endorphins

I am an emotional eater and eat sugar as a reward and find myself craving it when I am fatigued. Do you have clients on more than one amino acid?!

July 24, 2020 By Trudy Scott 24 Comments

This is a question I received from a stressed out mom in my community. She has identified when she craves sugar and the emotion connected to her cravings. Now she has questions about how to trial and use amino acids to stop her cravings, get her energy back and feel emotionally stable:

I know I am an emotional eater, I know I eat sugar as a reward and I do find myself craving it when I am fatigued. I also seem to crave it after a very savory meal; especially one with garlic. What is THAT about?! Do you have clients on more than one amino acid?!

I have been a caregiver for my son (multiple disabilities) for 30 years; he has uncontrolled seizures and my husband has PTSD. It is a stressful household.

This is what I shared with her about the brain chemical imbalances and amino acids:

Many of my clients need more than one amino acid but it’s best to trial one at a time. When I hear my client say they eat sugar as a reward we immediately consider a trial of DPA (d-phenylalanine) especially if they are also overly emotional/weepy and also have physical pain.
When I hear my client say “I do find myself craving sugar when I am fatigued” we consider low catecholamines and a trial of tyrosine especially if they also have poor focus, low motivation and a flat mood. If the fatigue is caused by low blood sugar this can cause fatigue, irritability/crankiness and anxiety and a trial of glutamine may be a better option. If the DPA helps the emotional-reward-eating after a week or two, then we may do a trial of tyrosine and/or glutamine (one at a time) and use them in addition to the DPA.
When I hear “sugar cravings after a savory meal” we consider low serotonin and a trial of tryptophan if it’s after lunch or dinner. Serotonin dips in the afternoon and evening triggering this type of craving. With low serotonin we also see worry, anxiety, depression, anger, PMS, insomnia and irritability. Let’s assume the DPA helps and the tyrosine helps with the fatigue, then we’d consider a trial of tryptophan and add that.

So yes I do have many clients needing more than one amino acid! But we always trial one at a time and find a good baseline before adding the next one or doing a new trial if the first one didn’t give expected results.

With regards to which amino acid trial to do first, I always ask my client which area is causing the most problem or distress in your life and we start there. Since she mentioned emotional eating and then fatigue and then cravings after a savory meal, this sequence may be best for her. But addressing the fatigue with tyrosine first may be a better approach for someone else.

With regards to cravings after a savory meal we also look into how much protein and healthy fats the client has in that meal. I don’t know why garlic would be a trigger other than it’s possibly stirring up candida. Candida is also a big factor when it comes to sugar cravings, fatigue and feeling sad/emotional so we would also possibly need to address this too.

Adrenal and sleep support is also key and I recommend this resource for additional caregiver support for her – The psychological trauma of coronavirus – nutritional support for doctors, nurses and their loved ones.

For her husband’s PTSD I recommend this resource – PTSD from 3 tours in Afghanistan: Can GABA help with the anxiety?

For her son’s seizures I recommend this paper, Ketogenic Diet and Epilepsy: What We Know So Far, and working with a practitioner who could offer consultation and guidance on a ketogenic diet. Another useful resource is this one – Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials.

If you suspect low levels of any any of the neurotransmitters and are new to using the amino acids and do not have my book I highly recommend getting it and reading it before jumping in to taking supplements: The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings.

There is a complete chapter on the amino acids and one for pyroluria, plus information on real whole food, sugar and blood sugar, gluten, digestion and much more. If you’re not a reader there is now also an audible version.

Here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution and additional information on Anxiety and targeted individual amino acid supplements: a summary

Please also read and follow these Amino Acid Precautions.

This lists The Antianxiety Food Solution Amino Acid and Pyroluria Supplements that I use with my individual clients and those in my group programs. You’ll find DPA, tyrosine and tryptophan listed here.

Please share your emotional eating and sugar craving success story if you have one using DPA.

And let us know if tyrosine helps with your fatigue and low-energy driven sugar cravings?

And does tryptophan help your afternoon and evening sugar cravings?

Feel free to post your questions here too.

How best to use the amino acid DPA for easing heart-ache, weepiness, comfort eating and a compulsive desire for food

May 17, 2019 By Trudy Scott 36 Comments

DPA (d-phenylalanine) is an amino acid that destroys the enzyme that breaks down endorphins. Endorphins are feel-good chemicals that you experience with an endorphin rush when you go for a run or when someone gives you a big hug, when you show kindness to someone or an individual does something nice for you.

Taking the amino acid, DPA, as a supplement helps to raise your endorphins and helps when you feel weepy and overly emotional AND reduces the need to self-medicate with treats as a reward or for comfort. This amino acid is a favorite with so many of my clients and community because it makes them feel so lovely.

My recommendation has always been to chew the DPA capsule for the best effects and to get results quickly (in 2-5 minutes) but I’ve now changed my recommendation. Instead of chewing the whole capsule I now recommend opening the capsule into your mouth.

