Here are my amino acid and pyroluria supplement recommendations. These are the products I use with my one-one clients and those doing my online group programs.
You can find most of these products in my online store at Fullscript – you’ll find details here on how to set up and account (you just need to do this once) and make your purchase.
Questionnaires and information
My publisher would not allow me to make specific product recommendations in my book so this list is a courtesy to those of you who have purchased the book.
If you do not have my book I highly recommend getting it and reading it before jumping in to taking supplements: The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings
There is a complete chapter on the amino acids and one for pyroluria, plus information on real whole food, sugar and blood sugar, gluten, digestion and much more.
Once you have read it you can use these blogs as summaries (they do contain some information that is not in my book).
Here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution and additional information on Anxiety and targeted individual amino acid supplements: a summary
Please read and follow these Amino Acid Precautions
Here is the Pyroluria Questionnaire from The Antianxiety Food Solution and additional information on Pyroluria, social anxiety, introversion: a summary
Here is a useful post: Pyroluria/social anxiety protocol: why aren’t I getting results? (trouble-shooting checklist)
Supplements for Low Blood Sugar (anxious, shaky between meals and intense sugar cravings)
Glutamine helps with low blood sugar, may help eliminate the strong desire for something sweet when opened on to the tongue, and is very healing for the digestive system
- Pure Encapsulations L-Glutamine 500mg: L-glutamine (free-form) 500 mg, vitamin C (as ascorbyl palmitate) 5 mg. The capsules can be swallowed or the capsule can be opened on to the tongue
- Designs for Health Glutamine Powder: This is a powdered glutamine that you can use right on your tongue or even mixed in water. The taste is quite pleasant.
Supplements for low GABA (stiff and tense muscles, anxious, panic attacks, use sugar/wine to relax)
GABA helps to raise GABA levels. I find GABA to be most effective when taken sublingually or opened on to the tongue. I find GABA to be more effective than pharmaGABA for most of my clients. I don’t ever use Phenibut (which the FDA recently removed from non-prescription use). Here are some GABA products that I like and use with clients.
Source Naturals GABA Calm (lozenges): This is a pleasant-tasting sublingual product that is my most popular and the most effective form of GABA I use with my clients. It is a lozenge that contains 125mg GABA, 5mg magnesium, 50mg glycine, 25mg tyrosine and 20 mg taurine. [AS OF NOV 24, 2021 THIS PRODUCT IS IN SHORT SUPPLY AGAIN]
[Note: this product is a lozenge with 125mg GABA and is not to be confused with the Source Naturals, GABA Calm Mind, 750 mg tablets]
Nutritional Fundamentals for Health GABA-T SAP: gamma-Aminobutyric acid (GABA) 300 mg, l-Theanine 150 mg. This is pleasant-tasting when opened on to the tongue and works very well when GABA Calm can’t be used. I find best results when it is used opened on to the tongue.
Thorne PharmaGABA-100: the label says Gamma-Aminobutyric Acid (GABA) 100 mg but it also states that the product uses Pharma Foods International’s Gamma-Aminobutyric Acid (PharmaGABA®). This is also pleasant-tasting when opened on to the tongue and is most effective when used this way. [AS OF NOV 24, 2021 THIS MAY BE UNAVAILABLE]
Thorne PharmaGABA-250: as above but contains 250mg of PharmaGABA®. This is also pleasant-tasting when opened on to the tongue and is most effective when used this way. [AS OF NOV 24, 2021 THIS MAY BE UNAVAILABLE]
Designs for Health PharmaGABA Chewables: gamma-amino butyric acid (pharmaGABA) 200 mg in 2 chewable tablets. It’s quick-acting and convenient like GABA-Calm because it’s chewable. This does contain xylitol, natural flavors, stevia and some other ingredients so taste may be a factor and xylitol can cause gas, bloating and diarrhea when too much is consumed.
Natural Factors PharmaGABA: gamma-amino butyric acid (pharmaGABA) 200 mg in 2 chewable tablets. It’s quick-acting and convenient like GABA-Calm because it’s chewable. However it also contains organic cane sugar and natural fruit flavors so it’s a little too candy-like for my preference, especially if you have low GABA-related sugar cravings. Also 2 chewable tablets – 4g of carbs which is almost 1 teaspoon of sugar!
[January 22, 2021/November 24, 2021: I’ve included this as a stand-by option for occasional use when Source Naturals GABA Calm is in short supply or if Designs for Health PharmaGABA Chewables are not available.]
Now Foods GABA Powder: 1/4 Level Teaspoon (500mg). This is pleasant-tasting when opened on to the tongue and is most effective when used this way. The only challenge with powder like this is making sure you don’t use too much by mistake. And it’s especially challenging when you only need 100mg. A mini measuring spoon set like this one (my Amazon link) is so easy and convenient to use and allows for accurate dosing.
Quicksilver Scientific Liposomal GABA with L-Theanine: 2ml (4 Pumps) provides (Gamma Amino Butyric Acid) 240mg, L-Theanine 100mg and Phosphatidylcholine 120mg (from purified sunflower seed lecithin). Spray and hold 30 seconds before swallowing. It does contain ethanol so would not be suitable for alcoholics or young children.
GABA-Pro Calming Effect Chewable: This is a chewable that contains 100 mg of pharmaGABA in 1 tablet. It is pharmaGABA even though the product says GABA-Pro on the front and the label states Gamma Amino Butyric Acid (GABA). It does contain natural flavors and xylitol. [This product is a reasonable replacement for Source Naturals GABA Calm when it’s not available (Nov 24, 2021)]
GABA-Pro Calming Effect: This contains 100 mg of pharmaGABA in 1 tablet. It is pharmaGABA even though the product says GABA-Pro on the front and the label states Gamma Amino Butyric Acid (GABA). This capsule can be opened onto the tongue. It does contain rice flour which can be an issue if you have a rice allergy/sensitivity and/or SIBO.
Designs for Health Stress Arrest: Niacin (niacinamide) 100 mg, Vitamin B6 (pyridoxine HCL) 10 mg, Pantothenic acid (d-calcium pantothenate) 100 mg, GABA 300 mg, Glycine 200 mg
Supplements for low serotonin (worry, rumination, negativity, afternoon and evening cravings and insomnia)
Tryptophan and/or 5-HTP can help to raise low serotonin. I typically recommend starting with tryptophan and don’t recommend 5-HTP if you have high cortisol as it can raise cortisol. Some people do better on tryptophan and some do better on 5-HTP.
Lidtke l-tryptophan 500mg: I only recommend the Lidtke brand for tryptophan as quality is a big consideration when it comes to this amino acid. This can be opened and/or chewed but doesn’t taste good. It can be mixed with inositol powder to make it more pleasant (see below) or with mashed banana. NOTE: This is not the same as the Lidtke Tryptophan Complete which has ingredients other than tryptophan making it more difficult to titrate up.
Lidtke l-Tryptophan Chewable: tablets contain 200mg L-Tryptophan per 2 tablets. This chewable form is both good and bad. It’s good because it’s a nice 100mg of tryptophan per tablet, is chewable, tastes good and is suitable for kids and “pixie dust” individuals (who need a very small amount). The bad aspect is that it does contain sugar and is quite sweet. Because you are continually consuming something sweet you may end up over-consuming them if sugar addiction is your issue.
Pure Encapsulations 5-HTP 50mg: Some of my clients do better on 5-HTP and some find taking this during the day and tryptophan at night works well for them.
Designs for Health Inositol: is fabulous for obsessive thoughts/behaviors that the tryptophan isn’t quite enough for. It’s also been shown to be very helpful for OCD itself. The powder has a slightly sweet taste and I recommend taking it in the powdered form. You can take up to 18g a day but I suggest starting with 2g a day and building up as needed. I think it makes a great addition for mixing into the nasty tasting tryptophan – I suggest starting with 2g inositol per 500mg tryptophan.
Douglas Labs 1mg melatonin sublingual: If the tryptophan isn’t enough for sleep issues, adding this often helps if you can’t fall asleep (and if it’s a low serotonin/low melatonin issue). Start with one and increase to 3 as needed
Douglas Labs 3mg melatonin prolonged release: If the tryptophan isn’t enough for sleep, adding this often helps if you wake in the night and if it’s a low serotonin/low melatonin issue. Start with one and increase to 2 as needed.
Supplement for low endorphins (comfort and reward eating, weepy, pain issues)
DPA or D-Phenylalanine is the amino acid that helps to raise endorphins and eliminates the comfort/reward eating and the feelings of “I deserve this” and LOVING certain foods
Lidtke Endorphigen 500mg: Riboflavin 5mg, Pyridoxal 5-phosphate 5mg (enzymatic form of vitamin B6), D-Phenylalanine 500mg. This is also one of my top products that I recommend. I used to recommend simply chewing the capsule to get the quickest and best effects and this worked well when it was produced in a gelatin capsule. Now it’s made with a cellulose capsule and chewing doesn’t work at all well so opening the capsule (or just biting off the top) and tipping the powder into your mouth works well. It does taste quite pleasant – some of my clients think it has a dark chocolate-like taste. A few people don’t like the taste at all but even then, it can be very effective when low endorphins are an issue.
Supplement for low catecholamines (tired, coffee-drinking, blahs, poor focus, low motivation)
Tyrosine is the amino acid that helps to raise low catecholamines and can often help you quit coffee if you “self-medicate” due to low catecholamines.
Progressive Labs tyrosine 500mg: 500mg l-tyrosine. This is the last amino acid I trial with my anxious clients because it can make you more anxious (although with one client it reduced her anxiety because she was able to focus better at work).
Vitamin C for negating the effects of any amino acid
Vitamin C 1000mg is used to negate the effects of any amino acid. I used to use EmergenC but this still contains folic acid, so here are some good alternate vitamin C recommendations:
Designs for Health C + Biofizz: Vitamin C 2569 mg (as Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate) Quercetin 20 mg Hesperidin 20 mg Rutin 10 mg. This one mixes nicely in water and can also be added to a smoothie but tastes quite sweet for many people. I personally prefer less of a sweet taste.
Designs for Health Buffered Vitamin C: Vitamin C (as ascorbic acid) 2000 mg, Calcium (as calcium ascorbate) 80 mg, Magnesium (as magnesium ascorbate) 160 mg, Potassium (as potassium bicarbonate) 200 mg. This one doesn’t mix very well in water and can also be added to a smoothie. The taste is not very pleasant.
The supplements for pyroluria
Zinc, vitamin B6, evening primrose oil and a good copper-free multivitamin are what I use for my clients with pyroluria or for those who score above 15 on the questionnaire:
Solaray OptiZinc 30mg. Zinc (as Zinc Monomethionine [OptiZinc®] 30 mg, Vitamin B6 (as Pyridoxine HCl) 20 mg. The zinc in this form seems to be well absorbed by many of my clients and is available over the counter. This also does not contain copper. Be aware as there are other OptiZinc products on the market that do contain copper (Source Naturals is one example)
Douglas Labs Opti-Zinc: Zinc (from 150 mg Zinc Monomethionine) 30 mg. The zinc in this form seems to be well absorbed by many of my clients. This also does not contain copper.
Metagenics Zinc Drink: Zinc sulphate monohydrate in a base of distilled water. Each 2 tsp provides Zinc sulfate monohydrate 8 mg. Use this for testing your zinc status as described here: Zinc deficiency is common: using liquid zinc status test as an assessment tool
Here are a selection of 100 mg Vitamin B6/pyridoxine products. Use dream recall as a way to monitor if it’s working, plus social anxiety and mood improvements. If this doesn’t work you may need to use the activated form in conjunction with or instead of this one (see below)
Progressive Labs 100mg Vitamin B6 (contains rice flour)
NOW 100mg Vitamin B6 (contains rice flour)
Vital Nutrients 100mg Vitamin B6 (Only B6 and glycine)
Klaire Labs 250mg Vitamin B6 (Use this one if you find you do better with more i.e. 250mg)
Pure Encapsulations P5P 50 (activated B-6): pyridoxal 5 phosphate (activated B6) 50 mg, vitamin C (as ascorbyl palmitate) 3 mg. This activated form of B6 may be needed if the 100-500 mg B6/pyridoxine doesn’t work or may be needed in addition to vitamin B6/pyridoxine. Use dream recall as a way to monitor if it’s working, plus social anxiety and mood improvements.
Designs For Health P5P 50mg: another good product with pyridoxal 5 phosphate (activated B6) 50 mg
Now Foods Super Primrose 1300mg: Evening Primrose Oil (Oenothera blennis) (Seed) 1.3 g (1300 mg) – 120 count. GLA is often low in pyroluria and EPO helps with zinc absorption and PMS symptoms.
Designs for Health Twice Daily Multi: This is a good copper-free multi. It also contains Folates (NatureFolate™ blend) 400 mcg instead of folic acid (no DFH products contain folic acid).
Free form amino acids and magnesium
Pure Encapsulations Amino Replete: A free form amino acid powder blend that does contain tryptophan. It does contain fructose, flavors and luo han guo
Allergy Research Free Aminos: A free form amino acid blend in capsules. It contains 5-HTP and not tryptophan. I’d prefer it if it had tryptophan.
Designs for Health Amino Acid Supreme: A free form amino acid blend powder that does contain tryptophan. It is sweetened with stevia and contains natural flavors.
Designs for Health Magnesium Malate 360mg
Liquid and powder options for children
Here are some liquid and powder options for children (or for adults, if you have a hard time swallowing pills):
Carlson 100mg B6: Use dream recall (and no more nightmares) as a way to monitor if it’s working, plus improvements in social anxiety and mood.
Designs for Health 50mg P5P (with a little zinc and magnesium): This is the activated form of B6. Use dream recall (and no more nightmares) as a way to monitor if it’s working, plus improvements in social anxiety and mood.
Pure Encapsulations 15mg Zinc gluconate: A liquid zinc option.
Metagenics 15mg Zinc (as zinc sulfate): A liquid zinc option.
Designs for Health Zinc Challenge: Zinc sulphate monohydrate in a base of distilled water. Each 2 tsp provides Zinc sulfate monohydrate 8 mg. I use this for testing zinc status but it could be used as a supplement too.
BodyBio evening primrose oil: Gamma Linolenic Acid/GLA (omega-6) 473 mg. GLA is often low in pyroluria and EPO helps with zinc absorption, eczema and PMS symptoms.
Klaire Labs Vitaspectrum multivitamin/mineral: This is a great copper-free, iron-free powdered multi for kids. You can mix the powder directly into room temperature or cold foods or beverages just before serving.
Pure Encapsulations Amino Replete: A free form amino acid powder blend that does contain tryptophan. It does contain fructose, flavors and luo han guo.
Pure Encapsulations Magnesium Citrate 250mg powder
Designs for Health Magnesium Bisglycinate Chelate 300 mg powder: This one does have stevia and natural flavors
Also see chewable tryptophan, GABA Calm and inositol powder, plus powdered Vitamin C (all listed above).
What about international orders?
Unfortunately, Fullscript does not ship internationally.
So we suggest folks try an intermediary shipping service like www.shipito.com (we haven’t used them as of yet, so do your own research, and if they or someone else does work out please let us know in the comments below).
An alternative is to use iHerb to get similar products, as they ship worldwide and may even have a branch in your country for free shipping.
Here is the link for iHerb and to get 5% off, and if you are interested in iHerb’s exclusive brands to get 10% off here.
Hi Trudy,
Thanks for this list. I’m going to experiment with my dose for Pyroluria rather than continue on my compounded dose. Mind you I can do a bit of trial and error with my current dose which is 3 capsules. So I can currently take 1/3 or 2/3 of the dose and add other things and know pretty much what I’m taking.
I’m wondering however when you talk about taking a good Multivitamin, you don’t seem to count the dose of Zinc and B6 within this multi in your daily dose of Zinc and B6.
Currently I’ve been taking Zinc Piccolinate 75mg, B6 150mg, P-5_P 50mg and Mag 200mg in my compounded dose but to this I’ve added the Basic B Complex from Thorne Research and some Manganese BisGlycenate (15mg) and some D3 (5000IU). plus of course the EPO which I was taking two capsules of 1300mg and some Iron as I’m deficient. Do have some tingling in the extremities but no or unfrequent dream recall so I want to diminish the B6 and try using the P-5-P to see if the tingling goes but the dream recall ensues. I’m currently taking 2/3 of my dose (so only 100mg of B6 and 33mg of P5P) and I have less tingling. But I have to get some P5P to ad to this.
Anyway could you tell me if you count the B6 in your multi. The current B complex I take has a very small amount of B6 like 10mg so i haven’t been counting that but it has higher amounts of other B vitamins. I like Thorne products because they have no starches and they don’t use magnesium stereate which Design for Life seems to use. Is there any reason you don’t recommend Thorne Research. I do have easy access to them. Also their P-5_P is 33mg rather than 50mg so you can increase in smaller amounts. I live partly in Australia (where my compounded capsules are made) and partly in Canada (Vancouver mostly (mid June to Mid September) and sometimes Montreal (May to mid June).
Thanks again
Anne
Anne
I don’t count what is in a multi as it’s typically a very small maintenance amount. I’m not against Thorne I just haven’t used them so can’t comment on how good they are
Thank you Trudy!
Trudy, what about B6 toxicity, which seems to be becoming an increasing problem, especially when someone experiences ‘tingling’ etc? I have a few online friends that have been damaged by excessive B6, sometimes at quite low levels of B6, and are now trying to detox it out, which causes great discomfort. I now am anxious to test my B6 levels as wonder if this could explain why I had progression and now regression.
Hello Trudy,
Thank you so much for all the info you are providing us. I am wondering if this supplements list is up to date, ie. Nov 2020. If not, what would you add to it?
Thanks again and stay safe.
Gigi
It was recently updated with some new additions. Do you have a specific question about a certain product?
Apologies for the delay in your comment approval and my response. We had a computer glitch where a large number of comments were hidden from view in a spam folder. It mostly affected new folks who were commenting for the first time but it’s hopefully resolved now.
Hi Trudy
I followed your information with interest. I tried Gaba in the past and fell nothing. The same with 5-HTP but I may try the brands and amounts you recommend and see if it works. I have a question: I have low magnesium but I don’t seam able to absorb it: I take huge amounts and I still have night cramps and my intestines don’t work better, so I am not dealing with it well and my cravings for chocolate should be related to this. Any formula of magnesium that you would recommend I took several magnesium glycinate douglas lab ( 6 x 100mg / day ) and even so no change in my cramps and intestines. Thanks
Alexandra
I find that some people need more than 600mg a day of magnesium and have my clients increase to bowel tolerance i.e. cut back slightly when they have lose stool. We sometimes add magnesium oxide to help with constipation (and of course look for other causes of constipation)
Thank you Trudy and what kind / brand of magnesium would you recommend?
Hello Trudy,
I notice you recommend supplements that are copper free. Is there a specific reason to avoid copper??
Thank you,
Cherie
I would be very careful taking B6 as supplement. I took it for years and ended up with tingling and nerve issues. When measured, my levels were sky high (even though B6 is supposed to be water soluble). It took over two years to bring it back to normal.
Paramjit
Thanks for sharing and sorry to hear. I just did a blog post on this topic https://www.everywomanover29.com/blog/why-is-vitamin-b6-toxic-for-some-and-why-dont-symptoms-resolve-when-vitamin-b6-is-stopped/ Feel free to join the discussion in the comments there.
I’d love to hear what vitamin B6 marker you tested and what the level was?
I have aura migraine , is it save to try tryptofan ? Other tips for sleep , heavy pms , obsessive thought s ?
Irene
I have used tryptophan with success for migraine but migraines can be challenging in terms of finding the root cause. Here is a blog with some info https://www.everywomanover29.com/blog/migraines-anxiety-depression-gluten-chronic-headache-migraine-summit/
That said, with migraine, sleep issues, PMS, obsessive thoughts I would suspect low serotonin. More here https://www.everywomanover29.com/blog/tryptophan-for-pms-premenstrual-dysphoria-mood-swings-tension-irritability/
Do You know What the reason could be for really bad smell of the sweat before menstruating ? How can i find out if i have Ok mentylation ?
Irene
Body odor can be related to low zinc
Hi Trudy,
I’m interested in GABA supplement, but I am on a low histamine diet. Can I take GABA?
I read GABA is derived from fermentation of cabbage – though I am unsure of the accuracy of this – but that makes me think I wouldn’t be able to take it, as it would be high in histamines.
Can you please provide some insight?
Thanks !
Bri
PharmaGABA can be problematic for some folks with histamine issues. More here https://www.everywomanover29.com/blog/pharmagaba-vs-gaba-when-you-have-histamine-issues-mcas-does-pharmagaba-ease-physical-anxiety-or-make-things-worse/
Regular GABA is well tolerated when GABA levels are low https://www.everywomanover29.com/blog/amino-acids-pyroluria-supplements/
What do you recommend for pyrolurics who are also OVER methylated. How do those two conditions affect each other? Pyrrole disorder causes low serotonin and GABA. Over methylation causes high dopamine, high serotonin, and low GABA.
So as I write it, I might see that serotonin might be balanced. But dopamine would be high and GABA low?
Janet
I have everyone do the amino acid questionnaire and base trials on how they score, and the supplement according to how they respond to the respective amino acids. I don’t feel we can generalize and make the statements you have made.
Hi Trudy, just wanted to ask if the amount of 1 MG of copper in a multivitamin hinders the zinc levels greatly? I know you mentioned to get a multi without the copper. I found a really good multi but it has that small amount in it.
Elizabeth
Yes it often does but it also depends on the amount of copper/zinc in the diet and if someone has pyroluria and a higher need for zinc. Other sources of copper play a role too: copper pipes, contraception etc
Hi Trudy,
This is a VERY helpful post- thank you!
I’ve contacted you before in regard to pyroluria since I tested positive for it. Is it an issue if the multivitamin also contains zinc if we are already taking OptiZinc separately? I’m not sure if I need to go above the 30 mg contained in the OptiZinc supplement which is why I thought I’d ask about the zinc contained in the multivitamin.
Thanks again!
Darla
Glad it’s helpful! I don’t count what is in a multi as it’s typically a very small maintenance amount. I would use other markers – zinc challenge, alk phos, low zinc symptoms like smell/taste/joints and overall improvement in social anxiety
Hello! I just bought your book after hearing your recent session with Sean Croxton. I really appreciate the brand recommendations. Both the L Tryptophan and GABA calm make me feel light headed, so I will try the tryptophan at night only and the GABA sparingly, as needed. Does that mean I am taking too much? I am just at starting doses. I don’t wake up feeling very well rested. Any suggestions for that?
Also, if I am not recalling dreams at starter Pyroluria doses, should I increase doses of all 3 supplements? (I haven’t been on all of those for a full week yet. Just got the Evening Primrose Oil 2 days ago.) Thank you!
Holly
Adverse effects from the aminos mean too much, you don’t need them or inferior quality.
For pyroluria and dream recall, it’s the vitamin B6.
Thank you!
Thank you Trudy for making such a comprehensive post (especially during a time where you are rightfully focused on your mother)! I am sure I will put this to good use with my niche. Well done!
Wonderful Sarah!
I find it interesting and a little problematic that your amino acid test only deals with low neurotransmitters. I don’t fit your tests! What about high serotonin or dopamine that is the result of overmethylation? I base my studies on William Walsh. I also like Joan Larson.
If I take 5HTP or SAMe, I become very witchy! I do great with DMAE and AlpaGPC which help to lower dopamine. I also like GABA which can be low in overmethylators.
Janet
It sounds like you have figured out what works for you.
I too like and respect the work of William Walsh and Joan Larson. As I said before I don’t feel we can say that everyone who is overmethylated has high serotonin or dopamine – we are all so unique.
I do like the idea of high serotonin and high dopamine questionnaires. Do you know of anyone who has these?
Hello Trudy
I wanted to know what you think about using bio- identical œstrogènes ( They’re low) to help with anxieties and panic attacks? Could they be the cause and good help for low serotonin or low gaba?
H
I like to use the amino acids first for a few cycles and then consider bioidentical hormones like estrogen. And yes estrogen and serotonin go hand in hand
Janet,
I am a fellow overmethylator(supposedly). I am also high in homocysteine, and low in histamine. I am trying to follow Dr. Walsh’s suggestions–so far I’m having a rough time. I will definitely look into Joan Larson’s theories too. I would really like to exchange ideas with you.
Dave
Hi Trudy,
I listened to your interview with Sean and I was VERY impressed. I never heard of pyroluria before (or catecholamines) but when reading your checklists they resonated strongly. I bought the pyroluria supplements and took your recommended dosage and almost immediately felt better! (thanks so much!)
however about 1 week into the supplementation I started to get pains in my hands (finger joints) and feet. maybe like a constant 4 on a scale 1-10. I’ve taken zinc and b’s before, so Im thinking its the Primrose, so I discontinued it for 2 days so far.
I’m wondering if you’ve ever encountered this symptom before from your pyroluria or low catecholamine patients?
Many thanks and eagerly awaiting your book,
Raymond
Hi Raymond – I have not had anyone experience this and it makes me think it could be one of the fillers in the supps. I would assume they are gluten-free?
Thanks so much for replying Trudy! My plan is to discontinue these supplements for 1 week then I will restart them. I will post my next results afterwards.
I thought my reaction may have been what you describe in question #4 on your pyroluria questionaire where question #4 reads:
Excessive reactions to tranquilizers, barbiturates, alcohol, or other drugs, in which a little produces a powerful response (low vitamin B6) – For
I really did feel quite good for the week i took the 3 supplements, and look forward to starting again 🙂
Best regards,
Raymond
Thanks for the lists, your book has helped me a lot. I purchased Lidtke l-Tryptophan and time release melatonin and notice a big difference in my sleep. Instead of waking up every two hours I’m sleeping better but still wake up at 4 am a few nights a week and can’t get back to sleep. Gaba hasn’t helped. What can I take to get back to sleep and what are your thoughts on Seriphos Phosphorylated Serine? I think my anxiety has to do with my adrenals because I wake up in a sweat and am way past menopause.
Jo
Good to hear about the improved sleep. I have my clients try more tryptophan and more melatonin until sleep improves. If it doesn’t then we’d look into high cortisol (adrenal saliva test) and then Seriphos would be my choice to lower it. With early morning awakening I’d also look into parasites, SIBO, sex hormone imbalance and low blood sugar.
Hi Trudy! I’m trying to get off the 0.25mg of Klonopin I’ve been taking daily for years. But I still need help for daily anxiety and panic. Would GABA be something to try while weaning myself off? Is that the most comperable to a benzo? Many thanks!!
Amy
GABA would be one of the nutrients I’d use with a client wanting to wean off Klonopin. I’d have them work with their doctor too of course and go very very slowly. Benzodiazepines are challenging to quit – this is great blog post from Season 1 of the Anxiety Summit https://www.everywomanover29.com/blog/anxiety-summit-benzodiazepines-risks-vs-benefits/
All the other factors that can contribute to anxiety would also need to be addressed – gluten, sugar, caffeine etc (see https://www.everywomanover29.com/blog/60-nutritional-biochemical-causes-of-anxiety/ for all factors)
Thank you! What a kind person you are to respond to all of these comments!
I have read that GABA does not cross the blood-brain barrier unless the brain is leaky. Is this true or is there another mechanism for it to work?
Scott
There is evidence that GABA works peripherally so may be exerting it’s calming effects this way. This blog has some research – https://www.everywomanover29.com/blog/anxiety-summit-targeted-individual-amino-acids-eliminating-anxiety-practical-applications/
I’m not convinced about this: “GABA does not cross the blood-brain barrier unless the brain is leaky” and would need to see some research to convince me of this fact. I am planning to look into some of the leaky BBB testing that Cyrex offers and will share what I find via a new blog post so stay tuned
Interesting. I want to try it but most of the supplements available in England are 500mg capsules. The only one available in lower doses is GABA calm by Source Naturals. Would that be ok?
Here are the ingredients:
Magnesium (as magnesium chelate) 5 mg <2%
GABA (gamma-aminonutyric acid) 125 mg **
Glycine 50 mg **
N-Acetyl L-Tyrosine 25 mg **
Taurine 20 mg
Scott
This my favorite GABA product and is the one I find most effective for most of my clients. It’s a nice small amount and I like the glycine and taurine, plus it has a little tyrosine to counter some of the GABA. You do need to check the precautions for tyrosine https://www.everywomanover29.com/blog/amino-acid-precautions/
The big bonus is that it’s sublingual and GABA seems to be very effective when taken this way.
With a 500mg, I have my clients open up the capsule and take less and hold it in their mouths for better absorption.
Do please keep us posted as to how you do with it
Trudy, do you think taking GABA would help a person to wean off Gabapentin? Any other suggestions?
Lorraine
Yes GABA would be one of the nutrients I’d use with a client wanting to wean off Gabapentin. I’d have them work with their doctor too of course. Plus all the other factors that can contribute to anxiety would need to be addressed – gluten, sugar, caffeine etc (see https://www.everywomanover29.com/blog/60-nutritional-biochemical-causes-of-anxiety/ for all factors)
Hi Trudy,
Thank-you for all you do to support and enhance the health of those you work with! Personally your book has made a world of difference in my life.
