In the recent Truth About Cancer docu-series hosted by Ty Bollinger, founder of Cancer Truth, interviewed Dr. Russell Blaylock, M.D. and Dr. Blaylock said no to glutamine supplementation because it feeds cancer like sugar.
Here is what Dr. Russell Blaylock said during Episode 4 – Excitotoxins that Fuel Cancer:
Cancer cells use two major fuels, they use glucose and they use glutamine. Of the two, glutamine is the more powerful stimulant for cancer cell growth.
The Warburg effect is the fact that normal cells use both anaerobic and aerobic system, the Krebs cycle. The cancer cells only use the anaerobic system, it was thought. Glutamine can work the aerobic system and product a lot more energy. So if you’re eating a lot of sugar and you’re eating a lot of glutamine, you’re really stimulating your cancer powerfully. So the idea is you want to cut down your glutamine intake. A lot of people are promoting glutamine as a way to heal the gut—the leaky gut syndrome. So, they’re saying, take five, six, ten grams of glutamine. That is a powerful stimulant for degenerative brain disorders, a powerful stimulant for cancer growth. You don’t want to do that. There’s a lot better ways to repair the GI tract—they work better and safer and actually inhibit cancer.
Dr. Blaylock, author of Excitotoxins: The Taste That Kills, has been saying this for years. His coverage of MSG and how harmful it is, is very powerful groud-breaking work but many practitioners disagree with his glutamine-feeding-cancer comments.
As a result of this recent interview I’ve been getting a lot of questions about glutamine because it’s something I use with most of my clients for blood sugar control, carbohydrate/sugar cravings and gut healing.
In order to reassure folks I started looking at the current research and getting feedback from trusted colleagues.
I have now gathered 20+ studies showing glutamine to be beneficial in cancer: it heals the gut, helps boost glutathione, helps with muscle wasting, helps when someone is going through chemotherapy and radiation, and is useful for bone marrow transplants. Studies as far back as 1990 state it has benefits and doesn’t promote tumor growth, with 5 of them published this year.
This 2010 paper Glutamine as indispensable nutrient in oncology: experimental and clinical evidence summarizes many of the benefits:
Within the last two decades, 36 (24 oral/enteral, 12 parenteral) clinical studies evaluating the tolerance, safety and effects of glutamine in various patient groups have been published. In the great majority of these clinical studies, glutamine supplementation in cancer patients improves host metabolism and clinical situation without increasing tumor growth. Potential mechanisms of glutamine effects include maintenance of mucosal integrity, improved immune competence, inhibition of cell proliferation, increased apoptosis rate, increased synthesis of glutathione, induction of heat shock protein synthesis, and increased synthesis of glucagons-like peptides.
In various clinical situations, appropriate exogenous glutamine supply is safe and can beneficially contribute to diminish risks of high-dose chemotherapy and radiation. In addition, there is some evidence that adequate glutamine availability can beneficially affect outcome, especially in patients undergoing bone marrow transplantation.
With new research coming out all the time, a paper published in 2010 may seem very old and yet there are some more recent papers stating similar benefits, many of which were published this year and in 2014. Here are a few excerpts from some of these papers:
- Oral administration of [glutamine] plus [elemental diet] may prevent chemotherapy-induced oral mucositis in esophageal cancer patients. Link to paper
- This study suggests a beneficial role of oral [glutamine] use in prevention and/or delay of radiation-induced esophagitis, in terms of esophageal transit time and serum immunological parameters, as well as weight loss. Link to paper
- It also appears that glutamine may significantly reduce the duration and severity of objective oral mucositis during radiotherapy. Link to paper
- These results suggest that [glutamine] is an effective way to reduce radiation morbidity to breast cancer and is associated with the increased expression of a novel serum protein biomarker. Link to paper
- A promising supplemental therapy agent in the field is glutamine. Glutamine (Gln) is an amino acid that is produced in physiological conditions in human cells. However, in pathological states, glutamine production is often insufficient. In the clinical setting, glutamine has been shown to decrease metabolic side effects resulting from cancer treatment and to improve patient outcome. Link to paper
- Prophylactic oral glutamine could ameliorate the neoadjuvant chemotherapy-induced increase in intestinal permeability, but had no significant positive clinical effect on stomatitis and diarrhea and did not interfere with the antitumor effect of chemotherapy. Link to paper
- Oral [glutamine] increased [glutathione] levels and lowered IGF-I and TGF-beta 1 in a range that is considered clinically significant. However, the effect of [glutamine] in maintaining normal gut [glutathione] production in the presence of DMBA was much more significant. Link to paper
I’ve also posted the glutamine-cancer question in a number of online practitioner groups I belong to and have received this feedback:
- Some practitioners still feel glutamine supplementation is very safe to use up to 10-30g a day for a month and then titrated down to a maintenance dose
- An integrative cancer doctor says she is more cautious and would not recommend greater than 5g per day if someone has active cancer
- One practitioner shared that long term studies haven’t shown changes in mortality due to glutamine supplementation in cancer settings but glutamine may be used for fuel by cancer cells
- Glutamine is not neurotoxic as has been suggested in the book Excitotoxins:The Taste That Kills according to Dr. David Brady and other researchers
- Many consider bone broth to be safe, some feel bone broth should be avoided during cancer treatments
It’s clearly a controversial topic with very divided opinions and it seems the jury is still out. We are also very individual beings with unique biochemistry so there is never a once size fits all approach and it’s very likely that some won’t benefit from glutamine and some may have adverse effects.
I do list cancer as a possible issue under the glutamine precautions and recommend that you check with your oncologist if you are currently undergoing treatment.
I do want to share safe and valuable information with my clients and with you (my community) and am not afraid to back down and say I was wrong. BUT right now I don’t believe we have enough information to say NO-ONE should be using glutamine as a supplement. I’m gathering information and feedback, am learning a great deal and will be sharing more in future blogs on this topic. And I hope to get some feedback from Dr. Blaylock himself!
I hope this helps with questions you’ve been having or may have in the near future.
In the meantime I’d love your feedback…
- If you’re a practitioner I’d love to hear your thoughts and approach, what cautions you offer and do you recommended a safe upper limit?
- If you’re someone who uses glutamine or has used glutamine what does your practitioner say about it? Have they cautioned you about glutamine? Have they recommended a safe upper limit? What benefits have you seen when using it?
- If you’ve been treated for cancer, has your cancer team recommended glutamine? And did it help?
UPDATE: Feb 26, 2016 (The post above was originally published on October 30, 2015)
I promised to come back and share additional information from someone working in the area of cancer and so here we are – an update on the glutamine cancer concern:
Paul Anderson ND shared a literature review and practice implications in an called “Glutamine and Cancer: What do we know?” (Update Sept 2021: it was published on Emerson Ecologics but the link is no longer active)
When I read this reassuring literature – based on the 2015 paper, Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism. Oxidative Medicine and Cellular Longevity – I reached out to Dr. Anderson and was given permission to share the link and excerpts from the article:
L-Glutamine the amino acid is one of the most widely used therapeutic substances in natural and integrative clinics as well as some allopathic practices. It has benefit in gastrointestinal illnesses and repair, post-surgical care, renal support, muscle mass maintenance, cachexia and a number of other conditions. Given its wide use in the integrative medical community the concern regarding potential for any adverse or untoward event associated with its use is significant. The primary potential issue is the “feeding” of cancer cells and another related issue is increasing glutathione stores and thereby inactivating standard therapies.
He shares some of the same potential benefits of glutamine that I mentioned above:
- Post-surgical healing
- GI repair and maintenance
- Immune system recovery and maintenance
- Muscle cell maintenance and recovery
- Glutathione pool restoration
Dr. Anderson shares that:
the availability of glutamine even in a supplemented person is often too low to do much more than feed the deficient GI cells, so peripheral use is limited with oral doses.
The one common exception is glioblastoma multiforme (GM). In the case of GM, it is theoretically possible that amounts of glutamine that were able to cross the GI barrier could be metabolized in a manner promoting of GM energy and health. In the case of GM the authors point out that restricting carbohydrates would likely make the glutamine effective in an anti-GM biology.
And he shares a number of take home points for clinical practice: oral glutamine supplementation is likely safe across most tumor types in patients with cancer, it’s indicated for GI damage, the timing and doses, and how he uses carbohydrate restriction for certain cancers (when also using glutamine).
Based on his clinical experience Dr. Anderson states that:
Glutamine used appropriately is an excellent adjunctive therapy in the oncology setting.
Dr. Paul S. Anderson is medical director of Anderson Medical Specialty Associates, a clinic focusing on the care of patients with cancer and chronic diseases. Former positions include professor of Pharmacology and Clinical Medicine at Bastyr University and Chief of IV Services for Bastyr Oncology Research Center. He is a graduate of National College of Natural Medicine and began instructing classes at naturopathic medical schools in the early 1990’s. He continues to hold board review classes and CME courses for most of the US and Canadian ND programs. He also is a founding board member of the Academy of Parenteral Therapies specialty group and an instructor and author for the International IV Nutritional Therapy training group.
His book, Outside the Box Cancer Therapies: Alternative Therapies That Treat and Prevent Cancer (here is my Amazon link) discusses glutamine and some of the research and benefits when used with cancer patients, and also recommends consulting with your physician.