New DPA recommendation – open the capsule instead of chewing it

I’ve updated the Antianxiety Food Solution Amino Acid and Pyroluria Supplements blog as follows:

I used to recommend simply chewing the capsule to get the quickest and best effects and this worked well when it was produced in a gelatin capsule. Now it’s made with a cellulose capsule and chewing doesn’t work at all well, so opening the capsule (or just biting off the top) and tipping the powder into your mouth works best.

When it was in a gelatin capsule, the warmth of the mouth dissolved the gelatin and you could eat the capsule together with the DPA. With the cellulose capsule, chewing it leas to much of the DPA getting partially stuck in the chewed capsule, which is not very pleasant to chew and swallow. The DPA is simply much more palatable and effective when it’s opened up into the mouth, rather than chewed. There is one caveat – the taste of the DPA itself – but if you’ve been chewing it you’ll be fine opening the capsule going forward.

My favorite DPA product is Lidtke Endorphigen. It contains 500mg and a tiny amount of vitamin B2 and vitamin B6.

You’ll notice the bottle says: “Maintain healthy endorphin levels to ease minor pain.” Physical pain relief is one of the side-benefits of DPA, but you could easily replace this statement.

Results for weepiness and a deep heart-ache, and the taste of DPA

Missy shares how DPA helps her deep heart-ache sort of feeling:

I have found I was using this product incorrectly. If you are feeling fine, you do not feel much of anything from it. But today I was weepy and felt that deep, heart-ache sort of feeling. I chewed 1000 mgs (2 capsules) and it DID help lift that awful feeling within 15 minutes.

Notice that she said if you’re feeling fine you don’t feel much at all. This is true of all the amino acids – they only make a difference when you need them.

Missy chewed the capsule but with the new cellulose capsule it’s much more palatable when it’s opened up into the mouth. She also reported what about half my clients say:

Tastes like slightly bitter dark chocolate. 🙂

The remainder of my clients don’t like the taste at all, although many say the taste grows on them. I’ve always been in the dark chocolate camp and find it quite pleasant tasting.

If you have a really hard time with the taste of the DPA, you can mix it with a small amount of GABA powder (assuming low GABA is also an issue) or inositol powder (if low serotonin and obsessions and ruminations are also an issue) as both of these are naturally quite sweet.

Results for a compulsive desire for food

Nanner finds that opening a capsule into her mouth gets rid of the compulsive desire for food:

It really helps! Whenever I notice I am opening cupboards when I cannot possibly be really hungry, I open one capsule and pour it into my mouth, let it dissolve. I like the taste! The compulsive desire for food goes away, and I am able to re-focus my attention and get on with my day. Amazing! Now, I just need to form a new habit and remember to DO IT!!! Lol

Take note how quickly this works for her. She is actually opening cupboards and on the prowl for a treat or reward, recognizes this and has some DPA and viola, she no longer needs the sweet comfort she was seeking. In an ideal world she would be taking DPA a few times a day until she has good levels of endorphins. In this instance there would be no cupboard prowling. But as you can see, it can be used on-demand with excellent results.

DPA, glutamine, GABA, tryptophan (or 5-HTP) and tyrosine are ALL powerful for eliminating sugar cravings – is it low endorphins?

The individual amino acids DPA, glutamine, GABA, tryptophan (or 5-HTP) and tyrosine are ALL powerful for eliminating sugar cravings, often within 5 minutes. It seems that this wonderful benefit – over and above the anxiety-reducing and mood-boosting benefits – is often overlooked or poorly understood.

If you’re not certain if your cravings are comfort/reward cravings the best way to figure it which neurotransmitter deficiency is affecting your sugar cravings is to do the amino acid mood questionnaire and also review the list on this blog for further clarification: The individual amino acids glutamine, GABA, tryptophan (or 5-HTP), DPA and tyrosine are powerful for eliminating sugar cravings, often within 5 minutes

The big clue with low endorphins is that you may also feel weepy, overly emotional and sometimes experience physical pain. The emotional connection to the treat – be it chocolate or ice-cream or cookies – feels very real and very strong too and you can’t imagine having to give up this treat you clearly deserve.

Resources for you related to this blog

Here is one paper, which discusses how DPA inhibits or breaks down enkephalins (endorphins are closely related compounds) and as a result helps with depression and pain, and acts as an anti-inflammatory. This paper, discusses beta-endorphins and the reward mechanism and how they can induce euphoria, reduce pain and ease addictions and distress. Despite that fact that this is discussed in the context of drugs and alcohol, more and more research is showing parallels between drug and food cravings.

Here is the amino acid questionnaire

You can find the DPA and other amino acid products I use with my clients here.

As always, thanks for sharing your feedback and questions on my facebook page and in all the blog comments. It allows me to write blogs like this and share your own feedback and experiences.

I have to say that I agree with Sandra’s sentiments and so do most of my clients:

Honestly I think the whole world needs this!

Do let us know if DPA has helped you with reducing weepiness, comfort/reward eating?

Has it also helped with easing physical pain too?

And have you noticed DPA works best when opened up onto your tongue? And are you in the dark chocolate camp and find it quite pleasant tasting?

