Tyrosine

Tyrosine had an amazing effect: he had more clarity, could interact with people and joke, and he started reasoning in a more organized way

September 20, 2024 By Trudy Scott 2 Comments

I tried tyrosine yesterday, and Wow! What an amazing effect!

I answered positively to many of the low catecholamines symptoms and I’m also trying to break my coffee addiction – I take espresso shots throughout the day to get through.

So I gave it a try and took 300 mg of tyrosine yesterday at 4pm.

I had more clarity, I could interact with people, I could joke, I started reasoning in a more organized way.

I can’t believe how powerful tyrosine is. Now I finally understand that my brain fog is a result of low dopamine among other neurotransmitters and me drinking that much coffee is just a symptom of low dopamine and I would not need it otherwise.

Today, thanks to tyrosine, I’m better equipped to break this addiction, although I’m a bit scared about a few things before I can use it more spontaneously.

Steve shared this wonderful feedback in a blog comment. I said how happy I was for him and thanked him for sharing.

He also asked a few questions about his sleep being impacted, the chances of getting dependent on tyrosine and concerns for thyroid health. I addressed his questions (read my feedback below) and links for further reading about the catecholamines and using the amino acid tyrosine as a supplement. I also share some tyrosine research, my tyrosine recommendations for quitting coffee, and a key nutritional deficiency to address (low thiamine/vitamin B1).

Tyrosine impacted his sleep (and how to prevent this)

This was the first of his questions:

I could not fall asleep last night because of tyrosine. I was awake 3 hours after my regular bedtime. Maybe because I took it in the afternoon and I drank 2 cups of coffee that morning? Coffee never kept me from sleeping.

There is a simple way to get the benefits of tyrosine and not have it impact your sleep. Tyrosine is best used on waking, mid-morning and only mid-afternoon (no later than 3pm) if sleep is not an issue. If sleep is an issue we start with using it on waking and mid-morning.

I recommend having the bottle of tyrosine beside the bed especially if an espresso shot (likely in Steve’s case) or cup of coffee is needed to get going first thing. Right away it’s helping with the caffeine addiction and offering energy and clarity or focus. It’s also boosting dopamine and improving mood … “I could interact with people, I could joke”.

He could trial just twice a day and then consider another tyrosine no later than 3pm and see how he feels and watch for sleep impacts.

I mentioned to Steve that all this is explained in my book “The Antianxiety Food Solution” which I recommend everyone reads before using amino acids.

One important consideration with high caffeine consumption like this, is a strong possibility of vitamin B1/thiamine deficiency. I share more about this here. Zinc and other B vitamins can become depleted too.

Will the brain adapt and become dependent on tyrosine?

This is a common question I get about the amino acids and Steve was justifiably concerned about it too:

If I’m taking tyrosine to correct low dopamine in my brain, don’t you think that the brain will adapt and will be dependent on tyrosine to create enough dopamine? What is the real cause behind the brain lacking dopamine? I took psychiatric medication in the past and I know they can affect the brain long term; so isn’t it the same about tyrosine?

Using a foreign substance to hijack the brain’s normal working and chemistry and then be dependent on it to produce the right amount?

How will the tyrosine correct this imbalance and help me heal? Do I go back to low levels when I stop it?

There are no concerns about dependence. Tyrosine is addressing low levels of dopamine, one of the catecholamines. It should be a short-term solution when other nutritional imbalances (like low zinc, low vitamin B1 low vitamin B6, low iron etc) are addressed and the dietary changes (all laid out in my book) are implemented too.

Short-term could be a month to 3 months for one-person and up to 6-12 months for someone else. It really depends on the complexity of health issues and other compounding factors (like Steve’s past use of psychiatric medications).

As you can read below, Steve is already gluten-free and dairy-free so this is a great start.

A question about tyrosine and thyroid concerns

I have a history of hypothyroidism in my family and I’m afraid that tyrosine could trigger that for me? I’m healthy now and I eat Gluten/Dairy free

Tyrosine is actually one of the raw materials the thyroid needs and uses for the synthesis of the thyroid hormone thyroxine so there is no issue with it triggering hypothyroidism (an underactive thyroid).

There is, however, an issue with Graves’ disease, an autoimmune disorder that can cause hyperthyroidism (or overactive thyroid). Tyrosine should not be used in this instance. You can read all the amino acid precautions here.

Tyrosine and the research: cognitive performance

Here are some excerpts from this paper: Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands–A review

Consuming the amino-acid tyrosine, the precursor of dopamine and norepinephrine, may counteract decrements in neurotransmitter function and cognitive performance…

Tyrosine does seem to effectively enhance cognitive performance, particularly in short-term stressful and/or cognitively demanding situations.

