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GABA the calming amino acid: common questions I get asked

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gaba common questions

GABA is the main calming neurotransmitter and the amino acid GABA is wonderful for boosting low levels of GABA and thereby eliminating physical anxiety, tension, panic attacks and overwhelm. It can also help reduce pain and insomnia. I get asked great questions about GABA on the blog all the time and here are some common questions that you may find helpful.

GABA, new found peace and do I need more at different times of my cycle?

I have taken your recommendations I heard you speak about on your most recent Anxiety Summit about GABA – and have been experiencing some new found peace that I thought was forever lost to me. It has been truly wonderful! Thank you!

I have a question – in your experience, have you found that different levels/amounts of GABA were needed at different times in a woman’s cycle? I would be interested to know if there is any research or observational data related to GABA receptors and how they are affected by the hormonal ups and downs – AND how to respond to that with supplementation and/or food and lifestyle adjustments.

Here is my response: I love this – new found peace!  GABA is closely related to progesterone which we know fluctuates during our cycles so for some people mirroring this can help even more i.e. some of my clients find it’s beneficial to take extra GABA just before their period or earlier if their anxiety symptoms increase. I have them use their symptoms to guide increasing and decreasing their GABA.

Here are two studies that support this connection in women with premenstrual dysphoric disorder and women who are perimenopausal:

Increasing evidence has suggested that the GABAergic neurotransmitter system is involved in the pathogenesis of premenstrual dysphoric disorder (PMDD) … dysregulation of the amino acid neurotransmitter system may be an important neurobiological mechanism in the pathogenesis of PMDD

failure of the GABAA receptor to regulate overall GABA-ergic tone in the face of shifting levels of these neurosteroids may induce HPA axis dysfunction, thereby increasing sensitivity to stress and generating greater vulnerability to depression.

I have not seen any research on GABA supplementation in the second half of the cycle (luteal phase) but recently blogged about how tryptophan helps PMS symptoms of anxiety, tension and irritability.

I write about GABA, pyroluria and low cholesterol in this same blog.

A question about GABA, tyrosine and other neurotransmitter imbalances

GABA Calm – who can take this as it has tyrosine? Can someone with low serotonin or high serotonin take this? Or is it best to take straight GABA for those who are not meant to take tyrosine. Can a person who has low GABA have other neurotransmission issues i.e. high dopamine or low serotonin?

Here is my response: The GABA Calm (by Source Naturals)  has a very small amount of tyrosine so unless it’s contraindicated it’s the one I use with most of my clients. You would not use it if you have melanoma or Grave disease and would watch carefully if you have high blood pressure or migraines. You can read all the amino acid precautions here.

Many people with low GABA levels may also have signs of the other low neurotransmitters. The best way to figure this out is to do the amino acid questionnaire and do a trial of the relevant amino acid.

You mention high serotonin and high dopamine so I’m guessing you have had the urinary neurotransmitter test done. I’d like to share that I don’t place much value in urinary neurotransmitter testing and prefer to have my clients do a trial.

A question about migraines and getting a red flush with GABA

I’ve had lifelong migraines along with anxiety and depression that have waxed and waned. I’d like to try the aminos and curious if you have any special recommendations or contraindications for migraine with aura.

I’ve tried GABA in the past but ended up with a red flush like a niacin flush. Any ideas on why that might have happened? I suspect maybe the dose was too high. I wanted to try the GABA Calm since it has a low dose of GABA but I’m not sure if tyrosine is a potential migraine trigger.

Would love a little enlightenment on all the above so I’m not so gun shy and doing more harm than good.

Here is my response: Tyrosine is an issue with migraines and I avoid it with clients with a lifelong history of them especially if they are still having them (please see the precautions). If they choose to try a product with tyrosine they simply stop if a migraine is triggered.

Too much GABA can cause a flush and breathlessness. I find this to be the case when 500mg or 750 mg and above is used to start. I have my clients start on the 125mg found in GABA Calm and slowly build up.

When GABA Calm can’t be taken, opening a capsule of a GABA-only product is what we do. You can find the GABA/theanine products I use here. Some of my clients are pixie dust people and need 1/10th of capsule or 200mg GABA so starting low is important for everyone but even more so if you have had a reaction in the past.

I blogged about the large variation in GABA dosing here.

Don’t forget that 1000mg of vitamin C can help to negate the effects of an amino acid. Hopefully this will give you more confidence to do a trial.