Mycotoxin illness is real! Is mold the root cause of your mystery symptoms and unresolved anxiety?

January 21, 2019 By Trudy Scott 13 Comments

Do you suffer from mystery symptoms and unresolved anxiety? Toxic mold is one possible unrecognized root cause – it can create hormonal imbalances, brain disrepair and neurotransmitter imbalances, chronic gastrointestinal issues and multiple autoimmune conditions.

Almost 20 years ago, your host, Dr. Margaret Christensen, was a successful OB-Gyn with a booming practice. She began having debilitating fatigue, was unable to think clearly and she ached all over, to such an extent that she had to close her practice.

Her family also showed symptoms: learning difficulties, insomnia, severe mood swings, migraines, ADD, asthma and bronchitis, tremors, sinusitis. After 8 years of sickness, they finally found toxic mold in their water-damaged house.

You should suspect and look into mold toxicity if you are:

Enduring terrible mood swings, anxiety and/or depression
Suffering from sinus infections, bronchitis and migraines
Weakened by gut issues, brain fog, fatigue, neurologic symptoms
Constantly challenged with sleep issues
Reacting to chemicals, smells, foods, medications

You may have told mold toxicity isn’t a real issue or that it is a pseudo condition. I was digging through the recent research and it’s not surprising that many doctors say it’s not real especially with studies like this one: Toxic mold: phantom risk vs science:

Indoor mold growth is variable, and its discovery in a building does not necessarily mean occupants have been exposed. Human response to fungal antigens may induce IgE or IgG antibodies that connote prior exposure but not necessarily a symptomatic state.

When mold-related symptoms occur, they are likely the result of transient irritation, allergy, or infection. Building-related illness due to mycotoxicosis has never been proved in the medical literature. Prompt remediation of water-damaged material and infrastructure repair should be the primary response to fungal contamination in buildings.

There are a rather large number of studies that reach the same conclusion (it’s not real) but the good news is that there is a 2013 paper – A review of the mechanism of injury and treatment approaches for illness resulting from exposure to water-damaged buildings, mold, and mycotoxins acknowledging that mycotoxins are an issue for many individuals:

Illness results from a combination of factors present in water-damaged indoor environments including, mold spores and hyphal fragments, mycotoxins, bacteria, bacterial endotoxins, and cell wall components as well as other factors. Mechanisms of illness include inflammation, oxidative stress, toxicity, infection, allergy, and irritant effects of exposure.

And ask anyone who has lived through mold toxicity and then healed and thrived, just how real and debilitating it is trying to figure out if it is in fact toxic mold that is the root cause and then what to do about it.

This same paper reviews commonly used treatments

such as glutathione, antioxidants, antifungals, and sequestering agents such as cholestyramine, charcoal, clay and chlorella, antioxidants, probiotics, and induced sweating.

All of the above will be covered in the summit (and much more).

Here are a few highlights and insights from me.

The interview with Dr. Ann Shippy – “Overview of the Journey to Recovery” – is just that, a very useful summary of all the mold connections and it highlights many of the other speakers and topics. She also shares this about Lyme disease, toxic mold and your total toxic load

Patients can have Lyme disease and not be sick but when they are sick it’s often because mold is suppressing the immune system and causing symptoms. It may not even be Lyme but mold instead.

Yuli Horesh covers: “Diffusing Probiotics to Defend Your Environment.” It is a fascinating interview I look forward to seeing some long-term research on the safety aspects. Other than this it makes so much sense and is a very exciting approach together with everything else. I also want to say that we don’t want to be thinking of this as a short-cut/quick-fix and not doing anything else.

Dr. Mary Ackerly’s interview is fabulous and is not to be missed– “Brain on Fire: The Role of Toxic Mold in Triggering Psychiatric Symptoms”. It’s very exciting to hear a psychiatrist who is so knowledgeable and passionate about this topic. I loved that she talked specific testing and about group 1, 2,3 and 3B in terms of how sick folks are and how quickly they respond to treatment and what needs to be done in terms of remediation.

I was also thrilled to learn about the International Society for Environmentally Acquired Illness (ISEAI) and encourage you to check them out as a resource for both your own recovery and if you’re a practitioner, for learning. They are hosting their first conference in May: “Healing Complex patients in a Toxic World”.

I was hoping to learn more about the NeuroQuant Triage Brain Atrophy Report (from Cortech) from her and other speakers. I wanted to know if a contrast agent is needed during the MRI as many folks have issues with gadolinium toxicity when having MRIs and I’d be very concerned about adding to the toxic load. It seems the contrast isn’t needed.

In Dr. Jill Carnahan’s interview – “Metabolic Endotoxemia and the Gut-Brain Connection”, she recommends a provoked or challenged urinary myctoxin test with some glutathione or sauna because you can get false negatives if you don’t do this before testing. She also shares all her favorite binders: charcoal, clay, zeolite, glucommanan and citrus pectin.

They also talk about SIBO (small intestinal bacterial infection) and say that a lot of SIBO is really SIFO (small intestinal fungal infection), how toxic mold can impact gut motility and and how antifungals rather than anti-bacterials are the way to go in this instance.