The conclusion made by the authors is in line with how I recommend using tyrosine i.e. only when “dopamine and/or norepinephrine is temporarily depleted.” This is the same for all amino acids and we use the symptoms questionnaire as a starting point to indicate the possibility of low levels of each of the neurotransmitters.

Tyrosine can also be calming and help with sugar addiction too

As you can see from these blog posts, tyrosine has many applications:

And this blog is a good introduction to using tyrosine for improved focus, motivation, energy, a good mood and even for easing anxiety

Additional resources when you are new to using tyrosine and other amino acids as supplements

As always, I use the symptoms questionnaire to figure out if low low dopamine/catecholamines or other neurotransmitter imbalances may be an issue.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control (this is covered in an entire chapter too), sugar cravings, anxiety and mood issues.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Wrapping up and your feedback

I appreciate Steve for sharing his success with tyrosine and asking these questions. I do hope this information has been helpful for you and for him too.

Now I’d love to hear from you – does any of this resonate with you? Have you had success like this with tyrosine or experienced other benefits?

If you’re a practitioner is tyrosine one of the amino acids you use with your clients/patients?

Feel free to share and ask your questions below.

A 12 year old’s Diet Coke consumption and obsession with collecting the cans: can tryptophan and tyrosine help him quit with ease?

March 24, 2023 By Trudy Scott 14 Comments

A concerned mother, Rebble, posted a request for help for her 12 year old son who has suddenly started drinking Diet Coke and obsessively collecting the cans. I explain about the biochemistry of addiction and obsession. If your child, another loved one or even you, are hooked on Diet Coke, this blog offers practical solutions in the way of amino acids to balance brain chemistry and make quitting no longer about willpower. I share why I’d consider starting with the amino acid supplement tryptophan for serotonin support and the amino acid supplement tyrosine for dopamine support. And then looking into low blood sugar. I also share some of the many harmful effects of soda/diet soda and some practical tips for her as she encourages her son to make changes.

Here are her questions and what she has already tried to help him quit:

To my horror, my 12yo son has just started buying/consuming Coke and principally Diet Coke regularly from our village shop. He has got obsessed about collecting the cans, some of which are from his friends’ consumption but more and more from his. He used to hate these drinks but now peer pressure has kicked in and he wants to consume what his friends (who live on the stuff and a horrendous amount of sugar) consume.

I’ve pointed out the ingredients, that they are toxic to his brain. He doesn’t care.

I’ve shown him a brilliant video clip of Renaldo removing coca cola bottles from the press table and promoting water instead (with good effect).

Yet still he keeps buying the stuff.

I’ve made it known with the shopkeeper that I don’t approve of my children buying caffeinated sugary drinks full of neurotoxic ingredients but he doesn’t wish to police my children (though he did give me a refund on the 8 cans he had just sold my son!) which I understand.

Do you have a short summary of why it’s so bad, for children in particular? Either something I could show my children, their friends and/or the shopkeeper?

Is it the caffeine that makes it addictive?

My son does exhibit some challenging behaviors (e.g. torturous noise at home, not able to sit still without fidgeting with things at meals, etc.) but seems to be able to turn this on / off at will. I don’t think he does this at other people’s homes or at school. I can’t say they are necessarily linked to the drinks as they precede the start of him consuming them but I’m certain the drinks cannot help.

This is tough but I’m glad Rebble is horrified and working to do something about it. Sadly many parents have no idea how harmful these drinks are for pre-teens and teens.

She mentions his challenging behaviors preceded his diet soda drinking. It’s common that we see someone self-medicating with sugar and/or artificial sweeteners. And it’s likely that that peer pressure was the tipping point for him and then once she started he was well and truly addicted.

This is the feedback I shared for her and my observations on where to start: when I hear obsessed, peer pressure and challenging behaviors, I immediately think neurotransmitter or brain chemicals imbalances and would look into low serotonin and possibly low dopamine because of his inability to sit still. Low blood sugar may also be an issue.

What emotions are driving his addiction and obsession?

With an addiction you need to figure out what emotions are driving the addiction and use the respective amino acid supplement/s (one or more of them) to help break the addiction and improve the mood/behavioral symptoms at the same time.