Did your oncology medical team recommend use of glutamine while you were in cancer treatment and did it help?
Or did they say no to supplemental glutamine and share why?
Feel free to post additional glutamine questions too.
Re: Russell Blaylocks statements about glutamine in The Truth A bout Cancer Series, Ep. 4. This worries me since I am vegan and really depend on beans as a source of protein. Beans are a high glutamine source. Recently I also learned that phytic acid in legumes (defamed by Paleo adherents) can also be used for chelation of heavy metals, so I am distressed to learn that glutamine (as in beans) along with sugar are the two main sources of energy for cancer cells. No. This can’t be!
Gloria
Dr. Blaylock actually says no to legumes if you have cancer. I had not heard that advice before. And phytates can block mineral absorption and legumes are also high in carbs.
I’m afraid to say I’m not a fan of a vegan diet and I find that my clients with anxiety and mood problems do so much better when animal protein is incorporated into their diets. There is also research supporting this. I had a great interview with Lierre Keith (https://www.everywomanover29.com/blog/anxiety-anxiety-depression-vegetarian-diet/) on the last Anxiety Summit and Dr Felice Jacka shared how grass-fed red meat is beneficial for women (https://www.everywomanover29.com/blog/anxiety-summit-the-research-food-to-prevent-and-treat-anxiety-and-depression/)
I am also a vegan and I love my beans and my mushrooms which I eat almost everyday. Also in the list they showed was yeast extract and yeast nutrient…Kombucha contains yeast (one of my fav drinks) and I also consume very often nutritional yeast. SO CONFUSING!!!
Personally since I became a vegan I am happier and I just feel great =), anyway, I hope we can get some kind of answer to our questions soon.
Such is the efficiency of the glutamine sourcing machinery of the cancer cells, that they will always have enough from the glutamine that is produced in the body. It is our healthy cells which become depleted and lose out. For example, with low glutamine comes low glutathione in our natural killer cells impeding their ability to defend our healthy cells and promote immune function which may be necessary in the cancer battle. With more than 90% of the body’s glutamine supply in muscle, this will become heavily depleted creating a serious negative nitrogen balance. It seems likely that this depletion is tied to the common occurrence of cachexia and that supplementation of glutamine could confer great benefit. The clinical importance of cachexia is emphasised by the fact that it is the principal cause of death in about one third of cancer patients. While academic consensus still does not exist, a large body of evidence is now available to support glutamine supplementation in cancer patients; improving clinical outcome and quality of life, as well as reducing the risks of high dose chemotherapy and radiation.
Sources from http://www.huffingtonpost.co.uk/aidan-goggins/glutamine-and-cancer_b_2740348.html
George
Thanks for the very eloquent response and link
let me just say thatif vegan are vegan’s. It isn’t just because of their health but also and mostly because of the fact of animal suffrances…and the awful feeling that we eat cadaver….and this is above all health considerations…you will have to admit that the mind most of the time is above matter…..
So if there is a whole part of humanity that lives without eating meat ..means that it is possible”…..i know that most doc..only sees health problems and not the mind consideration….
Thanks for commenting. I hear you on the mind consideration but encourage you to check out this interview and her book if you have any health issues https://www.everywomanover29.com/blog/anxiety-anxiety-depression-vegetarian-diet/
If no glutamine then how do I stabilize my gut, which is wretching with anything I eat. Renew Life Intestinew has 800 mgs L-Glutamine in it. It seems to help my gut but if that is not a good idea I need an alternative. Thanks.
Robyn
Why would you want to avoid glutamine if it helps
Could it be that the source of glutamine is an over riding factor? I know that legumes are detoxifying & cancer is generally about toxins.
The other thing that I want to know is where the $$$ trail ends for each of the studies.
I personally resonated with the idea that the fruits eaten ripe off the trees give molecular protection if not removed too soon. Dr. Blaylock understands plant based medicine. I understand why people are questioning, & see that you are not discrediting his work. I appreciate you addressing this.
I understand studies are often done with a bias & a person like me will never be able to tell them apart. I studied medical research & know how to find “reliable” information, but I’ll trust a practitioner who has won my trust over any study I will ever read.
Respectfully,
Kim
Kim
Dr Blaylock’s MSG work is incredible and yes, I’m just questioning his advice about the fact that no-one should take glutamine.
It could well be that the source of glutamine could be a factor for some people. In the same interview he actually says no to legumes if you have cancer because of their high glutamine content. I had not heard that advice before. It’s very interesting about fruits too.
I do like to share research though because it shows that science supports so much of this. But I do hear you about studies and money and vested interests!
I heard some cancer survivors ..in addition chris wart…and others they all did take vege and fruit juices .,ate Green salades with all sortes of vege and with nuts and sometime red peas…..etc. Of course no meat….lots of rest and exercices…and vit b17apricot kernels..iv vit c…and some infra red sauna….etc…….
Surely some supplements..don’t remember which ones…
I never did hear anything about glutamine….and they git rid of their cancer..so…..all this is very disturbing..even if there has been studies about either or not is nourrishs cancer…or not…specially for people who are very attached about not eating anything where we are suppose to mistreat animals to take their milk or cheese etc…the moral is sooo very important when we hve to deal with cancer …
The treatmnt just cn’t only be onky.about nourrishment…up to a certain point .lother reasons are also as important..like…how does one eat…in silnce…thinking bout what he is eating and being grateful for his meal and vege etc. That he is eating..why?..because in the vege etc…their are some etheric subtil particules that nourrish’s the body and the mind….
Look when you fast…after a certain number of days..you can smell things a lot better..the very subtil perfum come to our nostrils…and this is the proof that we not only nourrish our cells with what we eat but what we can’t see but smell….
so what do you think about l-glutemine? I have inflamation of the gut and leaky gust a host of neurological symptoms and I thought this would be my answer. I am also allergic to so many foods and yet my diet needs diversity! I am lost. Please any information would be helpful. I have spent a fortune with minimal success. Thank you!
Everyone is different though I have take L – glutamine for about four years now. 2-3 servings a day @ 5g per serving.
The benefit for me is that I have three kids and train at the gym 5 days a week. I couldn’t tell the benefits until a year later comparing my last years health to the years before.
I noticed that when I did get sick no matter what the issue was my recovery was quick and when I say quick I mean it took half the time in recovery.
I was amazed!
As they say it builds your immune system and increases your recovery.
I also noticed that I was only sick a couple of times a year compared to 3 – 6 times a year especially have kids that pick up germs as they do.
The best one for me was that my mum had a lot of problems with her stomach ulcers/leaky gut/ bloating/ reflux and the list goes on, anyway to the point I asked my mum for two years to take it and wouldn’t because she was very skeptical, I suppose as most would be. After all I’m not a doctor and can only tell of my experience.
But mum pulled through after two years, $100 mth on pills that have more side effects that glutamine and still continued to have her issues internally.
Keeping in mind you can buy L-glutamine for $80 for 3 kg which will supply you for 3mth !!!
This is the best bit?????
Mum called me after the first day of using it ( 24hrs = 3 servings/ 5grams per serve and said ” I feel alot better and more energized” and then it wasnt until the second day mum called and said ” I cant believe it has stopped”
I said what and mum said my insides are normal again 🙂
What do you mean mum?
she said all her pains and bloating and everything else has gone.
It took 2 days!!! unbelievable!
Point is which one would you rather take:
In mums case
Pills that have side effects that could range from headaches to death ( $300 for 3 months) or
L-glutamine which you body naturally produces small amounts with no side effects ( $80 = 3kg L-glutamine for 3 months)
anyway hope this helps
good luck 🙂
Stan
Thanks for sharing about the great results you and your mum have seen! this is wonderful!
Hi Stan and Trudy
I am interested in the most reliable make of l-glutamine to purchase as I have read that the free form is the best. On Iherb (where I purchase all my supplements from) there is only one free form l-glutamine make which is from Source Naturals.
Therefore Stan where do you purchase yours from as I need to make my dollars stretch to be able to get all the supplements I need.
I have MTHFR, depression, menopause issues, Fibromyalgia and Hypoglycemia and have just got over a second twisted bowel op and need to get my digestion working again to give me energy, help me sleep and cope with the stress and anxiety that I constantly suffer from.
Also I suffer from insomnia and have tried various herbs etec for this. I also take SAME rather than antidepressants (which I quit after 30 years of continued use), B12 and Methyl Folate for the MTHFR which my doctor in NZ discovered 4 yrs ago.
I make my own kombucha and organic goat keffir and eat organic meat but still find my energy levels are very low.
Look forward to your reply.
