An amino acid supplement with DLPA, glutamine and 5-HTP (and a few other nutrients) eases alcohol withdrawal symptoms at an inpatient detoxification program. Other than anxiety (I’ll share more on this below), there was also a significant decrease in psychiatric symptoms. Here is an excerpt from the study, The use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytriptophan in the alleviation of alcohol withdrawal symptoms:
We described the use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytryptophan in the alleviation of alcohol withdrawal symptoms in patients starting a detoxification therapy.
Since abstinence from ethanol causes a hypodopaminergic and a hypoopioidergic environment in the reward system circuits, manifesting with withdrawal symptoms, food supplements that contains D-phenylalanine, a peptidase inhibitor (of opioid inactivation) and L-amino-acids (for dopamine synthesis) were used to replenish a lack in neurotransmitters and alleviate the symptoms of alcohol withdrawal.
First I cover some translation issues and then more about the actual product and study results. I also share my commentary on the amino acids and dosing used in the study (and the fact that anxiety did not resolve). I include how to apply this information if you have a loved one in an alcohol treatment/rehab program or if you recognize social drinking is an issue for you. And I wrap up with additional resources if you are new to using GABA as a supplement, the GABA Quickstart online program and the practitioner training.
The study was completed and published in Slovenia and there are a few translation issues I’d like to clarify:
- The study title states D-phenylalanine (DPA) was in the amino acid product, however DL-phenylalanine (DLPA) was actually used. You can read about the difference between DPA and DLPA here. In summary, DPLA works on both dopamine and endorphin support and DPA works on endorphin support only.
- As you can see from the excerpt above, hypodopaminergic refers to low dopamine and hypoopioidergic refers to low endorphins. During withdrawal from ethanol/alcohol, both low dopamine and low endorphins cause withdrawal symptoms.
- L-5-hydroxytryptophan is incorrectly spelled as L-5-hydroxytriptophan and reward system is incorrectly spelled as reword system. (Clarifications are provided for facilitating online searches in the research literature.)
More about the product, the study and the conclusion
It was a small randomized, double blind study with just 20 patients and the amino acid product was used for 40 days of the inpatient alcohol detox or rehab program.
This is the actual combination product used:
300 mg DLPA
150 mg glutamine
5 mg 5-HTP
1 mg vitamin B6
50 mg calcium gluconate
25 mg magnesium oxide
0.01 mg folic acid
Psychiatric symptoms were measured using the SCL- 90R and included assessing for “somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid, and psychoticism.” During their rehab there was a significant decrease in these categories of psychiatric symptoms in the study group, except for their anxiety symptoms.
The authors conclude that “abstinence causes a major stress for the patients. The use of a food supplement containing D-phenylalanine [it was actually DL-phenylalanine], L-glutamine and L-5-hydroxytryptophan alleviates the withdrawal symptoms.”
As expected, once alcohol consumption was stopped, cortisol levels, liver enzymes and total bilirubin all decreased in the study group and the control group.
My commentary on the amino acids and dosing used in the study (and the fact that anxiety did not resolve)
Keep in mind the same dosing was used for all study participants. What I use clinically with folks with low levels of these neurotransmitters, is an individualized approach based on each person’s needs, for endorphin and dopamine support (from the DLPA), blood sugar support (from glutamine) and serotonin support (from 5-HTP). This means identifying symptoms in each category and doing a trial of each respective amino acid, starting low and increasing based on symptom resolution.
Given that anxiety symptoms didn’t resolve in the study group, I would have loved to see the amino acid GABA included, also dosed according to individual needs. GABA helps ease the physical tension-type anxiety and low GABA tension often drives the need to self-medicate with alcohol in order to relax and fit in socially.
The authors do mention GABA too: “the physiological craving for alcohol may be the result of a deficiency of the naturally occurring opiate like substances as well as other neurochemical deficits (i.e., dopaminergic, GABAergic, and serotonergic).
Also, an animal study shows that GABA helps with gut damage caused by alcohol consumption, so there is this additional benefit.