Jeff Bookout’s interview on “Non-Toxic Remediation for Chemically Sensitive” is wonderful. They cover dry-fogging, using non-toxic citrus based oils, practical tips for travel and hotel rooms, keeping dorm rooms safe from toxic mold and how best to clean the HVAC (heating, ventilation and air-conditioning) system so you’re not dispersing toxic mold throughout the house. This is a very practical and common-sense interview.

If you didn’t register yet, I’m hoping this inspires you to register and tune in. It’s one of the most popular summits I’ve promoted and I feel it’s a topic we all need to learn about and ideally before it’s a problem because when you’re in the midst of it, it makes it that much more challenging to deal with. You just never know when you may need this information. Take for example all the people affected recently by the dreadful floods in Townsville in Australia, and elsewhere.

If you are in the midst of dealing with your own mold toxicity I know you’re getting great resources for remediation and recovery. Be sure to have a friend or loved one who has not been affected, listen in and read the transcripts so you’re not alone in figuring things out.

Even if you don’t currently have symptoms of mold toxicity, it’s an excellent resource so you can be prepared the next time you have water damage in your home, office or school. It will also allow you to make sure you don’t have a growing mold problem which may affect your health down the road.

The Toxic Mold Summit health experts, air quality experts and mold remediation specialists will help you identify if you have mold exposure and share the latest tools and techniques for dealing with toxic mold.

When you register be sure to check out the ebook, “Got Mold? Now What? Hope for Health and Home: Overview of Toxic Mold and Biotoxin Illness!” It covers why you get the following symptoms and the mechanisms, total toxic load, recommended testing for you and your moldy home (or work place or school etc.), resources to make you more resilient, basic treatment steps and dietary approaches to consider.

Here are symptoms and illnesses caused by toxic mold exposure. Dr. Christensen explains that mold/biotoxin illness may present in many ways, even within the same family who have been exposed to mold, and often with some kind of pain or inflammation, and in almost any area of the body:

Chronic recurrent upper respiratory and sinus infections
Chronic headaches/migraines
Severe chronic fatigue or ongoing flu-like symptoms
Fibromyalgia (tender, sore muscles)
Neurological issues (tremors, neuropathy, brain fog, ADD, learning issues, etc.)
Neuro-degenerative diseases (Parkinson’s, MS, ALS, Alzheimer’s and other dementias)
Severe gut symptoms (IBS, Crohn’s, ulcerative colitis, SIBO/SIFO)
Autoimmune disorders (thyroid, Hashimoto’s, psoriasis, rheumatoid arthritis, eczema, hives)
Multiple chemical sensitivities and histamine intolerance (rashes and hives)
Night sweats (common in men of all ages, as well as women)
Psychiatric symptoms (anxiety, depression, panic attacks, bipolar symptoms, psychosis)
Severe sleep disturbances
Recurrent interstitial cystitis, bladder infections and frequent urination
Hormonal imbalances (adrenal and thyroid hormones)
Infertility, heavy periods and cramps, endometriosis, PMS, PCOS
Cardiovascular disease
Lyme and co-infections, including viral infections like EBV, HHV6
Cancer (especially hormonal, leukemias/lymphomas and bladder/kidney)
Children: chronic ear, throat and upper respiratory infections, asthma, allergies, ADD/ADHD, sleep, irritability, bedwetting

In the testing section she does state that “HLA genetics tests are not necessary but can be interesting” and I was intrigued to hear this because I considered this a gold standard test to have done.

Here are some of the excellent topics and speakers:

Chemical Sensitivity and Detoxing Your Home with Bridgit Danner, LAc, FDNP
Heavy Metals, Fatigue and Detox with Wendy Myers, FDN-P, NC, CHHC
Essentials Oils to Treat and Prevent Mold Toxicity with Jen Broyles, CHC
Mold Inspection and Detection with JW Biava
Mold, Mental Illness and Suicide Prevention with Jill Sheppard Davenport, MS, CNS, LN
Mold, Histamine and Multiple Chemical Sensitivity with Gail Clayton, RPh, MS, CNS
Brain on Fire: Mental Illness and Mold with Mary Beth Ackerley, MD, MD(H), ABIHM
Advanced Therapies for Mold Recovery with Mark Hyman, MD
Finding a Quality Mold Inspector and Remediator with Jason Earle, IEP

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UPDATE: March 28, 2021
This summit is being re-released for a third time on April 26 – May 2, 2021 due to the high demand and excellent content.

I was thrilled to be invited to speak on this summit AND my interview, Immediate Relief for Anxiety, also happens to be one of the registration gifts so you get access right away!

We initially cover some of the many connections between mold toxicity and anxiety and low mood. I share from this 2018 paper, Effects of Mycotoxins on Neuropsychiatric Symptoms and Immune Processes:

the presence of mold and dampness was associated with the prevalence of depression and emotional distress
it’s unclear whether neuropsychological problems are due to the adverse effects of mycotoxins or the emotional and financial stress of keeping a house clean in the face of recurrent mold [it’s very likely both + the loss of treasured possessions for some folks too]
a low sense of control may lead to an elevated risk for anxiety and depression.