Here is my question: I am a pediatric nurse practitioner in a busy, mostly medi-cal pediatricians office. As a PNP I always talk about wellness for my patients especially in regards to diet and nutrition. I also have several adolescent patients with anxiety/depression etc. Most of
our families can’t afford treatments or medications outside of what their insurance will pay for and many do not have internet access.
I am a long time fan of natural medicine myself including chiropractic, supplements, etc. and have seen the benefits of that to promote mental and physical health. I have been searching for a book or website or journal where I can go for good information on treating children holistically and more naturally. So much of what I have found is anecdotal
info but I am looking for more details and studied topics. My education was focused on traditional “western” medicine and was lacking in these areas! I know a more
holistic/natural approach can make a huge difference for kids with many different complaints. I wondered if in your studies and research you have come across any books/resources that specifically relate to kids.
Any suggestions you have would be greatly appreciated!
You will find this an excellent source of well-documented studies on all sorts of health issues:
http://www.greenmedinfo.com
There is a tremendous amount of information in the archives that can be accessed for free, but if you are serious you will want a membership. Sayer Ji also sends out an email newsletter containing articles that summarizing numerous studies that are all related to a specific health condition. Excellent content – there is nothing out there that I’m aware of that even comes close to this level of professional quality. Please share it with others, especially health practitioners.
Thanks Michael – I love this site!
Hi Trudy,
I did read that you dont test for Pyroluria. I had the test and the reading was very high. I did your questionnaire and only scored about 5. I was on the supplements but needless to say they were not effective. And my blood tests showed that my B6 levels and zinc are all in range. So does that mean that the test is unreliable?
However I do have anxiety. I tend to wake up during the night with dreams, sweating and anxiety. I am taking bio-identical hormones and so my hormones are now balanced. I have started taking 2 grams of Glutamine in the morning and before bed as I think my blood sugar level drop during the night. I have had some improvement with the sweating and anxiety but I am still dreaming which wakes me up. Any suggestions for this. I worked with someone for 6 weeks using the Amino Acids but they didn’t seem to work. She also was a student of Julia Ross. About a week ago I also started taking 10 mg of Lithium Orotate morning and evening. You have never mentioned this supplement. I think that may be helping with they anxiety. But I have found I feel much better after breakfast. So how do I address low blood sugars levels dropping during the night? thankyou.
for low blood sugars during the night, eating a bedtime snack of protein helps me
Maria
Good to hear and yes this helps many of my clients too. Having a good breakfast with protein is a big plus too
Trudy,
Once I figure out which of the many things you have told us about is causing the anxiety in the first place, I’d love to get off my Pristiq. What regimine do you recommend to ween off of antidepressants, and what supplements do you recommend to help to build up seratonin and help with the withdrawal?
Also, do you work with any doctors or naturopaths in Utah that follow your philosophies and protocols? I need help figuring out the root cause.
Carrie
For everyone I work with I start with the basics of real whole food, organic, no coffee, no gluten, so sugar, quality protein and healthy fats + I have them start on amino acid and the pyroluria supps if they score high on the questionnaires. Then we start digging deeper. When someone is on an SSRI then we work with the prescribing doctor and eventually taper while often increasing serotonin support further (tryptophan or 5-HTP).
I don’t work with any doctors or naturopaths in Utah that follow my philosophies and protocols but am happy to help long distance consulting – you can read more here https://www.everywomanover29.com/services.html
Hello Trudy
Thank you for all the great information! I’m just a little confused about the section above that says “Vitamin C 1000mg is used to negate the effects of any amino acid” – so should we avoid Vitamin C when taking amino acids? but you said you take EmergenC?
Or are you talking about side effects of amino acids?
Thanks Michelle
Michelle
The vitamin C is to negate a possible side-effect of an amino acid – sorry for the confusion
Hi Trudy.
I am looking for relief for my 19yr old son’s OCD. He currently takes Lithium Orotate and supplemental L-Theanine for assistance with anxiety, but neither seems to work great with the OCD. He has tried Inositol 1950mg 3x per day with little effect. I really like what you have to say about the Lidkte L-Tryptophan and would like to give it a try for him. He currently works with Mensah Medical (for Pyroluria) and I have been advised to run any new supplement I want to try for him, past them first. They told me that since he has low/normal histamine levels, the L-Tryptophan may calm OCD only momentarily, and then hype him up. I don’t see how the two can be linked together. They do not think the L-Tryptophan is a good idea for him, but have not offered another solution. Have you ever heard of this issue? I really want to try the L-Tryptophan, but thought I would check to see if you have any knowledge of the low histamine/tryptophan problem. Also, can someone take both the L-Tryptophan and L-Theanine at the same time?
Thank you for your endless kindness and dedication to helping all of us to achieve a healthier state of being!
Hi Kim
If I was working with your son I’d have him do the amino acid acid questionnaire and if he has low serotonin symptoms, do a tryptophan trial (and let the Mensah Medical folks know) and see how he does. I feel we are all so individual that to say “since he has low/normal histamine levels, the L-Tryptophan may calm OCD only momentarily, and then hype him up” is generalizing.
Tryptophan can help with OCD but I usually also add inositol – up to 18g a day. I’d also look into PANDAs/strep and other possible bacterial causes.
There is typically no issue with taking L-Tryptophan and L-Theanine at the same time.
Please do keep us posted on how he does
Hey!
I’ve experienced really good results when taking the starter pyroluria supplements but after a week I felt a tingling/numbness feeling on my arms so I tried the other form of B6 wich is P5P (33,8 mg) and my tingling slightly disappeared but it’s still there, even though my dream recalll and social anxiety symptoms became much better! Do you think I should lower the dose?
Also, do you recommend me taking l-tryptophan/5-htp with Gaba to reduce social anxiety? I scored high on the amino acid questionnaires on both serotonin and gaba, and thought this approach may be better for me if I need to stop the pyroluria supplements.
Hi Trudy, I have a 14 year old and an 11 year old son that also have
extreme sugar cravings. Can they also do the L – Glutamine protocol? if
so how much and for how long? I also might have adrenal fatigue and wake
up every morning very anxious what supplements and how much and how many
times a day should I take for adrenal issues? How would I know if I have
adrenal issues? Thanks Mary
Trudy,
How would I know if I have candida?
Trudy,
If we are taking the amino acids should we be taking any vitamin C if is negates the affects of the aminos?
Hi Trudy. I have suffered from social anxiety for over a decade. I recently read a study which suggested SA is a problem of too much serotonin – http://www.uu.se/en/media/news/article/?id=4918&area=2,6,10,16&typ=artikel&lang=en
What would you recommend in terms of supplements?
Thanks
I READ RECENTLY THAT SEROTONIN DOES NOT HAVE ANYTHING TO DO WITH MOODS ETC
Nancy
It’s on my list to address this study/topic as an entire blog post. It’s not true and is really saying SSRIs don’t improve serotonin.
Regarding the chewable tryptophan, how many tablets do you suggest starting out with and then working up to? And do you suggest letting them dissolve under the tongue or is chewing them better (looking for whatever is most suggested by you)? Do you prefer your clients to be on the capsule over the chewables? I see you say that the capsules “can be opened up and/or chewed” so I am guessing you do not recommend swallowing them whole?
Thank you in advance for answering these questions. Look forward to your response!
Kaylyn
It’s very individual. Typically 500mg is the starting amount of tryptophan. For sensitive clients we may start with 100mg. 2000mg twice a day seems to be tolerated well.
Chewables can just be chewed and then kept in the mouth for awhile/1 minute. The opened capsules don’t taste great and then the chewables could be used. I would say 90% of my clients are taking capsules – opened if results are better this way, or swallowed
I ordered the twice daily multi from Designs for Health but when I received the product, I noticed this difference: Product online shows idodine from (kelp). When I received my multi – ordered same one – it shows iodine from potassium iodide. I was not happy with this.
Biotin 300 mcg
Pantothenic Acid (as d-Calcium Pantothenate) 50 mg
Iodine (as Kelp) 75 mcg
Zinc (TRAACS® Zinc Glycinate Chelate) 15 mg
Hi Cindy
It seems the online store doesn’t have the latest label information. It could be that DFH changed it very recently. It’s not good for them to be out of sync and if you’re not happy I suggest you return the product.
Hi Trudy, I recently saw your interview with Sean in the Depression Sessions and was really excited about the information you shared. I’ve since read your pyroluria and amino acid mood questionnaires and feel as though things are beginning to make sense. I’m keen to start taking some amino acids but am now a bit confused because I scored quite highly in each category! So my question is, what aminos should I start on first? They all do different things so they are all important. I have just started zinc, B6 and l-glutamine (mainly because I had them on hand) but feel that Tryptophan, GABA, DPA and Tyrosine would all be beneficial. I’m in NZ so unable to access the Lidtke brand of Tryptophan. Should I therefore just choose a brand I know to be reputable? Also, how long would I take one for before starting a different one?
Many thanks for sharing all this incredible information.
Susie
Glad to hear you’re excited. I like to do one area at a time so you have a good feel for what is working. Pick the one area that resonates the most and start there. I have my clients do each one for a week, assuming they are seeing results. Typically with the trial we are seeing a result immediately (2-10 minutes) if it’s needed and within a week you’ll know for sure
I started taking 500mg at bedtime to help with my anxiety due to adrenal fatigue. I have seen a reduction in my anxiety but I feel really groggy the next morning. When I take it with magnesium, this grogginess is worse.
I know that my magnesium is low because I had a Mg RBC ran. I take vegetable capsules. Is there anyway to cut the dosage of this or spread the dosage out more so I will not feel like this in the morning or when I take my magnesium? Any assistance with this matter would be greatly
appreciated.
Marlana
I’m guessing you are taking 500mg tryptophan? When a client feels groggy with tryptophan I have them back off and take less, starting with 100mg and building up. Keep in mind there are other causes of anxiety and you’d want to look into those too
Hi Trudy!
I have been struggling with increasing anxiety and recent panic attacks. Just read your book last week and had 21 of the most common pyroluria symptoms you name. Talked with my naturopath and am going to start supplements. I have a few questions as I get started:
1) If my multivitamin has copper in it will it say “copper” on the nutritional breakdown? or are there additional names I need to look for?
2) On page 142 of your book you say to start with 240mg of evening primrose — is this correct? I noticed that the capsules you list above are 1300mg.
3) I have been taking 100mg of P5P for the last few weeks (but without the zinc and primrose oil) and haven’t noticed any changes in anxiety. (My naturopath had me begin P5P as a result of some blood work but not as part of a pyroluria treatment plan). Does this mean that pyroluria treatment may not work for me? or do I need to have the zinc and primrose oil all at once along with the P5P to know if it will make an impact.
Thanks so much — I am hopeful that there may be a way to address the issues I am experiencing after months of trying other alternative treatments. I appreciate the specific information you offer. Invaluable!
Renee
Renee
(1) yes it will say copper
(2) EPO- 1300mg provides 120mg of GLA
(3) It’s no problem to add zinc and EPO now
Glad the info in helpful – please keep us posted on how you do
Thank you so much for the list of recommended supplements. You are such a valuable resource! I appreciated listening to you today on the Healthy Heart Summit. I always learn something new!
Wonderful Sharon! I really enjoyed being a part of The Healthy Heart Summit and have gotten so much out of the other speakers. I haven’t listened to all of them but so far I would have to say Dr. Sinatra’s talk was my favorite! I also really enjoyed Dr Jonny Bowden’s interview https://www.everywomanover29.com/blog/cholesterol-myths-healthy-heart-summit/
Why and under what condition would it require to use vitamin C to negate amino acid supplementing?
Peggy
You use vitamin C to negate adverse effects of an amino acid – such as feeling too tired or groggy (for example, too much GABA or tryptophan), feeling too wired or jittery (for example, too much tyrosine) and so on.
Hi Trudy! I have just begun treatment for pyroluria and wondered if any of your patient’s have had Significant dizzyness along with anxiety and panic attacks? My naturopath prescribed lithium to address my light-headed symptoms and it has helped a bit. The dizzyness intensifies with the anxiety.
Is this something you have seen in your patients? If so does it require any special treatment beyond your recommendations for pyroluria supplements?
Thanks so much. Renee
Hi Renee
With dizziness I always consider low B12 and/or adrenal issues. I have not used lithium (I assume lithium orotate) for dizziness and have not heard of it used for this purpose so it’s good to hear it helped a bit
Hi Trudy! I tested myself for pyroluria by a lab and got 86 as a result, which is very high. I was advised by my doctor to take in the
morning:
500 mg of vitamin B6, 100 mg P5P, 1000 mg of Vitamin C, 1000 mcg of biotin and 500 mg of omega 6.
Evening:
1000 mg of Vitamin C, 500mg/250mg Calcium/magnesium and 100 mg of zinc picolinate.
When I took the supplements in the evening I suddenly felt pain on my arms with a slight tingling in my veins. I took out all the supplements and brought them back one-by-one to see what was making me feel this way and it was the zinc. What can I do to make this feeling go away?
Hi Gisele
I always recommend checking with the doctor who made the recommendations. I can tell you that I start my clients on 30mg zinc
Is there an issue with the corn (being GMO found) in the melatonin 1mg sublingual by Douglas labs? Do you have another brand to to recommend or is this the melatonin you’ve found to work best like the tryptophan lidtke brand?
Kaylyn
Great question and thanks for asking! I believe all their products are GMO free but I can’t find the 1mg sublingual on the Douglas site!? This label from the 3mg sublingual says GMO-free but does have different ingredients (http://www.douglaslabs.com/media/DL81322LB.pdf). I’ve contacted Douglas Labs to get an answer
Kaylyn
This is what Douglas labs sent to me:
“Douglas Laboratories makes every effort to source non-GMO ingredients. To the best of our knowledge, the products from Douglas Laboratories do not contain any genetically modified organisms based upon GMO-free documentation provided by our raw material suppliers.”
Addendum: I am addicted to coffee – big problem for me! I try to cut down and drink decaff but that just doesn’t seem to do it. I know I should quit coffee….. ugh!
Yes Cindy – coffee can be at the root of many anxiety problems and has to go. Find the reason you need it (lack of sleep, low thyroid, adrenal issues, anemia, low catecholamines) and address that and then it’s easy. Vitamin C and tyrosine help a lot!
I posted this earlier but it seems to have disappeared. I did add an addendum on coffee above, as well.
I have about 19 of the symptoms on the pyroluria questionnaire. I say 19 because those are the only ones I am sure of. I don’t really recall in childhood whether I had the shyness or not, but very possibly. I have not done the zinc challenge yet. I used to have bizarre dreams and nightmares often but not so much since I have changed my diet drastically and began taking OptiZinc. I have just begun Designs for Health multi. I do recall more dreams now. As far as alcohol, when I used to drink, I had horrid hangovers the next day while other people I drank with did not. I rarely drink nowadays, since about 8 years. I drank to self-medicate many times. I do have 3 other sisters, and the youngest one has social anxiety. She fits pyroluria perfectly to a T. Palest in family. If you put the same wig on all of us, we’d all look pretty much the same – very, very similar in looks. I have 2 brothers. I also have the afternoon and evening carb cravings and sugar cravings, even though I have cut about 95% of sugar out of my diet. So, there’s work to be done yet. The symptom that bothers me the most is that I do get frequent bouts of depression and fatigue. I’ll go along just fine for a period and then, ‘boom’ I get exhausted and then some depression follows. Rest usually picks me up. Strange! What do you suggest for me? I haven’t taken the 100 mg of B6 yet, but I do take 1 multi which has some B6, if I’d take 2 would give me 50 mg daily, and then the OptiZinc has 20 mg of B6. I do consider myself one of those ‘pixie dusters’ so I am afraid to overtake anything. I feel I am sensitive to drugs, multivits, and even some over-the-counters.
Cindy
I have pixie-dusters start low but even for them the typical pyroluria protocol seems to be fine – 30mg zinc, 100mg vitamin B6 and 1300mg EPO (over and above what’s in a multi and B complex)
Hi Trudy,
Your information on pyluria is game changer!
I seen a practioner who told me for copper
toxicity, it’s always best to start with pumpkin seeds
To sloooowly get rid copper as going straight into
Zinc could dump the cooper too fast. Is this possible?
Also for us “pixie-dusters” who are sensitive
Do you know why that may be?
When I was young I could take anything.
In my teens I smoked marijuana heavily –
Almost Daily… and later on in my early 20’s ..
I noticed I developed this sensitivity to
Almost any natural supplements, herbs,
and multi-vitamins. Even basic plant enzymes.
Things like 5-http made me feel stimulated/jittery
In super baby amounts. Only things that helps
To take edge off when I feel it is super low dose kelonipin
Which I take sparingly.
Anyhow, Is it something to where we have to be extra patient
And just start super low and build our way up?
It makes it very difficult when your system is sensitive
to do anything! This has stumped me for years and ive always wondered about This. Thanks!
You recommended 2mg of inositol and 500 mg tryptophan for obsessive thinking. Should they be taken together between meals or bedtime or both?
Sharon
Amino acids like tryptophan are always taken between meals. Tryptophan is best taken midafternoon and evening/bedtime.
Inositol can be taken with or away from meals and up to 18g can be taken per day. I typically have my clients start on 2g (grams not mg) a few times a day
Thanks Trudy. Can either 5htp or Tryptophan be used when starting inositol?
I typically start with tryptophan unless I have cortisol results as 5-HTP can raise cortisol
Hi – can this protocol be used with SSRIs? I take 10 mg of Lexapro but it’s just not helping my obsessive ruminating.
Bee
SSRIs and tryptophan/5-HTP cannot be taken at the same time (please read the precautions link). I have my clients talk to their doctor to get an SSRI taper protocol and the approval to take the SSRI in the morning and tryptophan or 5-HTP midafternoon/evening (at least 6 hours from SSRI). We boost serotonin first and then they start the SSRI taper (with the doctor’s monitoring and my guidance).
I would recommend that everyone does it this way: doctor’s approval to taper the SSRI and use amino acids, and working with someone knowledgeable in amino acid use. OR with the doctor’s approval to taper the SSRI and once they have stopped then add in the amino acids.
Hi Trudy
Thanks for your generosity in answering questions. In the book you say to take 240mg of GLA — wouldn’t that be 2600mg EPO? I have been doing 2600mg of the EPO but am wondering if I should have started with 1300 like you mention above?
Secondly I was wondering about B6 and dreams: I am dreaming now every night which is a giant change. They are sometimes still on the anxious/scary side — does this mean I need to increase B6 or just give it more time? I have been on 500mg for about a month.
Thanks again!
What do you think of GABA (gamma-aminobutyric acid)by Source Naturals – “Serene Science GABA Calm Mind” – in the powder form? This way a person could start off with a pixie dust amount because suggested use is 1/4 tsp. Thank you so much, Trudy!
Cindy
It sounds good but I can’t find it online – if you share a link that has the ingredients listed I’ll take a look. Have you tried it and found it to be helpful for you? and if yes, how much?
Here is the link:
http://www.sourcenaturals.com/products/GP1397
There are 3 tabs to the left – Capsule, Powder, or Tablet. Click on ‘Powder.’ Then up top, there’s a tab for the price. I have not tried it yet but I will. I also checked Vitamin Shoppe online and they sell it there as well. I have a local Vitamin Shoppe here so I plan to get it there and will try it and when I have, I will post here on how it worked or did not work for me.
Cindy
1/4 Teaspoon = approx. 750 mg. This is a lot and would be too much for most people so if I was going to have someone use it, I’d have them start with dabs or 1/16 teaspoon. To compare, GABA Calm has 125mg GABA.
Hi Trudy! You mention 5-HTP can raise cortisol. I have Adrenal fatigue and I suspect low serotonin. My 4x/day saliva test shows: high, very low, very low, normal. Could taking 5-HTP be helpful if taken during the day when my cortisol is low? Or do you have any other suggestions?
Thanks so much!
Amy
As long as 5-HTP doesn’t make someone feel wired-tired and is addressing the low serotonin symptoms then I’d have someone use it. Serotonin support is typically mid-afternoon/evening but some people do better when they also take 5-HTP earlier.
I would also use the complete adrenal protocol (Vitamin C, pantothenic acid etc) to heal the adrenals and also figure out why they are burned out (and address the root cause – like food sensitivities, parasites etc). And Seriphos or lactium to lower the high cortisol. Plus provide lifestyle stress-reduction advice.
Thanks for your reply! Is there a place on your website where you go into more detail about adrenal protocol? Or a particular plan you recommend?
Hi Amy
I don’t have a blog on this topic and it looks like I need to create one – stay tuned
In the meantime, here are links to 2 adrenal interviews I did on prior Anxiety Summits
Dr. Alan Christianson on “Adrenals – Master glands of anxiety / tranquility” https://www.everywomanover29.com/blog/adrenals-anxiety-tranquility
and
Dr. Amy Day on “Adrenal health for more energy, less anxiety and balanced hormones” https://www.everywomanover29.com/blog/anxiety-summit-adrenal-health-energy-less-anxiety-balanced-hormones
In watching the depression sessions one of the speakers spoke about the benefits of Empowerment Plus by True Hope – how does that work with the polyloria and amino acid protocols that I learned in your amazing amino class and book? Can I take all the supplements or just the Empowerment plus?
Thanks
Hi Mary
True Hope typically says not to do other supplements but it would be best to contact the speaker who presented on this topic.
My 2 cents – it could be considered a good multi but it does have copper if that is an issue (often the case with those with pyroluria). As a standalone product, there is research showing it does help with anxiety, stress, ADHD etc. One of the main researchers is Julia Rucklidge and I interviewed her on this topic on the Anxiety Summit (https://www.everywomanover29.com/blog/anxiety-summit-nutrition-to-treat-anxiety-depression/)
Thank you for the info in GABA studies. I will share them with my Dr.!
When do u take the larger dosage of GABA…at bedtime? I thought GABA calm has tyrosine in it? I can’t take tyrosine due to Melanoma history. I am having trouble with staying asleep.
I so appreciate being able to ask my questions and the support!
Yes, on the GABA 1/4 tsp. – agree, way too much. What I meant is that if you could buy it in powder form, you could then just take a little dust of it and see, then another, or whatever, and then measure the amount you need. This would eliminate breaking open a capsule, etc. I would never start out with the recommended dosage. Thanks for taking a look, Trudy!
Yes, absolutely!
Hi Trudy,
You’ve been gracious enough to help my husband and me in the past regarding brands of products you trust. Could you tell me what brand of Kava Root you recommend? I know they vary quite a bit. I didn’t
know if you preferred powders, tablets, etc.
We both thank you!!
Hi Rosie
Kava is not a product I use with my clients so I’m afraid I can’t offer any advice. My first choice for physical anxiety is GABA, and tryptophan for the anxiety in the head/worry/ruminating thoughts.
A speaker in one of your Anxiety Summits expressed concern about a link between L tryptophan and quinolic acid. Are there special cautions in using tryptophan?
Hi Trudy!
Do you test your patient’s ceruloplasmin levels along with copper and zinc? If so, how does this information inform your treatment of patients? I am just getting started on the pyroluria protocol and my doctor ordered a zinc and copper blood level test. I wondered if ceruloplasmin should also be included to compare bound and unbound copper ratios.
thoughts?
thank you!
Renee
Renee
I don’t typically test zinc, copper or ceruloplasmin but if you’re testing copper, it is recommended to also test ceruloplasmin
I found tryptophan in powder form, rather expensive though, but is this the same as from Emerson Ecologics? http://store.lidtke.com/products/l-tryptophan-usp-250grams-powder
Thanks!!
Cindy – all Lidtke tryptophan is good quality and Emerson sells Lidtke yes
Hi Trudy!
Sorry, but it’s me again. Can you please tell me what the best Vitamin C is as far as addressing adrenal problems? What kind of Vit. C should I look for? As far as “kind”, I mean tablet, powder, ascorbic acid, etc. I read recently that the buffered powder form of Vit. C is often best tolerated, absorbed, and useful, and that bioflavonoids are important. Is that correct, or can you give me a better description of the “kind” of C that I should use? I learned that taking Vit. C as ascorbic acid is often not the best way to go and often not absorbed very well. I’ve always wanted to learn about Vit. C since there are so many out there. Confusing as far as what to believe! I do trust YOU though.
Anyway, I’d really appreciate your guidance on what to look for in a Vit. C supplement…and even a brand you like.
Thank you!
Do you find that L glutamine works well as a precursor to GABA? I have read that the body will stop producing its own GABA if you continually supplement with GABA instead of glutamine.
Hi! I was wondering if I could use GABA Calm for my 7 year old. If so, what dose? Also, I tend to get a lot of my anxiety when I drive, specifically on the highway. What would you recommend? I currently take GABA Calm and it and your guidance have changed my life !
Thank you!
Salena
I’d focus on other factors with a child that young – are they getting enough quality protein and especially at breakfast, is there caffeine in the diet, is there gluten and too much sugar in the diet, looking at salicyclates/additives/colors, candida/parasites, low zinc etc
And then I’d likely use tryptophan (100mg chewable by Lidtke) which helps with worry/ruminating anxiety. GABA is for the physical anxiety. We always go thru the amino acid questionnaire but I’ve very seldom used GABA with kids.
I’m glad to hear the GABA Calm is helping you. For situational anxiety like driving a person could take more but I like to look at the whole picture and get overall anxiety down so it’s not worse when driving or in other situations
Hi Trudy,
I bought the zinc challenge stuff and flunked the test (it tasted just like water to me). So, after a few days of use I began to notice my tongue is tasting it. Thank you.
My problems are low slow mood, lack of motivation, very little anxiety, poor sleep, SUGAR CRAVINGS. Can’t stay on a diet and tend to be depressed. I took 500 mgs. of tryptophan one day and got a headache, so I don’t use it.
I am well passed menopause and don’t use hormones. I am the sort that depends on food for a lift. I am chubby, but I eat healthy except for the sugar and carb cravings. I think looking in the mirror at my chubs get me really down more than anything. What would you do if you were me, to shred the fat off? I think the entertainment in my mouth props up my mood (but barely).
When I lost my hormones much of my vim and vigor went “poof!” Thyroid is just fine and all labs are good.
You are such a lovely lady to listen to. Loved you on Sean’s summit.
Beebs
Glad to hear the zinc is working.
If I was working with you I’d have you do the amino acid questionnaire and then try the corresponding amino acids – possibly tryptophan or 5-HTP (low mood, depressed, sleep), tyrosine (motivation, depressed) and DPA/Endorphigen (“the entertainment in my mouth props up my mood”). You may be a pixie dust person and need to start with a few dabs of tryptophan?
And consider that candida may be an issue if the amino acids don’t help.
Thanks for saying I’m lovely to listen too and glad you enjoyed my interview on The Depression Sessions
Trudy, thanks for your generosity in responding to these questions. Where can I purchase the liquid zinc to test myself for deficiency? Also, can you please provide a link to the amino acid questionnaire?
I’m tapering off Cymbalta – currently taking one pill every second day, so on the day without I’ll take 5HTP. I have longstanding sleep and motivation issues and OCD. I hyper focus on inappropriate things (addictive) and have lack of focus otherwise. I also have sugar cravings. I scored high for pyroluria. I’m taking the B6 and EPO so now I just need to get the zinc.
I’m 63 and have been on AD’s and sleeping pills for most of my life. I’m looking forward to feeling better without all the side effects of drugs.
Trudy my grand daughter has high anxiety and hasn’t been able to to make it through more than one or two weeks of school for four years! She is nine years old and also has terrible mood swings. She has threatened to harm herself and has anger problems. Is the optizic okay for children? She is not on any meds. Is pixie dust GAba okay? Or the gaba calm? Please help! We would gladdly come to see you or work on the phone. We are in Las Cruces new Mexico and have no one available. We need to get help before we lose her. Thank you. love kelly
Kelly
I’m so sorry to hear about your grand-daughter. As I mentioned in one of the comments above I’d focus on other factors with a child that young – are they getting enough quality protein and especially at breakfast, is there caffeine in the diet, is there gluten and too much sugar in the diet, looking at salicyclates/additives/colors, candida/parasites, low zinc etc. A blood test to look at low vitamin D, low iron etc is important too.
And then I’d likely use tryptophan (100mg chewable by Lidtke) which helps with anxiety, anger and may help with the threatening to harm herself. GABA is for the physical anxiety. We always go thru the amino acid questionnaire but I’ve very seldom used GABA with kids.
Even if it’s in the genes it can be changed with nutrition so have hope and don’t stop looking for the answers. I do work via phone if you need help
Oh yeah, This is genetic she is third generation. Thank you!
Hi Trudy,
I see that you recommend Emerson Ecologics for buffered Vit. C. I know they’re currently out of stock, but I was just wondering why you recommend that particular Vit. C since I notice that it comes in the form of ascorbic acid which is the synthetic form of C. I’ve always been told by health professionals to stay away from the synthetic form. I was led to Pure Synergy’s “Pure Radiance” (among others) which is natural Vit. C from berries, organic, wildcrafted, etc. Any thoughts? Thank you, Trudy!!