A higher dose of glutamine and/or 5-HTP may have also helped ease anxiety. They used 150 mg glutamine whereas a typical starting dose for glutamine is 500 mg (and we increase from there). Going up to 1000 mg to 1500 mg three or 4 times a day is not unusual and is typically very beneficial for alcoholics – for blood sugar stability, an additional calming effect and for healing the leaky gut which has been damaged by the alcohol consumption.
With regards to 5-HTP, they used 5 mg 5-HTP which is considered extremely low. I wonder if it was in fact 50 mg, which is a typical starting dose? Going up to 150 mg 5-HTP use 2 or 3 times a day is not unusual. Serotonin support with 5-HTP (or tryptophan) is very beneficial for the worry-type of ruminating anxiety.
For some individuals DLPA may have been too stimulating and contributing to anxiety via a dopamine boost. For these individuals, DPA may have been a better option for endorphin support.
I am not in favor of folic acid and prefer methylfolate, and although magnesium is an important cofactor for neurotransmitter production, magnesium oxide does not provide much usable magnesium.
Outside of the amino acids and other nutrients used, a vitamin B1 (thiamine) deficiency would need to be addressed and any other deficiencies (such as all the B vitamins, zinc, vitamin D, magnesium etc.) caused by chronic alcohol consumption. This is not a comprehensive list and a full functional workup will help to identify all possible deficiencies.
Despite my quibbles, the outcome of the study is very encouraging, I appreciate the researchers and I hope to see it replicated and refined in other settings.
How to apply this information if you have a loved one in an alcohol treatment/rehab program
Unfortunately the amino acids are seldom incorporated at in-patient detox and rehab centers but they should be. Your options are to:
- Share this study and my blog with the treatment center
- Educate yourself (on using the questionnaire and doing the amino acid trials) so you can use them with your loved one once rehab is over. This is key for preventing a relapse and for swapping alcohol addiction for sugar or caffeine or nicotine addiction.
- Introduce one amino acid at a time so you can figure out which one/s they need and how much
- Read my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, and share a copy with the treatment center (and your loved one and their treatment team)
- Address diet, nutritional deficiencies and gut health
Keep in mind that the amino acids are used with success for cocaine, heroin and other drug addictions.
How to apply this information if you recognize social drinking is an issue for you
New research shares that “low-level alcohol consumption is commonly perceived as being inconsequential or even beneficial for overall health, with some reports suggesting that it may protect against dementia or cardiovascular risks”, however, as the authors suggest “even low-level alcohol consumption is associated with premature brain aging.”
Social drinking is the norm and is way too prevalent. And it’s often used as a calming measure in order to relax and fit in socially. If this sounds like you:
- Educate yourself (on using the questionnaire and doing the amino acid trials) so you can use them to quit drinking easily with no willpower and no feelings of being deprived. This is key for preventing the swapping out the need for alcohol (to relax or fit in socially) with a sugar or caffeine or nicotine addiction. In this case, GABA helps a young man who has recently given up alcohol, Adderall and nicotine.
- Introduce one amino acid at a time so you can figure out which one/s you need and how much
- Read my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, and share a copy with your loved one/spouse/partner and practitioners/therapists.
- Address diet, nutritional deficiencies and gut health
Resources if you are new to using the amino acids as supplement
If you are new to using the amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the low neurotransmitter symptoms).
If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the team you or your loved one is working with.
There is a section on alcohol but keep in mind that all the sections on sugar craving/addiction apply to alcohol addiction and self-medicating with alcohol too. Some individuals use alcohol to numb out and some use sugar. Many use both and once alcohol addiction is addressed, it’s often replaced with sugar and caffeine addiction. This is why addressing neurotransmitter imbalances is key.
The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.
If you don’t feel comfortable reading my book and figuring things out on your own (doing the symptoms questionnaire and doing respective trials), you can get guidance from me in the GABA Quickstart Program (online/virtual).
If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. It’s an opportunity to interact with me and other practitioners who are also using the amino acids.