These are the questions I review with my clients who have a Diet Coke addiction, or other diet soda or regular soda addiction (or even alcohol or carb addiction):

If you drink it to feel happy (and especially from late afternoon into the evening) then your cravings are likely due to low serotonin, and tryptophan (or 5-HTP) stops the cravings and boosts mood and reduces anxiety.
If you drink it for an energy boost or to give you focus then it’s likely due to low catecholamines and tyrosine will stop those cravings and give you a mood and energy boost, and also help with mental clarity.
If you have to drink it when you haven’t eaten in awhile it’s likely low blood sugar. Glutamine on the tongue stops the desire almost immediately and also helps with the low blood sugar symptoms of shakiness and irritability.
If you stress-drink, your cravings are likely due to low GABA, and GABA will stop the stress-drinking and calm you down too.
If you drink it for comfort or a reward then it’s likely due to low endorphins and DPA (d-phenylalanine) will stop that feeling of “I deserve-it” and also give you a hug-like mood boost.

Ideally mom would have him complete the amino acids symptoms questionnaire in order to figure out which areas are issues for her son.

This is where I would start

I don’t have all this information but based on mom’s feedback this is where I would start: serotonin support, dopamine support and address low blood sugar.

We do know he is obsessed with collecting the cans. Obsession and cravings for a sweet taste is a clear sign of low serotonin i.e. a big clue that #1 may apply to her son and that he may benefit by using tryptophan or 5-HTP.

We do also know he is “not able to sit still without fidgeting with things at meals.” The Diet Cokes may be helping him focus and this is a big clue that #2 and low dopamine may also apply to her son, and that he may benefit from tyrosine. Keep in mind tyrosine also helps to break the caffeine addiction too.

I’m not sure what his “torturous noise at home” could be related to but it may be a clue to #3 i.e. low blood sugar and irritability. It may also be a symptom of rage or anger, also a sign of low serotonin and #1.

I would also look at his diet and make sure he is eating for blood sugar stability (quality protein for breakfast with healthy fats, healthy fats/protein at each meal and healthy snacks). And address everything else I cover in my book – gluten, microbiome etc.

It’s not unusual for someone to have imbalances in multiple areas. If this is the case, I always recommend doing a trial of one amino acid at a time, so it’s easy to see the benefits.

Role models, the harmful effects of soda/diet soda and other things I’d try with this young man

On one hand, you could be surprised that the Renaldo press conference clip removing the Cokes (watch it here) didn’t make enough of an impression because having a sporting hero as a role model is powerful. BUT on the other hand, based on what I know about soda/diet soda.caffeine and addiction, role models are unfortunately just not enough for some folks.

I shared these other things I’d try:

1) Have someone other than mom tell him about the harmful effects of diet sodas – a respected teacher, favorite uncle or nutritionist.

2) Appeal to things that may make him think twice about it like acne and not being fit enough to play his favorite sport. Concerns about weight gain or not being able to get into his desired university (because of impacts on his academic grades) may be a driver too. It’s doubtful that he’d be concerned with tooth decay, adrenal dysfunction, diabetes, heart disease, inflammation, increased risk of osteoporosis or increased anxiety/depression and insomnia.

3) Suggest that he does a school project on the topic so he understands the many harmful effects and facts (the research confirms that adolescents lack knowledge regarding health risks of soda and diet soda consumption. The project could hail Renaldo as a hero and he could get his buddies to help.

4) Help him find something else he likes to drink. Fruit juice isn’t a good option but fizzy fermented drinks are and so is fruit-infused water.

5) Be sure the rest of the family is setting an example at home and when you go out

6) Keep planting the seeds with love and encouragement

However, none of the above or flat-out saying he cannot buy diet sodas will work if there is the addiction aspect and unbalanced brain chemistry.

Keep in mind there is a continuum with sugar/carb/artificial sweeteners/caffeine addiction i.e. some kids (and adults) can quit sugar/carbs/artificial sweeteners/caffeine more easily and others need some nutritional support and some need much more support for balancing brain chemistry with amino acids. If there are also behavioral issues/signs that’s the clue they likely need the amino acid support.

Once he has the facts and understands the harm he also has to be willing to make the changes to break the addiction if it’s severe. I have parents gently recommend a month trial to see if it will work. “No diet soda forever” is too much for a pre-teen/teen (and adults too) to grasp and be ok with especially when they are addicted.

Rebble posed her question on a blog about Diet Coke addiction: I need help with my Diet Coke addiction – when I stop, my fatigue, brain fog, anxiety/depression increase big time!

Be sure to read the above blog for further insights.

I appreciate her for reaching out and hope this additional information helps her son and helps you too.

Resources if you are new to using tryptophan or GABA as supplements

If you are new to using tryptophan or GABA as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the symptoms of neurotransmitter imbalances, including low low serotonin and low doapmine).

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues (which include rage/anger/irritability/self-harm).