A question about insomnia with SIBO/candida and GABA and 5-HTP

What do you do or recommend for people with SIBO/ yeast Overgrowth and can’t sleep well as a result (can’t stay asleep)? I have played with 5-HTP and GABA in the past, but they seemed to have the opposite effect (caused more insomnia). I have read that with overgrowth issues, these products can travel down the wrong metabolic pathway. Have you found this in your clients?

Here is my response: The amino acids will only help with sleep if neurotransmitters are low i.e. GABA will help if GABA is low, 5-HTP or tryptophan will help if serotonin is low. There is actually a great study that shows that a combination of GABA and 5-HTP may help insomnia.

If they are making sleep worse I’d wonder if doses are too high, and I’d look at quality and fillers. I’d also do a trial with tryptophan as 5-HTP can be an issue with high cortisol and this could impact sleep.

Tryptophan can convert to quinolinic acid without the correct co-factors, so taking zinc, curcumin and B vitamins etc. are important. Some people find the Lidtke Tryptophan Complete to be more helpful that the 500mg Tryptophan if they don’t have the co-factors as part of their current protocol.

It goes without saying that foods that make SIBO and candida symptoms worse should be avoided as they may cause bloating and would keep you awake.

With insomnia I’d also look at the following: low blood sugar, parasites, high cortisol, gluten, being on the computer, prior or current benzodiazepine prescriptions.

Resources if you are new to using the amino acids as supplements

If you are new to using any of the amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the symptoms of neurotransmitter imbalances).

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, blood sugar control, sugar cravings, self-medicating with alcohol and more.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA Quickstart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support. There are many moms in the program who are having much success with their kids.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

With much appreciation for these women for sharing their stories and allowing me to provide my insights for them and you. We all have much to learn from each other.

Can you relate to any of these questions and have some of these GABA adjustments helped you?

If you have questions please share them here too.

(Most recent updates: June 24, 2022)

Yoga increases brain GABA levels and reduces anxiety

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triangle-pose

In a 2007 study published by the Division of Psychiatry at the Boston University School of Medicine – Yoga Asana sessions increase brain GABA levels: a pilot study – researchers had 8 yoga practitioners complete a 60-minute yoga session and 11 comparison subjects complete a 60-minute reading session.

The study objective was to compare changes in brain levels of gamma-aminobutyric acid (GABA) – our calming neurotransmitter – in those completing the 60-minute yoga session and in those reading.

These were the results that were reported:

There was a 27% increase in GABA levels in the yoga practitioner group after the yoga session but no change in the comparison subject group after the reading session.

And here is the conclusion the authors reached:

These findings demonstrate that in experienced yoga practitioners, brain GABA levels increase after a session of yoga. This suggests that the practice of yoga should be explored as a treatment for disorders with low GABA levels such as depression and anxiety disorders. Future studies should compare yoga to other forms of exercise to help determine whether yoga or exercise alone can alter GABA levels.

In this study, GABA levels were measured with magnetic resonance spectroscopic imaging (MRS/MRSI) before and after the yoga and reading sessions. If you really want to know how yoga improves your anxiety you could do the GABA section of the amino acid questionnaire and rate your before and after symptoms:  

  • Anxiety and feeling overwhelmed or stressed
  • Feeling worried or fearful
  • Panic attacks
  • Unable to relax or loosen up
  • Stiff or tense muscles
  • Feeling stressed and burned-out
  • Craving carbs, alcohol, or drugs for relaxation and calming

The above study looked at experienced yoga practitioners but there is so much research on the many benefits of yoga for everyone and for many conditions. Here is a small sampling of some other studies that include anxiety as well as depression, stress, hormonal imbalances and sleep issues:

If you’ve never done yoga or if you haven’t been doing it for a while this blog will hopefully give you the motivation to start a yoga practice or get back into it.

You may ask: how do I get started?

The important thing is to find the joy in doing it so I encourage you to try different classes until you find one you love. I love Iyengar yoga but it’s not for everyone (it can be seen as too slow for some people.) Here is a yoga DVD for more advanced Iyengar yoga students: Iyengar Yoga with Gabriella.

If you already do yoga this will confirm what you already likely know. Please share what yoga you enjoy, how often you practice and how it leaves you feeling.

If you’re a health practitioner, please share if yoga is something you recommend to your clients or patients.

GABA-consuming bacteria discovered: Evtepia gabavorous

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bacteria

New bacteria that consumes GABA, the main calming neurotransmitter, has been discovered. It has provisionally been named KLE1738 Evtepia gabavorous (vorous means “eating”).