I also share how much I learned from Dr. Neil Nathan’s presentation at one of the IMMH conferences: “Mold Toxicity as an Unrecognized Cause of Mental Health issues.” He shares that “mold toxicity may directly trigger anxiety, panic attacks, depression, depersonalization and hallucinations AND mast cell activation, multiple chemical sensitivities, secondary porphyrias, methylation dysfunction and pyroluria” … all of which plays a role in anxiety/depression.

I go on and cover the solutions for the anxiety and panic attacks (often directly triggered by mold toxicity) and the sense of loss while you are dealing with the mold toxicity and home remediation or move:

mold anxiety and how to use GABA and serotonin support to ease the anxiety, fears, insomnia, worry and panic attacks that are so common with mold toxicity (so there is not the added toxic burden of psychiatric meds)
how certain mycotoxins may actually lead to high serotonin and what to do in this instance
using DPA (an amino acid that boosts endorphins) to help comfort folks who may lose their homes and beloved contents/books/photos due to mycotoxins

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If you or a loved one suffers from mystery symptoms and/or unresolved anxiety I encourage you to tune in to learn more.

I’ll see you online at this educational summit when you register here.

Can you relate to any of this? Have you been ill as a result of toxic mold exposure? Or do you suspect mold is one of your root causes?

Have you remediated a moldy home and healed your self with a functional medicine approach?

Gut bacteria, pain and anxiety connections: Klebsiella and ankylosing spondylitis

December 28, 2018 By Trudy Scott 21 Comments

We know about the gut-brain connection where the health of our microbiome impacts how anxious or depressed we feel, but we often forget that there is a gut-pain connection too and how addressing dysbiosis and bad bacteria in the gut can have far-reaching benefits.

An old work friend recently reached out asking for help for her husband who had been diagnosed with ankylosing spondylitis, ulcerative colitis and gluten sensitivity, and was not seeing results with conventional treatment. I did some digging for them and a colleague mentioned that they had addressed Klebsiella when they discovered that her husband had genes predisposing him to ankylosing spondylitis. Read on to see what I’ve learned.

Klebsiella as a precursor to ankylosing spondylitis

The paper shared with me: The relationship between Klebsiella infection and ankylosing spondylitis, discusses the HLA-B27 gene and the Klebsiella connection:

Klebsiella-reactive arthritis is the precursor stage occurring in the early and active phases of ankylosing spondylitis.

Let’s learn more about Klebsiella, ankylosing spondylitis, the anxiety connection and prevalence, the role of neuro-inflammation and genes, the problems of a high carb diet and the role the amino acids GABA, tryptophan and DPA play in pain and anxiety relief and being able to quit the carbs easily, plus provide sleep support.

In case you’re not familiar with Klebsiella, this excellent FX Medicine article describes it as follows:

Klebsiella pneumoniae (KP) is a type of gram-negative rod-shaped bacteria that can cause different types of infections ranging from pneumonia (lung), blood infections (septicaemia), wound or surgical infections, urinary tract infections, small intestinal bowel overgrowth (SIBO), ankylosing spondylitis, Crohn’s disease, ulcerative colitis and meningitis (brain).

Ankylosing spondylitis is an inflammatory disease of the spine

In case you’re not familiar with the condition ankylosing spondylitis (pronounced like this) the Mayo Clinic site provides this summary:

Ankylosing spondylitis is an inflammatory disease that, over time, can cause some of the vertebrae in your spine to fuse. This fusing makes the spine less flexible and can result in a hunched-forward posture. If ribs are affected, it can be difficult to breathe deeply.

Ankylosing spondylitis affects men more often than women. Signs and symptoms typically begin in early adulthood. Inflammation also can occur in other parts of your body – most commonly, your eyes.

They say there is no cure and the treatments include pain medications and physical therapy to ease symptoms (and surgery in some cases).

I’m all for physical therapy but you’ll notice there is no mention of gut health or Klebsiella. This is why we have to keep searching for root causes – and work with a functional medicine practitioner – no matter what the health condition, be it ankylosing spondylitis or anything else.

Prevalence of anxiety in ankylosing spondylitis

As with most physical conditions there is a connection with anxiety. This paper: Prevalence of psychological disorders, sleep disturbance and stressful life events and their relationships with disease parameters in Chinese patients with ankylosing spondylitis reports that

AS [ankylosing spondylitis] patients had more severe psychological disorders, sleep disturbance, and stressful life events.

Prevalence of anxiety, depression, and sleep disturbance was 31.6%, 59.3%, and 31.0% respectively.

We have to ask ourselves if we have anxiety, depression and insomnia because of the pain being experienced or because of one or more of the root causes that contribute to both pain and anxiety.

Microbiota disturbance, neuro-inflammation, and anxiety

Often the research focuses on the former but we know that there is Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice. In this 2018 animal study treatment with lactobacilli suppresses this neuro-inflammation.