Have you used amino acids with success as part of an alcohol detox program (for yourself or for a loved one)? Or to help stop social drinking of alcohol?
Which neurotransmitter imbalances were driving your need to self-medicate with alcohol and which amino acids helped?
If you’re a practitioner do you use the amino acids (via an individualized approach) to help with alcohol withdrawal and cessation with your patients and/or clients?
Feel free to ask your questions here too.
Any recommendations for supplemental support that can be given when someone is hospitalized with alcohol detox symptoms?
Does this work for nicotine withdrawal
Belinda
Yes the amino acids are very helpful for nicotine withdrawal. As with any situation it’s important to identify what is driving the addiction and using the respective amino acids. Low GABA and physical anxiety/tension is a common one when self-medicating with nicotine.
For some individuals, using acupuncture or auricular therapy/ear beads and/or hypnotherapy and/or guided imagery offers additional support when quitting nicotine. This can help with any addiction but for some quitting nicotine is more challenging than say quitting alcohol.
If you are new to the amino acids (and other anxiety nutrition solutions like real whole food, quality animal protein, fermented foods, organic produce, health fats, gluten/sugar/caffeine removal, blood sugar control, gut health, pyroluria etc) my book “The Antianxiety Food Solution” is a great place to start. More here https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/ It’s a comprehensive approach – amino acids AND diet. There is a short section on nicotine and the nutritional deficiencies caused (vitamin C and B vitamins etc) so addressing this is important too.
If you feel like you need guidance and support with using GABA, consider joining the online GABA Quickstart program so you can get help figuring it out https://www.anxietynutritioninstitute.com/gabaquickstart/
KM
Per the blog, for someone in hospital I’d follow what I shared under “How to apply this information if you have a loved one in an alcohol treatment/rehab program.” It’s probably unlikely the medical team would be open to any of this but you won’t know unless you ask. It’s also worth a try even if it’s just to plant the seed for the next person they treat.
One thing I didn’t mention that would possibly be permitted in a hospital setting is bringing in nutrient-dense organic home-cooked meals. Calming essential oils like lavender or orange (https://www.everywomanover29.com/blog/orange-essential-oil-ptsd-fear-stress-anxiety/) may also be permitted and could be diffused or rubbed on the feet with a carrier oil.
With a hospital setting and treatment center there are 2 other things to consider: where in the process of detoxification they are and what medications they have been prescribed. For example, benzodiazepines are often used to prevent seizures.
Unfortunately, most of the time, it’ll be a matter of using the amino acids and nutritional approach with your loved one once rehab is over. This is key for preventing a relapse, improving any residual anxiety/insomnia/mood issues and to prevent the swapping alcohol addiction for sugar or caffeine or nicotine addiction.
How do I purchase this product? Thanks
River
This product is not available commercially. It was created just for this research but could easily be replicated if needed.
However, there is no one-size-fits-all approach when it comes to situations like this. As I shared in the blog, what I use clinically with folks with low levels of these neurotransmitters, is an individualized approach based on each person’s needs, for endorphin and dopamine support (from the DLPA), blood sugar support (from glutamine) and serotonin support (from 5-HTP). This means identifying symptoms in each category and doing a trial of each respective amino acid, starting low and increasing based on symptom resolution.
And, as I also mentioned, many of these folks may well have benefited from GABA and higher doses of some of the other amino acids too.
If you are new to the amino acids (and other anxiety nutrition solutions like real whole food, quality animal protein, fermented foods, organic produce, health fats, gluten/sugar/caffeine removal, blood sugar control, gut health, pyroluria etc) my book “The Antianxiety Food Solution” is a great place to start. More here https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/ It’s a comprehensive approach – amino acids AND diet.