This new discovery was presented at the recent American Society for Microbiology conference in Boston in the Microbial Mind Control session.

Here is the entire abstract: Gaba Modulating Bacteria of the Human Gut Microbiome:

The gut microbiome affects many different diseases, and has been recently linked to human mental health. The microbiome community is diverse, but 50-80% of its diversity remains uncultured. We previously reported that uncultured bacteria from the marine environment require growth factors from neighboring species, and by using co-culture, we could cultivate novel diversity. In the present study, we used a similar co-culture approach to grow bacteria from humans stool samples. KLE1738, a “Most-Wanted” member of the human gut microbiome only known by its 16S rDNA signature, was found to require the presence of Bacteroides fragilis KLE1758 for growth. Using bio-assay driven purification of B. fragilis KLE1758 supernatant, γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter of the central nervous system, was identified as the growth factor for KLE1738. We found no other tested compound but GABA supported the growth of KLE1738, and genomic analysis suggests an unusual metabolism focused on consuming GABA. Due to this unique growth requirement, we provisionally name KLE1738 Evtepia gabavorous. Using growth of E. gabalyticus as an indicator, we then identified novel GABA producing bacteria from the gut microbiome. Reduced levels of GABA are associated with depression, and we found fewer GABA producers in a human cohort of depressed individuals. By modulating the level of GABA, microbial producers and consumers of this neurotransmitter may be influencing host behavior.

If you’re anxious and especially if you have physical anxiety, it’s worth considering if low GABA is an issue and addressing your anxiety by trying to raise your GABA levels by taking GABA as a supplement, with lifestyle activities like yoga sessions, by eating a real whole foods traditional diet and by addressing gut health.

There is much research supporting the gut-brain connection and how imbalances of the microbiome i.e. intestinal dysbiosis, can contribute to:

Could Evtepia gabavorous be a factor in all of the above? It’s too soon to know but I expect we’ll know more as more research is completed.

If you’re looking for more information on GABA and the gut:

We certainly appreciate Postdoctoral Research Associate, Phillip Strandwitz and his team for the work they are doing. Strandwitz shares this on his bio:

my work has led me to focus on the gut-microbe-brain axis, specifically microbes able to modulate levels of neurotransmitters

I reached out to I asked him why he is interested this area of research and he shared this with me:

I think mental health is an incredible burden to society and there is not nearly enough spotlight nor funding to understand and treat these issues. I believe the microbiome is involved (at least to some capacity), and I’m passionate about trying to understand this involvement to create novel therapies to help those in need. I’m also a strong supporter of diet/lifestyle changes for better cognition!

How wonderful is this!

It’s early days and right now we can only speculate but it may be worth to considering if the presence of Evtepia gabavorous may be a reason why some individuals continue to need to take GABA supplements long-term to keep anxiety at bay. It also gives us additional reasons to focus on addressing gut health and boosting good bacteria to help to reduce the need for ongoing GABA supplementation.

As soon as the paper is published, I’ll have more details to share. In the meantime, enjoy the fascination and wonderment of the human body and our microbiome.

Please share if you have signs of low GABA and have you been taking GABA supplements long-term? Do you also have gut issues and dysbiosis too (based on stool testing)?

PS. So many of you contacted me with a link to this preliminary research so I’d just like to say thanks!

Tryptophan for PMS: premenstrual dysphoria, mood swings, tension, and irritability

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tryptophan for pms

In a study published in 1999, A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria, tryptophan was found to reduce symptoms of PMS when used in the luteal phase or second half of the cycle (i.e. after ovulation):

37 patients with premenstrual dysphoric disorder were treated with L-tryptophan 6 g per day, and 34 were given placebo. The treatments were administered under double-blind conditions for 17 days, from the time of ovulation to the third day of menstruation, during three consecutive menstrual cycles.

They looked at dysphoria, which is defined as a state of unease or generalized dissatisfaction with life, plus mood swings, tension (and anxiety), and irritability and they found a 34.5% reduction of symptoms with tryptophan compared to 10.4% with placebo.

The paper concludes:

that these results suggest that increasing serotonin synthesis during the late luteal phase of the menstrual cycle has a beneficial effect in patients with premenstrual dysphoric disorder.