Ankylosing spondylitis, Crohn’s disease, genes and a high carb diet

The above FX Medicine article shares the connection between ankylosing spondylitis, Crohn’s disease and ulcerative colitis, as well as the genetic susceptibility, together with the problems of a high carb diet:

Genetically susceptible people, such as those who have the HLA-B27 allelotypes and consume a high starch/carbohydrate diet, can trigger a growth in Klebsiella in the bowel, the starch becoming a main food supply for the Klebsiella.

The amino acids for pain, carb addition, anxiety and insomnia

The amino acids come into the picture again, helping to ease the pain, provide precursors for neurotransmitter production until the microbiome is balanced, and eliminate carbohydrate cravings so they can be given up without willpower.

As always figuring out your own imbalance and doing an amino acid trial is key. Here is a summary of how they may help in this instance, assuming you have low levels of GABA, serotonin and/or endorphins:

GABA helps with stress eating of carbs, eases physical anxiety, eases some pain.
Tryptophan helps with afternoon and evening carb cravings, eases mental worry-type anxiety and depression, and also eases some pain. Both GABA and tryptophan help with insomnia.
DPA boosts endorphins providing acupuncture-like pain relief and provides the emotional comfort that starchy treats often do.

The FX Medicine article has treatment and prevention tips for you to share with your functional medicine doctor, who will be able to run a functional stool test such as the GI-MAP offered by Diagnostic Solutions Lab.

Just because there are these gut bacteria, pain, anxiety, Klebsiella and ankylosing spondylitis connections, it doesn’t necessarily mean everyone with ankylosing spondylitis has Klebsiella or that everyone who has Klebsiella will go on to develop ankylosing spondylitis (as stated above) or even that everyone with ankylosing spondylitis will have anxiety. I’m simply connecting some dots so you can start to think outside the box.

I’d love to hear what has worked for you or a loved one with ankylosing spondylitis and/or if you’ve seen elevated Klebsiella on your stool test or have the genetic predisposition?

Have the amino acids and a low-carb diet helped the healing process and eased some of your anxiety while addressing the underlying Klebsiella infection?

The individual amino acids glutamine, GABA, tryptophan (or 5-HTP), DPA and tyrosine are powerful for eliminating sugar cravings, often within 5 minutes

November 30, 2018 By Trudy Scott 28 Comments

The individual amino acids glutamine, GABA, tryptophan (or 5-HTP), DPA and tyrosine are powerful for eliminating sugar cravings, often within 5 minutes. It seems that this wonderful benefit – over and above the anxiety-reducing and mood-boosting benefits – is often overlooked or poorly understood.

I recently posted this on Facebook: GABA for ending sugar cravings (and anxiety and insomnia) and I’m writing this blog today because it’s clear there is some confusion about this cravings aspect.

Let me first recap Melissa’s experience with Source Naturals GABA Calm during her family holiday trip (the link above has all the details):

I’m glad I bought it before traveling home for Christmas – I was cool as a cucumber at the airport and was much calmer when visiting family and friends compared to last year! I notice a general calmness and am sleeping well.

As well as the calming benefits of GABA, Melissa found this unexpected reduction in cravings for sweets, chocolates, truffles and ice cream after about a week of taking it:

I didn’t even realize this until I was grocery shopping and out of habit walked towards the ice cream – I stopped and realized I didn’t want ice cream. So I walked toward the chocolate – same reaction. For once in my life, I was not craving sweets. I made truffles for a NYE party and only ate two. But what is really shocking is that the leftovers are still in my refrigerator two days later and I haven’t touched them.

This is a very typical response that I see with my clients and when I shared the above blog, others on Facebook shared similar experiences and surprise about the connections. Kim found it fascinating and very timely saying:

I ran out of GABA a month ago. Not only has my anxiety been very difficult to manage but literally I haven’t been able to stop eating. Sugary, high carb, total junk has consumed my thoughts. I never realized the correlation.

April also seemed surprised to learn that GABA was also actually helping with her sugar cravings too:

I think my sugar cravings are down (not looking for something sweet every night after dinner, maybe I treat myself to once a week and not overindulge when I do) and when I think about it, I’ve lost a bit of weight as a result. Most of all it helps me sleep and reduces tension in my neck.

In the above examples, due to low GABA levels in these women, GABA was helped with both the anxiety and the stress-eating, leading to a calming effect and reduced sugar cravings. If you have low blood sugar cravings then glutamine is the amino acid to use; low serotonin cravings then tryptophan or 5-HTP will help; low endorphin cravings then DPA will do the trick; and low catecholamines then tyrosine is the amino acid to use.