Fionayrs
Fiona
You can see the products I use with my clients here https://www.everywomanover29.com/blog/amino-acids-pyroluria-supplements/
With the depression, anxiety, insomnia and fibromyalgia, I encourage you to do the amino acid questionnaire and consider addressing low GABA and low serotonin https://www.everywomanover29.com/blog/amino-acids-mood-questionnaire-from-the-antianxiety-food-solution/
You may find this blog useful https://www.everywomanover29.com/blog/fibromyalgia-tryptophan-5-htp-for-anxiety-depression-pain-and-insomnia/
I have unlimited gut symptoms, food felt like poison. I am mostly following Dr. Amy Meyers diet. I am also under a Dr.s care, diet/supplements. Nothing felt like I was truly healing. It has been a few months. Then as per Amy Meyers book, I bought L-Glutamine caps, 500 mg (she suggests a higher dose). I took one, woke up the next morning and noticed I felt better and happier then I had in a very long time. I did not relate it to the L- Glutamine. After randomly taking 1 or 2 caps in a day, I can now directly relate the feeling of having an appetite and wellness, to that small amount of L-Glutamine. I am very cautious to claim I finally found the remedy, along with my new diet gluten free, Organic and daily protein ( I was mostly vegetarian, small amount of chicken and salmon) but it sure feels like it so far. I am very aware of cancer, my husband passed way too young from Brain and lung cancer. We did everything to get control, Pharma and Natural Drs.. I have done a lot of research on Cancer. This small dose of L-Glutimine is a blessing so far. But I always take less than Dr’s suggest, one size does not fit all. Good Luck to those with GI issues, not fun stuff!
Janet
I am sorry to hear about your husband. These glutamine results are just wonderful to hear! and I love the diet changes too! Thanks for sharing
Glutamate is an excitotoxin in the brain. And glutamine is an amino acid that is converted into glutamate.
I have a horrific pain condition called Central Pain Syndrome. It’s been found in conditions like this that there is a high amount of glutamate in the portion of the brain that controls pain and emotion.
It’s been referred to as the “glutamate pain cascade”, and having too much glutamate in the brain seems to lead to irregular pain processing seen in Fibromyalgia and Central Pain Syndrome (like Fibromyalgia times a gazillion).
Therefore, I am afraid to take l-glutamine. There are other, safer ways to heal the gut. However, if you’ve found contradicting evidence, please do let me know.
Kimberly
I’m sorry to hear this – I’m not familiar with Central Pain Syndrome and the glutamate connection. I do know that fibromyalgia pain often responds well to other amino acids like tryptophan, 5-HTP, GABA, DPA and even glutamine (since much converts to GABA in many individuals).
If you react to glutamine then I’d avoid it and use other approaches to gut healing.
Actually, I saw that episode with Dr. Blaylock. The one I saw was Episode 4, and he does not say that glutamine is an excitotoxin. He says GLUTAMATE is. And GLUTAMATE has a role in cancer.
He said that ANYTHING that says glutamate is an excitotoxin. As in MSG: the worst thing about it is the Glutamate. He said every cell in the body has glutamate receptors. They can trigger and stimulate growth of cancer tumors; it acts as fertilizer.
But if you block the glutamate receptor, the cancer cells start dying; but other cells are fine. However, we don’t want to block ALL glutamate receptors, as some of it is needed.
The big problem, he says, is actually the glutamine –> glutamate conversion. Therefore, this is where glutamine would be a problem. Though he mentioned the enzyme that converts it as the problem. But DON’T want to take glutamine for this reason; it’s a powerful stimulant, and there are a lot better ways to heal the gut.
So, that’s what I heard him say, and the notes I took during the film. He never actually said that glutamine was an excitoxin; it’s glutamate. He just said that glutamine was a more powerful cancer stimulant than glucose… mainly because of the conversion to glutamate, according to what I heard.
Kimberly
You’re spot on – he did say all of this.
I am questioning this section: “The big problem, he says, is actually the glutamine –> glutamate conversion. Therefore, this is where glutamine would be a problem. Though he mentioned the enzyme that converts it as the problem. But DON’T want to take glutamine for this reason; it’s a powerful stimulant, and there are a lot better ways to heal the gut.”
Many people do very well with glutamine supplementation as I share in this blog https://www.everywomanover29.com/blog/glutamine-blood-sugar-stability-calming-gut-healing/ and it does a wonderful job healing the gut (as do other nutrients and foods too), and appears to have many benefits during cancer as I’ve shared here.
If you don’t do well with glutamine then you don’t use it. If you have active cancer you would discuss using it with your oncologist.
Could you share what the other ways to heal the gut are if thats possible?
I had surgery on my small intestine and appendix removed and my health/digestive system has not been the same since has caused a lot of problems for me and time off of work(for 15 years), have tried many different diets, herbs and medications and finally learned about glutamine and thought it may be my answer along with digestive enzymes.
I’ve also had acid reflux for the past 3 years, my food feels like it just sits in my stomach, I get gas with everything I eat, im constantly exhausted. Have been tested for celiac and lactose but no allergy for either.
Yam
Sorry to hear about this. I am a big fan of glutamine (and will be posting an update to this cancer blog). In the meantime here is more info on glutamine for gut healing https://www.everywomanover29.com/blog/glutamine-healing-leaky-gut/. Licorice root/DGL (deglycyrrhizinated licorice), probiotics, zinc, slippery elm, marshmallow root and quercetin are other supplement options for gut healing if you can’t tolerate glutamine for some reason.
With gas, I’d keep a food log and look into SIBO (https://www.everywomanover29.com/blog/sibo-small-intestinal-bacterial-overgrowth-questionnaire/), candida, and parasites.
And keep in mind that negative allergy tests for celiac and lactose doesn’t mean they are not a problem – especially if you had IgE tetsing.
read Dr. Sherry Rogers book “No More Heartburn”
Can Glutamine interfere with sleep?
What is the difference between Glutamine and Glutathione?
Deborah
Too much glutamine could potentially interfere with sleep. For many people it helps sleep, especially if low blood sugar is an issue.
Glutamine is an amino acid, glutathione is an antioxidant
Trudy. I SO APPRECIATE you addressing this issue, as it was absolutely stunning to me when I heard this said about glutamine. I am not taking any right now; but I have used it before in the past. Thank you for giving the other side of the coin on this. Blessings, Pam
You are most welcome Pam! Would you mind sharing how much you typically used and for what purpose? Hopefully you feel less concerned now.
I have read all the posts here up to this point, and YES, I understand that it is the conversion of glutamine to glutamate that is the concerning issue. I do eat medicinal mushrooms, and Dr. Blaylock said “mushrooms” are high in glutamine. I didn’t know quite what to think of that since I know medicinal mushrooms, such as Chaga & others, are good for the immune system, and fighting cancer. I thought that perhaps it was just the every day button mushrooms he was talking about. I haven’t searched that out yet to see what I can find.
I also sometimes wonder if a food source of a nutrient plays out in a more balanced way than simply taking a single L-type created amino acid supplement.
Ty did address this glutamine issue as a big question during one of the question/answer sessions. I know athletes often supplement with glutamine. I don’t know how much of an expert Ty is on this subject; but he mentioned that the big problem with glutamine is for those who don’t get much exercise. When people get exercise, they use up the glutamine they take in, before it converts to glutamate. If they don’t get much exercise, and then also take lots of glutamine in supplementation or food, the glutamine is not used up before it converts into glutamate; which is then the problem. I am still “wondering” about all of this 🙂
Then there is the late Dr. Nicolas Gonzales who really stresses there are many different body types who do well on completely different food programs; and our food programs and food supplementation needs to be very specific to our own body. I understand that Dr. Gonzales was getting marvelous healing recovery in the many varied people he worked with.
I have even noticed in myself that as I journey through many decades of life, my body tells me what it needs at a given moment, if I prayerfully listen for healthy choices. My specific needs can change from week to week and day to day, though there is an overall pattern that works for me. As I age, I have noticed that I need to make diet changes, and it is not due to digestion. My digestion is good now. Though for years I was highly amalgam mercury poisoned, and that made me need more sulphur protein foods, and of course relief of the mercury poisoning. This is all very interesting and I am eager to learn more about all of this. Blessings, Pam
Pam
I was also surprised to hear Dr Blaylock mention mushrooms especially with all the research on mushrooms and cancer. Here are a few studies:
white button mushroom effect powder on serum PSA and prostate cancer levels http://www.ncbi.nlm.nih.gov/pubmed/25989179
“Intake of mushrooms, particularly white button mushroom, seemed to be inversely associated with the incidence of epithelial ovarian cancer in southern Chinese women.” http://www.ncbi.nlm.nih.gov/pubmed/24257554
“both common and specialty mushrooms may be chemoprotective against breast cancer.” http://www.ncbi.nlm.nih.gov/pubmed/20921274
“These results suggest that diets high in mushrooms may modulate the aromatase activity and function in chemoprevention in postmenopausal women by reducing the in situ production of estrogen.” http://www.ncbi.nlm.nih.gov/pubmed/11739882
I agree with the late Dr. Gonzalez – we are all unique and have different needs. Many individuals do really well when supplementing with glutamine so a blanket statement like this doesn’t apply: “the big problem with glutamine is for those who don’t get much exercise. When people get exercise, they use up the glutamine they take in, before it converts to glutamate.”
Here are some of the many benefits or oral glutamine supplementation https://www.everywomanover29.com/blog/glutamine-blood-sugar-stability-calming-gut-healing/
Glad I found this discussion; I exercise heavily and have taken glutamine in the past, so Dr. Blaylock’s interview gave me cause for concern.
Kelcey
Thanks for your comment. Would you mind sharing how much you typically used and for what purpose? Hopefully you feel less concerned now.
