrosine or DPA
and much more

It was a pleasure to be on the show of someone whose work I deeply respect. Dr. Nicole is a unique combination of clinical psychologist, nutritionist, and special education teacher, and shares these resources for help with improving your child’s behavior naturally: her book Life Will Get Better, blog, and the Better Behavior Naturally Parent Program. and tune in to my interview and some of the other excellent interviews.

If you’d like to learn more about these supplements, look at my supplements blog here

There is also a “Liquid and powder options for children” section on this blog – with other products you may find useful for children.

I’d also like offer a caution about the 100mg chewable tryptophan This chewable form is both good and bad. It’s good because it’s a nice 100mg of tryptophan per tablet, is chewable, tastes good and is suitable for children and “pixie dust” individuals who need a very small amount and for when doing the initial trial. The bad aspect is that it does contain sugar and is quite sweet. Because you are continually consuming something sweet you may end up over-consuming them if sugar addiction is your issue. I’ve seen the same with children who want to eat them like candy. So, what I do most of the time is use the chewable tryptophan for the trial and then switch to the 500mg tryptophan after that. We did that with the 11-year old with anger issues, anxiety and candy cravings.

One more thing: Lidtke is the only brand of tryptophan I use and recommend because of its quality. I forgot to mention that in our interview.

Have you benefited from using any of the amino acids and then found they also help your child/children?