Rosie
I’m not familiar with Pure Synergy’s “Pure Radiance” and will check it out
Hi Trudy! Thank you so much for the great information you provide. My question is, “can one get over Pyroluria?” I tested positive ( the highest my doctor had seen) and started treatment. I had modest improvement and was retested a year or so later and my test was negative and was negative again the following year.. I am still positive based on your questionnaire, but my doctor thinks I no longer have it because my Lyme disease symptoms have improved and the test is negative. Could it be gone or is it more likely that I got false negatives? I can’t help but wonder what might happen to the sample in the shipping process., I.e. degradation, etc. Thanks so much!!!
Cindy
It will be negative if you’re on the correct combo on supplements. If you stop them it should show up positive but false negatives are very common. If you have pyroluria it’s for life but I have heard some Lyme docs say it may look like pyroluria due to the Lyme and not actually be pyroluria. It’s an area I need to learn more about – right now I’m not convinced 🙂
I’d love to hear if you used the same lab for all 3 tests? and which lab/s you used? thanks
Yes, I understand, but I’m still curious as to why you recommend a Vit. C product that’s synthetic…ascorbic acid. I’m wondering what I’m missing. Thanks again!!
Yes, and it is the only thing I am allergic to is ascorbic acid.
Hi Trudy! Thanks for you reply. Yes, I did use the same lab every time. I believe
it was Vitamin Diagnostics. I was instructed to stop my supplements for 48 hours prior to the test. I always feel better when taking the supplements, so I think that for me it is for life. Thank again!
Cindy
If someone feels better taking the supplements and scores high on the questionnaire that is enough for me! Glad to hear it.
Thanks for letting me know re Vitamin Diagnostics. Prior to 2010 we used Vitamin Diagnostics and found the pyroluria urine test results correlated with the questionnaire. They then changed the way they did testing and we saw tons of negatives despite the > 15 score on the questionnaire. I have a follow-up question if you don’t mind. What year was your positive results and what year were your negative results?
Trudy,
I’m afraid I don’t have a copy of the original test, but to the best of my recollection, the first test was done in 2009 or 2010. I was retested in 2014 and I think in 2012.
Thanks Cindy – that seems to fit the dates when the lab changed their testing method. I’m always gathering information I can share with my community and this is good to know.
I am curious if there are any other multi vitamins you recommend. I live in Canada and they do not ship them here. (And if you order on Amazon, they are over $200!)
I have another question as well, one that confounds me. Perhaps I am just weird. But the same amino acid can have a different effect on me at different times. I tried tyrosine one night when I was obsessive and spacey, and it was amazing. I tried it again a few days later – the same thing. But when I started taking it regularly, for a week, it didn’t seem to have the same effect on me. So I stopped taking it.
I tried GABA, which had no effect, and lysine, which seemed to ease my anxiety. But today Lysine made me more anxious, so I took GABA again (since I still had the bottle) and felt better.
You recommend doing a test, and if the amino acid helps, to start taking it on a regular basis. I haven’t done this, since things seem to change around so much.
Are there some people that just need amino acids periodically, rather then on an ongoing basis?
OMG! My zinc challenge arrived in the mail. I put 2 tablespoons in a cup and put it in my mouth swished it around and tasted nothing except sort of like stale warm WATER…. wow! Held it there for 30 seconds, and I’d say after about 25 seconds I noticed a very dry aftertaste in my mouth and then I spit it out, but it took THAT long for that to even occur…! I was shocked! I guess I need zinc!!! I was truly amazed at this….. 🙂
Yes Cindy, zinc is commonly low and this is not atypical to see
I have read on the internet that the taste test is not reliable but I don’t see why not. It should taste terrible right away. I’m going to finish up this bottle, get another one and then see how things are. Or maybe just go to our local vitamin store and buy the Optizinc with B6 and save the zinc challenge for taste testing. Is there a reason why Optizinc includes 20 mg of B6? And, thanks so much Trudy. Your book has been of great value. Just one small question, if you get time… Do you think a little GABA would help for anxiety for long car trips (a 3-4 day’er). I don’t do well on these trips and avoid them but need to go home and visit. Any advice is greatly appreciated.
i have generalized anxiety, muscle tension, tingling and “jumpy” muscles in my back and abdomen. I have nerve issues in my neck and back that causes dizziness, then an off balance feeling when my neck muscles are tight. I have a tight occipital area that spreads down the back and arms and back of legs. L taurine helps some with the anxiety, GABA with it too….but I got the wrong kind so back to the store I go) I have had melanoma so I have to stay away from Tyrosine. My neurologist has me on .25mg of Clonopin per am. I am low GABA, Low endorphins, and low serotonin. I don’t know where to go with all these suggestions….I wake up every day really early and can’t get back to sleep. I feel like a mess and taking all these supplements without guidance makes me nervous. I would like to know what to start with….what to take and what dosage and then tweek if from there. Can you help me?
Christine
I’m sorry to hear all this. You have a lot going on and I suggest finding a practitioner to work with. And get my book “The Antianxiety Food Solution” so you have a solid understanding of the basics. I’d also question how much the benzodiazapine is contributing to all this. I’ll be doing a talk on this in a few weeks “Say NO to benzodiazepines for anxiety!” https://www.everywomanover29.com/blog/no-to-benzodiazepines-for-anxiety/
how do you know when you need to take the vit c to counter act the amino acid?
Trudy, I have so much anxiety and don’t know what to do! I am on luvox and unfortunatel on 2 mg. Of alprazolam. Can I try gaba or tryptophan to help? I am gluten free and eat beautifully. I take a good B complex and optizinc. I also take a great magnesium supplement and probiotics. How would I try gaba or tryptophan? Thank you:-)
Get off the benzodiazepines!!!!!!!!!!!!! It literally has ruined my life and other people that I met through my taper process, which VERY few people/docs know how to do correctly, by the way…don’t trust most docs of any kind…do your homework, but GET OFF THEM!!! Please!!
Thank you Rosie, Believe me I know! I have become soooo aware and have changed everything (whole foods no gluten gmo free and now have a prediabetic A1C. I’ve lost 60 pounds and at age 56 I now weigh what I did as an aerobic instructor at age 24. Unfortunately I did not know the benzo problems. I have a severely handicapped son and took what was prescribed me. Now I must change that!
Chiming in a bit late here and didn’t read every single post to see if this was mentioned, but…..
For those of us with Hashimoto’s thyroiditis, taking 600 mg inositol daily along with selenium (study dosage was only 83 mcg, but 200-400 mcg selenomethionine is the usual recommendation), reduces thyroid autoantibodies more effectively than taking selenium alone. Here’s a link to the study: http://www.ncbi.nlm.nih.gov/pubmed/24224112
I tend to recommend the NOW brand product, as it’s less expensive than the DFH product and is very clean. Consumer Labs consistently rates NOW products as providing exactly what they state on their labels and as being very low-to-no in toxins.
Thanks for sharing this interesting research Jodi – it’s new to me. I’ve recently being seeing quite a bit of research showing overlapping symptoms of underactive thyroid and anxiety (and even social anxiety) so this makes sense.
I’m assuming you have Hashimoto’s thyroiditis and take it? do you find it helps with anxiety and obsessive thinking too?
Thanks for the NOW – Consumer labs feedback. I like the DFH powder because my clients often need higher amounts and the powder is simply more convenient
The NOW product IS a powder, without anything else added. A quarter teaspoon provides more than 700 mg inositol.
I do have Hashimoto’s and my thyroid peroxidase autoantibodies, which are the main diagnostic autoantibodies, have come down since I added inositol to the selenium. Both low AND high thyroid hormone levels can lead to anxiety, as can low cortisol, so proper testing is critical.
Both inositol AND selenium can be helpful for anxiety, and I figure that anything that helps with anxiety helps with obsessive thinking, which often arises from the anxiety itself. (Selenium study: http://www.ncbi.nlm.nih.gov/pubmed/1873372).
High dose niacinamide can also be helpful but may cause nausea. And 2.64 grams each lysine and arginine have been found to be especially effective (http://www.ncbi.nlm.nih.gov/pubmed/17510493).
Thanks Jodi and love these additional studies! nutrients are so powerful
Hi Trudy,
Can you please clarify what you mean about Vit C for negating the effects of amino acids? Does that mean if I’m taking Vit C at the same time as tryptophan or GABA (which I am at the moment) those amino acids won’t be effective? I take vit C in the morning and the amino acids at night.
Thanks for your help with this! And thanks for all the info on your site (which I also discovered after seeing your interview on the Depression Sessions). I’ve been trying tryptophan and GABA and they seem to be helping! I’ve also started on zinc and B6 as I think I most likely have pyroluria although I haven’t been tested, but my daughter has been tested and has pyroluria, high histamine, candida and probably low methylator… and I think I pretty much have the same issues!
Just wondering if you have any experience with amino acids and ADHD / autistic tendencies? I was going to try to give her a bit of GABA to see if it helps with some of those issues but read in one of the comments you don’t recommend it for children? I read another blog by a mum of autistic children who gives her sons 1000mg GABA daily. Just wondering what amino acids you would give to a child (5 years’ old) in this situation, and how much?
Thanks for your help! 🙂
Hello Trudy,
I was diagnosed with social anxiety 15 years ago and have been on 10mg of paxil. Well, I’m still anxious and was wondering if u could recommend a way of me getting off of it?
Thank you,
Jeannie
Jeannie
I have my clients talk to their doctor about doing a taper in the future but first work on nourishment like real whole food, no gluten, no caffeine, addressing gut health, addressing nutritional deficiencies (like low D, zinc, iron), looking at neurotransmitter imbalances, stress reduction, adrenal health etc
Hi Trudy
In ref to the summit about L-Trytophan for insomnia
you recommended the Lidtke L-Tryptophan;
and I got that one Lidtke 500mg caps;
but did not help and getting some like buzzing in ears..
not sure what that is ?
Thank you for letting me know, what I could take.
Romy
Not everyone benefits from tryptophan and there are many possible causes of insomnia. If it’s low serotonin then tryptophan and/or melatonin may help (and sometimes 5-HTP). Otherwise other cause/s need to be investigated and addressed – low blood sugar, low GABA, gluten issues, SIBO, high cortisol and medication side-effects/withdrawal effects (like benzodiazepines) etc
Any time a client has negative effects from a supplement, it is stopped. I have not had anyone report buzzing in the ears from Lidtke tryptophan but anything is possible.
Thank you Trudy !
I will try it again and open the caps.
Not taking medz. no gluten diet no SIBO.
Thank you.
Romy – If anything, I’d have a client with this issue start with a dab and increase slowly over a week. Although with no benefits from 500mg it’s unlikely that smaller amounts will help
oh ok I see thanks Judy !!
Trudy: I am on bioidentical hormones but feel horrible. I sweat all night long and feel weak from it. I have hashimotos and had a discotomy in July so am on oxycodone, xanax, flexeril and armour thyroid. I have pyloruria and take all the supplements you recommended but wondered if I can take endorphigen from Lidtke or is there a reason not to for me?
Thank you! Diane
Diane
There are no medications that interact with DPA/endorphigen. If it helps, many folks find that incorporating acupuncture helps even more. Many people on muscle relaxants like flexeril find that GABA helps a great deal and allows them to stop of use less.
I’m not a fan of Xanax and I encourage you to educate yourself about concerns with the benzodiazepines https://www.everywomanover29.com/blog/benzodiazepines-more-harm-than-good/
All the best with getting your hormones balanced too – restorative sleep is key for overall healing.
Hi Diane D.,
As a person who had well over 22 years of their life stripped away as a result of benzo use, I’d HIGHLY recommend that you get off that poison…no matter what anybody says!! I’ve been going through liquid titration for a long time to get off a different, but equally as horrible, benzo. I’m not sure how much you’re taking or how long, but as enthusiastically as I could say, PLEASE get off that horrible poison no matter how much or how long you’ve been on it. It’ll ruin your life, not to mention interact terribly with other meds you’re taking. I was simply following doctor’s orders, but believe it when I tell you that most of them are clueless about what they do to a person, their family, loved ones, and how to titrate off them. You have enough other challenges as it is. Getting off the Xanax would only help. The tolerance symptoms of using the drug beyond several weeks will cause so many other problems. I wish I could say it stronger (but Trudy wouldn’t allow it), but ditch the benzo and I BET your life gets remarkably better. Just takes some time. Prayers headed your way!!! BTW, hormone therapy doesn’t mix well with benzos at all (surprise!)…with the Armour, you’re probably O.K., but hormones affect the metabolizing of the benzo and vice-versa.
For what it’s worth and just because I’m on a mission to get the word out about benzo use…
Rose – thanks for your encouragement and sorry to hear what you have been through
Trudy – I was taking the Lidtke EndorphiGen for cravings and had a bottle with the label “Pain & Cravings” but Lidtke changed the label and it’s now “MINOR Pain”. I checked my current bottle with the label “pain & cravings” and the new “Minor Pain” labeled bottle has the same ingredients as the old label (Riboflavin 2mg; Pyridoxal 5-phosphate 2mg; and D-Phenlalanine 500mg) confirmed when I received a new bottle from Emerson. Lidtke is now selling 2 versions of EndorphiGen. The other bottle they are offering has the label “COMMON Pain” and they RAISED the first 2 ingredients to 5mg (the D-Phenlalanine is still 500mg). I don’t know which bottle you’d recommend but I am continuing the with the Minor Pain labeled bottle as that’s the bottle you referred to above in the embedded link. I didn’t know if you were aware of this change. Do you think this change in doses (along with the label change) matters when ordering EndorphiGen? Would the new bottle “Common Pain” be even better when trying to reduce cravings? It’s too bad they took the word CRAVINGS off the label, because it works really well to curb them. I use the item (“Minor Pain” label) for my cravings by taking one in the morning and it has dramatically reduced my cravings, especially in the afternoon.
Lynn
I was not aware they had changed the label and amounts of B vitamin co-factors. It doesn’t even seem terribly clear on their site – perhaps they are in transition.
The main thing is that the DPA is the same and that it’s working so beautifully for you for your cravings! I love hearing success stories like this!
Hi Trudy,
Just a quick question about protein powders: I’ve been reading in your book where you mention using protein powder in a smoothie. However, in the book “Nourishing Traditions”, which you have endorsed, they are really down on using protein powders and talk about their carcinogenic properties, etc. (due to the way they’re processed).
So … is there any protein powder out there you’d recommend – one that hasn’t been processed at high temperatures, etc?
Thanks,
Francine
Francine
Yes getting a clean, gluten-free one that hasn’t been processed at high temps is key + one that is tolerated – whey, rice, pea are all options. There is even a beef option now but I’d say just eat some beef! I do not like soy.
I like Designs for Health and recommend their plain or vanilla ones as I find the flavored ones are way too sweet (even though they use xylitol and/or stevia).
Here are a few links:
Whey cool plain https://www.emersonecologics.com/Products/EmersonMain/PID-WHEY5.aspx
Paleocleanse https://www.emersonecologics.com/Products/EmersonMain/PID-PALEC.aspx
Pure pea protein https://www.emersonecologics.com/Products/EmersonMain/PID-D03132.aspx
PurePaleo (hydrobeef) https://www.emersonecologics.com/Products/EmersonMain/PID-D04122.aspx (this one is very sweet!)
Hydrolyzyme (this really helps for shake digestion since it’s liquid and passes through the stomach quicker than a real meal) https://www.emersonecologics.com/Products/EmersonMain/PID-D03965.aspx
I know some practitioners and groups like WAPF have concerns and agree that eating a real whole foods breakfast is ideal. But if you’re traveling or rushed or have pyroluria (and can’t stomach a big breakfast) or just starting to move away from a junk food diet, having a shake with quality ingredients is a good option and better than no breakfast at all!
Trudy, I started tryptophan (lidtke 500mg) and inositol (2g per 500mg of tryptophan). Do you recommend taking them at the same time? I take 1 tryptophan in the MA and 2 at BT but i feel like i would benefit more from taking them in the morning because most od my anxiety starts early mornings. Would that be ok? I know you reccomend taking 5-HTP in the morning insted of tryptophan but I can’t due to high cortisol.
Stef
Initially taking supplements separately helps me and my clients figure out what is working well – then they can be combined. If tolerated and needed tryptophan can be taken in the morning – many do well on it at this time. Some people do fine on 5-HTP too, even when cortisol is high – we just need to monitor how a person feels.
With high cortisol I always add Seriphos (Interplexus) or Destress and we work on figuring out why the cortisol is high.
Looking into possible low GABA is also an option
Thanks Trudy! That has been my biggest strugle, trying to find the cause for the high cortosol. The doctors keep saying that I am stressed which is NOT the case. I have no or very little stress in my every day life. Where do I even start looking for the cause of the high cortisol? Any idea is very much appriciated!
Stef
You are unique in not having stress in your life – good for you! Keep in mind that physical factors like gluten, parasites, toxins, infections, inflammation etc are also stresses and can affect cortisol
Excuse my ignorance, Trudy. How does 5-HTP interfere with high cortisol?? I have high cortisol late at night (3am), and I was told that taking the 5-HTP in the afternoon and early evening would help with sleep. Again, how does 5-HTP relate to high cortisol levels? Thank you!!!
Dear Trudy, yes I am very thanksful to God for the live I have 🙂 i already eliminated the gluten and eat healthy and feel better, but still not where I want to be. I am in the process of eliminating the toxins. I know you can’t offer any spesific advice, but how do I eliminate the other things you mentioned? Are there any spesific tests I should get done? I dont recal reading about it in your book.
Thanks! Stef 🙂
Stef
Parasites/candida/dysbiosis: a functional stool test; SIBO: a breath test; inflammation: hsCRP; toxins: hair analysis. These are a few to consider. Here is a blog post with testing information https://www.everywomanover29.com/blog/nutritional-testing-find-cause-anxiety/
Rosie
Many people do very well taking 5-HTP afternoon and evening for sleep and anxiety. For some people 5-HTP can be too stimulating especially if they feel wired-tired and have high cortisol. This study found that 200mg 5-HTP raised salivary cortisol levels http://www.ncbi.nlm.nih.gov/pubmed/12073163.
High cortisol at night can affect sleep so we don’t want to increase it. In this instance I’d have my client try tryptophan and use Seriphos or Destress to lower the high cortisol + try and figure out why it’s high.
Thank you for that 5-HTP info, Trudy! Gotta ask… 1) How DO people go about finding the root cause of the high cortisol and, 2) Can you direct me to the Destress supplement? I did a search but must have missed something. Again, thank you! P.S. I did try tryptophan sublingually, but no luck at all.
Trudy- how do I go about ordering some of the high cortosol tests you mentioned above? It seems that the labs you mention on your web site require a doctor order and my doctor is not very coperative when it comes to ordering tests. Is there any way other way these tests can be ordered?
Thank you 🙂
Hello Trudy! I was wondering why you don’t recommend zinc products that contain copper? Doesn’t taking a lot of zinc cause a copper deficiency?
Katy
Hi Trudy,
My MD thinks that if GABA works for mood then I must have leaky gut and my brain-gut barrier is leaky. What do u say?
Hi Chris, I’m a holistic nutritionist and former curriculum writer for a nutrition school, and I have found that this is most likely NOT true. There are several studies, done on both anxious and healthy not mood-disordered individuals, that show that GABA supplementation does indeed reduce markers of stress and anxiety via a number of actions. I’m going to post links to these studies for you. If your doctor gets defensive, he may say things like, These people probably weren’t really healthy, or, These studies were done on groups that were too small. I say that if you can obtain good results without having to resort to huge numbers of people, you’ve got a good product on your hands (I refer you to the book, Death by Food Pyramid, by Denise Minger, for a discussion of the problems with big research studies). Here are the links: http://www.ncbi.nlm.nih.gov/pubmed/26227783 http://www.ncbi.nlm.nih.gov/pubmed/22203366 http://www.ncbi.nlm.nih.gov/pubmed/16971751
Jodi
Thanks for weighing in here. It good to hear from other nutrition practitioners who use GABA with success. I’m curious about the forms and doses you use with your clients
Thanks too for sharing those studies. There isn’t much research on GABA but these ones are good ones.
I also like to share the fact that we have GABA receptors all over the body (muscles, pituitary, pancreas, adrenal glands etc) and that GABA is likely working at a peripheral level too https://www.everywomanover29.com/blog/anxiety-summit-targeted-individual-amino-acids-eliminating-anxiety-practical-applications/
I was previously using PharmaGABA, due to its supposed superiority over regular GABA powder, but because it’s so expensive, I decided to try regular GABA. It seems to work as well or maybe even better. Right now I’m using Integrative Therapeutics “GABA,” 750 mg v-caps. I don’t have a big amino acid practice, so I don’t have a lot of client experience to back this up.
Thanks for the information regarding GABA reception throughout the body. Makes sense, of course.
Jodi
Good to hear – I find regular GABA works best for most of my clients too. I typically start them on GABA Calm which has 125 mg GABA and we go up from there. When starting out 750mg tends to be too much for most of my clients but we may get up to that amount eventually and often at night.
Chris
I don’t agree with this. We have GABA receptors all over the body (muscles, pituitary, pancreas, adrenal glands etc) and GABA is likely working at a peripheral level too.
You can read more about this here https://www.everywomanover29.com/blog/anxiety-summit-targeted-individual-amino-acids-eliminating-anxiety-practical-applications/
Thanks! I feel better on GABA. I take what Trudy recommends from Emerson. I would like to find one I can buy at the store. I can’t take Tyrosine so can’t take GABA Calm. Thanks!
Hi Trudy,
I know this is a little off topic to most recent posts, but I still thought I’d ask since you’re the nutrition guru 🙂 Anyway, long story, but what would you say is a really good curcumin supplement? I know that absorption can be a challenge sometimes (and they all claim to be the best), so I’d really value your opinion.
The same question for Resveratrol too, if you don’t mind.
We all thank you for ALL you do!!
Rosie
NeuroBiologix has a topical form. I would be curious what Trudy thinks of it too.
Chris
The Calming Cream by NeuroBiologix (http://www.neurobiologix.com/Calming-Cream-Topical-p/168.htm) is new to me and sounds interesting. I’d love to see some with just GABA/theanine and no tyrosine or 5-HTP too. Have you tried it? with success?
Hi,
What are your thoughts on Pure Encapsulations Inositol? Is it a good product? And, do you like gaba calm best for physical anxiety/panic? Or just straight gaba? Thanks in advance for your help 🙂
I like Pure Encapsulations Inositol. Some people do great on GABA Calm and some do better on straight GABA. It depends on the amino acid precautions and how the person responds to the trial
Trudy, why do you think someone has a low gaba or seretonin? I guess i am trying to understand the root cause of having low neurotransmiterrs. Could bad gut bacteria/leaku gut cause it? Does this go back to your 60 causes of anxiety?
Michele
There are many causes and gut issues could be one of them. We made neurotransmitters in our gut and absorb nutrients from our food to make neurotransmitters. Stress and toxins and diet and yes all the 60 possible causes could be factors.
Thank you so much for this info! I am trying to determine the best protocol to start with for low GABA AND low serotonin and a bit of low blood sugar. What are the dosages for a 15 year old who is 85 pounds? My child also has one copy of a MTHFR mutation–she is A1298C heterozygous–which basically means it is harder for her to utilize B12 and Folate and make neurotransmitters. Do you have any recommendations on the best protocol for this? Where do I start? Thank you soooo much!!
Susanne
I use 120lbs as the cut-off for adult doses so would start with half for an 85lb 15 year old. I have my clients do the amino acid questionnaire and we do one amino acid trial at a time. I typically address low blood sugar first and make sure to make food changes like adding protein at breakfast. Of course all the other diet changes too like real food, no sugar, no gluten, no caffeine, addressing gut health, getting enough sleep etc. If you need step by step guidance my books spells it all out and so does the Amazing Aminos for Anxiety program https://www.everywomanover29.com/aminosforanxietyhs/
HI Trudy,
So, if a person is taking higher amounts of Vitamin to support their adrenals, then it is also working to negate some of the benefits of taking the aminos? In that case, do you find it not even worthwhile to take the aminos or do they have to go on even higher dosages to see a benefit?
Trudy – do you see side effects from the pyroluria treatment? My son is following a protocol for pyroluria (Dr Albert Mensah) which is like yours. My son claims he is having trouble urinating and with sexual function (erections). He also however does drink alcohol regularly. Have you heard of such problems with treatment? Thank you.
Chris
I have not received this feedback and I’d suggest checking with Dr. Mensah and his team.
I was looking at the recommendations for low serotonin levels. I am interested in the Inositol. Does it have to be taken with tryptophan or can it be taken alone first and just go from there?
Carol
It’s very individual. Some of my clients do well on both, some just one or the other
Thank you. Just wanted to make sure.
Trudy, as I mentioned on the Anxiety Summit call last week, I thought Lidtke changed the formula on the 100mg chewable. I sent them an email and told them it was not working in early December, and they just sent the reformulated chewables to me. They do not work for me, they are stimulating, and do not create restful sleep, nor do they create “normal sleep patterns”. I just sent them an email and they responded that they are aware of the issue, that is a manufacturing issue but that they have not reformulated the chewable, and are still using the highest quality of ingredients. They are working on the manufacturing issue at this time. I only needed 2 chewables in the evening. I have high cortisol so 5-htp is not an option. I tried opening Pure Encapsulations tryptophan (500mg) capsules onto my tongue, mixing them with some gaba powder from the T-SAP caps to mask the bitter flavor of the tryptophan powder. That didn’t seem to really work well for me either. I then ordered Lidtke’s new “CBD oil with tryptophan” liquid, put that under my tongue just as I got under the covers in bed and, finally had restful sleep!! I am so happy they had this as an option. I saw it on your Facebook page and decided to give it atry. I am going to use this new product until they get the chewable manufacturing issue resolved.
Lynn
Thanks for the update on Lidtke chewable tryptophan. I was not aware of this. Did Lidtke say when the new product will be available? I wonder if they’ve done a recall? I will reach out to them too.
I’m glad to hear you’ve found an alternative with the CBD oil. Would you share how much of that is working for you?
I’m also curious to know if you also tried the Lidtke 500mg tryptophan or only the Pure Encapsulations tryptophan opened? I’m asking since the Lidtke 500mg tryptophan has historically provided better results
Lidtke said they’ve been inspecting & testing for several weeks now and will continue that process but did not mention a time frame, nor a recall. They said they will not stop until they get them just right, but that there are hundreds of steps in the manufacturing process so it takes time. They stated they never cut corners for the sake of cost, that they use the best ingredients they can find. As far as the CBD oil with tryptophan goes, I used one dropper full, which equals about 30 drops. I am going to try using less and see if that will work, but I’ve used one dropper full for 3 nights and that dose has worked great. I also have the Lidtke 500mg caps and tried them as well (swallowed & opened-they are HARD to open), going up to 1000mg. I think I need a sublingual, because swallowing the caps didn’t help me sleep, especially when compared to the 200mg chewable that I was using, or this dropper full dose.
Lynn
I called Lidtke and have been assured that the chewable tryptophan do still work the same as they always have, there are no issues with the formula, and they have no complaints from anyone else. As you mentioned, they shared that they did recently change the agent that holds them together so they would be less hard and not so grey.
Please keep us updated on how you do if you trial them again and let’s see if we hear issues from anyone else. If you still have issues with sleep then it could be that you no longer need serotonin support and it’s simply too much. Too much of any amino can cause a reverse effect. Then I’d look at other causes of the sleep issues – like the high cortisol, low GABA, parasites etc
Thanks for the CBD oil information
Lynn, I have a question for you, if you don’t mind. You sound knowledgeable and may have already looked into this, so I pose this question so I can gain more information for myself and my nutrition practice clients. If you know you have high cortisol, are you also taking supplements that can lower it, so you can sleep? Phosphatidylserine? Lemon balm? Adaptogenic herbs? Melatonin? (http://onlinelibrary.wiley.com/doi/10.1002/ddr.20014/abstract). So, just wondering, really, if you’re finding aminos to be the most effective formulas for you, as opposed to these specific cortisol-lowering supplements. Thx.
I am using Seriphos in the evening. I take 3 capsules. I have tried Melatonin sublingual 1 mg by Source Naturals which works to get me to sleep but I am groggy in the morning – that’s why I preferred two Lidtke chewable tryptophan – they didn’t make me groggy in the AM. I also tried the Douglas Labs (both the 1mg and the 3mg prolonged release) but that left me groggy in the AM as well. I am currently using Pure Encapsulations l-glutamine capsules in the AM, endorphigen for cravings during the day, and was using the original chewable tryptophan before bed. I have some T-SAP gaba caps and when I get my Pure Encapsulations tryptophan caps on Saturday I am going to try taking one T-SAP cap along with one tryptophan 500mg cap opened on my tongue to see if that will help mask the bitter taste of the tryptophan and see how that works. I guess a combo of both cortisol lowering supplements and aminos is what is (was) working for me.