Thank you
Hi Trudy, I just want to thank you for all of the information you are sharing. I have been slowly trying to figure all this stuff out for my own sanity’s sake for 8 years or so. This information is life changing (life giving?) and I am so thankful. I don’t know how often you hear this so thought I would share. Please continue to do this work! Much love,
Kw
Katie
What a delightful message! Thank you so much for taking the time to post this 🙂 I hope you continue to make progress
In one comment you mention when an individual has high glutamate and low GABA, that GABA could help them.
In my understanding glutamate and GABA are supposed to convert to each other when there is an imbalance, in order to keep the body in balance.
This makes me wonder, have you encountered those who clearly have that type of an imbalance, yet respond with aggression instead of a calming response when taking a gaba supplement? My brother does that, so I’m curious if maybe he isn’t converting them properly and what solutions might be available for that scenario?
Thank you for all that you do and the value you share with us.
Kim
Some glutamate converts to GABA but not the other way around.
An aggression response to GABA is highly unusual and I’d be curious how much GABA was used, which product and if it happens every time? How many times has he had this reaction? How long does the aggression last? And does taking vitamin C work as an antidote right away? And does he have low GABA symptoms and if yes which ones? (symptoms here https://www.everywomanover29.com/blog/amino-acids-mood-questionnaire-from-the-antianxiety-food-solution/)
How does he respond to glutamine and does he have low blood sugar symptoms too? And low serotonin symptoms? (aggression/rage/anger is common with low serotonin)
If you’re willing to share other information like his diagnosis, any genetic testing or other relevant labs that may help me provide feedback too?
Hi Trudy – have you ever considered changing your domain name to be different than “everywomanover29”.? There are many who would benefit from your info that don’t want to read a blog with that name. For example young men who might be embarrassed by that….
Kal
Yes the plan is to change it to anxiety nutrition solutions. It’s a huge job but is in the works.
Hi Trudy,
Is there a recommendation on what time of day these supplements should be taken (morning on empty stomach? at night before bed? with a meal?). In my research I have not seen this particular topic covered.
Lisa
Always away from protein and it’s different timing depending on the amino acid eg serotonin support with tryptophan/5-HTP midafternoon/evening; DPA, glutamine and GABA through the day, DLPA and tyrosine from morning and not later than midafternoon.
It’s all laid out in great detail in the amino acids chapter in my book The Antianxiety Food Solution https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/
My 59 year old husband has been suffering anxiety and tremors in his chest with heart flutters since quitting cafeine cold turkey 3 years ago. A life time of caffeine dependency of 1000 mg a day for 45 years to 0. I believe he is in constant stress due to the brain not making dopamine. He feels very depressed thinks about death daily and has reached for sugar and fatty foods to give him some happiness. All wrong, I know. Please tell me I can help him with some kind of formula. He is a sports man but competitive sport now makes him so nervous. He physically shakes when having to concentrate which causes embarrassement and more stress. He wants to go back on caffeine, but I believe this will confuse the brain even more? Please help…
Marlou
Sorry to hear your husband is struggling. Unfortunately there is no formula – we need to figure out what each person needs. I start with looking at the symptoms questionnaire and doing trials of the respective amino acids https://www.everywomanover29.com/blog/amino-acids-mood-questionnaire-from-the-antianxiety-food-solution/
Someone with depression, anxiety and cravings often benefits from tryptophan, tyrosine, GABA, DPA (or DLPA) and glutamine but we start with one trial of one amino acid, based on the person’s actual symptoms and go from there.
My book is a great resource when you are new to the amino acids – The Antianxiety Food Solution https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/
When someone reports “tremors in his chest with heart flutters” and physically shaking, I recommend a medical checkup to rule out anything medically serious.
With heavy caffeine use we also consider the impacts on the adrenals and B vitamin deficiencies especially vitamin B1
When someone is suicidal it’s important they are closely monitored and ideally working with a therapist too.
Thank you Trudy. He medically checks out fine. He runs around a tennis court like a youngster. He has been left with high anxiety after quitting the drug that is caffeine which has not gone away and it is wearing him out mentally. He will do as you recommend and your book is on it’s way. I am glad there is finally someone I have found who possibly has a solution to this; we will try. Thank you.