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs. You can find them all in my online store. The above oral lavender products are available in my online store too.

Has one of the amino acids helped with your preteen’s soda or diet soda addiction? Which one/s helped?

What helped your preteen be open to the idea of using the amino acids to quit?

What else helped?

Has any of the above helped you too? Or your clients/patients?

If you have questions and other feedback please share it here too.

Tyrosine erases severe performance anxiety in a female musician: no more shaking, sweating, panic attacks and passing out

June 4, 2021 By Trudy Scott 42 Comments

Today I’m sharing the case of a female musician with severe performance anxiety. It was so severe that she would shake, sweat and actually pass out. She also had problems breathing which happens when you’re having a panic attack. Surprisingly, the amino acid supplement tyrosine eliminates – or as she says, erases – all these anxiety symptoms very quickly. It’s surprising because tyrosine is typically not used for easing anxiety symptoms and is instead used to support the low catecholamine symptoms: low motivation, low energy, poor focus, feeling flat and depressed (the curl-up-in-bed kind), cravings for sugary foods for better energy and the need for caffeine.

I share her story in her own words and explore some possible mechanisms around serotonin, cortisol, dopamine and GABA.

Pam initially shared on a Facebook thread how tyrosine erased her extreme performance anxiety and we dug deeper. This is the start of the conversation:

I’ve been performing (music) ever since I was seven, but I always hated it. For extreme performance anxiety, I found, way too late, that 1,500mg of l-tyrosine simply erased the shaking and fainting, and I was “just nervous like everybody else.”

I responded saying what a great result this was and shared that I found it so interesting that tyrosine erased the shaking and fainting that she experienced with her performance anxiety.

As I mentioned above, tyrosine is typically not used for anxiety. Instead, it’s used to improve the low catecholamine symptoms of poor focus, low energy and low motivation. (More on this here)

I also always want to understand the mechanism as to why an amino acid helps ease anxiety symptoms – or in this case erased them. I share more on that below.

When I asked what she meant by “just nervous like everybody else“, this was her response:

It means pretty much everyone gets performance nerves, but not to the point of fainting on stage. Knowing intellectually that that was ridiculous did not make any difference in the fact that it occurred.

I don’t even remember why I tried tyrosine, but I do remember the first time I took it 40 minutes before a performance. I waltzed out on stage ahead of time and sat in my chair warming up, showing off even, to a hall that was filling with people.

That was and is inconceivable without the tyrosine support, which I have to assume is putting my dopamine at a normal level. Yes, I get a little wired, which can be a good thing, but passing out, having my intestines demand to be emptied, not being able to breathe [is this a panic attack?], shaking, sweating….it fixes all of that.

It’s wonderful to hear such powerful results from 1,500mg tyrosine and how quickly it works. The latter is not surprising as this is typical with all the amino acids. They work quickly if it’s what you need and you have the ideal dose for your needs.

What is surprising is that tyrosine erased her severe performance anxiety symptoms. I immediately started trying to understand possible mechanisms.

What is the mechanism – a serotonin boost to improve confidence?

When I read “I waltzed out on stage ahead of time and sat in my chair warming up, showing off even, to a hall that was filling with people” I immediately thought of how tryptophan or 5-HTP works to give you a serotonin boost that improves your confidence.

However, Pam doesn’t feel the mechanism is related to low serotonin:

You would think, if it were serotonin, that SSRIs would be effective. They are not and cause me to have terror attacks.

She also shared that she recently gave 5-HTP a trial and it did nothing so that further supports her theory/gut feeling that her extreme performance anxiety is not related to low serotonin:

I think there is a belief system associated with serotonin that is not cognizant of the fact that the other neurotransmitters can be the culprits. I read someone’s web site sometime not that long ago, that detailed how to test all the major neurotransmitters, find out which ones were to low OR too high, and what amino acids to take to fix the imbalances. To me, this is a more comprehensive view than being stuck on serotonin.

Anxiety is not always caused by low serotonin or low GABA (although these causes are very common). I’m with Pam on finding which neurotransmitter imbalance you have. There is no one-size fits all and results can happen without us fully understanding why. It does sound like this is very much dopamine related for her but I wanted to understand how it was helping her.

What is the mechanism – lowering cortisol under extremely stressful situations?

I started looking into the research and found that one possible mechanism could be that tyrosine lowers the high cortisol that occurs after an extremely stressful situation – like going on stage to perform – and eases anxiety this way.