The best way to figure it which neurotransmitter deficiency is affecting your sugar cravings

The best way to figure it which neurotransmitter deficiency is affecting your sugar cravings is to do the amino acid mood questionnaire and also review this list for further clarification:

If you have to eat sugar when you haven’t eaten in awhile it’s likely low blood sugar and glutamine on the tongue stops the sugar desire almost immediately and also helps with the low blood sugar symptoms of shakiness and irritability
If you stress-eat your sugar cravings are likely due to low GABA, and GABA will stop the stress-eating and calm you down
If you eat sugar or carbs to feel happy (and especially from late afternoon into the evening) then your sugar cravings are likely due to low serotonin, and tryptophan (or 5-HTP) stops the cravings and boosts mood and reduces anxiety
If you are a comfort-eater then it’s likely due to low endorphins and DPA will stop that feeling of “I deserve-it” kind of reward-eating or comfort-eating and also give you a hug-like mood boost
If you eat sugar for an energy boost or to give your focus then it’s likely due to low catecholamines and tyrosine will stop those cravings and give you a mood and energy boost, and help with mental clarity

It’s not uncommon for my anxious clients to have issues in all these areas and I have them address low blood sugar and each neurotransmitter deficiency one by one (for 2 through 5) and very methodically so they know exactly which areas are problematic for them.

When it comes to low blood sugar, addressing adrenal health is also key. And as always, we need to be making dietary changes, fixing gut health, addressing other deficiencies, removing toxins and more, using a complete functional medicine approach.

How quickly can you expect to get results?

However, using the amino acids in a targeted way like this gets you results quickly while you’re figuring out everything else.

You may say “what exactly do you mean by quickly”? When opened onto the tongue and used with the trial method, based on your unique needs, if you have low levels, you can expect to notice effects in as quickly as 5 minutes and sometimes up to 15 minutes in some cases! This is why I like to refer to them as the amazing amino acids! They truly are amazing for eliminating cravings, reducing anxiety and improving mood and even sleep – provided they are needed.

Each of the individual amino acids

Last year I wrote a series of blog posts on each of the above-mentioned amino acids. If you missed them you may find them helpful for getting a better understanding, even though they are not specific about sugar cravings:

You can find the amino acid supplements that I use with my clients here.

The amino acids help you make dietary changes with ease

Keep in mind the amino acids are intended for relatively short-term use so the goal is to work on your diet, gut health, adrenals, nutritional deficiencies etc. so they are no longer needed or only needed in times of added stress. My book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings (my Amazon link), covers in-depth how to implement much of what is mentioned in the above article: a real food Mediterranean diet, red meat, oily fish, the importance of zinc, vitamin D, antioxidants and so on, and the powerful role of nutrition in immunity, inflammation, sleep, stress, anxiety and food cravings.

The amino acids help you make those dietary changes with ease, end your cravings and stress-eating or excessive drinking, so no will power is needed and you don’t feel deprived.

Pandemic stress pushed people toward overeating, mostly looking for sugary “comfort foods”

(UPDATE 4/17/2020 for coronavirus pandemic)

Keep in mind that in times of added stress – like being in the midst of a pandemic such as the coronavirus – you may find your sugar and carbohydrate cravings have increased, and you may be over-indulging, emotional-eating, comfort-eating and/or stress-eating as a way to self-medicate in order to feel calm and good.

This paper, Nutritional recommendations for CoVID-19 quarantine, published just a few days ago, shares how continuously hearing or reading about the pandemic without a break can be stressful and may be

pushing people toward overeating, mostly looking for sugary “comfort foods”. This desire to consume a specific kind of food is defined as “food craving”, which is a multidimensional concept including emotional (intense desire to eat), behavioral (seeking food), cognitive (thoughts about food), and physiological (salivation) processes.

We can apply this knowledge and logic to any stressful situation we may find ourselves experiencing.

Self-medication with alcohol as a way to calm down

You may also find you are more drawn to alcohol as a way to calm down and relax i.e. self-medication with alcohol. According to this Forbes article, Nielsen reports that online sales of alcohol increased by 291% compared to the end of March 2019.

You may be surprised to learn that the amino acids also help with reducing alcohol cravings and the need to self-medicate with this “drug-of-choice.” If one glass of wine leads finishing to an entire bottle in one evening or if you’re drinking beer or spirits excessively, know that the words “sweets”, “sugar”, “carbs” can be substituted in the blog post below with “alcohol” and consider trials of the respective amino acids.

This blog post illustrates this perfectly: Tryptophan had the added benefit of turning me completely off alcohol when I took it to improve mood and sleep during perimenopause.

Resources if you are new to using amino acids as supplements

If you are new to using amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the symptoms of neurotransmitter imbalances, including low GABA, low serotonin and low endorphins).

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs. You can find them all in my online store.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms too). This is a paid online/virtual group program where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Have you found any of the amino acids to help you eliminate your cravings for sweets, chocolate, ice-cream and other high-carb foods? Were you pleasantly surprised to experience this lovely benefit when you were initially looking for anxiety-relief?

Were you / are you drinking more and have you figured out which amino acids help you quit?

If you’re a practitioner, do you see similar cravings benefits with your anxious clients/patients?

Are you still struggling with comfort-eating, stress-eating of carb/sugar or drinking alcohol to “self-medicate” and feel better?

Feel free to ask your questions and share challenges and/or successes you’ve had too.