Thanks, Lynn, that’s really good information for me to have. I like the Seriphos, too. This is also a good reminder for me that we all have unique requirements and we all metabolize substances differently.
You mentioned alternative Vitamin C products. Why would folic acid be a problem and is it only recommended if you take amino acids?
I was wondering, what do you think of probiotics. Should they be taken as a supplement or do we get enough from food? And will a probiotic supplement mix bad with any of the recommended supplemnts or amino acids?
Hi. Is the opti-zinc you suggest also good for folks with very low hcl levels?
Thanks.
Catherine
I’m not aware of any form of zinc being better when HCl is low but you do need good HCl levels to be able to absorb zinc so I’d address that too.
Zinc also plays a role in the maintenance of gastric HCl levels, so addressing both simultaneously may lead to the best results, i.e., take some betaine hydrochloride AND your zinc at meal time. This will help stomach secretions and the absorption of zinc.
Hi Trudy,
Have you read any research on MTHFR by Dr. Kendall Stewart? He has supplants by Neurobiologic. I would like to know your thoughts on his research and perhaps with the Anxiety Summit plans….he could be involved too? The topic is so confusing to me
Thanks!
HI Trudy,
What protocol do you recommend to taper off of Cymbalta?
What are your thoughts about using Naltrexone as a treatment for Hashimotos?
Thank you!
Hi Lynn
This medication taper question is one I get a lot so let me create a blog post and I’ll come back and share the link.
I don’t have any experience with low dose Naltrexone and Hashimoto’s thyroiditis but have heard good things. I highly regard the work of Izabella Wentz, PharmD and author of “Hashimoto’s Thyroiditis: Lifestyle Interventions for Finding and Treating the Root Cause” (http://www.amazon.com/gp/product/0615825796/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=0615825796&linkCode=as2&tag=wwwantianxiet-20&linkId=IXHYK3RLHECYZG4Y) and here is an article she has written on the topic http://thyroidpharmacist.com/articles/low-dose-naltrexone-and-hashimotos
LDN didn’t do anything for my Hashi’s, but it may be because my Hashi’s isn’t really active. I always have autoantibodies but no progression of the disease, and it’s been over 10 years. What has worked for me though, to bring down the TPO autoantibodies, is selenium with myo-inositol (aka inositol), which has done a much better job for me than selenium, alone. It can also help lower elevated TSH (http://www.ncbi.nlm.nih.gov/pubmed/24224112–full study is available). The study used 600 mg inositol but only 83 mcg Se, which is pretty low. I use 200 mcg selenium as methylselenocysteine. Selenium, necessary for production of the body’s main endogenous antioxidant glutathione, is itself a potent antioxidant and a critical nutrient for thyroid function. Myo-inositol’s role is less well understood but may have to do with its effects on cell membrane signaling of hormones, including TSH. These nutrients together affect both TSH and immune function, so trying this combination first, before using a drug, might be preferable, because they can address root causes: immune imbalance, oxidative stress.
Jodi
Thanks for sharing and love the results you’ve seen. I agree, addressing this from a nutritional point of view would be my focus too, with medications as a last resort. I’m curious about the form of selenium you use: methylselenocysteine? can you please share more?
I really like inositol but am finding that more people are reacting to it, due to them having SIBO. Have you see this with your clients? How much are you using?
Selenocysteine and selenomethione are the organic forms of selenium found in foods. From what I’ve read, as supplements, either one of these is fine to use. However, according to the research, selenocysteine is the form of selenium most abundant in the thyroid gland, as a component of the enzymes used to regulate thyroid hormone production (http://www.physicianspractice.com/articles/dietary-supplements-selenium-update). Deficiency is associated with Hashimoto’s. I’m not sure what the methyl group provides other than, perhaps, enhancing bioavailability.
I don’t see a lot of clients right now, so don’t have the experience you have with the inositol. For thyroid support, I use ¼ tsp of pure inositol powder, which provides 730 mg inositol, a little more than what was used in the studies. For anxiety (which I had when my cortisol flat-lined), I used 1 tsp 3x/day (8.76 g), which is what my naturopath recommended and far less than the 12-18 g used in clinical trials. I found it very effective. I could see that inositol would be problematic in SIBO, though, given that it’s a sugar alcohol.
Thanks Jodi! good to know re selenocysteine and selenomethione as supplements!
And yes I have use up to 18g of inositol with a number of clients, with great success
Is Izabella’s book good for people who have say, hypothyroidism, and not Hashimoto’s per se?
….or, what IS a good resource for hypothyroidism (since 99% of doctors are clueless)?
What kind of reactions do people with SIBO get to inositol? I just purchased some based on your recommendations – do I need to rule out SIBO first?
Bloating and gas – and you’ll know pretty quickly
Hi Trudy,
In your book, you recommend a free form amino acid blend to be taken at each meal if supplementing with DPA. What specific brands would you recommend?
Amber
You want to always use one that does contain tryptophan. Some do not. I’ll swing back with some links to products I like
I just want to follow this when you put the links up.
Hi Trudy,
In your book you mention that when taking amino acids you will get immediate feedback: positive effects, adverse or no changes. If you don’t get either positive or adverse effects, do you continue at the highest recommended dose until an improvement is felt/symptoms resolve?
I guess I’m asking if a client doesn’t feel an immediate effect, how do you judge a good dose? And of the clients that don’t feel an immediate improvement, is there an average time that they begin to feel improvement (a week, a month)?
Many thanks, Susan
Susan
With the amino acids the effects are immediate and can be seen within 15 seconds to 5 minutes typically, sometimes 10 minutes. If someone is not seeing any effects in 2 days (and that’s a long time to wait) I have them increase until they get an effect. If they don’t ever get good results (or if they get an adverse effect) we stop and look elsewhere.
I am a 63 year old woman with a history of Celiac Disease, Hashimoto’s, anxiety and depression, and Osteoporosis. I have been taking 5,000 IU’s of D3 for my Osteoporosis for over a year, and recently when I had labs done, my D3 level was still severely low. My guess is that the brand of D3 that I have been taking has little to no vitamin D in it, so I was wondering if you could tell me where I could obtain a pharmaceutical grade vitamin D. Thank you.
Barbara
As I mentioned above liquid may be a good option for you and you may need less than the 5000 – this one by Thorne is a good one https://www.emersonecologics.com/Products/EmersonMain/PID-T00018.aspx
I have had good results with the Designs for health Vitamin D Supreme it has 5000IU and vitamin K and K2. https://www.emersonecologics.com/Products/EmersonMain/PID-VIDS6.aspx
If you’d like to purchase from Emerson (all professional grade supplements), this blog has a link on how to set up an account https://www.everywomanover29.com/blog/amino-acids-pyroluria-supplements/
I would also consider low magnesium to be a factor and addressing this can help. Also, if you have an expressing VDR gene mutation this may be a factor.
Trudy,
I can’t thank you enough for the work that you do and the way that you make yourself available to the public. I shall be forever grateful.
I’m going to try the new Vitamin D that you suggested along with the Vitamin K and K2. If that doesn’t work, I’ll proceed in getting tested for the VDR gene mutation. I have the MTHFR mutation, so having another mutation wouldn’t surprise me.
Again, thank you for all that you do.
My pleasure! Check out http://www.23andme.com for the gene testing. You can get this and many more for $199 and its an at home kit.
Hi Trudy,
I’m a pixie dust, very sensitive person so really have to go low and slow with supplements and trying a new food. I have Lyme, mold, methylation problems and still have gut issues. Do you know if using supplement powder from purebulk.com is ok for some people? They have no added ingredients which would be great to try pyroluria supplements or amino acids without any other ingredients. Thanks so much!
Michelle
I’m not familiar with purebulk.com. I like the idea of something with no added ingredients but the other thing to consider is the quality of the actual active ingredient. I recommend Lidtke’s tryptophan because I know there are quality issues with tryptophan.
Thank you so much Trudy! I will order from the supplements list you have used and trust. I have found some on your list with less added ingredients so I will order those and give them a try. I’m signed up for the Lyme Summit and really enjoyed your interview! It was a big A-HA moment for me as I do believe I have pyroluria. I scored about a 25 on your questionnaire. I will be talking with my Dr. about this soon. I also have Lyme and mold infections and I’m homozygeous for A1298C MTHFR SNP and other SNP’s as well. Thanks again for all you do! 🙂
Something important to note is that those of us with autoimmune diseases often have fewer or less responsive vitamin D receptors, so it takes a greater amount of D to increase serum levels. In my nutrition practice I use Rx brand “Liqui-D3.” All it is is olive oil and vitamin D. One drop (not dropper) = 2,000 IU, so dosing is easy and convenient. It’s a professional level supplement but is likely available online. For osteoporosis, though, you’ll also want some vitamin K2. It helps calcium get to your bones, where it belongs, and not into your arteries.
Thanks for sharing what you’re doing Jodi – I also like liquid which is also helpful with folks with malabsorption issues. And yes the K2 is important
Do you approve of Country Life Gaba Relaxer? I didn’t see it on your list of recommended supplements. I’ve taken Gaba Calm and have also taken inositol separately.
I like Country Life GABA Relaxer and it was one of the products I took when I had my bad anxiety in my late 30s. I used it at night.
Hi Trudy. Thank you for the list of supplements. Do you have any opinion on using ‘raw whole-food’ based supplements? Garden of Life is one of the brands I’ve looked at. Any pro’s or cons to using food-based products when supplementing for pyroluria?
Disregard the ‘Garden of Life’ raw supplement inquiry … something tells me it might be best to stay away from their products .. (and I’ve learned this isn’t their first offence either) http://www.foodqualitynews.com/Food-Outbreaks/CDC-reports-more-Salmonella-illnesses-linked-to-Garden-of-Life
Thanks Lisa – I was not aware of this. It seems to be the RAW meal products that they’re having the issue with. This recall doesn’t apply to their other products. But I do find that people with mood issues do better on supplements that are not food based simply because they often have higher therapeutic levels of the various nutrients.
How often do you suggest taking the Gaba? Morning and night? or 3 times a day?
Melissa
Typically 4 x day, on waking, mid-morning, mid-afternoon and evening, based on a person’s needs. I encourage folks to read my book “The Antianxiety Food Solution” as the aminos chapter has detailed protocols and all the precautions.
Hello Trudy,
I have just been listening to one of your talks which has been
fascinating. After reading your book I tested positive for Pyrroluria
at the KEAC laboratory in the Netherlands. They call it HPU – there seem
to be many names!
I am curious about fatty acids. My fatty acids test says that I have normal levels of EPA/DHA but that omega-3’s as a percentage of total fats is a bit low (2.5%). My Linoleic Acid (LA) and Arachidonic Acid (AA) are on the border of ‘high’ but my Gamma-linoleic Acid (GLA) is on the border of ‘low’.
My question is: If I take a supplement such as Evening Primrose Oil (which is often around 1000mg LA and 130mg GLA per capsule), surely I am pushing my LA up even further just to get the GLA (and too much LA is not a good thing right)? Does this make sense?
Interested to hear what you think!
Many thanks,
Gemma
Gemma
When we see high LA and low GLA we want to think what could be affecting LA converting to GLA. Some things to consider: a high sugar diet and trans fats in the diet, smoking/alcohol, chemicals, infections, diabetes, hypothyroidism and other hormonal issues, inflammation etc.
Also, the delta-6 desaturase enzymes which makes the conversion needs vitamin C, vitamin B6, vitamin B3, zinc and magnesium as co-factors for the conversion to work well.
Thanks for getting back to me Trudy. I am pretty clean living (no smoking, alcohol, minimal chemicals), thyroid tests all ok. One interesting thing on my fatty acid test was raised Trans-vaccenic acid (23.8 – ref <15) and borderline Elaidic acid (25.2 – ref <25). I am thoroughly confused by this as three months prior to the test i was dairy free and having read up on trans-vaccenic acid it seems to be a natural trans-fat coming from dairy!
Hi Trudy, I just wanted to let you know that I ordered Lidke’s L-tryptophan powder because I thought it would be more economical, plus I find it hard to swallow too many pills. As it turns out L-tryptophan is very hydrophobic and will not mix with water at all. It will disperse in fat and alcohol…but who wants to do that? I emailed the company but they never responded with any suggestions. So I will try to put the powder in empty capsules until I run out of patience.
Sharon
Have you tried mixing in some mashed banana? that seems to work well It also mixes well with coconut oil. Both mask the taste a bit but adding carob makes a big difference. Using it mixed with inositol straight on the tongue works for some people too. I’d love to hear what you think?
I’m sure you’ll hear back from Lidtke too
Hi Trudy, Thank you so much for this blog post. This is extremely helpful! I listened to your talk on the Women’s Wellness summit this past week. You have such an amazing way of inspiring hope and I always feel so encouraged after listening to you. On that talk, you mentioned that good levels of HCL are needed for zinc absorption. Do you recommend using a supplement to increase HCL or are there effective ways to do so without a supplement (like using apple cider vinegar before meals). Also, when is it appropriate to take an amino acid complex (such as the Genestra amino complex) vs. individual amino acids? Thank you!
Jill
For some people apple cider vinegar is enough, for others adding HCl supplements are needed.
I like a free form amino complex for clients who are vegetarians or don’t eat much animal protein (with the latter we are working on diet changes), are recovering from injury, on SSRIs (and are not doing individual tryptophan or 5-HTP yet), nursing or have very low endorphins (and the DPA alone isn’t enough).
Trudy, After reading through your book and many blog posts on supplementing with amino acids, I’m planning on trialing some amino acids, starting with tryptophan (based on the questionnaires). I also feel that I would benefit from starting an amino acid complex as I’m struggling to get enough protein in my diet at the moment. I will start with just trialing one (i.e. probably the tryptophan first), but if I feel that both of them are helpful is it okay to take both within a day (i.e. tryptophan between meals and the amino acid complex with meals)? I wondered if it would be okay since they both contain tryptophan.
Jill
Yes, this is how I would do it
First of all THANK you for all you do!!
I am positive for the pyroluria questionnaire, low GABA and serotonin (I had post-partum depression – tend to respond well to 5-HTP, from all girls family, husband’s mom all girls look-alike family, etc.). I am currently under a lot of stress and am very physically tense, worrying, ruminating.
I now have EPO, zinc, B6 as well as vit.C , 5-HTP, GABA in my arsenal. I wonder how I should take all these during day (am, noon, supper, evening). I also have been using Relax-Max From Xymogen before bedtime PRN with good effect already.
Hi Trudy,
I know you recommend Lidtke L-Tryptophan. I live in Canada and it is difficult to find here. What do you think of Source Naturals L-Tryptophan or is there another company that you could suggest? I thought of Source Naturals as you recommend their GABA Calm and I noticed that Emerson Ecologics sells this L-Tryptophan.
Also, I started GABA Calm one week ago and since the past few days I sometimes feel agitated or hyper. Have you heard of this with GABA?
Thank you.
Nancy
I have not found other tryptophan products to work as well as Lidtke tryptophan. Emerson sells Lidtke products.
Too much GABA can make you feel agitated and the tyrosine in GABA Calm could do that too (even though it’s a very small amount). When this happens I have my clients try less of the GABA Calm or switch to a GABA only product.
Hi Trudy,
Thank you for your reply.
I was looking through your book once again and read something which I had not focused on before starting the GABA. You say not to take GABA when you have low blood pressure, which I have.
What does GABA do if you have low blood pressure?
Is it harmful to me?
Does this mean that I should never take GABA?
Thank you.
Nancy
It’s a caution only – watch and see how you feel. If a client feels worse on GABA then they stop.
Hi Trudy! I have listened to you speak at three different online summits now and am always fascinated! Thank you for your dedication to learning!
I am positive for pyroluria according to your questionnaire, and I have been on the supplement protocol for a couple weeks now. I haven’t noticed any changes, and I’m wondering if I need to increase my dosage. But if so, do I increase the dosages of all the pyroluria supplements? Or one at a time? Is there one I should start with? Thanks so much!!
Laurie
Zinc is increased based on the zinc challenge and B6 based on dream recall. I like to do one at a time
Hi Trudy,
I scored high on your questionnaire and my urine test from Health Diagnostics and Research Institute (formerly Vitamin Diagnostics) came back normal. I’ll try the supplements and see how I feel. When trying the P-5-P (I ran my 23 and Me report through Nutrahacker and it says to avoid B6 and take P-5-P instead) and zinc should I start with one of them first (since I’m really sensitive and still have gut issues) for about a week and see how I feel and then add the other one in case I have trouble with one and wouldn’t know which one it was if I started them both at the same time?
Also, do you still recommend the P-5-P capsule from Designs for Health? I didn’t see it on the above list but thought I had before (I may have missed it) and it seemed to only have P-5-P in it besides the ingredients of the capsule and I could just empty it on my food.
Thanks so much!
Michelle
Michelle
Doing one at a time is best for sensitive individuals. I do like DFH products and just added the P5P.
Thanks for letting me know about your results with your urine test from Health Diagnostics and Research Institute (formerly Vitamin Diagnostics) despite scoring high on the questionnaire. This is a lab I used to use when working at Recovery Systems with Julia Ross. It was accurate then and correlated with the questionnaire. They have since changed the testing and it appears to often be false negative.
Would you mind sharing your score and some of the key symptoms now? and please do let us know if you see improvement on the supplements.
I’d also love to know more about the Nutrahacker report and the fact that it says to avoid B6 and take P-5-P instead – which gene was it?
Hi Trudy,
Thanks for your reply and information. I guess there’s no other Lab that’s more accurate? I don’t think i’ll test again…just try the supplements instead.
Sure, I don’t mind sharing my score and symptoms – my score was: Urine volume – 1800 ml, HPL – 161/l and Kryptopyrrole 24h urine – 176 ug/24h.
I have Lyme and co-infections and my key symptoms are fatigue, nausea (any time of day), anxiety, depression,doom and gloom feeling when wake up, ruminating thoughts, gut pain/bloating, inner tension, bladder irritation feeling, stress out easily, irritable, joint pain, back pain, allergies, don’t sleep well, constipation, itchy rashes (eczema?), cognitive issues and worse when stressed. I have had white spots on my nails as a child but haven’t had them maybe since I went gluten free in 2008 and not long after went grain, dairy and sugar free. I had social anxiety as a child and it may have gotten a little better when I changed my diet.
My Dr. recommended Nutrahacker.com and it does have a lot of information. You can purchase all reports for 60.00 or just the gene mutation report and you get 2 free (can’t remember which one’s, sorry) for 37.00. The gene that said to avoid Vit. B6 but P-5-P was ok was CBS rs1801181, Folate One-Carbon Metabolism/Methylation (FOCM) and I’m heterozygous for it. I have encourage B6 on CBS rs234706, FOCM, and I’m heterozygous for it. I assume I would need to take P-5-P only though. I also have encourage B6 on MTHFR rs1801131, A1298C, homozygous but I assume I’ll need to take P-5-P.
I think my Dr. knows some about pyroluria because he warned about the false negative and may know to look at other bloodwork markers, etc. and symptoms and trying the supplements. I’ve got a list of markers Dr. Klinghardt looks at and I believe I read you have a list in your book for what else to look for? I haven’t ordered your book yet but will soon. I need to order the supplements and meet with my Dr. but will let you know how I do once I start the supplements. Hoping to feel better soon.
Thank you so much Trudy for all you do! 🙂
Michelle
Hi Trudy – Just wanted to add that the heterozygous CBS gene SNP that said to avoid b6 but P-5-P is ok was CBS A360A (rs1801181). The heterozygous CBS C699T (rs234706) has “encourage B6” and as I said before, I assume the P-5-P form is the one I should take.
Under the category “neurotransmitter levels”, I have 8 homozygous SNP’s (4 COMT, 2 GAD1, 2 MAO-A) and 6 heterozygous SNP’s (1 CHRNA5, 1 GAD1, 2 MAO-B, 1 NTRK2, 1 TH). Thought I’d let you know about this since it seems like a lot. Thanks!
Michelle
Dear Trudy,
I keep trying to have Tryptophan and D- Phenylalanine, and even if I have it in the middle of the
night, 6 hours away from food, I get _really bad_ wind problems.
I would like to take the Tryptophan for depression, and helps me sleep. The 5HTP worked well for sleeping
but made me really stroppy and snappy. The Tryptophan I have taken is Drs Best.
I live in Australia and can’t obtain the Lidtke brand here as far as I know. To order 1 bottle of 60 capsules will cost $29 USD ($39 AUS) and on top of that $55 Australian for postage. 2 bottles of 180 tab is $129 Australian and the $55 Aust postage. Sorry Trudy but I think that is impossible for me. Is there no way I can buy the Lidtke brand here in Australia.
Will it cause the same typhoonic bowel problems anyway? Thank you. I would appreciate a reply if you can answer. Kind Regards
Anne
Anne
I’d do one at a time to make sure you can see which one is causing the digestive distress. And then switch to another brand and try that one and see if it still happens.
As far as I know Lidtke Tryptophan is not available in Austrlia and doe have to shipped from the USA. I’ll ask them when I talk to the owner next week if they have plans to change this.
Hi Trudy, Thank you for replying. Yes I do only have one
at a time. Will try an other brand and see what happens.
Thanks for all your wonderful, helpful information that you put out there.
Anne
Dear Trudy,
Would you explain why amino acids should be taken between meals, either 30 minutes before or 60 minutes after a meal with protein?
Thank you for your blog and consideration on the questions submitted!
Dana
It’s so they don’t compete for absorption with the other amino acids in the protein you eat in a meal
HI Trudy
I was looking thru this post and I noticed that you might not suggest Opti-Zinc 30 Douglas Labs. That is what I’m still taking after our meeting. Any changes on this brand?
Darla
Glad it’s helpful! I don’t count what is in a multi as it’s typically a very small maintenance amount. I would use other markers – zinc challenge, alk phos, low zinc symptoms like smell/taste/joints and overall improvement in social anxiety
Jeff
Yes I like Opti-Zinc 30 Douglas Labs
Hi Trudy,
I have your book and I love it! I’m a holistic health practitioner and a holistic behavior therapist and I use your work as a resource with a lot of my clients.
Today, I write today about my daughter, Sophia. She’s 10 years old and has struggled with serious emotional and social anxiety challenges since infancy. We have seen therapists, had several rounds of psychoeducational testing conducted, have tried nutritional interventions (and had some success here and there). But, she remains plagued by intense anxiety and seems to fit the profile for pyroluria. I am desperate to find help for her, as she struggles with emotional regulation (intense meltdowns), is highly sensitive to environmental influences (sounds, etc), is very emotionally sensitive and experiences intense fears/anxiety everyday. It has caused a tremendous amount of stress and discord within our family.
My initial reaction is to want to start her immediately on B6, Zinc and EPO as you recommend. I’m a bit overwhelmed and I’m not certain where to start.
In my research, I found a website that sells a laboratory urine test for pyroluria. I think it might be prudent for me to go ahead and get the testing done, as it seems that I can do this without even having to involve a physician. Here is the link: http://store.riordanclinic.org/product/LPyr.html
Have you heard of this group?
Again, I would be eternally grateful for any and all advice you can send my way! I am desperate for answers and relief for my precious daughter.
With great appreciation,
Heather
Heather
I’m sorry to hear about your daughter. I use the questionnaire and response to the supps as the testing can be false negative. Many people choose to do it anyway and it may provide the results you’re seeking. I would also look into low serotonin and low GABA.
HI Trudy,
I was wondering if you new anybody that you could recommend in the San Jose, San Francisco or Marin County area for some follow up help. After you recommended the Zinc it change my symptoms for the better greatly. But I still have some things I would love to work on. I’m a person that likes one on one help in person. Also, I was wondering if you had any thoughts on the Empower-plus product from Session 3 Julia J Rucklidge I see a lot of good and bad reviews. I guess its a multi level marketing company. The good reviews sound so life changing that I wanted to give it a try. I also, just purchased session 4. Cant wait to listen to them
Thanks for any help that you can give me
Jeff
Glad to hear the zinc helped you! A colleague in Marin just moved to southern CA so let me check for you. You could also look at the NANP directory http://www.nanp.org for a local nutritionist.
I have heard that some people do really well with it (and of course there is plenty of supporting evidence to this effect as Julia Rucklidge shared) and there are an equal number who don’t seem to do well. I’ve heard as much as a 50:50 split of good:bad. I’m not thrilled about them being a MLM and prefer a multi with no copper – it may be the high copper individuals that don’t do so well on it but I can’t be sure.
Enjoy season 4!
Thanks for the help. I looked into NANP and it looks like nobody specializes in what you do. If somebody comes to mind in the future keep me in mind please. I have studied the Pyroluria Chapter of your book. It says Primrose oil. When I got the bottle is Says for Woman & PMS Can I take this also.?
Jeff
I have plans to start training practitioners for this reason – it’s my next big project
If anyone has low GLA the EPO is fine. Most pyrolurics need it and it helps zinc absorption. It’s also good for many women who have PMS hence the label
Hi Trudy
Do you know if any of the supps you suggest have mag strearate in them, what are your views on it as a filler, I’ve read that it can slow down absorption of nutrients, I think Suzy Cohen just wrote a blog about it.
Jane
I’m afraid many do and ideally it would be best to avoid this filler especially if you’re not seeing an improvement or are super-sensitive. That said, I have excellent results with these products that I currently use
I loved your talk. I have had daily migraines for 16 yrs which has ruined my health. No meds would help and I started on benzos. Sorry I did. I wonder if this would interfere w Gaba. My reg doc put me gabapentin. Horrible. I just got some Pharma GABA . Just took it. No effect so far. It’s been 3 hours. Should I continue. I have a lot of severe muscle pain in shoulders and I know its a stress response. After trying everything I am now taking morpine. I meditate. I will try some of the other amino acids
Thanks youl
laurastack
Laura
Oh no – sorry to hear this. Have you looked at the following for migraines:hormones, high histamine foods, high tyramine foods, low magnesium , low B2, low B6, low folate, low serotonin, heavy metals or tried melatonin, lithium orotate? all can be factors with migraine as can structural issues in neck and head
If GABA is going to work it’s a noticeable effect on anxiety and physical tension in 10 mins – GABA opened on to tongue. PharmaGABA swallowed could be an hour so more than means it’s not enough or it’s not low GABA.
Hi Trudy – why is the multi-vitamin you recommend only available for practitioners?
Cindy
I’m not sure I understand the question? It’s sold via a professional grade company that can only be purchased via health professionals – maybe that’s what you mean?
Hi,
I got your name from Leif at Lidtke. I desperately want to take Tryptophan again ( used it for many years but haven’t for about 10). My problem is that I was diagnosed with MCTD (Mixed Connective Tissue Disease) with features of Lupus and Scleroderma. In my reading it seems that Tryptophan is contraindicated for people with autoimmune issues. Are you able to shed any light on this for me.
Thanks so much.
Rose Kaval
Rose
I am not aware of any issue with use of tryptophan or 5-HTP with lupus or scleroderma but have not worked with anyone with either condition so I don’t know for sure.
In this 2015 paper patients with the autoimmune disease systemic lupus erythematosus (SLE), “had decreased serotonin levels in serum and platelets as compared to healthy individuals” and “reduced serum serotonin levels in SLE patients were related to severe disease phenotype.” http://www.ncbi.nlm.nih.gov/pubmed/25897671
The paper discusses IDO, inflammation and the production of kynurenine and some practitioners don’t feel tryptophan should be used when there is known inflammation. The Lidtke Tryptophan Complete product was created with co-factors to help prevent this potential problem
Until I have evidence as to why tryptophan could not be used, I’d defer to the doctor and with their approval have a client with lupus do the amino acids questionnaire and a trial of tryptophan if they have low serotonin symptoms.
There is a similar discussion about tryptophan and lupus in the comments of this blog (just search for lupus) https://www.everywomanover29.com/blog/amino-acids-mood-questionnaire-from-the-antianxiety-food-solution/
I would also recommend an autoimmune dietary approach such as The Wahls Protocol by Dr. Terry Wahls or The Autoimmune Solution by Dr. Amy Myers.
Also check out these 2 blogs on EDS and connective tissue disorders https://www.everywomanover29.com/blog/the-anxiety-summit-closing/ and https://www.everywomanover29.com/blog/joint-hypermobility-ehlers-danlos-syndrome-pyroluria/
Hi Trudy,
We can’t get Lidtke in Australia without paying over $100 in postage or $90 per bottle. Amazon won’t post it to us. Is there ANY other brand you can recommend from iHerb at all?
Cheers
Karen
Karen
I have not had a chance to look into the quality of other brands of tryptophan. Have you looked at prices when purchasing directly from Lidtke?
Yes it is the postage that is the killer. Thanks for your time Trudy I know you are a very busy lady.:)
I think we need to talk to Lidtke about trying to get a distributor there – would you ask and I will too
Will do Trudy.
Just wondering if you have had time to follow up this comment from above?
Hi Trudy,
In your book, you recommend a free form amino acid blend to be taken at each meal if supplementing with DPA. What specific brands would you recommend?