Just to give you an idea of my workout schedule, I teach water aerobics 4-5x/week; I also train for triathlon so I am biking, swimming and running 2 to 3x/week for EACH discipline (although I do of course periodize and cut back during rest weeks and off season); I also do resistance training and PT in the gym 1-2x/week. So I have been using about 6 grams post workout in a time-release powder form with my post workout meal. I also eat mushrooms and beans frequently and take an immune mushroom supplement during cold season. Maybe I”m getting enough from food? Thanks for your time!
Trudy
I have experience with L-glutamine and cyst growth, I think you will find this interesting…
I have a fatal cyst/non-malignant tumor deep in my brain (third ventricle), which was stable for 20 years and is being monitored with regular MRIs, and I’ve also had 7 concussions.
Last year I developed severe food allergies to almost every food (diagnosed FODMAP). I found Datis Kharazian’s brain book and he recommend taking L-glutamine for healing the gut, and he also mentioned that post-concussive patients all develop severe food allergies with in 3 years of brain trauma ( which is exactly what happened to me). I began taking L-glutamine last November 2014. It gave some relief to my gut, and I was happy with the direction it was going.
In March 2015 I had my regular brain MRI and it showed the tumour had grown SUBSTANTIALLY, thus I needed to have brain surgery right away to have it removed. This same MRI ALSO showed that I had a NEW cyst on my pituitary gland, and a subsequent MRI in May 2015 showed this cyst grow 4mm in 2 months! This all occurred with the commencement of L-glutamine – that was the only change in my lifestyle/diet during that time.
I am torn as I cannot say for sure that L-glutamine CAUSED my cyst growth, but the “coincidence” is too profound to deny.
What are your thoughts? I’ve currently, regrettable, stopped taking L-glutamine, and my gut issues have become very bad 🙁
Lastly, my tumour causes “sudden death”, and because of this, when it was discovered, neurosurgeons wanted to remove it immediately. I refused surgery back in 1997 when it was discovered, and I lived with it STABLE for 18 years!! The numerous doctors I’ve seen are AMAZED by this, as apparently people often die with this.
The reason they attribute my success… I’ve been VEGAN for 46 years and have lived a very healthy lifestyle (have never drank alcohol, eaten junk food, or meat …). I know you don’t support a vegan lifestyle, and that’s perfectly fine, but when it comes to disease… I’ve been told that I’m an example of it’s beneficial effects.
Trina
Trina
I am sorry to hear all you have been through and commend you for your courage and staying stable for 18 years. We truly are all unique and there is no one size fits all and I love that your vegan lifestyle has provided these benefits for you.
I’m sorry to hear about the recent tumor growth and new cyst. It could well be connected to the glutamine. I don’t know enough about the possible mechanism on how glutamine may be an issue when you do have cancer. I don’t think anyone knows why some people are affected and some not. Which is why right now, the advice is no glutamine when you have cancer. If you have cancer and want to use it, do check with your oncologist. I’m curious what your doctors and oncology team think about you having used glutamine and if the glutamine caused the increased growth? And have advised you to stop using it now?
Re gut health, I’d talk to your doctor about using aloe vera, probiotics, DGL, slippery elm, zinc and other gut healing nutrients. Dr K has a whole list in this great book.
I really appreciate you sharing this here. We do need to hear all sides, both good and bad. I wish you continued healing and stability.
Hi Trina,
Just my 2 cents here. I recently developed cerebular ataxia (was constantly dizzy, also had thick brain fog, sore stomach, speech problem – all developed at the same time). Neurologist couldn’t help so I went on a very strict elimination diet, including healing leaky gut, zero gluten, zero cross-reactive foods, etc etc) Two months later all my symptoms have been resolved.
Hope this is helpful to you,
Rosemary
Rosemary
What wonderful results – I’m so happy for you! The power of food! thanks for sharing
Did you use glutamine for healing the leaky gut? anything else? And may I ask what other foods you had to remove, other than gluten
Hi Trudy,
I used aloe vera gel from my plant (I live on a little Caribbean island), raw ginger root, fermented turmeric kefir for probiotics, digestive enzymes, coconut water and coconut meat. Besides gluten I had to remove dark chocolate (that was hard!) and ‘gluten-free’ products, rice, tapioca and dairy (even though I’d been using organic, raw goats’ milk). I’m unable to do the antibodies test here so I just had to remove anything that I thought I might have developed antibodies to.
What a wonderful assortment of healing gut nutrients/foods!
I happen to be doing research about glutamine and cancer since I was considering using it for “leaky gut” and saw this thread. I want to bring to your attention a supplement that may be helpful to you, it actually is made for brain tumors and it works by reducing glutamate levels. I take this supplement in another form, Benagene, a life extension supplement. Anyway I hope this can help you, if you need any info contact Alan Cash, he is the man behind oxaloacetate, he is a genius and can help you, his contact info is on this site. Good Luck!
John
http://cronaxal.com/
John – thanks for sharing. I’m not familiar with this product but the concept sounds interesting and I’ll look into it
Trina
I’m sorry to hear what you’ve been going thru. I’d like to suggest you start using FRANKINSENSE Essential Oil right away. Make sure its a pure brand like DoTerra so you know there’s no “fillers” Put 1 drop under the tongue in the AM and 1 drop in the PM.
Its proven to shrink cancer and tumor cells. There have been multiple people interviewed on Ty Bollinger’s “Truth about Cancer” series and people first hand at my church / area that’s said it helped them. Look it up and RESEARCH it. God Bless! praying for you!
Debbie
Thanks for sharing – the research is interesting https://www.ncbi.nlm.nih.gov/pubmed/27346540.
Trina
I would suggest working with your integrative doctor on this and other approaches
Trudy,
After hearing Dr. Blaylock, I was very upset since I have had cancer and I was taking l-Glutamine for leaky gut. At this point, I am questioning who in the world is right. I threw out my whey protein and stopped the glutamine and beans. i was still taking Great Lakes Gelatin but it has glutamine too I think. I am so glad you addressed this but I am still confused as to what is okay and what isn’t. The Truth About Cancer was great but it opens up a lot of questions and the sad thing is that most people cannot afford the alternative treatments. My supplements alone are staggering each month and my functional doctor’s fees are really high I don’t know how much longer I can continue to keep it up. I heard you speak on one of the other summits and I am taking some of the things you suggested for anxiety and they have helped. Thank you for reaching out with this information. It is all pretty overwhelming!
Jenny
I’m really pleased to hear your anxiety is better!
I’m sorry to hear you were upset about Dr. Blaylock’s information. Unfortunately you are always going to hear differing opinions and even differing research. Nutrition is an evolving field and we have to evolve with it. This keeps us on our toes and keeps us searching for answers. In writing researching and writing this blog I learned so much – thanks to Dr. Blaylock’s comments! and now you and all my readers get to learn too!
My advice is best to stay informed (as you are doing) and make your own educated decisions (based on what you learned from trusted sources). And be cautious of blanket statements like no-one should take glutamine supplements. Leafy greens like kale are incredible but not everyone should eat them – people with oxalate issues cannot tolerate them. There are only a few instances where one size fits all – one example is no one should smoke. Hope this helps!
Trudy, I tried taking a small amount of powdered glutamine for healing my leaky gut and had a bad reaction to it. I already have leg and foot pains and had massive pains down my legs after taking it. Why would this happen? It is always recommended for healing a leaky gut. I have Hashimoto’s and fibro. Thanks.
Linda
I’m sorry to hear this. I haven’t had feedback like this before but we are all biochemically unique and not everything works for everyone. I’m curious how much you used and what brand? and what is the cause of your leg and foot pain as this may provide a clue?
Hi Trudy, the brand I tried was Jarrow Formulas. Serving size is 1/4 teaspoon so I tried that or less. I have Hashimoto’s (low antibodies), celiac, leaky gut, fibromyalgia (diagnosed and undiagnosed depending on the doctor, just a label). I am homozygous for C766t. I am taking methylfolate and methylcobalabin B12. No one knows why I have calf pains and cramps in my feet, bad the last 3 years and disabling for walking. I am gluten-free, grain-free, and lactose-free but it hasn’t helped. Clean, organic diet but no improvement. Any ideas? Thanks
Linda
I’m afraid I don’t have an answer for you regarding the glutamine and why it made the pain worse. I would consider low magnesium, low iron, low GABA and possibly oxalate issues. Many of my clients with fibromyalgia find that raising serotonin and endorphins with tryptophan and DPA/Endorphigen helps.
Thanks Trudy. Regarding the glutaimine making pain worse. I take magnesium 3X a day, used to have low iron but solved that. I will look into your suggestions of low GABA and oxalate issues, raising sertonin and endorphins with tryptophan and DPA/Endorphigen. I do suspect low serotonin since I have gut issues and most of serotonin is made in the gut. I have started low on GABA and haven’t noticed anything yet. I will look up this Endorphigen if it is a product. Thanks again. Linda
Great – you can find the Endorphigen here https://www.everywomanover29.com/blog/amino-acids-pyroluria-supplements/
Linda,
I too suffered serious cramping in my legs, toes, and twitching in my eye. All this went away after I started taking magnesium. It has been found that 80% of people are deficient in magnesium, and it cannot be measured accurately in a blood test, as the body will steal from other sources in the body to make the blood balance out. Every system in the body needs magnesium. I cannot stress enough how important it is. My migraines went away as well (although I do believe going gluten-free had something to do with it). Magnesium oxide is junk. Poorly absorbed. I recommend 200mg am, and 200mg pm. Magnesium has a short half life, and the body only absorbs so much at a time. In the form of citrate, or chelated glycinate is best. I have found magnesium oil works very well as well. If I miss more than 2 doses, my cramping in the legs come back. So you will see the difference! Good luck to you!