DPA for weepiness, pain and comfort and reward eating

September 20, 2017 By Trudy Scott 63 Comments

Today I’m reviewing DPA (or d-phenylalanine) for weepiness, pain and comfort and reward eating. This amino acid is a favorite with so many of my clients because it helps with the above by boosting your endorphins and when you open a capsule onto your tongue you feel like you just got a big hug. It’s a really good feeling!

I’m also sharing some additional resources for you on DPA.

DPA and endorphins

DPA is an amino acid that destroys the enzyme that breaks down endorphins. Endorphins are feel-good chemicals that you experience with an endorphin rush when you go for a run or when someone gives you a big hug, when you show kindness to someone or someone does something nice for you. Taking the amino acid, DPA, helps to raise your endorphins.

Low endorphins and weepiness

With low endorphins you’re very weepy. You may be overly emotional. If you watched a TV ad or you watched a really sad movie, you may be more prone to crying than the average person.

It’s also known as the break-up pill and is very helpful when going through a relationship split.

It’s also extremely helpful after a stressful event. I spoke with a friend who was impacted by Hurricane Harvey and recommended DPA for the weepiness she was starting to feel a few days after the clean-up efforts. It’s one of the amino acids I recommend in my blog: Nutrition solutions for psychological stress after a natural disaster

Low endorphins and pain

As well as being sensitive to emotional pain (the crying and the weepiness), you also tend to be sensitive to physical pain when endorphins are low.

We know acupuncture raises your endorphin levels and eases pain. Using DPA helps physical pain in a similar way. Pain can be caused by low GABA and low serotonin, an inflammatory diet, a high oxalate diet or nightshades, something physical like a fall, osteoarthritis or an autoimmune condition like rheumatoid arthritis. If there is also a low endorphin aspect to your pain, DPA can provide some pain reduction.

Low endorphins and comfort/reward eating

Another symptom of low endorphins is comfort/reward eating. You may relate to the term emotional eating. It often goes like this: “This is my reward. This is my treat. I absolutely deserve it.”

And when you consume those carbohydrates – that bowl of ice cream, that bowl of cereal, that chocolate chip cookie, that chocolate cup-cake – you feel like “this is my reward, this comforts me.” When you use DPA you can literally take it or leave it. Really!

DPA is one of the amino acids that help you easily quit sugar without having to use massive willpower and without feeling deprived. The best way to figure it out is to do the amino acid mood questionnaire

Here is a summary to help you figure out which brain chemistry imbalance is driving your sugar cravings (and mood issues):

if you have to eat sugar when you haven’t eaten in awhile it’s likely low blood sugar and glutamine on the tongue stops the sugar desire on the spot
if you stress-eat your sugar cravings are likely due to low GABA, and GABA will stop the stress-eating and calm you down
if you eat sugar or carbs to feel happy (and especially from late afternoon onwards) then your sugar cravings are likely due to low serotonin, and tryptophan stops the cravings and boosts mood and reduces anxiety
if you eat sugar for an energy boost then it’s likely due to low catecholamines and tyrosine will stop those cravings and give you a mood and energy boost
if you are a comfort-eater or big emotional eater, then it’s likely due to low endorphins and DPA will stop that “I deserve-it-reward-eating” and also give you a hug-like mood boost

And remember it’s not unusual to need to address all areas. You can have low GABA anxiety and low endorphins too and low blood sugar. If this is the case I have my clients address one at a time.

If addressing low endorphins helps reduce or eliminate the reward eating and helps you eat less or no sugar it means less impact on your adrenals and more even blood sugar levels and therefore less anxiety too.

As with all the amino acids, when using DPA:

Start low (500mg is a typical starting dose) and increase as needed.
Do a trial to determine if the emotional eating is due to low endorphins. I always do this with clients before starting any amino acid. Be sure to read how to do an amino acid trial. It has the amino acid questionnaire, the precautions and information on how to use targeted individual amino acids.
Take between meals and away from protein for the best effects

This blog post is part of the series of amino acid product reviews:

The resources in this blog and my other articles are intended to be used in conjunction with my book: The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings. If you do not have my book I highly recommend getting it and reading it before jumping in and taking the amino acid supplements:

There is a complete chapter on the amino acids and one for pyroluria, plus information on real whole food, sugar and blood sugar, gluten, digestion and much more.

The Lidtke Endorphigen 500mg product is the one I recommend. You can find this DPA product and the others I recommend on this blog: The Antianxiety Food Solution Amino Acid and Pyroluria Supplements.

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Update Feb 20, 2020:

DPA is one of my top products that I recommend. I do find it much more effective than DPLA (for endorphin boosting) so I no longer recommend or use DLPA.

I used to recommend simply chewing the capsule to get the quickest and best effects and this worked well when this product was produced in a gelatin capsule. Now it’s made with a cellulose capsule and chewing doesn’t work at all well so opening the capsule (or just biting off the top) and tipping the powder into your mouth works well.

It does taste quite pleasant – some of my clients think it has a dark chocolate-like taste. A few people don’t like the taste at all but even then, it is still very effective when low endorphins are an issue.

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I’d love to hear if DPA has worked for you and how it’s helped?

If you have questions please post them below or on the supplements blog