Karen
There are some listed here on the blog
I have been on ativan for 16 yrs starting at 1 mg., niw 5.1/2 mg. I suffer from migraines daily for 16 yrs. How is best way to get off bento and will Gaba help as I go down? Have a lot of tense muscle pain due to stress. Need open for collapsed abdom wall. Lots of tummy pain. Bug Mess.
I also take litium orientate. jiposomal turmeric. feverfew/dogwood extract for pain and migraines. Not much helps.
Thanks.
Hi Trudy. I really admire how you are helping others. My 19 yr old son has trouble with depression. He started on the Litdke Tryptophan and worked up to 2X daily. His mood improved somewhat. It didnt seem to do enough so we added tyrosine in the morning and also some essential oil blends for mood.He also started on the pyroluria supplements. His cloud totally lifted and he dropped down to taking trytophan at night. He takes 2 500mg tyrosine on awaking and 2 500 mg tryptophan at night. After 6 weeks of feeling great, things have slowly gone downhill.What would you suggest? Thanks for your help and kindness.
Lorna
When this happens we have to look at what has changed – the dose, the brand, new foods added, other supplements added, accidental exposure to gluten, new stressful situations
Hi Trudy,
In your long experience with Tryptophan how many people would you say have adverse reactions? Have you worked with any older people taking it and if so are the dosages lower?
Thanks,
Rose
Hi Trudy. I am wondering in why or jnwhat circumstances you would recommend the Emerson blend of animos rather than individual ones? I ask because I feel like my symptoms resonate with many of your descriptors perhaps slightly different from days to day but I don’t quite know where to start. I feel I am low on seratonin, and endorphins also have some anxiety and alcohol/coffee desires and urges to mood elevate. Many thanks for all you do. Really looking forward to the customizing therapeutic diets webinar tomorrow!
Gillian
A blend is often helpful as well but using individual aminos provided more effective results. I often use both
Hope you enjoyed the customizing therapeutic diets webinar!
Hi Trudy,
About oysters: I know they are high in zinc and have a good ratio of zinc to copper( 14:1 ), but having a 13 mg zinc portion of 3 or 4 oysters gives you approx. 1 mg copper which some charts show as 100% RDA for copper. Eating more copper in other foods, like nuts,would make your daily intake of copper high.
Wouldn’t this be a risky amount of copper to have? Hope you’re doing well.
Dave
Dave
I find oysters to be a great source of zinc and encourage my clients to eat them if they enjoy them. Small amounts of nuts seem to be fine but not baked goods with nut flours.
Trudy,
Thanks for your answer.
So, you don’t think it’s bad to have over 1 mg. copper per day because I thought copper interferes with zinc absorption?
Dave
I think it’s more important to be eating real whole foods
Thank you Trudy for all your generous work and to your supportive community. I have one question. Has anyone noticed weight gain using either the Calm Mind supplement or trptophan? Thank you.
Kim
I have not observed weight gain with GABA or tryptophan. My clients will often see weight loss as their carb cravings diminish. If it was not a quality product and has gluten or other fillers then I’d be worried about all sorts of effects
Hi Trudy!
How do we diagnose if a child has pyroluria?
Are there any tests?
Here are the symptoms I see:
Early grey hair. (around age 4)
Overly concerned beyond what’s appropriated for his age. (almost 9 yo)
Very recently, an unusual anxious reaction to noise and imagination that out of that something bad will happen. Like a child will get hurt or have to be rushed to the hospital (just because kids were being loud and kind of daring)
Are the needed supplements: Zinc, vitamin B6, evening primrose oil? Meaning: from your “kids list”, it is one zinc or the other, right? Not all the supplements listed, correct?
Any helps is VERY appreciated! Thank you!
Cynthia
I use the pyroluria questionnaire (https://www.everywomanover29.com/blog/pyroluria-questionnaire-from-the-antianxiety-food-solution/) and response to supplements – and yes just those listed under the pyroluria section
With any type of anxiety I’d also consider gluten, low blood sugar, poor diet, low GABA, low serotonin and all the possible underlying factors (https://www.everywomanover29.com/blog/60-nutritional-biochemical-causes-of-anxiety/).
When I hear “imagination that out of that something bad will happen” I also consider low histamine/histapenia https://www.everywomanover29.com/blog/methylation-and-anxiety-histadelia-and-histapenia/
Thank you, Trudy.
I will look into each one of those links.
I am referring to the same child in the same post, just different ages / stages of life.
I have GABA calm in my house (for myself. 🙂 ) what is the dosage for a 9 yo? 1/2 of a tablet? 1/3?
Diet is not a concern. This child eats very well (no junk, no candies, all organic and form scratch meals). I can remove his gluten again and see what happens.
I truly appreciate your time and attention in answering my question! Have an awesome weekend!
P.S.: I forgot to add: very persistent eczema. Started as a baby with cradle cap. It is more under control now, but he still has a persistent patch on the wrist.
I’ve never used primrose oil before. Any tips on how to apply it? Both for mom’s PMS and kiddo’s eczema? (Or does the label bring instructions on how much and how often?) Any particular brand you trust?
Thank you again!!!
Cynthia – I’d consider gluten or other food sensitivities as a very strong factor with eczema. And don’t forget topical sources like shampoo and creams.
EPO can help and you can swallow or open a capsule. There is liquid EPO available too
I use weight and not age – 120lbs for adult dose and 60lbs for 1/2 the adult dose. I start really low with kids and typically start with 1/4 to be safe.
Gluten removal would be #1
Hi,
In your experience, can GABA supplements and tryptophan cause weight gain? Thank you!
Hi Trudy,
I started with a tiny sprinkle (about 1 mg) of P-5-P and had dream recall on the 2nd day and seem to have it every night at that dose. Have you experienced clients needing that little of a dose? I took a few drops of the liquid zinc challenge and it didn’t taste – was like water and I felt better later on that day. I’ll try adding a tiny sprinkle of the Opti-zinc 30 from douglas labs since I’ve been on the P-5-P for 2-3 weeks. I should take the zinc with a meal right to avoid nausea? Also should I take the zinc anc P-5-P at different meals and maybe the zinc at evening meal? Thank you so much for all that you do!
Michelle
Michelle
Everyone is unique and some people do need very small amounts (although I see this more with the amino acids than zinc and vitamin B6). Zinc is best with a meal and any meal is fine for either of these (as long as sleep isn’t affected)
Thank you Trudy!
Hi again Trudy,
How can you tell if the P-5-P form of B6 is not right for you? No dream recall? I think it is since I felt better not long after taking a tiny bit the first time but after about 2-3 days of taking a tiny sprinkle everyday I had some depression and no appetite. I may need to go slower…maybe a sprinkle every 1-2 days? I’ve had some starchy, comfort food cravings (grilled hamburger, hotdog, French fries, macaroni and cheese and pizza). All things I can’t and don’t eat and my usual healthy grass fed meats and veggies were not appealing. I believe though that was caused from a camu camu powder I had started trying a little while after the P-5-P. I can’t eat any fruit as it will cause cravings of bad foods – I guess it’s feeding bad bugs and yeast/candida. I think I will try zinc soon without the P-5-P and see how I do with it. Thanks Trudy!
Hi Trudy!
I’ve had lifelong migraines along with anxiety and depression that have waxed and waned. I’d like to try the aminos and curious if you have any special recommendations or contraindications for migraine with aura.
I’ve tried GABA in the past but ended up with a red flush like a niacin flush. Any ideas on why that might have happened? I suspect maybe the dose was too high. I wanted to try the Gaba Calm since it has a low dose of GABA but I’m not sure if Tyrosine is a potential migraine trigger.
Also have tried L-theanine but if I take it before bed without fail I end up with an increased heart rate. Any ideas? Would love a little enlightenment on all the above so I’m not so gun shy and doing more harm than good.
Thank you and bless you!!
Mary
Tyrosine is an issue with migraines and I avoid it with clients with a history of them (please see the precautions https://www.everywomanover29.com/blog/amino-acid-precautions/). If they choose to try a product with tyrosine they simply stop if a migraine is triggered.
Too much GABA can cause a flush. I find this to be case when 500mg or 750 mg and above is used. I have my clients start on the 125mg found in GABA Calm and slowly build up. When Calm Calm can’t be taken opening a capsule of a GABA-only product is what we do. Some of my clients are pixie dust people and need 1/10th of capsule or 200mg GABA.
I’m curious how much GABA caused the flush for you? and what product?
Too much theanine could cause an opposite reaction too. I’d also like to know how much you used?
Hi Trudy!
I am 47 and have had 3 panic attacks. I have anxiety. I scored high on the questionnaire for low gaba, seratonin, & endorphins. I have seen a cardiologist, heart is great. Had a normal CT scan, and been to therapy for BPV. I had salivary cortisol testing-Genova Diagnostics. My 10 pm-12am cortisol was high, DHEA normal, and ratio of DHEA to cortisol is normal. Began Seriphos (1 am 2 at bedtime) April 8,2016. Also, Thorne Relora Plus 3x day, probiotic 1xday, and 100 mg progesterone E4m dye free at bedtime. Before supplements I was having sleep difficulty, waking in the night with racing heart and panic. I am doing better on that front. Now able to sleep 7 hours or so. Still wake a bit abruptly, but ok. Also, as of April I have had no caffeine, alcohol, tobacco, very little sugar and almost no gluten (still learning). Overall my diet has consisted of healthy veggies/protein, very little processed food and carbs. However, I am still suffering anxiety, hair loss, and some recent joint pain.
I also just completed neurotransmitter testing via Pharma Labs. This urine test showed low gaba, serotonin and norepinephrine. Elevated dopamine, & glycine. 5-HIAA, taurine, glutamate, histamine, PEA, DOPAC, & epinephrine were all in normal range. I am struggling .
I think tryptophan and gaba would benefit me greatly. I am considering GABA calm and Lidtke tryptophan. Should I be concerned about tyrosine in GABA calm. Thank you for listening and any advice is greatly appreciated. I have never before had these problems in my life. Very tired of “not living”!!! Thanks so much.
Paige
Good to hear the sleep and nightime panic is better. I’m sure you understand that I cannot consult via the blog. I will share that I don’t rely on urine n/transmitter testing and have my clients do the amino acid Q, review the precautions and do a trial https://www.everywomanover29.com/blog/anxiety-amino-acids-overview/. It really is the best way to figure this out.
Since you mention hair loss, anxiety and joint pain I’d also suggest asking your doctor re a comprehensive thyroid panel that includes both antibodies – to rule out Hashimoto’s thyroiditis
Thanks Trudy!
I had blood work in January and TSH thyroid activity normal, Free T4, normal range. Is that both antibodies? Also, is there any problems associated with being on Interplexus Seriphos for more than three months? I have ordered the Lidtke tryptophan and will start the trial upon receiving. Can I use tryptophan, gaba and Seriphos, and progesterone together? With the tryptophan trial, should I open the capsule and place it on my tongue? If so, how much? Thank you so very much for responding!!
Paige
The antibodies are antithyroglobulin and antithyroperoxidase.
The recommendation is for 3 months on Seriphos and then have a break. As long as we are re-testing salivary cortisol levels and cortisol remains high but is shifting I’ll have my clients continue with it.
I often have clients using tryptophan, gaba and Seriphos, and progesterone together
I have my clients open the capsule for amino acid trials. The starting dose is 500mg and less for sensitive individuals. I encourage you be informed and read the amino acid chapter in my book “The Antianxiety Food Solution”
Thanks Trudy-
One interesting thought, I have been researching the Relora Plus. I have found some research to indicate that it can affect thyroid….something to consider for me, as I have been taking 500 mg 3x day for 3 months per my Dr (MD who is very new to this). I will definitely have more thyroid blood work and look at the antibodies! Love your book. Thank you for taking your time to respond. Greatly appreciated!!
Paige
I’d love to see the Relora Plus and thyroid research you mention. Also for some people certain B vitamins can be problematic and trigger anxiety – one of them is L-5-MTHF (even 200mcg x3 – 600mcg). Dr Lynch covers this here https://www.everywomanover29.com/blog/anxiety-summit-methylfolate-anxiety/
Sharing link to Relora plus for other readers https://www.thorne.com/products/neurological-support/dp/relora-plus
Glad you love my book!
Can’t thank you enough Trudy!
I am so very discouraged. Had an intense panic attack a few hours ago, and have been having horrible headaches all week. I’m really at the end of my rope. I will not take any more Relora. I really seem to fit Dr.Lynch’s “bell curve” theory. I did well on this for a while, & just couldn’t understand why I started feeling so bad again. Methyl folate could be the answer. My doctor is very slow to respond, if he responds at all. He started me down this path 3 1/2 months ago and just kind of abandoned me. Time to find a new practitioner although I am very lost and confused. Can’t tell you how nice it is that a total stranger takes the time to listen and respond. This means a lot to an anxious/panicky person. You are very thoughtful and kind! Thank you!
Trudy – I appreciate your blog and book (I have read both) but I have to mention that I had diffuse, severe hair loss, and increase in libido, and developed eczema on my hands (which I have NEVER had) after taking only 20mg of zinc gluconate daily for about 5 months. It did help me tremendously in mood, PMS, etc. but I believe it threw off my calcium big time even though I do eat calcium-rich foods and take vitamin D daily. After months of eczema treatment and hair loss, itchy scalp, etc, I tried a TUMS for my stomach one night and the itchy scalp STOPPED. So I thought “Maybe this is a calcium issue?” Sure enough, hypocalcemia can cause eczema and hair loss. As soon as I stopped the zinc and started taking calcium citrate, the eczema started going away within a few days and was gone in a week. However, it’s been almost 2 years since then and I still struggle with eating ANY zinc. After a few days of eating nuts or red meat, I start with the hair-loss, scalp-itching, and eczema again on my hands. So I seem to have caused an imbalance with the zinc after reading your book and website. In addition, I follow up every so often with zinc challenge (just for taste – I don’t swallow it), and am still VERY replete in zinc. I think the 20mg of zinc was too much for me and threw off other minerals. You don’t address this anywhere, so could you please let me know what you’d recommend. I tried eating 2 bites of liver for a few days to see if I could potentially increase copper levels (in case I threw those off, too) but I noticed that made me feel bad mentally pretty quickly after ingestion. The copper hit me hard. The irony is that I benefit tremendously from the zinc but I can’t seem to handle it without repercussions. In addition, about a year after the zinc, I tried b6 via p5p (couldn’t tolerate it at all – nausea, dizziness) – and then via pyridoxine. I did well on the pyridoxine but again, started experiencing hair loss and what felt like an increase in libido. Could the zinc and the b6 have caused a shift of estrogen to testosterone as well? I have read these can be effects of both supplements? If you’re writing a book making such recommendations, it would help to address the potential risks. It appears that 20mg of zinc is too much for some of us. Thoughts?
Meredith
I am sorry to hear about the issues you’re having. I’m afraid I’ve not heard of severe hair loss, increase in libido, and development of eczema from 20mg of zinc gluconate. I’ve also not heard of hair-loss, scalp-itching, and eczema with nuts and red meat.
Since you do see mood benefits with zinc I would look into the other ingredients in the product – is it gluten/soy/dairy-free? free of GMOs? I’d also talk to your integrative doctor about a thyroid panel, sex hormone testing and a zinc/copper test and look at gluten sensitivity
Hi Trudy,
I have been a fan of yours for a long time now, ever since I heard you speak on The Mental Health Summit. I have joined you for every Anxiety Summit and I have learned so much since that first day – I listened to your talks over and over and you gave me the hope and motivation to keep going.
Anyway, I wanted to ask you a question which I can’t seem to find the answer to despite vigorous googling over the last few weeks. And I thought if anybody has or is close to the answer it’s you.
Q. “Abnormal fat distribution” is one of the symptoms mentioned regarding pyroluria, but where does it originate from?
Speculations;
1. I have come across an explanation that says it’s roots are in zinc deficiency; as zinc plays a role in blood sugar regulation and apparently there is a correlation between low zinc and insulin resistance.
2. I also came across a small reference in Dr Walsh’s book ‘Nutrient Power’; “A study of 67 schizophrenics found that pyrolurics were very deficient in arachidonic acid, an omega-6 fatty acid. This may explain the symptoms of dry skin and abnormal fat distribution associated with this disorder”
3. My own thoughts led me to wonder whether cortisol has anything to do with it or any other hormone, an article I read suggested different body fat accumulations are related to different hormone types, i.e having an imbalance of certain hormones; “Cortisol type – accumulation of fat on abdomen, Oestrogen – accumulation of fat on bottom and thighs” http://crm.ion.ac.uk/information/onarchives/autumnbiosignature-modulation-weight-loss-through-hormone-balance
I am so curious as to it’s roots, hopefully you have some insight.
Rebecca
You’ve done your homework and are spot on – all of the above can be factors.
I’m so glad to be source of motivation and hope for you!
Pyroluria – Who should I test through?
Looking online and want to use a testing/laboratory you recommend.
Thanks,
Carol
Dallas
Dear Trudy,
My GP has recommended I take St John’s Wort for mild depression and anxiety. I have taken 5HTP in the past and found it to be very helpful, but didn’t want to continue taking after using for 9 months. I do however often take tryptophan and or gaba calm at night as they help so much with sleep. Is it ok to combine St Johns Wort with these 2 amino acids – I was particularly concerned about the Tryptophan as didn’t want to make too much serotonin.
With kind regards,
Dear Trudy,
Have been recently diagnosed with very low Vit. D and started on prescription megadoses (weekly pills). I just want more people to be aware that this could be their problem instead of something exotic! Low Vit. D is entwined with many other problems, not just bone problems like osteomalacia.
Symptoms can be thyroid problems, COPD, polycystic ovary, kidney problems, brain fog, etc.
Please tell people to get themselves check esp. if over 40. Thanks.
Laura
Thanks for sharing. So pleased you have found answers. I agree low vitamin D is very common, has far-reaching health implications and everyone should be tested.
It’s been awhile since I blogged about it (https://www.everywomanover29.com/blog/vitamin-d/) so a reminder would be good.
I encourage you to look into daily vitamin D supplementation rather than weekly once you get your levels up. Doing it daily more closely mimics our physiological processes.
Hi Trudy,
I scored quite high on the pyroluria questionnaire. I would like to start taking the zinc, B6 and evening primrose oil, but I am breastfeeding my 4 month old baby. Could you tell me if it’s safe to use these supplements as a breastfeeding mother?
Also, I have a 3.5 year old son who is showing lots of signs of social anxiety, and also tests quite high on the pyroluria questionnaire (although many questions weren’t applicable to him at his age). Just wondering if he would be old enough to take the supplements as well? And if so at what dose? He eats a very clean diet already, and no gluten (which he has already shown to be sensitive to).
Thanks so much! I really appreciate being able to ask these questions here. I really admire the work that you do.
Hi Trudy,
I am in my late thirties and have experienced the effects that specific supplements and foods have had on my mood and overall wellness. I graduated from a nursing program last year and I would like to expand on my knowledge as nurse to help people using the pathways of nutrition, supplements, and other complementary therapies. Unfortunately, we did not learn much about any of these in nursing school and I am curious what pahways you would recommend to someone in my position these days? For example, would you recommend the nutrition program you attended at ACHS? Are there other paths you would recommend? My long term goal is to be able to function as an independent practitioner, but also as part of a team of others I can refer to. And I would like to find a way for it to be financially and personally sustainable. I am curious if you always had a goal of what you saw yourself doing when you started down this path, or if it became more clear what you would do as you started down it? Thank you for taking the time to read this and I appreciate any suggestions you are able to give! Sincerely, Jessica Johnson RN
Jessica
I love that you have experienced the wonderful effects of foods and supps on your mood and wellness! and now want to expand your knowledge!
I’m getting asked this a lot and really need to do a blog post on the topic so thanks for asking. My school closed down and I’d go to http://www.NANP.org (I am past president) and look at their programs for starters. There are masters programs and certifications they approve – some in person, some long-distance, some accedited, some not accredited.
Once you’ve done that there are many other advanced trainings being offered by my colleagues – like Julie Matthews special diets (https://www.everywomanover29.com/blog/customizing-special-diets/), Andrea Nakayama’s functional nutrition, Dr. Tom O’Bryan’s gluten practitioner, Dr Datis Kharrazian’s blood chemistry analysis etc. It’s a bit too much for a blog comment but I’ll include them in the longer blog post with links and which ones I did and why. And which ones I still want to do.
One other example is the practitioner training on amino acids that I’ll be launching soon. I’m getting ready as we speak and you can sign up here to be notified when we launch http://www.anxietynutritioninstitute.com/ The first module will be a deep dive into GABA and my goal is to build a community of like-minded practitioners who can support each other and to whom I can refer to. There is such a need for this work!
There are also all the wonderful live conferences to attend (like IHS https://www.everywomanover29.com/blog/david-perlmutter-microbiome/) and IMMH (https://www.everywomanover29.com/blog/neuropsychiatric-lyme-disease-suruchi-chandra/) and the summits like my Anxiety Summit http://www.theanxietysummit.com/. Basically I continue to study and love it!
My path to where I am now was a winding one and getting the nutrition basics and working with clients on general nutrition like weight loss, diabetes, high blood pressure, arthritis was a good foundation for once I was ready to focus on anxiety. But I always knew mental health was my passion – I studied psychology in college – and when the opportunity came to work in Julia Ross’ clinic for 2 years I didn’t hesitate.
Trudy, thank you for your response, this sounds like a great start. And I look forward to reading your blog about it as well. ~Jessica
hi
my daughter age 15 has panic anxiety disorder. she will experience heart racing and breathless during panic attack.
She also has depersonalisation meaning sometimes she feels shes not there. I have researched on the internet and they said its all due to anxiety. its the body natural mechanism to prevent the patient from further harm so much so that the patient feels non existence as if living in a dream or movie. everything seems not real.
I am against medicating her and since i came to know about her conditions 6 wks ago i have started her on the following supplements. She had this problem since beginning of this year
1. omega3
2. megafood b complex (also contain bacopa, lemon balm and 150mg L theanine)
3. sublingual b12 1000 mcg
4. now phosphatidyl serine 100 mg ( also contain 100mg choline and 50mg inositol)
5. vit d 2000iu
6. source natural gaba calm 125mg ( also contain glycine, L- tyrosine 25mg and taurine 20mg)
7. rhodiola
8. ashwagandha
9. zinc
10. mg
11. probiotic
12. digestive enzymes
13. turmeric
after 6 1/2 weeks of supplementation, she is seeing improvement in her panic attack and lesser episodes of depersonalisation but not in her ability to focus and she lacks motivation throughout the day.
Would appreciate if you can advise what supplement can be added for her lack of focus and motivation.
I tried giving her Now L tyrosine 500mg which i read is for focus and motivation but she seems to get more irritable and bad mood.
hence i stopped after 4 days.
Need your advice and help desperately
thank you
regards
tan
singapore
Tan
It’s wonderful to hear your daughter’s anxiety has improved. She’s fortunate to have you!
You don’t mention any dietary changes so if I was working with you and your daughter, I’d make sure to consider a gluten-free diet, fermented foods, protein at breakfast to keep blood sugar stable (for anxiety and focus), quality protein.
Low iron/ferritin can affect focus as can low omega-3s and low zinc (so more zinc or more fish oil may help). Less tyrosine can sometimes be enough to help focus without causing irritation. I have my clients open a capsule and trial 1/8 or 1/4 and increase slowly
hi trudy
I tried to put my daughter on Now Foods L tyrosine 500mg for third time but she seems to have adverse reactions even though i used 1/6 of the capsule.
She gets more agitated and lousy mood. Her biggest problem now is lack of focus in her study as a student and she gets extremely frustrated and depresssed and tried to bite her own hands. It pains me to see her in that state. would really appreciate your advice on what other supplement can i I try to bring her focus back
thank you trudy
regards
tan
singapore
Tan
I’m sorry to hear this. I stop when there are adverse effects. With focus issues I always also look at low omega 3s, low iron and low zinc
hi trudy
thanks for all your replies so far.
I would like to know why is it that my daughter’s stomach churned when i gave her raw apple cider vinegar and kimchi. Is there any supplement to address this problem and whats the likely cause.
Also she cant seems to drink carrot juice. the feeling is like there’s a void in the stomach.
Also she allergic to sweet potatoes and white potatoes. It will cause the flap in the throat to appear for a few days which make swallowing pills impossible
sorry for asking you so many questions as holistic dr are hard to come by in singapore and even if there is it is not affordable to me.
thank you trudy for all the help and support you have rendered me so far. thank you so much
Tan
The kimchi could be a histamine reaction, the apple cider vinegar may contribute to additional stomach acid. Carrots are high in sugar and issues with sweet potatoes and white potatoes may mean SIBO should be considered.
hi trudy
can i take kyolic garlic, olive leaf extract or coconut oil to treat sibo
thks
Trudy,
I have an 8 year old son who is experiencing phobia related to any medical visits. He also has a hx of perseverating over things like aliens and tornados, then it goes away and he’s on to something else or nothing at all. He’s hard on himself and critical when he makes mistakes. He fits many of the symptoms for low serotonin. I am wondering if you think the trypophan chewables you mention would help and what doseage and timing I should try. Sleeping is not an issue once he gets to sleep…
I feel so badly to see him struggling with this and I prefer not to go the medication route at this time.
(p.s. thanks to you and your book, using GABA Calm has been a lifesaver for me. It has changed my life!)
Hi Trudy,
If you have not yet looked into Irlene Syndrome I am hoping you will. This is a light sensitivity that influences the brain and Anxiety is one of the symptoms. Dave Asprey of Bulletproof has interviewed Helen Irlen a few times having the syndrome himself and I found the topic facinating. Apparently it affects about 50% of us and colored filters (very simple) help.
https://www.bulletproofexec.com/helen-irlen-your-glass-is-always-full-through-irlen-lenses-291/
https://www.bulletproofexec.com/98-transforming-lives-with-light-and-helen-irlen-podcast/
http://irlen.com/
Love your blog, newsletter and summit,
CP
Since I bought your book, quizzed high for pyroluria, bought your recommended Solaray optiZinc, any reasons why it burns my stomach. Tried with/without food, lots of water, powered through for 2 weeks. Just burning. Comments, reasons, anything appreciated.
Cheryl
Cheryl
I have not heard this feedback and have my clients stop immediately if a supplement causes an adverse effects. Please don’t power through.
Hi Trudy,
I am currently weaning off of cymbalta. I started weaning in March of this year and had been on it for a year. I was cutting my dose by 10% increments which is why it’s taken so long. Anyways, i am currently dividing the little beads in a 20mg pill into fours. This last dosage decrease brought on a bit of anxiety/depression. Nothing major and definitely bearable but I have to admit it makes me nervous. Anyways, I’m interested in taking tryptophan or 5htp because I believe I have an issue with low seratonin. Which one would you recommend and at what dosage? I have gaba but I don’t notice a difference when I take it. Cymbalta (and lexapro which I took for 8 months before I started cymbalta but then made me gain 30 lbs) worked very well for me but I don’t want to be on an antidepressant because of the side effects.
Hi Trudy-
My teenage son gets congested from taking supplements. We have tried just about every supplement and brand. He uses a topical magnesium. Do you know of any topical zinc supplements? I try to fill his diet with foods high in B6. It isn’t as easy to get zinc from the food choices listed due to allergies.
Thank you.
Rachael
Rachael
The only thing I can suggest is zinc oxide creams but I’ve not used this with anyone. Have you managed to figure out what it is in the supplement that causes congestion? and trying to find products without this ingedient?
Great article! Is there a multi b or individual bs you recommend for people with pyroluria and who are undermethylated?
Aisha
I assume you’re asking for those with high histamine in whole blood (or histadelia) and with no folate? I don’t with many people with high histamine but would check to see if Ben Lynch has anything at seekinghealth.com
Thank you so much for your work, I can’t tell you how much I appreciate it and I know I’m not alone 😉
I’m wondering if there is a distinction between Pyruloria and Copper Overload, or if they are one and the same, or related?
I can’t seem to find a discussion on copper overload on the blog. (I haven’t read your book yet, but I hope to soon 😉
Recently,(and thanks to the information you’ve provided on this site) I found that supplementing Zinc and B’s seems to help my panic/anxiety tremendously. My doc asked me to switch to one with copper in it and I quickly felt nauseous and anxious which raised my suspicions about copper.
Thanks so much!
Hi Trudy, I take GABA (now) 250mg, L-theanine 100mg(natural factors) everyday with 100mg 5 HTP twice a day for panic and anxiety. I was wondering what your advice is for long term use. I don’t find alot of information and most of the supplements always say to contact health care provider if taking longer than 3 months. Should I take on a rotating basis, like 3 weeks on 1 week off? 2 on 2 off? I have been free from citalopram for 9 months now but due to long time exposure to different SSRI’s I still suffer anxiety especially bad 10-14 days into my cycle. I am 46 years old
Kindly,
Chris
Hi Trudy,
Thank you so much for this wonderful website! I tried GABA for the first time yesterday for my chronic anxiety and it really worked! YAY! But the only problem is it made me feel really sleepy and I’ve woken today with this extreme sleepiness again and can’t seem to shift it. I ust wondered if there’s any way I can get around this? The GABA I’m using is Enzymatic therapy 250mg once a day (in evening)
Thank you ever so much
Jess x
Jess
So glad it worked! Tell me what anxiety symptoms you had and the effects you felt after taking it other than the sleepiness. Did you swallow or open it up on to the tongue? It’s likely too much. I have my clients start low and do a trial to find the idea amount – did you do this?