This is too complicated for me to understand but I thought I would share this article I came across, and maybe someone could sum it up for me.
http://www.hindawi.com/journals/omcl/2015/964321/
Thanks Donna – this looks like an excellent paper that I’ll share with some of my integrative cancer colleagues and have them comment
I would love to know what they think! Thank you!
Donna
Dr Paul Anderson has done a nice review of this paper and I’ll be sharing it shortly. Stay tuned.
I also have been taking glutamine for gut healing. I have hashimotos. Last spring I had an ultrasound for a hyper parathyroid and it also showed thyroid nodules, too small to biopsy. I had had an ultrasound 8 months before, and no nodules. Between the two tests I had been taking glutamine almost daily and also gelatin. I stopped taking both after hearing dr.Blaylock’s recommendation. I am now wondering if glutamine was the cause of the sudden appearance of the thyroid nodules?
Thank you Trudy for all you do to educate us.
Sara
Thanks for sharing. I’m not aware of a connection between glutamine use and thyroid nodules. Per this site (http://www.mayoclinic.org/diseases-conditions/thyroid-nodules/basics/definition/con-20021546), “The great majority of thyroid nodules aren’t serious and don’t cause symptoms. Thyroid cancer accounts for only a small percentage of thyroid nodules.”
I’m assuming you are gluten-free http://chriskresser.com/the-gluten-thyroid-connection/
Hi Trudy!
As always, greatly enjoying your work and insights! You have one of the most interactive websites out there, which of course is key to successfully helping people!
Glutamine supplementation possible problems is a cutting edge and misunderstood topic that needs to be addressed in regards to brain health. In an article written by Dr. Blaylock on Dr. Mercola’s website, Dr. Blaylock examines how glutamine, once converted to glutamate, causes many serious problems in the brain and body. One of these is when quinolinic acid is present in the brain. He states, “Another study found that by adding glutamine to the diet of animals exposed to another powerful excitotoxin called quinolinic acid, brain cell damage was increased significantly. Quinolinic acid is known to accumulate in the brain in most cases of viral brain infection as seen with HIV dementia and viral encephalitis.” This is a very serious problem for a few reasons. Everything that I’ve read about quinolinic acid implicates it in the cause of serious depression, and especially suicidal ideations. It also leads to dementia, Alzheimer’s, etc when left untreated. I do take exception to the cause of it in the brain. Besides as stated above, I’ve read it’s also made as a result of the Candida bacteria. BUT, and most importantly, it is the result of eating plant oils in place of the traditional animal fats, something that we’ve only been doing for just over a century now….since 1911 with the introduction of Crisco…hydrogenated cotton seed oil. At the same time a niacin deficiency compounds this. And instead of tryptophan being converted to seratonin, it becomes quinolinic acid. Taking a daily niacin supplement (to flushing) and avoiding plant oils is key to eliminating quinolinic acid…and significant brain damage. As an (important) aside, the nicotinic acid in cigarettes is what makes them so addictive…due to a niacin deficiency in the body. Begin supplementing with niacin and watch cigarettes cravings begin to lessen!
http://articles.mercola.com/sites/articles/archive/2004/05/01/glutamine.aspx
The second article by Kaayla Daniels also discusses the problems with glutamine in a compromised brain…leaky brain. It also explains how to continue to consume broth, but without the large doses of glutamine that long-cooking bone broths offer.
http://www.thehealthyhomeeconomist.com/bone-broth-msg-what-you-need-to-know/
Thanks for all you do Trudy!
Maureen
Thanks for sharing all of this. It really does boil down to biochemical individuality. Just because some people can’t tolerate glutamine supplements or bone broths (long or short-cooking, doesn’t mean no-one should consume them and get the many benefits many folks do see.
And yes, plant oils are bad news!
So pleased you are greatly enjoying my work, insights and website!
Such conflicting information out there. The only way to go is trust your body. If it doesn’t like it, don’t eat it.
B6 and the GAD enzyme work together to convert Glutamine to GABA. Perhaps people with B6 or GAD genetic SNP mutations should avoid glutamine supplements but others who are able to sppropriately concert the glutamine to GABA would be fine because there would be no excess glutamine pooling
Sorry- correction to my comment above. B6 and GAD convert glutamate to GABA. Glutamine is the precursor to glutamate. I think that would mean people low in b6 or with the GAD mutation should avoid glutamine supplements.
Jill
I wish it was that simple. Most of my clients are low in B6 and many have GAD polymorphisms and do wonderfully on glutamine.
And for those with previous head injuries or brain issues with GAD could be devastating, given the glutamate neurotoxin in the brain. I’d be careful about recommending glutamine to people with GAD.. unless you’ve found a way to work around it.
I’m curious where you think NAC may fall into this debate. I know people that can not go near NAC because they get horrible headaches, and I wonder about the conversion of the cysteine and excitoxicity. Seems to show similar issues as glutamate
Cath
I have not heard about NAC being linked to excitotoxicity. There is some interesting research on NAC for addition and the role of glutamate: “Preclinical literature has demonstrated the role of glutamate in addiction, suggesting that new targets for pharmacotherapy should focus on the restoration of glutamatergic function. Glutamatergic agents for SUDs/ substance use disorders may span multiple addictive behaviors and help demonstrate potentially overlapping mechanisms in addiction. The current review will focus specifically on N-acetylcysteine (NAC), a safe and well-tolerated glutamatergic agent, as a promising potential pharmacotherapy for the treatment of SUDs across several substances of abuse.” http://www.ncbi.nlm.nih.gov/pubmed/24442756
And this paper on NAC and trichotillomania: “This study, the first to our knowledge that examines the efficacy of a glutamatergic agent in the treatment of trichotillomania, found that N-acetylcysteine demonstrated statistically significant reductions in trichotillomania symptoms. No adverse events occurred in the N-acetylcysteine group, and N-acetylcysteine was well tolerated. Pharmacologic modulation of the glutamate system may prove to be useful in the control of a range of compulsive behaviors.” http://www.ncbi.nlm.nih.gov/pubmed/19581567
Since NAC is a precursor of glutathione, a potent antioxidant that plays a vital role in the detoxification of harmful substances, I wonder if headaches could be due to some of the detoxification that is happening? Other adverse effects of NAC include nausea, vomiting, dry mouth, dizziness, and/or abdominal pain.
I think the benefits and adverse symptoms of NAC, as with all supplements, are really so individualized.
Very interesting Trudy. What do you think about NAC and histamine? I’ve heard that may be why some people get the adverse reactions. I personally tried it one time, and had the most severe headache of my life!
I am VERY interested to hear more on this. I have had issues finding methylation supports that I can tolerate (I’m undermethylated but with multiple compounding snp mutations). My doctor recommended NAC and I felt horrible on a very small amount. I suspect very high histamines at this time either from mold (outside and maybe inside) as well as juniper pollen recently exploding in my area. Since the environmental factors have hit and likely pushed my histamine load, I have experienced extreme anxiety. I was wondering if I need to explore micro toxin testing from mold (assuming a detox reaction on NAC, but maybe it’s just a histamine reaction. Do you have links or more information on the connection? I know methylation is needed to make SAM-E which breaks down histamines. This explains why my histamines go up. How does NAC fit into the picture? Thank you!!
Thank you for this interesting discussion about L-glutamine, Trudy.
I had been taking 5 to 10 grams of L-glutamine powder every day along with my daily bone broth when I heard Dr. Blaylock mention his concerns about it while listening to the TTAC presentations. Since then, I have stopped taking it as a supplement while I tried to confirm his assertions AND while I tried to find out what he meant when he said, “…There’s a lot better ways to heal the GI tract – they work better and safer and actually inhibit cancer.” I was hoping that the TTAC program would specify exactly what supplements/processes he was talking about but unfortunately, I have not been able to identify what those “better ways” are.
Do you know what he might have been referring to when he made that statement? (aloe vera, probiotics, DGL, slippery elm, zinc…)
I’d love to get your input. Thank you in advance!
Best,
Holly
Holly
I think you’ll find this blog useful – why glutamine appears to be fine to use and some other options https://www.everywomanover29.com/blog/glutamine-healing-leaky-gut/
Thanks for your quick response, Trudy! It’s very rare to have someone of your stature supply answers so quickly to the myriad of questions posed to you and It truly sets you apart from all the other on-line experts.
You are very interactive with your “tribe” and we all very much appreciate the time and energy you invest in us.
Keep up the good work!
Holly
Thank you Holly! I so appreciate this lovely feedback! I love my “tribe” and love communicating and interacting. I learn so much too and we all need to continue learning!
Hi Trudy,
Because glutamine is considered an “excito-toxin and can interfere with sleep and the nervous system, I am not willing to even try this due to my already compromised adrenals and my sleep challenges. Someone I know received this information form her doctor after she used glutamine and started having sudden issues with her sleep.