An animal study supports this theory: Dietary tyrosine suppresses the rise in plasma corticosterone following acute stress in rats:

Acute, uncontrollable stress increases norepinephrine (NE) turnover in the rat’s brain (depleting NE) and diminishes the animal’s subsequent tendency to explore a novel environment. Pre-treatment with tyrosine can reverse these adverse effects of stress, presumably by preventing the depletion of NE in the hypothalamus.

In the present study, we found that pre-treatment with supplemental tyrosine not only prevented the behavioral depression and hypothalamic NE depletion observed after an acute stress, but also suppressed the rise in plasma corticosterone. These results support a role for brain NE in stress-induced corticosterone secretion and demonstrate that supplemental tyrosine can protect against several adverse consequences of such stress.

Keep in mind that cortisol is the primary endogenous adrenal steroid in humans, whereas corticosterone is the primary adrenal corticosteroid in laboratory rats.

What is the mechanism – dopaminergic system influence on anxiety-like behavior?

I dug deeper into the research and found that there is evidence that dopamine plays an important role in anxiety modulation in different parts of the brain and that both dopamine D1 and D2 receptor mechanisms are important in mediating anxiety.

This paper, The Modulatory Role of Dopamine in Anxiety-like Behavior describes some of this, together with the role of GABA and glutamate:

The activity of dopaminergic system is modulated by several neurotransmitters, including glutamatergic neurons from the medial prefrontal cortex (mPFC), GABAergic fibers from the nucleus accumbens (NAc) as well as the ventral pallidum and cholinergic fibers from the pedunculopontine nucleus and the laterodorsal tegmental nucleus. Thus, changes in the glutamatergic, and GABAergic, as well as mediated transmission in the mesolimbic, mesocortical and nigrostriatal dopaminergic system may influence anxiety-like behavior.

In the past I’ve blogged about tyrosine for alleviating anxiety and panic attacks and creating a feeling of calm focus so this is not an isolated case but it is pretty unusual. As I share in the above blog, a man and a woman saw dramatic reductions in their anxiety when using tyrosine. GABA and tryptophan had not helped and both individuals were also under extreme stress. It was work stress in their cases and both of them felt that their ability to now focus in business situations eased their severe anxiety.

Regardless of the mechanism, Pam saw profound results and that is all that really matters.

My additional feedback on dosing and timing

Here is some additional feedback from me on dosing and timing. On one hand I recommend caution based on my experience with the amino acids. And on the other hand, what she did worked so I’m torn about her approach but am going to say it anyway:

A typical starting dose is 500mg tyrosine and I would never have anyone start with 1,500mg (even though it was the sweet spot for Pam). However, if she hadn’t used that dose, she would not have had the same results. I’m waiting to hear back if she started with 1,500mg tyrosine or worked up to this. (Pam also told a friend of hers about her results and the outcome was very different for her friend:“She tried 100mg of tyrosine and it caused her extreme nervousness, the opposite of me. I have to assume that 100mg put her at too *much* dopamine, and her genetic profile was significantly different from mine.” We are all unique and there is no one-size-fits-all.)
I would also be cautious about trying a new amino acid for the first time right before a major event like a musical performance. I have clients trial the amino acids at home before heading out. However, if she had done that she would likely have not experienced the desired results.

I feel it would be helpful to know if she had done a trial of GABA or tryptophan before using tyrosine but it seems she doesn’t recall this or why she decided to use 1,500mg tyrosine. If she hasn’t done I trial with both GABA and tryptophan, I would love her to consider this now in order to potentially take things up a notch further and ease her feelings of just being “nervous like everybody else”.

I appreciate Pam sharing her amazing results with tyrosine and I’m really happy for her! I’m waiting to hear back with details of what kind of musical performances she does. I’ll share this and the other information once I hear back.

I say it often and I’ll say it again – there is not a one-size-fits-all. This case illustrates this very well. Sometimes it’s methodical trial and error (my preference) and other times it’s hit and miss when nothing else seems to be helping.

Resources if you are new to using tyrosine as a supplement

If you are new to using the amino acid tyrosine as a supplement, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution and a brief overview here, Anxiety and targeted individual amino acid supplements: a summary.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists tyrosine and other products that I use with my individual clients and those in my group programs.

As with all individual amino acids we use tyrosine for quick relief of symptoms, like Pam did. And we must also always focus on the foundations like diet, the gut, adrenals and stress levels.

Do you use or have you used tyrosine to help with performance anxiety – personally or with a patient/client?

And were you/are you surprised that this worked so well when tryptophan or 5-HTP or GABA had not worked as expected?

What other symptoms did/does the tyrosine help improve: focus, motivation, drive, low energy, low mood? And did/does it help reduce sugar cravings and the need for caffeine?

Feel free to post your questions here too.