Hi Trudy,
Thank you ever so much for replying- it’s so so so kind of you! Thank you for making all this incredible information available on this website.
I have anxiety about EVERYTHING. Constantly worrying about the future, always thinking the worst will happen, doom around every corner. When I took the GABA I felt suddenly I could cope better and a sense of stillness within. It was also as if my body was slowing down internally and more at peace. My mind didn’t do the worry after worry after worry thing and the worrying wasn’t getting out of hand like it usually does. I took 250mg in one go and swallowed it whole 🙂 How low should I start? Thank you SO much for helping me with this. Jess x
Jess
I start my clients on 125mg GABA (GABA Calm product https://www.everywomanover29.com/blog/source-natural-gaba-calm-anxiety/). With those symptoms I’d also look at low serotonin and tryptophan
Hi Trudy,
Love this information. I think it’s helping a lot of people.
Question: what kind of side effects would you get from using aminos? (You mention using vitamin C to stop side effects…)
Thanks.
Kristy
You can feel too tired from GABA or tryptophan, breathless or dizzy from GABA (I’ve only heard of his with doses that are too high – like 500mg/750mg and more), race-y from tyrosine, sometimes head pressure or a headache or just strange – often meaning it’s too much or you don’t need it or there is a quality issue with the product
Hello
My son has a newly diagnosed peanut allergy. I’m overwhelmed with emotion. Some days I am hopeful and other days I’m sad. Did I cause this? What is safe for him to eat? Will he have a reaction at preschool? I’m starting to do my research and I thought of you. I enjoy your blog and thought you might have answers or can lead me in the right direction. I am also reading your Antianxiety Food Solutions book. I wonder if the diet/microbiome approach could help him outgrow his peanut allergy? Do you have any knowledge you can share? I know there are trials but from what I read you have to eat peanut butter regularly after. My son is 3 years old so that may be hard. I am hoping he will out grow it or to try natural therapy before trying desensitization. Can you recommend any practitioners that specialize in peanut allergies or share articles? Thank you so much for your time!
Worried mom, SM
Shana
Dr. Maya Shetreat-Klein’s book “The Dirt Cure” (on Amazon http://amzn.to/2hxYsMe) talks about why allergies happen and how to regulate the gut and immune system. I have yet to read her book but she is an amazing practitioner who I’ve heard present a number of times. I’d use this book for finding a solution.
Dr Maya also recommends Robyn O’Brien as a powerhouse with amazing resources for fighting for kids with food allergy. I heard Robyn share the story of her kids allergies and she is on a mission to help moms and kids who are dealing with this. I heard her present at Holistic Mom’s conference the same year I presented there. I have her book “The Unhealthy Truth” (on Amazon http://amzn.to/2gKIRvq)
Here are a few good blogs of Robyn’s on the what’s and why’s
https://robynobrien.com/facts-kids-food-allergies%E2%80%8B/
and
https://robynobrien.com/food-allergies-the-hidden-truth-about-peanuts/
You’re doing the right thing educating and empowering yourself. It’s not your fault and it’s not unusual to feel emotional. Just make sure you support and nourish yourself ok?
Dear Trudy,
Flax Hull lignans can deplete B6!
I was just reading up on flax hull lignans and found a nice article from the US National Library of Health:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152533/
You are probably already aware but just in case I wanted to share that it states: ” Flaxseed meal also contains 10 mg/100 g Linatine (gammaglutamyl- 1-amino-D-proline) which induces vitamin B6 deficiency (Mazza 2008). ”
You’ll find this by scrolling down to the section on anti-nutrients.
Thanks for all you do.
Jennifer
Thanks for sharing this paper – I was not aware of this. Right below this sentence it says this “Ratnayake et al. (1992) and Dieken (1992) found that the linatine (a vitamin B6 antagonist) in flaxseed did not affect vitamin B6 levels or metabolism in people fed up to 50 g of ground flaxseed per day.” That’s about 3 tablespoons. But I can’t help but wonder if even this may be too much for someone with pyroluria?
Hi Trudy:
I just wanted to share some of my experiences with Pyroluria and dealing with my primary care doctor.
I found out Quest Diagnostics offers a test for Urine Pyrroles (Test Code 437) in the USA, which would be covered by my insurance (Yay!). It is performed by the Bio Center Laboratory in Wichita, KS.
My doctor was reluctant to test as he never had heard of it and some of his searching pointed to orthomolecular medicine, though he did eventually write up the lab request. While I was testing, I also had a vitamin D, Zinc / Copper Serum, and other blood tests.
My Results are as follows:
Vitamin D (25-OH): LOW at 27 ng/mL
Zinc: Normal at 111 mcg/dL
Zinc Tally: About a 1.25 – Almost no taste (Indicates the greatest need to supplement with Zinc)
Copper: Normal at 107 mcg/dL
Bilirubin: HIGH at 2.4 mg/dL (0.2 – 1.2 is Normal)
Urine Pyrroles: Normal/Borderline at 15 ug/dL (0 – 20 Normal)
Trudy’s Pyroluria Questionnaire: Highly Probable = 22 (15 in most common / 7 in less common)
My questions are:
Why did the Zinc Tally taste test indicate a need for zinc, where as the Zinc Serum test indicated normal levels?
The Urine Pyrroles test indicated supplementation may be helpful, though no urine specific gravity test was preformed, so maybe this was skewed by dehydration?
Basically, it sounds like this test was inconclusive? Would the next step be to trial Zinc/B6 and see if there is improvement in my Anxiety? Or is it time to look at other anxiety triggers.
Thanks for everything you do!
Scott
The reason I don’t do the urine test is because of false negatives. Zinc serum testing is known to be a poor reflection of zinc status. So yes, I use the questionnaire as a basis for doing the trail of the pyroluria protocol. And I always do a full functional nutrition workup and look for all possible root causes.
With elevated bilirubin I also address Gilbert’s disease.
Hi.
I need help getting the lidtke l tryptophan brand in the uk. I also need the correct titration upwards and dosage guide. Sleep ,mood and worries are my symptoms
Akim
You can order it directly from the Lidtke site. I’m afraid I can’t give specific guidelines for someone via the blog. I typically start with 500mg and do a trial and go up from there. If the person is very sensitive we do a trial with much less. Before using the amino acids I recommend everyone get a copy of my book “The Antianxiety Food Solution” (on Amazon here http://amzn.to/2kptFWm) and review the precautions. There is a whole chapter on using the amino acids too.
Dear, Trudy-
My 84yo, once very vital, mother has been suffering with
debilitating anxiety for 3 yrs now. It cam came on the heels of
close people passing away. In Aug of 2015 she had endoscopic surgery
on her esophagus for Achalasia which she dealt with for MANY years,
but became a critical issue with the onset of the anxiety. Her
surgical team recommended she remain on Protonix indefinately. She
took it for about a year, then I made the decision to wean her off
of it for the obvious reasons. She has been under the care of an ND
for 1 year, who has her on many SP supplements…..the anxiety
suppresses her appetite, though. Her psychiatrist has her on
Olanzapine 40mg at bedtime, and Xanax .25mg as needed (she tries not
to take the Xanax- make her groggy). Her lowest weight prior to the
surgery was 81lbs….she’s now about 93lbs at 4’11”. I heard you
speak about GABA- just concerned it may be contraindicated with the
meds that she’s taking….and of course the MD says all supplements
are contraindicated. Her ND is very nice, patient, and incorporates
EFT, MAT…..unfortunately not seeing much change in her spirit or
appetite.
We live in NY- do you offer long-distance consultations?Thank you
for your time.
Jo-Anne Valenti, D.C.
Jo-Anne
I am sorry to hear about your mother. I have used GABA with many medications and while it does provide immediate relief (and hope), together with tryptophan, I would also be looking into the root cause of the achalasia especially since you say it “became a critical issue with the onset of the anxiety.” My first consideration is gluten.
This is a new paper – The progression of coeliac disease: its neurological and psychiatric implications – “The present review discusses the state of the art regarding neurological and psychiatric complications in CD and highlights the evidence supporting a role for GFD in reducing neurological and psychiatric complications.” https://www.ncbi.nlm.nih.gov/pubmed/27976606
I’d also look at all her current medications as possible contributing factors. And all possible root causes – I list 60+ here https://www.everywomanover29.com/blog/60-nutritional-biochemical-causes-of-anxiety/
Right now I have a waiting list for long-distance consulting which will be starting again in the near future https://www.everywomanover29.com/services.html. In the meantime I highly regard the work of Dr. Kelly Brogan and Dr. Peter Bongiorono, both of whom are in NYC.
[A note for my other blog readers: Achalasia is a neurogenic esophageal motility disorder characterized by impaired esophageal peristalsis and a lack of lower esophageal sphincter relaxation during swallowing. Symptoms are slowly progressive dysphagia, usually to both liquids and solids, and regurgitation of undigested food http://www.msdmanuals.com/en-au/professional/gastrointestinal-disorders/esophageal-and-swallowing-disorders/achalasia ]
Thanks so much for your professional advice, Trudy.
At the time mom began to experience the anxiety symptoms (just about 3 yrs ago), she had not been on any medications, and the achalasia had been recently diagnosed almost 2 yrs ago.
I had reached out to Dr.Brogan, however she stated she does not work with senior citizens.
She had been under the care of Dr. Bongiorno early on for a few months, but did not note any improvement.
As mentioned, Her current ND is very nice, patient, and incorporates EFT, MAT…..unfortunately, a year later, not seeing any improvement in her spirit and anxiety.
SO am I assumimng there is no contraindiction with taking GABA while on Olanzpine and Xanax??
Thank you, again.
Jo-Anne
I have not seen an issue with GABA being used with these medications but I always have my clients let the prescribing doctor know when they start any supplements
Hello, again, Trydy. I’m feeling so frustratedand helpless re my mom’s anxiety issues. My sister and I have yet to see a change in her mood since the 3 yrs she’s been on Olanzapine 40mg at bedtime and Xanax .25mg as needed. She is still under the supervision of a psychiatrist, as well as an ND, but there is a concern with trying some nutraceuticals that there may be contraindictions. Her weight is very low as she doesn’t have an appetite- afraid that the food will get stuck even though she had a corrective procedure on her esophagus almost 3 yrs ago. She shows zero interest in participating in arts/crafts, community activities, eating, etc….. her facial expression always has an appearnace as if she’s in pain, but she denies any physical pains…always replies, “it’s my head, thoughts, fears.” I was given a small bottle of pure CBD oil by a friend who is an investor in Folium Biosciences, but no one can give me any answers re contraindications with her meds. She is on numerous She is on numerous Standard Process supplements, as well as L-glutamine powder, Antisid, fish oil, and has tried several homeopathic remedies to relieve the anxiety…. have had no success. Her prescribing MD always replies that he knows nothing about any of the supplements, herbs, etc that we ask him about… I am at a complete standstill. My mom is fully capable of walking, bathing, dresising, etc, without assistance…..it’s completely a morbid, worrying spirit. She’s been to several therapists, but, again, showed no improvement. My sister and I are becoming somewhat depressed over not being able to lift her spirits as well as see her show some interest inn eating so as to gain some much needed weight. When she does take Xanax it is quite evident as it make s her kind of zombie-llike for a few hrs. The Olanzapine does help her get some sleep (many yrs of poor sleep), so I’m hesitant to take her off it. Any suggestions /recommendations wou;d be greatly appreciated.
Thank you
Jo-Anne
So sorry about your mom – it’s so hard to see. If I was working with you I’d work on medication tapers with her doctors as this could be a big factor. Regarding her diet and weightloss, I’d focus on nutrient dense food like bone broths and shakes initially – both great when swallowing is an issue. Also low zinc impact appetite and mood so this should be considered too.
I would assume her diet does not include any gluten or caffeine
I’m curious why those with Pyroluria do not need Omega-3 supplements. Is it assumed that they are getting enough from their diet?
You mentioned (at the Hawthorne University Pyroluria Webinar Presentation), that you have a Pyroluria Questionnaire for children. Will you please let me know where I can locate that?
If a pregnant women has Pyroluria (and is unaware of the disorder), even if the child does not inherit Pyroluria, will the developing unborn child be affected by the mother’s Pyroluria?
You’ve explained that no dream recall or instead nightmares is due to a lack of vitamin B6. Would this also be the cause of a young child’s Night Terrors?
Thank you! AWS
Pyrolurics tend to be able to extract omega-3s from their diets but doing a fatty acid test will confirm the need or not.
I have yet to add this children’s pyroluria question to the blog
Unborn children are always affected by what’s going on with mom – nutritional status, diet, toxins etc
Yes nightmares or night terrors are often due to low B6
Thanks Trudy. But why is it I dont really feel sleepy at all even with 2000mg of L tryptophan and antihistamine.
is there something else I should be doing. Mood has improved.
Akim
It’s wonderful that mood has improved. Please share more – how did you feel before and how do you feel now? Is it 100% resolved?
If mood is not 100% and with sleep issues it may not being enough tryptophan, and there may be a need for melatonin too. I will also look at low GABA, low blood sugar, gluten issues, SIBO, high cortisol, parasites, candida, medication side-effects, low zinc, low vitamin B6, inflammation etc as it can be many factors
Hi,
mood is not 100%. I weaned off trazodone 150mg because I was not feeling any good while on it.
I was able to come off the drug using L tryptophan and True Calm. and have since increased my tryptophan to 9g per day in divided dosage, Tyrosine gives me chest pain so I am planning to buy Rhodiola Rosea for morning larck of energy.
I do not know how to go about further investigation of the sleep and mood issue, I was feeling 9 on the scale of low serontonin but now it is just like 4.
I wish you are taking more patient. I need to be guided regarding the next steps. Doctor said I have low Vit D and low Cortisol from blood test taken at 10am.
Thank you so much for answering my questions!
I am wondering, if you have ideas about how a developing fetus could be affected by an untreated pyroluric mother.
It may help explain the many different health problems of my children (7).
This is the second time in my life that I have been asked “Are you sure your child doesn’t have pyroluria?” So I bought your book.
I will only focus on one question? I (60 Years old) Started taking Zinc (gluconate) 50 mg, B complex 100 and B6 NOW 100mg from pyridoxine HCL about a month ago. Also I started working out at Curves about 2 months ago. This past week I finally was able to put in a really strong workout. When I got home I felt like I had hit a wall (This is not uncommon since I have hit menopause.)
I tested my Zinc with the Design for Health Zinc Challenge. It tasted like water. Therefore I increased my dosage to 100 mg Zinc per day in two doses.
3 days after the workout I have a terrible head cold which I for years hardly ever got sick.
Now the zinc challenge tastes sweet to me.
So is this a good sign that my immune system is kicking?
Does this mean I am going through a healing crisis possible a a candidas cleanse which I have heard zinc can do?
Or have I just overexercised? (I don’t think I was doing that much in that workout but ………)
Keep in mine, when I was a teen I was sick all the time, ate the SAD diet, had white spots on my nails etc. I did started eating better through the years and now have gone on a ketogenic diet because I feel symptoms coming on that are similar to my diabetic sister and my past dear sweet diabetic mom.
Also< I am trying to let my 5 daughters and son know about this disease.
Thank you so much.
Hy,
I just wanted to order Inositol, 5-HTP and L-tryptophan from Emerson but I cant. Its says: Restricted to Qualified Healthcare Professionals or their patients.
What to do?
Im from Europe.
Please give me some advice
thank you
Hi everybody,
Did Trudy make other “good copper-free
multivitamin” recommendations, apart from the *Designs for Health Twice
Daily* one ? I can’t find any provider that ships that brand in Canada,
Thank you.
Hy,
my sister have OCD. It is starts like she was washing her hands too much. And then her doctor gave her some drugs. She was not better just sleep all day. After some time she try to get off from drugs and she was ok several months and then her legs was restless, she cant sleep and she was hungry all time. After a week she tried to make a suicide. Then she was in hospital one mounth. Doctor get her new drugs. But her depression and OCD wasnt better. All the time she was suffering with obsessive thougts. After eight years suffering and three suicide attempts she is in situation that she can do anything because she think that everything is contaminated. Now she drinks Zoloft 50 mg in the morning and before lunch, Rivotril 3 times in day and Hellex. I am living in Europe and after I reed your book Im managed to get Lidke L-Tryptophan and she start 2 days ago to drink 1 capsule 6 hours after SSRI. She say after first that she didnt feel any improvements but after second she says that she some nice dreams. But she cant sleep until 3 ore 4 am. So can you please tell me when she can take 2 capsules Tryptophan? She have all caracteristics of lowe serotonin. And she also take blood test for serotonin and it was 3,5 and normal is from 95 to 250. So she is obviously low in serotonin, only is question whether it takes L-Tryptophan ore 5-HTP. Am I right? I also get some Inositol. I only can get from Vitacost brand NOW Inositol capsules 500 mg. She take it 1 capsules after breakfast about one week. Her obsessive thougts is still here. Today I tell her to take 2 capsules. Is it that OK ore what to do? Here I dont have any doctors who knows something about aminoacids so please help me with your knowledge.
Thank you very much Trudy
Kristy
I’m sorry to hear about your sister. Someone on 3 medications (Zoloft is the SSRI, Rivotril is a benzodiazepine and I don’t know what Hellex is) really does need to be under the care of a functional medicine doctor who is supportive and knows how to provide guidance and nutritional support.
I also can’t give specifics via the blog but here is my approach which you could use to help you find a doctor who can help you https://www.everywomanover29.com/blog/taper-from-antidepressant-tryptophan-amino-acids/. Dr Kelly Brogan has some good resources on her site too and this interview I did with her was excellent https://www.everywomanover29.com/blog/medication-tapering-withdrawal-kelly-brogan/
Some people do better on tryptophan vs 5-HTP but I would suggest starting with all the dietary changes first – like quality animal protein at breakfast, no sugar, no gluten, no dairy, no caffeine i.e. a real whole foods diet. I cover this all my book “The Antanxiety Food Solution” so I’m glad you have it already. Kelly Brogan’s book “A Mind of Your Own” (on Amazon here http://amzn.to/2n3aqmT) is good too.
Inositol is usually fine to use with medications and the research shows that up to 18g is helpful. I start low and increase slowly.
Hy,
my sister takes L-Tryptophan but it doesnt work, GABA also and B6. Only Inositol is OK but she have constantly disturbing thoughts. She have sweaty hands. So I dont know what to do. Maybe her OKP is connected with An adrenal gland? Do you have some sugestions?
thank you
Kristy
Disturbing thoughts is often a sign of low serotonin so if I was working with her I’d check to see if she has other low serotonin symptoms too. When I hear the amino acids are not effective these factors come to mind: it’s not a low serotonin or low GABA issue; the products are inferior or have additives; too much or too little was used; it’s another root cause (like high cortisol, gluten, SIBO, heavy metals, Lyme etc); low thyroid (makes aminos less effective); medication side-effects (benzos, SSRIS and even fluroquinolones)
I’m afraid I don’t know what this means: “Maybe her OKP is connected with An adrenal gland?”
Hy,
now I reed on your blog that is better take L-Tryptophan then L-Tryptophan complete. But I only can order that complete and chewable. So what to do with this complete? Is it difference in structure ore what? My sister drink 1 capsule 6 hours after SSRI after diner. But I think that she need more then 500 mg, so when she can take 2 capsules of L-Tryptophan complete?
thank you
I explain my thinking about 500mg tryptophan vs Tryptophan Complete here http://www.everywomanover29.com/blog/tryptophan-500mg-or-tryptophan-complete-lidtke/
Trudy, do you have a multivitamin alternative to the Designs For Health Twice Daily Multi you suggested? It’s not available in Australia and it’s very expensive to get shipped here!
Don’t know if this already was received
But I am a man so I don’t know if you’re going to answer this but I have been reading your things about anxiety and I was wondering how much L-tryptophan to use for anxiety I think I read somewhere it said 6 g but with 500 mg stats I believe six pills at least and that sounds like an awful lot. I have severe anxiety and depression and just wanted to add that SS our eyes no longer work for me that you stupid for some reason they make my anxiety worse
Greg
I start with 500mg twice a day with my clients who have low serotonin symptoms if the trial indicates that it will be beneficial. Using the amino acids is described in great detail in the amino acid chapter in my book “The Antianxiety Food Solution” (here on Amazon http://amzn.to/2kptFWm). I recommend everyone read this chapter carefully BEFORE starting on any amino acids. The rest of the book helps people address many of the other root causes of anxiety like low blood sugar, gut health, pyroluria etc.
Ssri is misspelled sorry as I dictated post
Hi Trudy,
I have been on a program for pyroluria, high copper and high histamine. After 8 months of dutifully taking my supplements, I am feeling better (more good days and less severe symptoms). To my surprise, my latest round of testing thru LabCorp showed all areas to be worse. At first, my practitioner challenged my compliance with my vitamin regimen. I assured them I am compliant as I want to get better and I am spending a considerable amount on my supplements . I questioned the accuracy of my test results but they tell me they trust the results. Trudy, if I am taking my supplements dutifully and showing improved symptoms, is it not possible that the lab made be off in reporting my copper, histamine and pyroles as higher than before treatment? I know you have written previously of not finding lab tests always reliable hence your use of questionnaires to evaluate progress. I welcome your thoughts on this frustrating situation.
The practitioner also wants me to only purchase supplements thru them saying thought I buy high quality and reputable brands, their supply may be superior and more effective.
Thanks so much.
Hi again Trudy, just had a few other things come to mind:
1. If I am releasing/eliminating excess copper and excess histamine, might the levels be higher in my bloodstream for a while and therefore show higher levels at this time? I am having copper detox symptoms off and on. I do not know if histamine elimination produces symptoms.
2. Do you think a hair analysis would provide better insight into my copper and zinc levels?
3. Is there any other test or is there a questionnaire that could be helpful in evaluating symptoms and progress with high whole blood histamine?
Thanks so much and thanks for being there.
( A dear friend said to me that if I FEEL better I must BE better regardless of what my lab tests say)
Susan
That is possible and yes I like hair analysis but it does need to be interpreted properly. Joan Matthews Larson has the questionnaire in her book “Depression Free Naturally” and uses whole blood histamine
Thanks so much Trudy.
We are all very fortunate to have you out there as a resource especially when so many of us experience difficulties with our testing results (and difficulties with our health care providers). More and more I understand why excellent nutritionists like you develop questionnaires as guides/tools to be used in natural and nutritional healing.
Gratefully yours, S.
Im currently take 1000 mg of Vit C daily as part of my vitamin regimen. I read on your blog, “Don’t forget that 1000mg of vitamin C can help to negate the effects of an amino acids.” So, my question is, if I want to supplement with amino acids, should I not be taking the vitamin C???
Thank you for your time!
Sarah
I have clients use vitamin C with meals and the amino acids between meals and it’s fine. I do recommend reading my book (here on Amazon http://amzn.to/2kptFWm) before starting on the aminos so you have a good understanding of precautions and how to use.
She does have homemade both broths and good quality shakes. No caffiene…some gluten containing foods. Wish you were taking on new patients!
hi trudy
my daughter who is 16 yrs old unable to fall asleep till 4 am in the morning. Mind racing, a lot of thoughts and feels moody after 10 pm in the night. Sometimes shes in tears for reasons she cant explain
please advise what supplements can help with her conditions.
Tan
If I was working with her I’d start by looking at diet (no gluten, no sugar, no caffeine, animal protein at breakfast), gut health, the adrenals and high cortisol and have her do the amino acid questionnaire and trials of tryptophan (for “mind racing, a lot of thoughts and feels moody after 10 pm in the night”) and then GABA. This is all covered in great detail in my book “The Antianxiety Food Solution” (on Amazon here http://amzn.to/2kptFWm) and on various blogs on the site – feel free to use the search feature
I’d also make sure no screen time after 5pm + exercise + nature-time especially first thing in the morning
Hi Trudy–I scored pretty high on the low serotonin questionnaire. I am currently on an adrenal supplement for adrenal fatigue and the morning anxiety (I need to cure the worlds problems before 6am syndrome) is making me more tired. I plan to purchase the L-tryptophan supplement you recommend but wanted to clarify why it can be chewed (the tablet). Is this for people who cannot swallow large pills or is it better to break it for lower dosage? I just want to be sure before I get started. Thank you for your time.
Colette
Many people do better on sublingual forms of the amino acids. This is certainly the case for GABA, less so for tryptophan. If less than 500mg of tryptophan works best then it does need to be opened. The chewable 100mg tryptophan is often a better option in this instance.
Thank you. I started on the Lidtke tryptophan Tuesday night, full 500mg, swallowed the pill whole, and I saw an immediate improvement in the racing thoughts and anxiety in the morning. Sleep is still a challenge–waking earlier than I wish–but I’ll take one step at a time and add GABA calm next and see how things go. One step at a time!
Colette
This is wonderful to hear. When I’m working with a client we continue to trial a supplement that is working and increase it observing continued benefits before doing a trial of a new supplement. I explain more about this approach here https://www.everywomanover29.com/blog/gaba-anxiety-add-tryptophan/
Thanks for the updated supplement list Trudy. I note Source Naturals 750mg GABA is not in there but rather ProThera 500mg GABA & Enzymatic Therapy GABA. Why do you prefer these other brands, is it because the amounts are less? I have been having some good results lately with Source Naturals 750mg GABA on the tongue at bedtime for improved sleep and calm.
How can I attain the low serotonin questionaire?
Is there one for pyroluria, too?
Hi Jo-Anne
There are links to both in the top section of this blog post. They are also in my book “The Antianxiety Food Solution” (on amazon here http://amzn.to/2kptFWm) – there is an entire chapter on the amino acids (including the questionnaire) and an entire chapter on pyroluria (including the questionnaire).
Hi Trudy,
I have a question about Tryptophan Complete. Two questions actually. I see that it contains Vitamin C. When I took your online “amino acids” course with Aimee Serafini, you told us that vitamin C was an “antidote” to use if we got an undesirable reaction to the amino acids. Why doesn’t the vitamin C in Tryptophan Complete cause problems with how it works? Also, I noticed that it contains folic acid. Isn’t that a no no these days?
Nancy
Great question – this is a small amount that acts as a co-factor to help make serotonin but it may also be why some people do better on the 500mg tryptophan or with a combination of Tryptophan Complete with added 500mg tryptophan.
Yes folic acid is a no. It used to contain folic acid and then they made it with folate from lemon peels. Now I am seeing folate from lemon peels and folic acid 200mcg on the label https://store.lidtke.com/products/l-tryptophan-complete – it seems the formula changed again! On Fullscript I see this on the product description: Folate (as folic acid) 800 mcg. Thanks for bringing this to my attention – I’ll be following up with them and will update the blogs once I confirm.
I order Ortho Molecular’s Fiber Plus powder from Emerson Wellevate as the price on Amazon went from $23.00 to $75.00, and I see it is not available for purchase at Fullscript. Will I still be able to order it through Emerson? I also see that Fullscript is in Canada so I wonder about the shipping costs, and how long it would take to get to me in California? I usually worry about the delivery (length of time) in the summer, as I don’t like my supplements to be in transit in 100 degree weather for a week or more. Emerson gets to me within 2 days, and has free shipping for orders over $49.00.
Hi Lynn
Yes you can still order through Emerson. I’m surprised that no Ortho Molecular products shows up in Fullscript and am checking with them. Fullscript’s head-office is in Canada but they have warehouses in the USA that they ship from. Fullscript also has free standard shipping for orders over $50
I have been taking L tryptophan since 8 months for depression and worrying thoughts. I have done relief for the depression but not for worrying thoughts. I take lithium orotate and inositol. Also seriphos. Still looking for how to stop the bad thoughts.
Can I get some help here on my symptoms. I need some support.
Thanks Trudy
Hi Trudy,
I am an Iridologist and naturopath based out of Mississauga, ON, Canada.
Do you have any conferences or meeting in ontario? If you do I would like to meet up with you.
I am a regular follower of your articles/website. Great website and very exhaustive information.
1. EPO is good for Pyroluria because of the GLA content, but Borage has more GLA than EPO, then why not use Borage?
2. Also I have seen copper supplementation has dramatically improved arthritic symptoms in many of my clients. Also it has been really beneficial in increasing memory/ thought recall and also in mouth ulcers. Can you share you experiences?
Rohit
I don’t have any meetings in Ontario. Glad you enjoy my content!