Thank you Trudy!
I would like to also say that Glutamine is an excito-toxin, and it can hinder your sleeping and interfere with the fact that one already has insomnia. I know for myself, that I am so sensitive and that I could not dare to risk taking this after a doctor shared this information with me and many of us. I think it is imperative to know this. Having sleep issues is difficult enough…….then having an excito-toxin in your brain on top of it all would be very difficult. I am passing this one because it was passed onto me…..and I want to pay it forward. Best of luck!
Hi Gloria
The objective of this blog is to bust the myth that glutamine is an excito-toxin. Thanks for being concerned and wanting to share but it’s really not true.
Hi there, my hubby has glioblastoma grade 4 and has a prognosis of 1-3 months although he looks great , you would never believe his diagnosis! We have been told he now has a leaky gut, due to the controversy surrounding this supplement i am reluctant to start it. What other ways can we heal his leaky gut.
Thank you
Helen
I’m so sorry to hear about your hubby. Regarding glutamine I would recommend talking to your oncologist as there are benefits even during cancer. If it’s off the table then I list some other options at the end of this post https://www.everywomanover29.com/blog/glutamine-healing-leaky-gut/
If you are looking for an integrative cancer team with brain cancer expertise I highly recommend Dr. Jeanne Wallace http://www.nutritional-solutions.net/
Helen
April 2nd, 2016 at 12:30 pm
Try the essential oil FRANKINSENCE..get a good reputable brand like DOTERRA that does NOT have FILLERS in it..one drop under the tongue in the AM and 1 drop PM..Research it..it really works! God Bless..
Debbie
Thanks for sharing – the research is interesting https://www.ncbi.nlm.nih.gov/pubmed/27346540.
Helen
I would suggest working with your integrative doctor on this and other approaches
Great blog post. There does seem to be questions in regards to glutamine supplementation and cancer. Dominic D’Agostino, Ph.D. addresses this very topic in the Found My Fitness podcast at 1:32:20
https://www.youtube.com/watch?v=lQ7pSXIWHrI&nohtml5=False
They basically say that glutamine feeds the gut and is very helpful with healing the gut, but it would not be a good idea with gut cancers. Cancers that are not gut related, it could be therapeutic.
The question would be: what about pre-cancer or early stages of any gut cancer when patients are unaware of their condition.
Helen, I am so sorry for you and your husband.
thanks
Shana
Thanks for the link – I have not heard Dominic D’Agostino’s podcast on this topic but will make time to review. As you can see there are professional differences of opinion and much research supporting the use of glutamine in cancer. Dr Anderson lists the many benefits and cautions with glioblastoma and how he uses it with carb restriction.
I would always defer to the oncologist and/or an integrative cancer naturopath.
Hi ! i have sarcoma in my stommach wall, i have always trained a lot meaning that I eat a lot of proteins, I still eat lot of proteins to try maintain/keep my muscles.. Does this mean that protein/glutamine food is not good for me and does make the cancer grow? must I stop eating protein??
Jani
I am sorry to hear this. This is not my area of expertise and I would recommend talking to your oncologist and/or a practitioner who focuses on cancer nutrition. You could always post your question on Dr. Nalini Chilkov’s blog http://www.integrativecanceranswers.com/live-well-blog/ or Helayne Waldman’s blog http://www.wholefoodguideforbreastcancer.com/whole-food-guide-blog/
Hello, Trudy.
I love your work and have your book. I have started out with the GABA first (baby steps, LOL) and am doing well so far. (I have found I have to cycle it – i.e. every other day and weekend breaks.)
I am soooo glad you have addressed the topic of glutamine. I hadn’t heard Dr. Blaylock’s comments on glutamine the first time “The Truth About Cancer” aired in 2015 (must have missed that episode) but finally heard it during it’s recent re-run last week. One friend, who is now cancer free after healing her Stage 2B breast cancer holistically, heard this and emailed me her concern and confusion in regard to it. I’m going to send her, and others the link to this post.
I’ve grown to be a firm believer that what works for some, may not work for everyone. In fact, this may sound silly, but I’ve grown to using a pendulum when considering supplements. I’ve gotten some strange looks. Sometimes I remind people about dowsing and the dowsing rods used to looking for water, LOL.
In any case, what I’m leading up to is asking: Are you familiar with Applied Kinesiology? It’s also called muscle testing. I know some chiropracters use it with some apparent success. My friend uses it via her NAET doctor (who is also a chiropracter). She’s had some very good success in discerning which supplements were the best for her. When she sees her NAET doctor for allergy clearing treatments, she brings in supplements, foods, etc. to be tested via Applied Kinesiology to see if she should be taking them (at the present time – as our bodies are often changing and may be able to have it at another time). Again, so far, it seems to be working for her. So I just wanted to share that just in case it might be helpful.
Peace!
Thanks for sharing – I am familiar with it but happen not to use it.
Glad you’re doing well on GABA. I’m curious about this comment re GABA: I have found I have to cycle it – i.e. every other day and weekend breaks. What form of GABA and why do you find the need to do this. I’ve only heard people needing to do this with phenibut (which I’m not a fan of).
Hi, Trudy.
Thanks for your reply.
The GABA I use is from Solgar. It’s the 500 mg veggie caps. I open the capsule and take half one time and half another.
The reason I have been cycling it is because my psychiatrist has asked me to. He believes that using supplements to help with sleep or calming are better when they’re not always taken on a regular basis. I alternate amongst the GABA, California Poppy, and another one whose name I can’t recall offhand. (I always run all my supplements by him, just in case of any issues.)
This whole protocol may change once I’m completely off prescription meds by this coming July. I can’t wait!!!
Take care.
Peace!
It’s wonderful that your psychiatrist is on board and helping with supplements! This is an interesting approach and not something I have found to be an issue. Now I’d like to know more as I love to learn and improve how I share information. Would you consider checking if it’s based on his experience with patients or if he’s seen research about this?
And this approach works well for you? You get the same amount of anxiety relief each day, regardless of which one you’re taking? May I ask which medication/s you’re on? I wonder if his advice is based on this too? I’d also love to know the 3rd nutrient you mentioned? Thanks!
Oops. Sorry. I didn’t realize my reply didn’t follow directly below yours. It’s just below this box. 🙂
Hello, again, Trudy.
Yes, I thought it was really great that he was so open to alternatives to medication or supplementing medication. We have done both over the years we’ve been together.
I am currently tapering off Effexor. The max I could use this time around without getting sick from the side effects was 25 mg. (In the past, from about 2000 to 2001, I was able to get up to 150 mg of Effexor with the main side effect being 150 lb weight gain.).
I’m extremely sensitive to medications, supplements, foods, etc., which I think is from the many different medications I have been on since the late 1990s.
(After listening to the current, “Hormones: A Women’s Wellness Summit”, and doing some research, prayer and a little more research, I think that besides the Complex PTSD from a 5-year-long traumatic “event”, and the resulting “fallout”, the medications I have been on over the years may have really messed up my hormones and neurotransmitters. (I’ll be mentioning this to him when I see him next.). )
I think he has based his working this way with me for both reasons – seeing research (which he has mentioned in reference to the California Poppy), as well as the way I’ve handled both medications and supplements. For example, he once recommended I try Gingo Biloba. He recommended the dosage (but I forget if he recommended the brand). I started having side effects from it on the lowest dosage available at that time. (I don’t recall what it was.). When I called him and told him my side effects, he had me get off the Gingko immediately.
Other psychiatrists I’ve had before him also were “stumped” with my extreme sensitivity to the lowest dosages they had me on. However, some of them were not very patient and some of them were downright rude.
Actually, this approach doesn’t work ULTIMATELY WELL for me, but pretty well. My goal is to come off the medication, detox, and follow your protocol in your book, along with eating “right” instead of well. (LOL, I learned that on the recent summit.)
Oh, the other supplement…it’s Source Natural’s Theanine Serene. (I don’t plan on continuing with it once I’m done with the bottle because of some of the filler ingredients.)
I hope this helps. 🙂
Peace!
Thanks for letting me know and all the best with your healing journey!
Awwww. Thanks so much, Trudy.
It’s been an amazing journey so far and I’m grateful I found your site and the wonderful information to help me on this next part of my journey.
Bless you for all you are doing.
Peace!!!
Hi Trudy,
I’ve had the privilege of hearing you talk on various Health
Summits, the latest being the Lyme Summit.
I subsequently found your blog about glutamine and cancer – a topic that I have also wrestled with for some time now, with many mixed feelings and concerns.
I really appreciate all the thought you’ve put into presenting an expansion on this discussion, and wonder if I may add some comments and ideas.
I notice that many of the studies quoted above – where glutamine was used in cancer situations – do indeed seem to validate how this amino acid does definitely help – but more with secondary issues within cancer e.g. oral mucositis; oesophagitis, etc.
Hence, it would seem that these studies are not really looking at the inherent safety of glutamine in regard to cancer per sec, but rather, how this amino acid does seem vindicated in health challenges we’ve long used it for – e.g. mucosal integrity and health, etc.