Let me share what I see with the women with PMS that I work with:

  • This is very typical when I’m working with someone with PMS and anxiety and other mood symptoms. It typically takes 2 to 3 cycles for an amino acid like tryptophan to have an impact on PMS itself. But it does typically start to work right away on the less severe anxiety and mood symptoms that may also be a factor during the rest of the month.
  • I don’t start with 6g per day of the tryptophan but rather have each person do the amino acid questionnaire, review the precautions and do a trial of tryptophan, increasing as needed to find the optimal amount for their needs (you can read more about this here on anxiety and the amino acid overview
  • We often find that adding GABA helps too, as this supports progesterone production
  • Many anxious women I work with also have pyroluria or signs of low zinc and low vitamin B6 and adding these nutrients, together with evening primrose oil, provide additional hormonal support (and help with the social anxiety).
  • Other factors to consider with PMS: low total cholesterol (as cholesterol is needed to make hormones), gluten issues, adrenal function and blood sugar control, gut health and the microbiome, and liver support
  • And finally, we can’t forget diet and need to switch to eating a real whole foods diet free from sugar, gluten and caffeine. Coffee and chocolate in the second half of the cycle can be especially problematic for many women

Together with the tryptophan and the above approaches (if needed as we are all so different), it’s not unreasonable to get the reduction of symptoms from 34.5% (as seen with the tryptophan) down to 100%. It breaks my heart when I hear women think they have to live with PMS symptoms when they don’t have to!

Have you used tryptophan for PMS? Do you take it all month or just in the 2nd half of your cycle? What about other changes that have helped: GABA or liver support or quitting caffeine? Or something else?  Please share.

Anxiety and the amino acids: an overview

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Here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution and additional information on Anxiety and targeted individual amino acid supplements: a summary

Please read and follow these Amino Acid Precautions before using any of the amino acids.

The best way to figure out if you have a particular brain chemical imbalance and if you’ll benefit from a certain amino acid, is to do a trial.   This is something I do with all my clients with anxiety, when we’re working one-one-one and with those in group programs, and it works really well.

Because the effects of amino acids can be felt within a few minutes to a few days, it’s easy to confirm whether you do in fact have a deficiency in a certain area and whether you’ll benefit from supplementing with the associated amino acid.

Here is information on how to do a trial.

Here are the supplements I use with my clients.

If you do not have my book I highly recommend getting it and reading it before jumping in to taking amino acids: The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings

antianxiety food solution

There is a complete chapter on the amino acids and one for pyroluria, plus information on real whole food, sugar and blood sugar, gluten, digestion and much more.

Once you have read it you can use these above blogs, and others on my site, as summaries. They do contain some additional information that is not in my book.

If all this sounds too overwhelming, check out the The Amazing Aminos for Anxiety homestudy program. This homestudy group program provides guidance with using each of the targeted individual amino acids and how to do a trial.

The Anxiety Summit – Closing

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Trudy Scott_Anxiety4_Closing

The host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution closes the Anxiety Summit Season 4.

Anxiety Summit closing: Neurotransmitter testing, amino acid questions, hyperflexibility/EDS and pet anxiety

  • Ehlers Danlos Syndrome/EDS, hyperflexibility, connective tissue problems and the connection to pyroluria/social anxiety
  • Natural anxiety solutions for cats, dogs and horses
  • Neurotransmitter and pyroluria testing: what works and what doesn’t
  • Amino acid questions I get asked and my feedback
  • Questions from you, the summit attendees

If this is your first summit and this nutritional info is new to you and you feel overwhelmed start at the beginning and take baby steps and start with the basics: switch to eating a real whole foods diet and dump the junk/processed food, eat to control blood sugar get off the sugar and get off the gluten and caffeine.

You can come back to the advanced topics like oxytocin and fluroquinoline toxicty and Lyme disease and heavy metals and Ehlers Danlos syndrome (and all the rest) later.

I shared these 60+ Nutritional & Biochemical Causes of Anxiety on my closing call  of  The Anxiety Summit season 3.   I hope they will help you put the puzzle pieces together to resolve your anxiety.

Here is some of the Ehlers-Danlos Syndrome and anxiety/social anxiety/pyroluria information from the blog I posted late last year: Joint hypermobility / Ehlers-Danlos Syndrome and pyroluria?