1. EPO is good for Pyroluria because of the GLA content, but Borage has more GLA than EPO, then why not use Borage? We found there were some quality issues with borage and also found better results with EPO
2. Also I have seen copper supplementation has dramatically improved arthritic symptoms in many of my clients. Also it has been really beneficial in increasing memory/ thought recall and also in mouth ulcers. Can you share you experiences? I typically find high copper to be an issue with my clients and have not ever used copper supplementation. May I ask what form you use, how much, with zinc and do you test copper and ceruloplasmin before recommending copper supps?
Hello Trudy,
First of all, THANK YOU from the bottom of my heart!.. because of the wonderful knowledge you are so willing to share with us all. God bless you. 🙂
I just placed the order on Amazon for your book- I can’t wait to start reading it. I know you have said, in several ocassions to read the book BEFORE we start on any supplement. However, based on the amazing benefits that a Zinc supplement can bring, I would like to start giving it (the one you recommended- “Solaray OptiZinc”) to my 13 year old once a day (who suffers from anxiety unfortunately) . Would that be too much for a 13 year old who is pretty healthy otherwise?
If you consider it’s ok, at what time of the day would the Zinc be better absorbed -with meals, after meals, right before going to bed..?
I also would love to have a one-on-one consultation with you. I just signed up to add me on the waiting list..Do you treat kids/teenagers too or just adults?
Thank you so much once again,
Angie
Thanks. Your info has been helpful to understand and treat pyroluria.
You mention that Vitamin C is used to negate effects of any amino acid. If I choose to take Vitamin C (from listening to Dr Saul about mega dosing) and also wish to take amino acids, how much time should I have between the two groups of supplements, so i don’t accidentally cancel out the benefits of the amino acids? Would the same thing be true of separating Vitamin C from whole food sources of protein?
Hi Trudy!
What a Godsend you are!
I just caught the bit about Inositol and SIBO on my way to this post.
That is a handy piece of info right there.
I am having issues with the Fullscript account.
It keeps asking me for my credentials.
I had an Emerson account when you were there. But I have not ordered in a while. Austin has the People’s pharmacy. I will be moving, and will not get to utilize that anymore.
How do I work with Fullscript again?
Thank you again for all that you do.
I look forward to hearing from you.
Samantha
New Zealand questions 🙂
Im very interested in trying the amino acids. I have read the Anti Anxiety book
and score highly on a lot of the questionaires.
As far as the online study course I see there is only one option for online study, is that correct?
Converted to from US to NZD $287.59.
>
I am also on a NZ waiting list to see an integrative practitioner
who has quoted me $858 nzd plus another $300+ for the follow up not including supplements, who tests heavily. This is very expensive for me but I would really like to sort my health out. I know Julia Ross and yourself Trudy don’t go down the testing route. So I am a bit unsure of if I am doing the
right thing in going down the testing route or if I can be secure with the questionaires and treat myself from that? Would really love some support and guidance.
>
I have contacted Lidke for l-tryptophan (Trudy’s recommended brand)
and been quoted $60 for postage not including the product. They
have 3 types of l-tryptophans, which one do you get? And I have
contacted another US firm, evitamins regarding GabaCalm.
>
As the freight is so much for me to get these products, do you know
of any other way I can access them from New Zealand that might be more cost effective?
Currently taking B-Complex, l-theanine, calcium, EPO, P5P, zinc and iron.
Thank you so much 🙂
Jay
Yes one homestudy course and many people do really well with the online information and some others need the additional guidance of working with a practitioner when it’s more than just the amino acids, mood nutrients (like for pyroluria) and dietary changes.
I wish Lidtke was available in Australia and New Zealand and had more affordable shipping until they are. I have clients start on the 500mg tryptophan. I write about the Tryptophan Complete here https://www.everywomanover29.com/blog/tryptophan-500mg-or-tryptophan-complete-lidtke/
Hello Trudy,
Do you have any thoughts on why I have a very high reading (198) for my pyroluria test but have virtually no symptoms. My wholistic dr has given me a script for a Pyrolle Primer (undermethylator) to be made up from a compounding pharmacy, but I am hesitant to fill it out as it is very costly and I feel well (apart from some anxiety sometimes)…..I was off Zinc and B6 before my tests….does caffeine affect the reading? As far as I know the lab treated the collection correctly.
Any thoughts would be much appreciated and thank you so much for all your work. I have been following your summits etc. for quite a while and find them extremely helpful.
Jan
Hello Trudy,
I contacted Clinical Labs in Melbourne where I was tested for the urinary pyrroles about my high results and was told the lab who they send the sample to (AAL in Q’land) have just changed their ref ranges and wondered if you had heard this. There has been new research and the ranges are now: 40 or less (normal) 40-150 (mild) 150-400 (moderate) and above 400 (severe) and needs further investigation. Apparently the earlier ranges were for children and they haven’t changed.
Jan
I’m not familiar with either lab or the change in ranges. What were the old ranges?
Previous ranges from (AAL) Applied Analytical Laboratories (a very reputable lab) were:
Less than 10mcg/dl (Normal)
10 – 20 (Borderline)
20 + (Elevated)
Thanks Jan – wow that’s a big difference. I do hope they are contacting all their clients who have been tested.
I started the low dose of tryptophan about 2 weeks ago and then today 5 HTP. from what I understand I should feel better but I actually feel worse. According to the questionnaire I should be low on serotonin. I suffer from OCD/GAD/depression. If I feel worse after the 5 HTP, should I discontinue or try a higher dosage? Thank you!
Ashley
If the amino acids make someone worse I have them stop or reduce the amount. We also always revisit the trial we did on the first day i.e. before and after symptoms and the ranking when trialing each amino acid. This is used to determine how much each client should be taking as a starting dose. I also have clients use only one amino acid at a time.
Thank you so much. After speaking with my therapist who is familiar with your work, we came to that conclusion. I took tryptophan this evening and I’ll just do that for a few days to see how I feel.
Ashley, I would like to ask you how much Tryptophan you are taking, if I may? Do you notice any improvements?
I have a daughter-13 yrs.- who has OCD. She’s taking 600 mg. at night, right before she starts doing her nighttime routine. No improvements so far.
Thank you! And I wish you good health!
I’m doing 1000 mg before bed. So far no improvements.
Trudy, my daughter reinitiated taking Tryptophan (she stopped because we were busy, had guests and she forgot and I forgot to remind her too..). She restarted taking it yesterday right before doing her nighttime routine. She’s taking 600 mg. (1 pill of 500 & 1 of 100 mg chewable). No improvements so far.
Should I increase her to one more 1 pill of 100 mg. tomorrow-Friday? And if I don’t notice any improvements on Saturday should I give her 1 more pill of 100 mg. OR should I wait more days to add one more?
Thank you Trudy so much for all your hard work..:)
I guess my question would be..if it’s ok to increase the Tryptophan dose one pill of 100 mg.per day until we see an improvement? Is it safe?
Thank you again!
I’m not sure about that, but info is being sent to Dr’s who have requested the test. Apparently, these earlier ref ranges were for children and they have remained the same. It has caused quite some some discussion on the Pyroluria Facebook group as you can imagine and people are now wondering if they really have it, some have definitely been helped with supplementation, others not so much….but as you know, tests are just another marker and symptoms are just as important. This research is quite new and just about to be released as far as I know.
Trudy, do you do out of state consultations?
Trudy, I wonder the same thing as Ashley.
I cannot find anybody around here (And God knows I’ve been looking around for some time now!) who works, and has experience, with amino acids.
Please advise..
Thank you.. again,
Angie
Is the Garden of Life RAW brand of Zinc ok to use? Also, what are your thoughts on turmeric for brain inflammation in regards to depression? I didn’t find relief with tryptophan which is really shocking so I moved on to pyroluria as I scored high for that as well.
Ashley,
The brand of Zinc that Trudy recommends is “Solaray OptiZinc 30 MG.” 🙂
Ashley
I haven’t used this zinc so I’m afraid I can’t comment. Curcumin has been shown to be beneficial for depression https://www.ncbi.nlm.nih.gov/pubmed/25046624
I’d be curious to hear how you scored on the low serotonin questionnaire, how your trial of tryptophan went, what brand you used and what results you saw.
I checked off 16 of the low serotonin symptoms. I used the lidtke brand tryptophan. I started with the 500 mg, didn’t notice much. I then put it on my tongue bc I forgot that part to see if I need it. I didn’t find it did anything for me. I have intrusive thoughts thanks to ocd and for some reason became really depressed a few weeks ago. It’s really frustrating.
Ashley
I have my clients continue to increase the amount during the trial until they see improvements. The fact that you say you “didn’t notice much” indicates there was some improvement. Even if it’s 1 notch improvement (on scale of 1-10) I find it’s worth continuing.
May I ask which symptoms on the serotonin questionnaire you were measuring in the trial and what the scores were before the 500mg tryptophan and after the 500mg tryptophan? For example, before: worry=10, intrusive thoughts=10, anxious = 10; and after: worry=8, intrusive thoughts=9, anxious = 8
Have read that IV of Vit C Plus amino acids is good for MDS patients is there a type of tryptophan that can be used with the Vit C IV ? Thankyou for this topic!
Joanna
I list Lidtke tryptophan on this page and it’s the brand I use. The aminos need to be taken away from vitamin C to be effective. I’m not sure what MDS is?
MDS is Myelodysplastic Syndromes, pre curser to Leukemia, am having Vit C IVs w/amimos. So this isn’t good?
Hi Trudy,
I’ve been reading your book and had a few questions. You say that it’s important to supplement with a free form amino acid blend when taking DPA or DLPA. I was wondering if there’s any particular brand that you recommend? I couldn’t find anything specifically called “free form” but I looked for a blend. I didn’t find much, but found something called Amino Complex by Now Sports. Is this similar to what you were referring to?
Also, is it ok to take with the other supplements? The instructions on the bottle say to take a few hours before or after other medication or health care products. I’m taking too many supplements (including zinc which also needs to be taken separately) to be able to do that, so I’m not sure how to take it.
It also says on the bottle to consult a heath care practitioner if taking hormone replacement therapy, which I am, as well as being up to date with mammograms and gynaecological evaluations prior to use. There are a host of other warnings as well. Just wondering why this is, and what your thoughts are on this?
I’m really finding help (and hope!) from your book. Thank you so much for all you do!
Hi Susan
So glad to hear you’re finding hope and help from my book!
This blog lists some free form amino acids that I use (sorry but I wasn’t permitted to include product names in the book). I can’t find the one you mention but the key is for them to contain tryptophan and many do not. All those warnings sound very unusual so feel free to share a link to the Now product and I’ll take a look. The individual amino acids like DPA are taken between meals and away from protein and the free form amino acids with a meal.
Ok, here’s the one I found…
https://www.nowfoods.com/sports-nutrition/amino-complete-capsules
I’m not sure how I missed the amino acids that you use, but I’ve found them now :). A further question though; the only blend you recommend that doesn’t have any drawbacks (genestra) plus the Now Sports (above) both have whey in them, and I have a dairy intolerance. The Pure Encapsulations Amino Replete would be good except I’d rather not have fructose, as I also have a intolerance to that. Any suggestions?
Thanks!
Does anyone know of a good way to order these supplements where you are able to return them if they do NOT work or are the wrong combination.
Hello, just want to ask if you can recommend a supplier of amino acids in the UK? Thanks
Do you think if someone is taking zinc and has pyroluria that there zinc levels when tested by blood would be normal or show high if they were taking the right amount for this condition? I am wondering if people in general with pyroluria and taking zinc are able to go by the zinc blood test as a guide at all or would the zinc taste test be the best way to tell.
Kim
A zinc blood test is not a reliable marker for low zinc. Dr. Anju Usman says this: “We look at plasma zinc and serum copper ratios. When you ratio plasma zinc to serum copper what you’re looking for is a ratio of 1 to 1.” https://www.everywomanover29.com/blog/zinccopper-balance-in-autismpyroluria-dr-usman/
I had my blood work done and my ratio was no where near a ratio of 1:1 as Dr. Anju Usman recommends while both the zinc and copper were in the labs range of normal. I took the zinc taste test today from Metagenics which is less than a week since the blood was drawn and it didn’t taste strong at all, just like water pretty much. So both tests seem to say I could use more zinc. Oddly enough I have been taking a zinc supplement for months working up to even 50mg of zinc glycinate from Orthomolecular. I did stop the zinc 3 or 4 days before the blood test to make sure there would be no inaccurate result. I do have several auto immune conditions, inflammation and possibly pyroluria so, I think I will try to get the zinc to the 1:1 and see if I notice a difference.
Trudy and Kim,
I was so grateful to learn from Trudy that plasma zinc is not a reliable way to detect low zinc and that the copper to zinc ratio is what is key (1:1). Using an experienced Walsh trained MD, I went thru several rounds of blood tests to check my zinc and copper levels. Each time my plasma zinc was in normal range and my serum copper elevated. My urine was positive for kryptopyrrole. The doctor said that I had pyroluria and that I was “deficient in zinc and B6” and needed to take high doses of each daily. I asked the obvious: if I had pyroluria and needed high doses of zinc, why was my zinc level in normal range?? When I pushed the point, the dr reluctantly stated that “maybe your zinc was over calculated by the lab.” No comment was ever made about my copper levels nor about my zinc/copper ratio. I knew then I could not rely on blood tests to manage my pyroluria or zinc/B6 needs. I gave the dr and lab route a try but have found that using Trudy’s book is the most effective method. The questionnaire and guidelines for identifying low zinc and low B6 work for me. As does the zinc taste test. I can share a colleague of mine did the same testing and dr consult and had similar results.
Trudy, in addition to addressing pyroluria and taking adequate zinc and B6, are there any other measures you find helpful for females trying to get their zinc and copper in proper balance? Could estrogen dominance, so common today, be behind copper levels being elevated?
Thanks so much! Thanks for being there for all of us trying to improve our health!
Hello Trudy, I would like to ask for your opinion please..
I would like to give Glutamine to my 10 year old daughter who craves incessantly for something sweet!! When reading your book/your blogs I thought this amino acid could be very helpful to her. I am planning on buying “Pure Encapsulations L-Glutamine 500mg”- which I know is one of the 2 supplements you recommend for low blood sugar. I tried to find a suggestion about a dose for minors, or at least a starting dose for adults and I couldn’t find any suggestion or I probably missed it.
I would like to ask you kindly.. What is a safe/starting dose for a relatively healthy kid? How many times a day? For how long should she continue on this supplement?
I also read the Amino Acid Precautions.. And NONE of the statements apply to her, thank God. 🙂
Thank you so much!
Angie
Hello Trudy,
First, I want to thank you SO MUCH for taking the time to write your blogs and then offering people the chance to post questions and then responding to them. You have been an IMMENSE help to me and so many others out here struggling through this Pyroluria issue. In a comment from one mother my heart went out to her as you could hear it in her words that she is a warrior and she will not give up searching to the ends of the earth trying to find a practitioner – (be it medical/functional/alternative/naturopath) to assist her in helping to effectively treat her child with Pyroluria. It seems like such a simple issue to diagnose and then treat, but yet it IS extremely difficult to find someone who is educated on Pyroluria and then able to work with the patient one on one for guidance. So again, I thank you! I also want to thank you for giving suggestions of brands to use for the supplements. Over the past 2 years of being misdiagnosed many times, for many different things, and being put on SO MANY different supplements, I have learned that quality IS very important and not all supplements are created equal. My question is this: You suggest the Lidtke brand Tryptophan (which is the only one use) Can I empty the capsule’s into applesauce when taking before bed? Or should they be opened and put into water? Or opened and put directly on the tongue? I was also wondering what your thoughts are on their brand of B6 which is called “True B6”. I believe it is the P5P form? My other question is: I believe amino acids are to be taken on an empty stomach, is that correct? If so, is an empty stomach considered to be – 2 hours after food?
Thank you so much Trudy! Have a blessed day
After taking 45 mg zinc for 5 days for pyroluria i noticed that I started fearing from small things. When I was talking 4 mg of copper a day then things did not bother me. But when only on zinc then fears started to creep in. Did anyone else notice this too. I think copper makes you calm and also helps in better sleep as its involved in making dopamine.
Hi Trudy!
I was wondering how much of the inositol powder to give to a child with autism. I’m also considering using GABA and tryptophan. What are the best starting doses? Thank you.
Hi Trudy – do you have a list of practitioners that apply your recommendations with regards to addressing anxiety/insomnia with amino acids? I have been experiencing nighttime-only anxiety and insomnia on and off over the last 4 months and have had some success with taking tryptophan and GABA (more success with GABA I believe than tryptophan) but still have nights (about once a week) where it seems like nothing works and I end up struggling for hours to fall asleep and only get 2-5 hours of sleep. I have been reading a lot on your blog and am getting your book but feel like I need more one on one support to help me run through a course of trying different things. The funny thing is I don’t experience a lot of anxiety during the day. I am definitely a type-A , “higher strung,” person, but overall don’t feel anxious during the day, just at night when I start to get the feeling I might have trouble sleeping. Thanks in advance for the help!
I found this on Julia Ross’s website: https://www.juliarosscures.com/practitioners/
It lists some practitioners that have been trained by Julia Ross.
I will use copper and glycine to help with insomnia in the night and take zinc and B in the daytime. Also I will try potassium in the evening for sleep. Let me know if you need more help.
Hi Trudy! I have a question and would love you’re opinion. I started taking Lidtke L-tryptophan about 1.5 months ago. (I took the chewable form at 100 mg and worked my way up to 500 mg). I felt good for awhile, but now I feel like I get heavy head when I take it lately at 500 mg. I also had an OATS test done and my quinolinic/5-HIAA Ratio is 2.2 . The lab is recommending that I take 5-HTP instead since it does not create quinolinic acid. I have taken 5-HTP for 3 days now at 50 mg but I still have anxiety symptoms, just not as strong. Should I increase my intake of 5-HTP to 100 mg? Or should I wait 2-3 weeks to see how I feel? Also I only take it once a day instead of twice a day per your recommendation in your book.
I am currently following your supplement plan with exception of taking individual B vitamins (such as B6, Biotin, and B3 since I am deficient in those) and I am cutting out dairy.
Another issue, my OATS test states that Arabinose is high (31 is my value). I have started taking a probiotic for this issue. Could this be why the L-tryptophan is not working?
Thank you so much for your time and I look forward to your response!
Jen
I can’t give specific feedback via the blog but can share this gneral feedback: too much of an amino acid can cause adverse symptoms just like too little can, some do better on 5-HTP and some do better on tryptophan, I’m not concerned about quinolinic acid on the OAT test unless someone is deficient in vitamin B6 and candida/dysbiosis always needs to be addressed and probiotics are likely not be enough.
Thank you Trudy for your response! Have a wonderful day!
Jen
Hi Trudy! I am a little low in B6 based on my results from the OAT test. I am also low in Biotin and B3. I have begun supplementing with extra Biotin, B6, and even Niacin to address the deficiencies. ( I think in my first post I made, it was confusing when I mentioned I was following your supplement plan. I do that instead of taking a B Complex because my B12 is normal to high and whenever I take the B complex my heart races and I become agitated.) I am definitely going to look into being tested for dysibiosis/Candida. I have been wondering about this and still have not been tested for it.
You’re book has helped me so much! Thank you for your response! I feel like I am finally getting somewhere in my journey of feeling better! Everything I have learned thus far has been fascinating! Thank you again!
Jen
Do you like the body bio liquid minerals? Do you think the taste test method of supplementing with minerals works? Thank you!
Hi Trudy! I have JUST discovered you, and felt that tingling of realization that I must have pyroluria, according to most of the symptoms. THANK YOU for taking the time to write this and respond to so many people’s questions. You are doing wonderful work in the world. I just have one question (about diet):
I can pretty much give up everything BUT CAFFEINE. 😀 I mean, I could of course, but coffee is the the only diet “no-no” that I really truly enjoy, and feel like it would be a truly difficult “sacrifice”. Sugar, wheat, supplements, everything else – no problem.
So I’m wondering…can you still drink coffee and perhaps make up for that in other ways, while curing pyroluria?
Thank you!
Hannah
Glad to hear you’re enlightened about pyroluria! Coffee is usually the toughest thing for my clients to quit so you’re not alone. Read this to see more about why you may want to really consider quitting https://www.everywomanover29.com/blog/12-ways-coffee-impacts-your-hormones/ It also depletes zinc which is key for pyroluria and is a big factor with anxiety
The important thing is to address why you need it – adrenals, low iron, low thyroid function, poor sleep so you need extra energy, food sensitivities etc. Tyrosine is a big help for many trying to quit and there are lovely alternatives
Hi,
I have stopped antidepressants 2 years ago after taking it for 2 months.
I have been taking tryptophan, B complex, seriphos, inositol etc since then and depression have reduced.
I am wondering why sleep issues did not improve, I cannot sleep without a tablet despite taking 200mg of tryptophan, 1000mg at night.
Kindly help. I have the type of depression that just want to cover up on the bed but i cannot tolerate Tyrosine.
What do I do to help myself further.
Thanks
Abiodun
Low GABA can cause insomnia as can low blood sugar. Sleep problems and depression can also be due to parasites, food sensitivities and SIBO too so figuring out the root cause is key. I also educate my clients about Wifi and EMFS
Thank you for your response.
I am just at a loss on what to do next because i have taken lots of supplements.
I even worked with a naturopath who helped with the supplement prsecription.
How best can i supplement for the things you mentioned.
Thanks alot
Hi Trudy,
Thanks for your kind guides on my conditions. Please how can I supplement for the suggestions you highlighted.
I live in the Uk and it is difficult to get a dr to Help me. Kindly help a bit further. Thank you.
Hi Trudy,
Thank you so much for all your research, and by taking your time to answer people questions (which I read them all). It has been really helpful!
I’ve wanted to try the Lidtke tryptophan, but unfortunatelly I couldn’t find any website that ships to my country (Brazil).
Is there any other brand that meet the quality criteria for this aminoacid?
Lucas
I believe Lidtke sends all over the world.
Hi there Trudy I suffer with Depersonalization or derealization and I was wondering if you knew anything that would help me with this, i also have anxiety and feel dizzy a lot of the times and shaky if you could recommend anything. Also I’ve read your book as I have it. Also I’ve started to do gluten free and I’m also breastfeeding so I can’t take many supplements. Kind regards
Tay
I would focus on going gluten-free. This new blog may be helpful – Non-celiac gluten sensitivity manifestations outside the gut: foggy mind, depression, anxiety, neuropathy, joint pain, headache, fatigue and IBS https://www.everywomanover29.com/blog/non-celiac-gluten-sensitivity-manifestations-outside-the-gut-foggy-mind-depression-anxiety-neuropathy-joint-pain-headache-fatigue-and-ibs/
Also key is addressing the low B12 you also mentioned. And if this is new since the birth of your baby be sure to discuss possible high copper with your doctor too.
Hi Trudy.
My 11 year old had the ruminating type of anxiety. I wanted to try the Lidtke tryptophan but their website says not to use it with an SSRI. He is on a low dose of Sertraline that isn’t quite enough but I’m not keen on increasing the dose. I’d prefer to go natural. Previous supplements from the Amen Clinic did nothing to help. I give him 1 capsule of Trancor by Metagenics at bedtime and It has some tyrosine in it. Im really bummed as I wanted to try the tryptophan.
What can help hot flashes for 46 yo early menopause?
Kelly
I start with adrenal support and look at gut health
Hi there, thank you so much for your incredibly informative blog. I am trying to help my husband… who is pretty resistant to making a lot of changes with diet, etc. He is willing to take some supplements that I recommend and my hope is that they will be a bridge towards feeling stronger and having more desire to make lifestyle changes ( I know food, etc are really the place to start… but it is just not going to happen right now).
His main struggle is extreme irritation/agitation in the morning. He is a smoker so part of it is withdrawal, but it is clearly more than that and has gotten exponentially worse in the past few years to the point that he literally cannot be present in the morning or things will get very bad.
He has taken some. 5htp with some success but he can’t take it immediately on waking ( makes him nauseous). Was thinking gaba as well but not sure on timing for either of them To encourage a better mood upon waking. Thank you for your time and I’m sorry for such a long entry. Any help would be much appreciated. I am happy to pay you for your services but it doesn’t look like you have opening at this time.
Renee
We need to get some great results quickly with the naysayers and the right amino acids can do that. When 5-HTP is too nauseating I use tryptophan instead. Smokers often need GABA support so I always do a trial based on their symptoms (physical anxiety and tension in the body)
Hi Trudy, My name is Melanie, I find myself needing to take 50-75mg of zinc (chelated) (2-3x25mg) a day since I moved to a more EMF polluted area (I´m EHS) whereas before 50mg was usually enough. I also need a lot of magnesium (1200mg +) and tryptophan (1000mg Lidtke or 1500mg Source Naturals, also use GABA). My question is whether this amount of zinc could pose any problems in the long run (It´s been 6 months now) When I try to drop down to 50mg again I become depressed and anxious after a few days. I have been recovering from mold toxicity these last 4 years and according to Dr. Walsh, L.A Gittleman and your
work I do believe I am an undermethylated pyroluric and have also been detoxing from copper. I became unemployed after the mold exposure at work (it was closed down) and have not been able to do any testing. My faith in God and prayer is what has led me down this road of healing these last 4 years, and praise God I am so much better but mainly struggling somewhat with EMF´s now. (I bought Nick Pinaults book). I would really appreciate some advice regarding the zinc, maybe it´s ok for me to take 50-75mg a day?
Alexandra
For many people higher amounts of zinc are needed especially when their levels are being depleted by EMF exposure and mold (both of which can depress the immune system). If someone has pyroluria and zinc levels are further depleted – stresses make pyroluria worse and both EMFs and mold are stresses on the body – then more is needed. Testing for pyroluria is always an option although false negatives are common. So is testing plasma zinc and serum copper looking for a ratio of 1 to 1. More from Dr. Usman on this here https://www.everywomanover29.com/blog/zinccopper-balance-in-autismpyroluria-dr-usman/
Hi Alexandra,
Sorry to hear you have struggled so 🙁 I recently bought a package of EMF detractor discs to put on electronic devices (cell phone etc) from a Canadian company, but to be honest I am not thrilled with their website info as not convinced they actually do anything…
But, I hope you don’t mind me asking… I was wondering how you detoxed from the EMF/mold exposure… It would be helpful to know specifically how to detox from the mold for now… What you did, for how long and if you might point me to any links/references or books…
Wishing you continued healing success sooner than later!
Bren
Hi Bren
I really recommend Nick Pinaults book “The Non-Tinfoil Guide to EMF´s” – really great advice there.
It´s been four years since I got sick from mould and WIFI, so I´ve been trying to recall the things I implemented.
Essential oils were so important, I used them instead of medications. Eric Zielinski, DC is a great resource.
I went on a course to learn the Buteyko breathing method (I was diagnosed with asthma and COPD because of the mould) which was very helpful.
I started to ground/earth myself by walking barefoot outdoors and I also bought a grounding sheet for the bed (do not use that in a high EMF environment, an EMF shielding bed canopy would be better in that case). This was a major factor in my recovery.
I adopted the Keto diet for a few months and am now mostly low carb.
I read “Nutrient Power” by William J. Walsh PhD. An excellent book that helped me find the supplements that I needed. It took me well over a year until the supplements began to take affect and I continue to take them now.
I need corn free supplements as I am very sensitive – it was causing hyperventilation at night.
I found Trudy Scotts blog and information about amino acids, took the questionnaire and use tryptophan and GABA every day. This was so helpful.
I pray/meditate every day.
I went through a course for emotional healing too, which was actually more important than I thought.
I exercised gently daily, walking outdoors or swimming and using the sauna.
I continue to restrict EMF´s as much as possible and do not use WIFI, only ethernet cable. My phone is mostly on flight mode now and I just turn it on to check regularly if anyone was trying to get hold of me.
I think that’s mostly all of it.
Hope this helps you Bren.
Take care
Alexandra
Alexandra
Thanks for sharing all this for Bren! It’s very kind of you!
Really glad my work has helped you too! Would love to hear how tryptophan and GABA helps and how much you use?
Thank you Trudy for your reply.
Hi Trudy, can you take gaba when taking an anti depressant?
Donna
I have had many clients safely take the amino acid GABA while they are on antidepressants. There is no known contraindication that I am aware of but it’s
always best to check with the prescribing doctor with the understanding you may need to do some education about the amino acids. My book “The Antianxiety Food Solution” has an entire chapter on amino acids and is fully referenced.
Hi Trudy, yes your work has helped me greatly! I had never heard of these amino acids before and the way they could help me after my mould toxicity and EMF problems. I use Lidke tryptophan 2x500mg before bed (have also had to use Source Naturals 3x500mg because it’s difficult for me to get hold of Lidke) but Lidke definitely works much better for my sleep. I still often wake up at around 3 or 4 o’clock in the morning in a sweat and hyperventilating and then I take about 1/8 or less of a teaspoon of GABA to get my wondering thoughts under control and get back to sleep which can sometimes take a while. I also take the same amount of GABA at bedtime. I use Buteyko to get my breathing under control again. All the best – Alexandra.