Therefore, although I agree that glutamine has amazing healing properties in so many conditions, my concern is nonetheless that even as it may be helping in those secondary health challenges seen so often in cancer and its medical management, it may be that glutamine is simultaneously also still driving that cancer into a more aggressive or heightened state?
The other thought is that with the stats now being so high for many Western people getting cancer – I’ve seen stats of 1:2 and 1:3 being quoted – this means that a great number of us would be walking around with at least incipient cancers.
And if glutamine truly does stimulate cancer, then this would surely mean that just about half (or so) of all people using glutamine nowadays, would also be potentially stimulating cancers that might not otherwise come to anything?
As a herbalist – now retired – I do find all this very confusing and concerning.
Blessing to you for all the wonderful work you are doing!
Namaste,
Peter
Peter
Thanks for weighing in and sharing your concerns. Do you have any references that would support your concerns or is this based on your experience as a herbalist? And how do you feel about dietary sources of glutamine? do we have to be concerned about these too?
I wish I did have references Trudy, but unfortunately not.
It’s just the extrapolations from the existing discussion that I couldn’t get out of my mind, especially the reality of the cancer stats meaning that up to half of us are already possibly walking around with incipient cancers, which we obviously don’t want to stimulate in any way.
By the same token, I find it hard to believe that glutamine in one’s diet can be as bad as Blaylock suggests it might be.
What would be interesting is to get retrospective information from as many people as possible who have used MEDICINAL doses of glutamine as part of their cancer protocol…. and are alive years later to tell the tale!
I realize such clinical “evidence” may not be enough for some, but getting any double-blind, etc. etc. trials set up would be neigh impossible. Nevertheless, retrospective clinical data would still be better than none, and could help settle this contentious issue at least somewhat.
Peter
“What would be interesting is to get retrospective information from as many people as possible who have used MEDICINAL doses of glutamine as part of their cancer protocol…. and are alive years later to tell the tale!” – great idea! I will ask Dr. Anderson if he has any information on this or if he plans to gather it. I’ll also reach out to some other integrative cancer practitioners and see if they are willing to contribute to the discussion.
“I find it hard to believe that glutamine in one’s diet can be as bad as Blaylock suggests it might be” – I’m with you on this one!
Hello!
I don’t know if you know, but TTAC (The Truth About Cancer) aired a Q&A Session over this past weekend in 2 parts.
In the first part aired on Saturday, at 1 hour and 25 seconds, the hosts speak a bit more about the issue of glutamine as presented by Dr. Blaylock. I found it very helpful.
Here’s the link: https://go2.thetruthaboutcancer.com/agq/qa-1/
I’m not sure how long the link will be available for.
All the best!
Hi DME – I didn’t find any info on glutamine at the link and time you mentioned, but it’s been a while since I watched Ty Bollinger’s very eye-opening series so a revisit won’t be wasted.
i am on the antidepressanteffexor 225 mg daily. it is controversial as it is dangerous if one goes off without tapering off. i did years ago and my gut became very acidic and i had terrible reflux.
consequently i changed my diet to eliminate wheat and all dairy and felt better. when i wished to return to an antidepressant my doctor felt effexor was still the best option for my gut. i did feel better as it creates mucous. i have noticed any digestive enzymes, no matter how natural, eliminate the mucous, and so do not take these.
but i would like to heal the leaky gut… i gained 15 pounds going back on effexor 4 Years ago and have not lost it. my stomach is always looking bloated despite my regular exercise. L-glutamine was suggested by nutrition/health coach. will glutamine work well with effexor? what doses? i do not have cancer.
my
Jody
Regarding dosing I’d suggest checking with the health coach who recommended glutamine. As far as I am aware there is not issue using it with Effexor.
If you’re still taking Effexor you may want to talk to your doctor about how this may be affecting your weight and bloating.
With the bloating I’d also consider looking into SIBO https://www.everywomanover29.com/blog/sibo-small-intestinal-bacterial-overgrowth-questionnaire/ and https://www.everywomanover29.com/blog/anxiety-summit-intestinal-bacterial-overgrowth-anxiety/
Trudy – I’ve just found your blogsite and it looks great. I’m looking forward to reading everything that you have published. So far my experience taking l-glutamine supplements I believe to have been useful. My digestive system was in bad shape after years of chronic stress and poor nutrition, resulting also in several bouts of possible auto-immune reactions. I did a very successful candida cleanse using Threelac and then supplemented with l-glutamine powder for about a year, having read about its ability to heal leaky gut. I think it did its job. However after reading some of the comments here I also realized that I suffered from very serious insomnia during this period, which I assumed was a side effect of menopause. The interactions of hormones in the body and brain is so incredibly subtle, it’s totally boggling to try to sort out what is actually happening. I do agree that the voice to listen to most is what the body is saying to me as I’ve tried different supplements over the years. Things that have been recommended by other naturopathic healers as being effective for other patients for stress and anxiety and sleep disturbance have in some cases caused bad reactions in me even at low doses (where I always start no matter the recommendation) and prescription medications affect me even more strongly than typical so I go very cautiously in the rare occasion that I take any chemical medications. At 67, I currently take no medications other than supplements. I hope to find more information in your blog along these lines. Thanks for being such a caring professional!
Chris
Welcome to my community. During menopause it can be challenging to figure what is causing what but glutamine can occassionally affect sleep. More often than not it helps sleep since it helps with blood sugar control and can help boost GABA
I had a kidney taken out almost 3 years ago because of cancer and I now take glutamine 5 gram’s a day I workout 5 times a week is it safe or not???
Hi I was reading an article from your website
https://www.everywomanover29.com/blog/glutamine-supplementation-cancer-concerns-benefits/
In which Dr Blaylock mentions other alternatives to repair leaky gut other than glutamine . Could you please maybe give me some advice on what else I can use . I’ve been on glutamine tablets for a year now 3 a day at 800 mg each and not getting any better and recently tried collagen powder which gave me a bad reaction . And also tried bone broth too . I have chronic fatigue syndrome also and I’m just so exhausted all the time and desperately want to get better .
Thank you
Lisa
800mg 3x day is pretty low for gut healing with glutamine. If tolerated much higher amounts can be used https://www.everywomanover29.com/blog/glutamine-healing-leaky-gut/. Keep in mind that licorice root/DGL (deglycyrrhizinated licorice), probiotics, zinc, slippery elm, marshmallow root and quercetin are other supplement options for gut healing if you can’t tolerate glutamine for some reason.
try picking up Sherry Rogers, MD book No More Heartburn
Thank you all for a fascinating discussion.
I have been taking L-glutamine powder for the past 3 days now: actually, 7 doses of 1/4teaspoon (c. 600 to 800mg) in all.
The immediate responses have been surprisingly positive. I have slept soundly each night and I suddenly realized that I feel more confident. That is, less fear and anxiety. It’s a quiet but marked change in mood.
I developed rheumatoid arthritis about 4 years ago after 6yrs or so of extraordinary stress as a target of persistent crime.
The RA was getting much worse and I developed a gall bladder inflammation. Eating became a battleground.
So I cut out all dairy (inc. eggs) – within 48 hrs my crucifying joint inflammation and pain subsided by about 60-70%. The gallbladder sx diminished hugely.
Four days later, I cut out all gluten. Again, there has been another bump in the upward trend!
I started reading up about RA and found lots of info on Leaky Gut Syndrome which fitted my signs and symptoms. So I decided on a course of L-glutamine to see if it could help repair what seems to me to be obvious damage.
It was therefore very worrying to read about glutamine’s potential carcinogenic properties.
It’s very early days yet for me on this dietary regime (which I and my body are enjoying immensely, believe it or not!). So I’ll continue taking the L-glutamine powder for a month alongside the new diet.
RA drugs are actually proven to be carcinogenic, some of these drugs increase chances of cancer by 10-15%. Yet doctors still push them hard and patients still take them. I never have and never will.
Frankly, I’d prefer not to be poisoned by Big Pharma. Nor by ‘regular’ food: clearly, my Big Food ordinary diet was poisoning me, despite all the fresh fruit and veg and ‘healthy options’.
Similarly, there are many foods that are toxic if eaten to excess. A fair number wouldn’t pass the food safety regulations if they were discovered today! Nor are MDs/GPs and mainstream specialists informed about food –
So it’s all swings and roundabouts. BUT it would be very good have have some definitive answers on glutamine and similar aminos, especially as many people take huge doses daily for years.
I’ll keep checking back here for more updates! Thanks once again for your sensible, factual and informative approach to this issue and associated problems.
Kate
This is wonderful to hear! Good for you for making these changes – powerful! so happy for you!
And yes RA medications have many side-effects and deplete key nutrients (one of them being folate that is cancer-protective)
The Mayo Clinic says “there is no cure for RA” http://www.mayoclinic.org/diseases-conditions/rheumatoid-arthritis/diagnosis-treatment/treatment/txc-20197400 I take that to mean there is no drug for it. It’s such a pity they don’t mention diet and leaky gut in this article
As I learn more I’ll continue to share and I know others will continue to post their experiences
I don’t buy Dr. Blaylock’s L-Glutamine warnings nor his explanation of how it works. 2 nice articles which would argue the opposite are:
Brian D. Lawenda,MD Feb 25, 2013 on Integrative Oncology Essentials (Trained as integrative oncologist at Mass Gen, Harvard Med School and Stanford-UCLA) Great article and explained in laymans terms with ample references. “Use Glutamine to reduce the severity of Muchositis and Neuropathy(During Chemo)
The second article is:
Huffington Post LifeStyle UK. Aidan Goggins (pharmacist and Nutritionist) 22/02/2013.. updated 24/April 2013.