Here is what we know from the research: disorder of connective tissue, premature osteoarthritis, intestinal dysmotility, and laxity in other tissues causing hernias or uterine or rectal prolapse, chronic pain some with serious disability

Here is the feedback I received from my blog reader: much higher than expected incidences of anxiety, depression, chronic pain which is often labelled as fibromyalgia, gastrointestinal problems, pyroluria, POTS (Postural orthostatic tachycardia syndrome) and MCAS (Mast Cell Activation Syndrome), leaky gut, less than ideal responses to nutrient therapies, many on cocktails of medications for pain, sleep, anxiety, depression, reflux, IBS, menstrual disorders etc.  [I appreciate her for posing the question]

There are a number of papers published in 2014 and 2015 linking EDS / Ehlers-Danlos Syndrome with psychiatric disorders, in one Swedish paper anxiety was as high as 74.8%.  In another paper they found preliminary connections with depression, ADHD, autism spectrum disorders, and OCD.

I have had many people with pyroluria confirm the connection and a number who get on the pyroluria protocol see their symptoms improve.  One person found a connection to Thin Basement Membrane Disease (an inherited collagen/connective tissue disorder diagnosed via kidney biopsy) and pyroluria and saw an improvement in both on the pyroluria protocol.

Here is the pyroluria questionnaire

Please see the above blog for links to the research I discussed and all the comments

Lisa Bloomquist shared this in the blog comments of her interview: Antibiotic Induced Anxiety – How Fluoroquinolone Antibiotics Induce Psychiatric Illness Symptoms

I agree completely, both that people with EDS should never be given fluoroquinolones (check this out ), and that fluoroquinolones can also exacerbate and cause EDS symptoms (and maybe EDS itself). Fluoroquinolones definitely cause connective tissue problems. They even have a black box warning on them noting the damage they can do to tendons. In addition to tendons, they can also damage cartilage, muscles, and collagen. I’m not sure whether the FQs trigger symptoms of EDS, or if they trigger epigenetic changes that lead to EDS. There are an unfortunately large number of people who have EDS symptoms post-exposure to these drugs.

The person who posed the question to me is a member of a FB group called: Ehlers Danlos Syndrome and Polysaccharide 

I haven’t had a chance to look into everything they recommend but I’ve been super impressed with what I’ve seen on this online forum.

Let us know if this resonates with you and if you have you been diagnosed with joint hypermobility or Ehlers-Danlos Syndrome?  If you have pyroluria to let us know if the pyroluria protocol of zinc, vitamin B6, evening primrose oil and a good copper-free multi has helped?

thundershirt

Pets and anxiety:

  • Anxitane, tryptophan, gluten-free diet and a Thundershirt (here’s an example of one)
  • Check with your vet about Rescue Remedy and pyroluria protocol (I’ve had feedback from people using both approaches)
  • Researchers have found that vets who were given pet dogs showed significant improvement in their PTSD symptoms. Here is the article

New research just out: Antidepressive treatment during pregnancy can affect newborn brain activity

New Medscape article – Fluoroquinolones: Not First-Line Treatment

Inspiring words of wisdom from a listener:

It was very helpful to hear of Tricia and her family’s journey with lyme, anxiety, pylouria, GABA, etc.  I am hoping that other parents will try “natural” remedies first for anxiety, panic, etc. I was put on antidepressants in my early teens and thus began a life long battle of trying to get my life back.

My parents didn’t know the repercussions of the medications I was on. I went from being an A student to being completely zoned out for a while in school, along with other problems from the prescription medications. Then came the thoughts of suicide and more. I had no idea what was going on with me.

Years later, a psychiatrist who seemed more open to natural remedies and who couldn’t find a medication that could help me or keep me from completely losing it, had an “enlightened moment” and when he went back over my history realized the “issues” I was having was most likely related to my hormones. I would indeed find out later that this was the case and that it had to do a lot with what we were eating growing up. My hormones were a mess as a young teenager and what we were eating a home was not at all healthy for us and filled with hormones, antibiotics, etc.

I want to impress on people that these prescription medications will ALWAYS do more damage than good. And my heart breaks when I hear of the young people around me being put on these medications. I just recently learned ECT (shock treatment) is now being used on the young.

Some time back, I cannot remember, I learned of you, Trudy, and your work. Even though I knew some of what you taught, I was still afraid to completely let go of the meds. It took some time, a great deal of struggle, patience and trust, but I eventually made the switch to a WAY MORE healthier diet, L-tryptophan, GABA calm and GABA, and have slowly begun to reclaim my life.

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here: www.theAnxietySummit.com

Missed this interview or can’t listen live? Or want this and the other great interviews for your learning library? Purchase the MP3s or MP3s + transcripts and listen when it suits you.

You can find your purchasing options here.: Anxiety Summit Season 1, Anxiety Summit Season 2, Anxiety Summit Season 3, and Anxiety Summit Season 4.