“Glutamine and Cancer-What you need to know”
Michael
Thanks very much for sharing these excellent resources which are new to me!
I’m sharing the links for other blog readers:
1)“Use Glutamine to reduce the severity of Muchositis and Neuropathy(During Chemo) https://integrativeoncology-essentials.com/2013/02/use-glutamine-to-reduce-the-severity-of-mucositis-and-neuropathy-during-chemotherapy-or-radiation-therapy/
I am curious about some of the precautions he lists – the section starting with – Do not use glutamine if you:
– Have kidney failure, kidney dysfunction, or if your kidney function is impaired or abnormal [THIS IS A PRECAUTION I USE]
– Have liver failure, liver dysfunction, or if your liver function is impaired or abnormal [THIS IS A PRECAUTION I USE]
– Have ever been diagnosed with or had a period of hepatic encephalopathy (liver function that affects your mental, emotional, or cognitive state) [NEW TO ME]
– Have a history of mental illness, especially bipolar depression (manic depression), mania, or hypomania [MENTAL ILLNESS IS RATHER BROAD AND I’VE USED IT SUCCESSFULLY WITH BIPOLAR CLIENTS WHEN I WORKED IN JULIA ROSS’ CLINIC – WE JUST WATCHED FOR SIDE EFFECTS OF MANIA AND DIDN’T SEE THEM IN MANY PEOPLE]
– Have a history of seizure disorders, such as epilepsy or are taking medications to control a seizure disorder.
– Have a history of allergic reaction to monosodium glutamate (MSG), a flavoring agent sometimes used in the preparation of Chinese food in restaurants [I SUSPECT THIS COULD BE VALID IN SOME INSTANCES BUT HAVE YET TO HEAR OF THIS ACTUALLY BEING AN ISSUE].
– Are taking or have been prescribed to take a medication called lactulose [THIS ONE IS TOTALLY NEW TO ME AND I’M VERY CURIOUS WHY].
I assume you use glutamine with patients? I’d love any thoughts and experiences you may have on the above? I’m also going to reach out to Brian D. Lawenda.
2) “Glutamine and Cancer-What you need to know” http://www.huffingtonpost.co.uk/aidan-goggins/glutamine-and-cancer_b_2740348.html
What I haven’t seen in my scan of the discussion on this topic is acknowledgement of the fact that Dr. Blaylock was using Glutamine and Glutamate in the same interview, almost interchangeably, and yet they are different acids. Glutamate is well known as an excitotoxin from my research, but not Glutamine. Is it perhaps possible that he accidentally switched to the word Glutamine during the interview without acknowledging it?
Seamus
Good question but I’ve seen other material where he says to avoid glutamine in supplement form. I wish I could find an article on a website article of his (and with references) but have not had any luck with that. Here is an article on Mercola’s site http://articles.mercola.com/sites/articles/archive/2004/05/01/glutamine.aspx
In this video presentation at the 14:08 minute mark he actually says intrinsic release of glutamate and not glutamate from the diet https://www.youtube.com/watch?v=_nxLm2LAPQo
I’ll check those out. Thanks Trudy. I have a fairly sensitive system overall and can usually tell very quickly if something is dangerous or disagreeable to my body when taking it in. I’ve been supplementing with Glutamine for about 2 years on and off and I feel great when I take it (only after workouts). The use of my cell phone alone makes me feel unwell, but glutamine never.
Used large amounts of l-glut having colon cancer on my liver and other tumors in the colon. 5 cycles of triple poison and everything is a no show on PET scans. I will keep using this.
what do you mean by ‘triple poison’. did you also had a carb restriction diet?
hi there, does anyone know if cancer cells revert back to glucose burning when it is available again? or is a switch to glutamine permanent? i tried a few days carb restriction and I read that it could make cancer cells more aggressive. if so, are there also nutrients/food that counteracts cel proliferation?
I suffered from terrible bouts of eczema, mostly in winter.
Tried everything.
Three weeks ago, read about Glutamine. Started taking 10 grams in the morning, 5 in the evening.
Within 3 days, Eczema GONE , clear skin.
Why don’t Doctors know about this?
This is crazy – spending trillions on Health care, and with a 60 second google, I get healed
Thanks for sharing Hiram – I wonder if it was the gut healing that had this effect?
Watch The Truth About Cancer and you’ll know exactly why doctors don’t know. We have to govern ourselves, including our health and stop relying on people outside of us. Taking our own health into our own hands is required. I’d rather it be me governing my body than someone else anyway.
Hi Trudy,
Thank you for your informative blog site. I have a son who had Ulcer Colitis and takes Glutamine supplements for his gut. I also have a second son who takes Gaba to help his Tourette’s. After reading some research, I am concerned about Glutamine stimulating cancer cells. I just read how using 3 plant based herbs blocked glutamine from cells thus stopping Prostate cancer: http://www.naturalnews.com/2017-06-30-prostate-cancer-breakthrough-combination-of-three-plant-based-nutrients-found-to-melt-away-prostate-cancer-cells.html
explained in the UTA (University of Texas Austin) article:
The new research paper also demonstrates how the plant-based chemicals work together. Combining ursolic acid with either curcumin or resveratrol prevents cancer cells from gobbling something that they need to grow, glutamine. This is a neat solution: blocking the uptake of a nutrient needed by prostate cancer cells with nutrients that are commonly in the human diet.
Hello Trudy,
See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385273/,
The key words in the article seem to be, “because glutamine consumption by tumors is almost absolutely dissipative, an increase in the growth rate of the tumor due to this process should not be expected.[63,64] The experimental data indicate that a dietary supplement diminishes tumor growth by restoring the function of natural killer cells and improves protein metabolism of the host or patient.[65,66]”.
Gilligan
Thanks for sharing this great study and quote! I still have my clients check with their oncologist if they are undergoing treatment – this is a great study/quote for them to share
Hello. 🙂 Haven’t found comments from this year, but here goes: I’ve been having GI problems (was tested for everything, did CT scan, MRI, endoscopy, colonoscopy) for more than 2 years now (was always sensitive, but not to this extent). The specialist told me 2 years ago that I have IBS as a secondary diagnosis, hasn’t found the cause. When I did the MRI they found: malformed gallbladder (no stones) and my right kidney is slightly off kilter (but works okay). Was prescribed Alive! multi vitamin (which helped a bit) and I have been taking Jarro-dophilus probiotics for more than 1 year (found it online). Problem is, my symptoms were still there (stomach burning, pain and cramping in the gut, weird bowel movements, joint pain, headaches, occasional dizziness). I know that I am lactose and fructose sensitive. About 2 weeks ago all the symptoms intensified and got back to where I was 2 years ago. I decided to try L-Glutamine 1000 mg capsules, as I heard that it really helps with these issues. Problem is, that now I am a bit confused and don’t know if I should try it or not (ordered it today, before finding this page). I also am on a gluten free diet from a week ago – my family doctor told me to try it and did the blood test for food intolerance (results will come next week). I apologize for the length. LOL
Lencsike
When a client has gut issues that include “stomach burning, pain and cramping in the gut, weird bowel movements, joint pain, headaches, occasional dizziness” (and issues with gallbladder and kidney) the first thing I consider is gluten removal as a priority. Glutamine helps with gut healing and it’s something I always have clients use.
If we’re not getting results or there are still some symptoms we look at all grains, dairy and oxalates too, plus parasistes and SIBO.
Thank you for your reply. I am completely off gluten now – hopefully it will help and I can keep it up, as where I live, it is hard to find gluten free products. I am doing the tests for parasites and bacteria now, as it’s been almost 2 years since I did them. I have heard of SIBO, but the problem is, here we don’t have tests for that. One thing that happened since I wrote my comment is, that I have had a bad reaction to gluten/lactose/chemicals free chicken frankfurts (mildly smoked and a bit greasy). Been sick all weekend. I now am struggling with my gallbladder. Can the gallbladder cause all of these symptoms plus the food intolerances? Could L-Glutamine help with improving my gallbladder function?
Hi. Ran across your site while trying to find out more about Glutamine. And most of my confusion stems from Dr. Blaylock’s comments about it as you mention above (I watched The Truth About Cancer series too). Everyone I had heard and read up to that point had said how good black beans and mushrooms are for you, killing cancer,etc, but then he says they are terrible. I have been whole foods, plant based also since having surgery for cancer last Dec. and have been having quite a bit of black beans and mushrooms because of how good they say they are for you. I have been doing a lot of research on this matter this year and are finding several reports that Glutamine does in fact feed cancer just as sugar does. Most of these reports are dated this year and I see your original answers were from 2016 and 2017, so am wondering if you’ve been finding any different info than you had back then. Also, most of the articles that mention about Glutamine being bad for cancer list foods high in Glutamine, and I have not seen any that list black beans or mushrooms in that category, but rather things like wheat, corn, barley, peanuts, soybeans, egg whites, and milk. The more I research, the more confused I get!