Alexandra
So wonderful to hear. And yes the Lidtke tryptophan is more effective but glad you have a substitute. When I have clients waking sweating and hyperventilating I think of high cortisol and Seriphos (https://www.everywomanover29.com/blog/seriphos-original-formula-anxiety-insomnia-cortisol/), low estrogen and also parasites. Often we find additional tryptophan helps and do a trial with more and with melatonin timed-release too.
Thanks Trudy for this information, I will definitely look into it these things.
I presume I could go up to 3×500 mg tryptophan at bedtime for starters and see if that makes any difference.
I was wondering if you could explain further about what this means below….it is included in your supplement recommendations…I guess Im confused because why would you want to negate the effects of the amino acid you’re taking? Is it if you overdose or something like that?? Or do you mention that because you want to take vitamin c and any amino acid separately? Thank you for helping me understand. I love your work and appreciate how passionate you are about helping women.
Vitamin C for negating the effects of any amino acid
Vitamin C 1000mg is used to negate the effects of any amino acid. I used to use EmergenC but this still contains folic acid, so here are some good alternate vitamin C recommendations:
Sarah
I have my clients do trials of the amino acids and if the one they use is not one they need or they use too much and they feel light-headed or say get a headache or feel too sleepy we use vitamin C to negate the negative effects. The benefits, if any, are negated too. This is explained in more detail in the amino acid chapter of my book “The Antianxiety Food Solution”
Thanks for your kind words!
Thank you Trudy! I plan on getting the book. 🙂
Hi Trudy,
Thanks for all the amazing information you share! I’m looking at the Genestra brand amino complex. You mentioned that it has tryptophan. However, they don’t list any of the amino acids on the bottle. Can you provide some insight on this and are there any other brands you would recommend that include tryptophan without fructose?
Thanks again,
Lisa
Do a lot of people with suspected pyroluria take a copper free multi vitamin and mineral, if so there a brand you recommend? In general they say as people age copper tends to increase in the body.
Kaye
Designs for Health Twice Daily Multi – find it here and details how to order https://www.everywomanover29.com/blog/amino-acids-pyroluria-supplements/
Hi Trudy–
After hearing your interviews on a few webinars, I have just purchased Lidtke L-Tryptophan. One question: if I need an occasional Ativan (for flying), is this contraindicated when taking L-Tryptophan? If so, how many days apart should I separate them?
I much appreciate your help!
Thank you, Debbie
Debbie
There is no known contraindication with Ativan and tryptophan but fear of flying can be due to low serotonin and many of my clients lose their fear and no longer need Ativan when using tryptophan
Trudy,
I don’t tolerate oral supplements well. Would using zinc soap help to raise my zinc even a small amount? I see soap online with 2% pryrithione zinc.
Thank you,
Rachael
Would like to buy the supplements while there 25% off, am looking thru their website, do u have a package one could order that has everything to do the trials, or a sample pack, or do u have to go thru and pick all of them individually?
Hi Trudy, what to do when on high dose of vitamin C (10.000mg divided per day, 1000mg per hour) and on Gaba and on Thryptophan. Using vitamin C after using Gaba and Tryptophan will take away the good things of the Gaba and Tryptophan. How many hours, minutes? do you need between The Vitamin C and the Gaba and Tryptophan? What is best to do? I also use L-theanine 100mg together with Tryptophan Lidtke, is that ok ? Thanks
What is the recommended dose for tryptophan for bedtime? I tried 500 mg of the lidke brand and still can’t sleep through the night. Last night I tried 1000 mg at bedtime and took another 500 when I woke up on the middle of the night. How much is too much? I’m thinking I should add some melatonin? I was also recently diagnosed with Pyloria through a blood test and have been taking all the recommended supplements hoping those would help me sleep to the night.
Suggestions please
Thanks so much for all the information!!
Hi, after reqading the articles on Triotophan and Gabba I am slightly confused. I am healing leaky gut and using bone broth regular as a half day fast from food then eating an AIP diet thereafter with more cabs in the evening meal. I am still struggling with sleep – initially falling asleep and then waking. I seem to fit the low seratonin model on the questionaire. Should I try triptophan and contiune the broth and if no changes then perhaps try Gabba? or stop the broth? Thanks for your ongoing support
Glen
I have clients trial one amino acid at a time so they know what is helping. I also recommend reading my book “The Antianxiety Food Solution” for a good understanding of the amino acids and all the foundational work
Hi Trudy
I have been following your work for years. I am from Australia but I’m currently living in New Zealand. I have had sleep issues on and off for over 10 years, I ordered Gaba Calm by Source Naturals, when I am having trouble falling asleep or when I wake up during the night and I can’t fall asleep I put one under my tongue, I am finding it definitely relaxes me and helps me to get into a deep sleep so even when I do have a broken sleep I feel refreshed the next day instead of having a hung over feeling.
Is it ok to take GABA Calm when taking fluoxetine?
Love your work 🙂
Warmest wishesJacqui Gee
Jacqui
So glad to hear it’s helping! I have many clients take GABA with their SSRIs
Hi there,
I have been researching your blog and various podcasts about doing an amino acid trial for anxiety. Do you have a suggestion regarding whether I should start to slow use GABA or L-Tryptophan for my symptoms?
I am a male in my mid-30s. I am happily married (12 years) with 3 young children. I have a corporate job as an engineer, mostly behind a computer. I am currently working with a naturopath/holistic doctor to repair my gut and my adrenal glands through diet, lifestyle, and supplements. None of my current supplements include significant amounts of serotonin or GABA.
The most acute anxiety symptom I am currently experiencing is intrusive/unwanted thoughts and rumination. I have a thought, and I get stuck in a brain spiral that I struggle to get out of. I reviewed the questionnaire from this May 2013 blog post, and I identified the most with the low GABA symptoms, although I do have symptoms from each of the categories. Here are the ones I identify with the most:
Have intrusive thoughts, perseverate or have an overactive brain
Or have unwanted thoughts – thoughts about unpleasant memories, images or worries (Updated Nov 17, 2017: new GABA research on intrusive thoughts) *
Poor focus *
Feeling worried or fearful
Unable to relax or loosen up
Stiff or tense muscles
Insomnia or disturbed sleep
Panic attacks
Irritability
Anger or rage
Lack of energy
Lack of drive and low motivation
Heightened sensitivity to emotional pain
Crying or tearing up easily
Craving a reward or numbing treat
Agitated, easily upset, nervous
I would like to slowly introduce small amounts of a targeted amino acid to help manage my symptoms (especially intrusive thinking and rumination) as I change my diet and lifestyle to address root causes. Please let me know if you are able to help point me in the right direction for where to begin.
Thanks!
Craig
I can’t give someone specific feedback via the blog but I can share that I have clients pick one area and focus on that first – it’s usually the area that they have the most issues with. With someone with intrusive/unwanted thoughts and rumination it’s typically low serotonin that we address first.
It’s wise to incorporate the amino acids as you change diet and lifestyle. It also makes it easier to make so many of the dietary changes.
I do suggest discussing the amino acid plans with your current practitioner and consider sharing my book “The Antianxiety Food Solution” with them too.
Thanks for the response Trudy. I’ve been on the paleo/autoimmune protocol diet for about 2 months now. I’ve also recently had an appointment with a naturopath and had some testing done to assess gut health, adrenals, and a few other things. I am planning to speak with her about targeted amino acids and your book at our next appointment.
I did begin taking low amounts of l-tryptophan about 4 days ago, and I could tell immediately that it helped to take the edge off some of my symptoms. I am staying at a very low amount until I speak with my naturopath. Thanks for all of the information that you’ve shared on this blog and through other media. It’s already been a big help to me.
Hi Trudy
What brand of l-tryptophan do you recommend? I live in NZ, I looked for Lidtke but can’t find it in NZ and can’t find a company to ship it to NZ. Can you take l-tryptophan and Gaba together? I have the source naturals brand.
Hello, l have been suffering from depression and insomnia for nearly four years. I managed to suppress the depression using l tryptophan which has helped much.
The only issue now is serious insomnia which I have taken many otc Supplements and not working.
Kindly help me
Thanks
Hello Trudy,
I’ve been following your posts on GABA and find them very helpful. In previous comments, I’ve asked you about the connection between blood pressure, hyperthyroid issues, and taking the right GABA supplements — and your responses have been very helpful.
Recently, I have seen a lot of info on taking lemon balm for hyperthyroid symptoms, which, as you know, often include anxiety. I’m on a low dose of an anti-thyroid medication, which is working to keep my levels stable (per my endocrinologist) but I still battle morning anxiety and insomnia. I have been following the work of thyroid specialists (including Elaine Moore) for advice on how to add supplements for anxiety relief. Again, lemon balm keeps coming up in the various articles. https://www.verywellhealth.com/the-health-benefits-of-lemon-balm-89388
In one article, it was mentioned that lemon balm influences GABA — which is why it works for anxiety. However, in some of the Amazon reviews I’ve read about specific lemon balm products, some users find that lemon balm makes them more agitated — at first. (This seems contradictory.) I’ve also read that you cannot take lemon balm long term — though it is unclear how long it’s safe to take or why it could be a problem if taken longterm. So I am hesitant to try this.
Do you have any thoughts or advice on this? I don’t see lemon balm mentioned in your posts on GABA, but I truly respect your opinion on this issue. Thanks so much!
Cindy
I haven’t looked in lemon balm so don’t have anything to share. Let us know what you find and experience.
I have been following your work for years. I am from Australia but I’m currently living in France. I have had sleep issues on and off for over 5 years, I ordered Black Seed Oil by GHO AHK Corporation, when I am having trouble falling asleep or when I wake up during the night and I can’t fall asleep I put one under my tongue, I am finding it definitely relaxes me and helps me to get into a deep sleep so even when I do have a broken sleep I feel refreshed the next day instead of having a hung over feeling.
Is it ok to take GABA Calm when taking fluoxetine?
Kristopher
I typically have clients use GABA, tryptophan, glutamine, melatonin or Seriphos for sleep issues. Glad to hear Black Seed Oils helps you.
I have many clients use both GABA Calm and an SSRI and recommend they discuss with their prescribing doctor
Hi Trudy,
Thanks for your kind guides on my conditions. Please how can I supplement for the suggestions you highlighted.
I live in the Uk and it is difficult to get a dr to Help me. Kindly help a bit further. Thank you.
Mack
I’m afraid I cannot consult via the blog. I recommend my book “The Antianxiety Food Solution” and all the blog posts here
Hi Trudy
I live in New Zealand, I looked for Lidtke L-Tryptophan online but can’t find it in NZ and can’t find a company to ship it to NZ. I ended up buying Source Naturals L-Tryptophan, I take 1 before bed. I also bought the Source Naturals GABA Calm, when I wake during the night I suck a GABA Calm and it helps me easily go back to sleep and I wake refreshed the following day even though I have had a broken sleep. Is it ok to take L-tryptophan and Gaba together? I am on a daily dose of 10mg fluox though very keen to taper off this. Love your work 🙂
Hello,
I recently bought Lidtke L-Tryptophan, and the outer seal on the bottle cap and inner seal on the opening were both intact.But inside there is a small square of thin, clear plastic sheet. Is it supposed to be there? Normally there is either cotton or silica sachet to keep out moisture, but this doesn’t have either, only the plastic sheet.
Also, is it ok to take Magnesium Buffered Chealate and Tryptophan at the same time (5mins before going to bed)?
Thank you!
Shalini
I have many clients using both
The Lidtke question would be something to ask the supplier. I have seen them used scrunched up plastic instead of cotton so perhaps it didn’t get scrunched up.
I checked again and it is indeed scrunched up plastic. Thank you so much for your response!
The Lidtke Tryptophan Complete you recommend Has been beneficial for my sleep, more so than Tryptophan alone. I’ve noticed though that they are now using folic acid and no folate at all. I’ve been told in the past that I should actually avoid folic acid partly due to issues with methylation. I spoke to someone at Lidtke and they could not answer my question as to why they don’t use methylfolate. Any insight? Thanks so much.
Vitamin C for negating the effects of any amino acid – does this mean that if I am taking my aminos in the same smoothie as my vitamin C that I won’t get any effect or a very reduced effect, from my aminos?
I see several references to no copper in supps or ‘copper-free’ – why is that important?
Thanks Trudy for all that you do – it is a great service to your earthly human companions! I appreciate you!
Michael
Correct – vitamin C is best taken away from individual amino acids. We typically have plenty of copper in our diets and zinc is a common deficiency
You’re most welcome!
I eat a lot of fruit, mostly frozen, all organic except for mangoes and avocadoes. Will the vitamin C in that interfere as well? Do I need to set aside two times each day where I just take my aminos and not eat or drink anything with significant levels of C in it, one for my morning aminos and one for my nightime aminos?
Why do they put copper in some brands containing Optizinc™ when we get plenty in the diet?
Thanks again!
Michael
Good question about high levels of dietary vitamin C. I have not seen this to be an issue so don’t have the answer and best would be to experiment.
I recommend Optizinc with no copper.
Apologies for the delay in your comment approval and my response. We had a computer glitch where a large number of comments were hidden from view in a spam folder. It mostly affected new folks who were commenting for the first time but it’s hopefully resolved now.
Hi Trudy,
I am guessing it is also Ok to take other brands of zinc sulfate for the zinc test? Metagenics is not available in my country, but, we do have other such pure liquid zinc sulfates, for the testing, at the pharmacy?
I am also wondering if it is safe for someone who have not been tested for pyrroluria, although checking all the boxes, to go ahead and use such a high amount of vitamin B6 and zinc in isolated forms, if also being deficient in other nutrients due to illness? – If it might cause further imbalances if using them in that way without having been tested?
Thank you! Really appreciate the help!
Ingrid
I’ve had clients use zinc sulfate from other companies and we are always looking at the big picture so consider diet, toxins, infections as well as all possible nutritional deficiencies.
If you are new to the amino acids (and other anxiety nutrition solutions like gluten/sugar/caffeine removal, blood sugar control, gut health, pyroluria etc) my book “The Antianxiety Food Solution” is a great place to start. More here https://www.everywomanover29.com/store/aafsbook.html
Apologies for the delay in your comment approval and my response. We had a computer glitch where a large number of comments were hidden from view in a spam folder. It mostly affected new folks who were commenting for the first time but it’s hopefully resolved now.
Hello,
I have insomnia, started once I got pregnant and has continued 2 yrs post partum. I don’t have trouble falling asleep but staying asleep. I also have depression and anxiety. I’ve taken 3 different types of gaba before and a long list of other supplements. Would tryptophan be safe to take while breastfeeding or are there any studies on it in regards to lactation?
Grace
Neither tryptophan or GABA have been studied during breastfeeding but a free form amino acid blend (that does contain tryptophan) is often very helpful.
If you are new to the amino acids and other anxiety nutrition solutions like gluten/sugar/caffeine removal, blood sugar control, gut health, pyroluria etc) my book “The Antianxiety Food Solution” is a great place to start. Much of this helps with anxiety, depression and insomnia too. More here https://www.everywomanover29.com/store/aafsbook.html
Apologies for the delay in your comment approval and my response. We had a computer glitch where a large number of comments were hidden from view in a spam folder. It mostly affected new folks who were commenting for the first time but it’s hopefully resolved now.
Hi Trudy,
I just took the Zinc tally test, and it came out with an slowly increasing unpleasent taste – almost none at first, and then increasing over the half hour or so. But, what also happened was an almost instant headache and nausea – what would be the reason for this?
My health situation could indicate low zinc, and it was basically tasteless at first, so I do not understand why this happened.
Can add that I also am extremely sensitive , towards everything (Food, supplements, enviroment) , in the first place .
I so appreciate the help!
Ingrid
Ingrid
Too much zinc can cause nausea but headaches are not a common issue
Apologies for the delay in your comment approval and my response. We had a computer glitch where a large number of comments were hidden from view in a spam folder. It mostly affected new folks who were commenting for the first time but it’s hopefully resolved now.
Hello again,
I believe I just posted a message, if it posted successfully, but, I forgot to add regarding copper, zinc and histamine – Could supplementing zinc and not thinking about copper, possibly give ill effects towards histamine, since copper keeps histamine levels in check?
I am dealing with extreme histamine issues, so therefore I am unsure – do not wish to exacerbate that issue.
Thank you for the help!
Ingrid,
I also have histamine issues and I have found that for me quercetin 500 mg capsules do an excellent job with that. It also helps to quiet my limbic system if taken before meals & improves my digestion all the way through, as well. I add it to my daily smoothie for sustained effect too.
Hi! Trudy,
I watched your Summit 6 and have a question: Where can I find Biocidins or Dentalcidins for oral care? Thank you for your response and all that you do!! I thoroughly enjoyed your Summit and the Encore weekend!! Now, my brain is blown–LOL!!
Have a great week and a very nice Thanksgiving next Thursday!!
Sincerely,
Renee
Renee
You are most welcome! Apologies for the delay but it’s good timing because there is a sale happening now over Thanksgiving. This is the link https://biocidin.com/?rfsn=4752263.c45638. I really like the DenticalCidin product
Hi! Trudy,
I’ve had urgent problems regarding my elderly Father’s well being and only today saw this email from you. 🙁 I looked up information about the Dentalcidin products and was wondering –with using the Dentalcidin toothpaste and/or mouth rinse if the essential oils are absorbed through the gums systemically? I would think so, but am concerned over time if one could become sensitive to these oils? I know with essential oils that one uses topically and perhaps from infusion, that one can become sensitive to individual oils and that one should rotate the use of oils every 4 weeks or so. Would you please address these concerns that I have?
Thank you so much, Trudy, and I wish you very HAPPY HOLIDAYS!!
Hi! Trudy,
I’ve had urgent problems regarding my elderly Father’s well being and only today saw this email from you. 🙁 I looked up information about the Dentalcidin products and was wondering –with using the Dentalcidin toothpaste and/or mouth rinse if the essential oils are absorbed through the gums systemically? I would think so, but am concerned over time if one could become sensitive to these oils? I know with essential oils that one uses topically and perhaps from infusion, that one can become sensitive to individual oils and that one should rotate the use of oils every 4 weeks or so. Would you please address these concerns that I have?
Thank you so much, Trudy, and I wish you very HAPPY HOLIDAYS!!
Renee
This is a very good question that I don’t have the answer for. I suggest reaching out to Biocidin. One option would be to use the Dentalcidin for a period and then use something else and rotate like that
Happy Holidays to you too! (and hope your dad is doing ok)
Hi Trudy,
Thanks for your response. I ordered the Dentalcidin toothpaste and mouth rinse yesterday, and will let you know if I find out anything regarding long term use of the products. Thanks for all of your research and the hard work that you do. I appreciate you and your wisdom. Thanks, also, for caring about my Dad. He is doing better. 🙂
BEST WISHES for an enlightening NEW YEAR!!
Hi Trudy,
I have read your book and am trying to do a trial with GABBA and then possibly tryptophan if this doesn’t work. I am a chronic insomniac not having slept an entire night for 40 years. This has also led to adrenal fatigue, high cortisol levels….. I tried to order your supplements from you but they don’t deliver to Australia.
I have been using GABA powder from rnLabs which is pure GABA powder (nothing else)… It says 1ml =500mg
trouble is, I am having so much trouble trying to work out how much to take…. I also have a pure tryptophan powder and am wondering about the same with taking that…. Can you please shed some light as to how to start taking it, how much etc….
Nerida
The powder products can be challenging to figure out but it’s doable. 1 teaspoon is about 5ml so 1/5 of a teaspoon of this product = 500mg and then 1/10 of a teaspoon is 250mg. As always I have clients start low and go up from there and it gets easier if we find they do need a higher dose.
thank you and Happy New year!
Is there anything that can be done for someone who reacts poorly to all forms of B6? Would love to bring down the social anxiety but It causes extreme foot pain (bottom of feet) that lasts for months. Even the smallest amount starts the pain cycle. Fluoroquinolone drugs may have started the neuropathy but whenever I add B6, it worsens greatly.
Thanks so much!
Tiffany
I would suggest looking into dietary oxalates as there is an oxalate/B6 connection https://www.everywomanover29.com/blog/oxalate-crystal-disease-dietary-oxalates-and-pain-the-research-questions/
Apologies for the delay in your comment approval and my response. We had a computer glitch where a large number of comments were hidden from view in a spam folder. It mostly affected new folks who were commenting for the first time but it’s hopefully resolved now.
Hi Trudy,
I have taken trytophan and evening primrose oil in small amounts, and both have caused side effects(headache and dizziness with tryptophan and stomach ache with primrose oil) and I have had to stop. So I want to try 5-HTP and melatonin to help with sleep.
I am taking GABA at night, which ironically is helping me with the excess gas and stomach ache rather than what it was indicated for in your blog 🙂
I would like to know if I can use the evening primrose oil topically ? (I can open up the capsule and mix the oil with olive/sesame oil and apply it on my face). I am having horrible acne and I hear primrose oil helps with that. I am in my late 30s and acne now is harder to get under control.
Are there any other forms of 5-HTP or melatonin I could try since I have digestive issues I am working on and may not tolerate taking them orally but I really need to sleep, and any help with that would be appreciated.
Thank you for taking the time and appreciate all your work, especially on the blog here.
Thank you,
Shalini G
What Else than tryptofan and gaba kan raise serotonin and gaba ? I have racing mind / chattering . Anxiaty , pre / menopause . Tried inositol but got heavy aura migrene . Often wakes up at 5 in the night . Hypotyroid use levaxin .
Irene,
It could be that you are deficient in key nutrients your body needs to produce GABA.
First, you need to have sufficient stores of the amino acid l-glutamine which is converted to glutamic acid and then GABA.
But other nutrients are used in this conversion process and if they are not present the GABA is not produced. They are zinc, vitamin B6 and another amino acid l-taurine. If you are deficient in any one of these your body will not be able to produce GABA.
Checking for and correcting any of these deficiencies would be a good place to begin and may help other issues you have as well.
Irene
I always start with tryptophan and GABA for racing mind, anxiety and sleep issues. Other ways to support neurotransmitters is are using other anxiety nutrition approaches like gluten/sugar/caffeine removal, blood sugar control, gut health, pyroluria etc. My book “The Antianxiety Food Solution” is a great place to start. More here https://www.everywomanover29.com/store/aafsbook.html
Hi Trudy,
I had depression and insomnia since 2016 abs have been well relieved of the depression using tryptophan and other supplements but the insomnia has persisted. I don’t feel sleepy at any time regardless of whether I did not sleep for days.
Please what else can I take. I have takes gaba abs tryptophan but no luck.
Kindly help. Thanks
Akeem
Glad to hear the tryptophan has helped relieve your depression. I know you’ve tried various things to help with sleep issues – what are they and I’ll see if I can suggest anything else. Are you still taking sleep medication or any other medication? Have you followed all the approaches I write about in my book “The Antianxiety Food Solution” too?
I have taken Gaba calm , glycine, ashwaganda, True calm, I stil take lithium orotate and a local sleep preparation from Nigeria. It help get like 3hours of sleep
Sleep medications don’t work for me.
I am grateful for your support.
Kindly help.
Akeem
I would work with a functional medicine practitioner and step by step rule out all possible causes https://www.everywomanover29.com/blog/60-nutritional-biochemical-causes-of-anxiety/ (these causes can affect both sleep and anxiety)
Hi Trudy,
Your blog post “GABA helps stressed young boy with episodes of “choking” or tightening in his throat” really caught my eye.
I am reaching out is because I suffer from very similar symptoms as this young boy but as an adult.
I’ve been diagnosed with Dysphagia, G.E.R.D, Laryngomalacia and Cricopharyngeal spasms. All head neck and throat related issues that Drs at Kaiser, UC Davis and Stanford have worked with me to resolve unsuccessfully.
After countless tests and multiple procedures (esophageal dilation, esophageal botox…) we have not gotten much closer to what is causing the issues or what to do to resolve them.
These issues make eating, breathing and sleeping very challenging in turn making daily life an ongoing struggle. Anxiety, sleep issues, loss of appetite, pain and exhaustion are common place. I am blessed and happy just really struggling.
I am left with pharmaceutical prescriptions as a last resort. I have opted to avoid most of them as they hindered my ability to manage my parental duties(and joys) as I would feel too drugged/out of it to do much at all. So I have pushed through with minimal relief using the prescribed PPI(for GERD) and very low(10mg) dose of Nortriptyline daily for the “side effect” of desensitization of hyperactive nerves.
I am very interested in the potential use of GABA and wondered if I may ask your thoughts on dosage(I have GABA Calm lozenges) and possibly your thoughts on using it with such a low dose of Nortriptyline (a non MAOI).
I have also purchased 5-HTP and wondered your thoughts on using it with the above mentioned meds and supplement or as a replacement.
Any insights would be greatly appreciated.
Hi Trudy
You are incredible and wanna thank you for all you do .
If we are experiencing low serotonin as you describe it (ruminations mostly ) and obsessive thoughts – where would you start ? I have ordered 5HTP, Lidtke l-tryptophan 500mg, inusol, GABA lozenges you recommended . is there a better way to start and test what may work first ? Are they compatible? Thanks so much
Chris
I did reply on your other post. I have had clients use all of these in some instances. I have the client decide which area is most problematic for them and we start there. If they pick low serotonin I typically start with tryptophan later in the day and add inositol for added support for OCD/ruminations and we may also add 5-HTP during the day. Once we have those issues resolved we switch to GABA trials.
Hi Trudy,
I have seen your summits which are very informative. Thankyou.
My husband has been suffering from anxiety/depression for 1 year . It’s all due to extremely high levels of stress at work.
His physical symptoms are taking a toll. Many times it feels like he’s having a heart attack. At nights, the constant thoughts keep him awake or wakes him up. These thoughts keep reeling around during the day as well.
He’s taking vitamin c,d,b12, omega 3. He has taken magnesium glycinate, b5b6. He’s tried a Ashwaganda, relora, rhodiola. More recently he’s tried Gaba (this made things worse)
He’s tried melatonin and phosphatidylserine at night to no avail.
His body is highly sensitive to pharmaceuticals. But he is now taking Fluoxetine and Relora. Can these be taken together or apart?
He’s also taking doxepin for sleep which he doesn’t like.
Any suggestions would be greatly appreciated.
Mary
Sorry to hear. I’m not aware of issues taking Fluoxetine/Doxepin and Relora but recommend discussing with the prescribing doctor.
GABA won’t work or can make things worse when it’s not low GABA or when too much is used. I start my clients with 125mg.
With constant/reeling thoughts I think low serotonin but when a client is on multiple medications we focus on diet, blood sugar, gluten/caffeine/sugar removal, gut health first. My book “The Antianxiety Food Solution” is a great place to start. And then they are well-informed when they are ready to incorporate the amino acids (such as tryptophan). More here https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/
Hi Trudy
Can tryptophan work to raise serotonin to help with chronic constipation ? I have methane dominate SIBO and nothing is working to move my bowels, not even any laxative whether herbal or OTC. I read serotonin works to move
the bowels. Just wondering if it’s be helpful.
I’ve been researching amino acids and just came across your information. You are so helpful!!
Quick question; Why do you suggest zinc without copper?
Thank you!
Hello
I’m exhausted when I try any of the amino acids. I thought I needed a micro dose but I see you recommend taking them away from SSRIs. I am on a SSRI reduction regime but they are slow release capsules. Should I just stay away from the amino acids until I’m on a low enough dose of SSRI that it doesn’t need to be slow release? Or off them completely?
I’m also surprised to not see NAC on the list when it featured so prominently in the last anxiety summit. Is there a reason it’s not there?
Thanks
Rosemary
Best is to read this blog and work with and discuss with your prescribing doctor as there is the risk of serotonin syndrome with SSRIs and tryptophan https://www.everywomanover29.com/blog/taper-from-antidepressant-tryptophan-amino-acids/
Hi Trudy
I read in your symptom questionnaire for low catecholamines that ‘boredom’ could be a symptom of this. Which amino acids would you say could be low for depression that’s a consequence of social isolation and the resulting boredom? Would you still say catecholamines or rather endorphins? I’m taking 5-HTP, which is helping somewhat at 250-300mg pd, but because I was reluctant to increase that dose further, I wondered if I should also be taking Lidtke’s EndorphiGen or address low catecholamines (when I’ve previously – ie not currently – tested my adrenals with saliva, the results both times were sufficient overall cortisol but low in the mornings)?
Thank you for your generosity in helping us!!
D
Boredom and depression relates to low catecholamines and tyrosine is the amino acid that helps. Endorphigen helps low endorphins.
If you are still confused about some of the amino acids (and other anxiety nutrition solutions like gluten/sugar/caffeine removal, blood sugar control, gut health, pyroluria etc) my book “The Antianxiety Food Solution” is a great place to start. More here https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/
Hi I just found this blog , first I would like to say I’ve been on anti depressants for 10 years and at the time it was life saving. I’m an avid gym lover but recently relapsed into anxiety after drinking far too much and took cocaine for the first time in my life. I was horrified with myself and still recovering. I’ll live and learn but big mistake and I didn’t even realise there was a come down after taking that garbage.But i thought I’d share my experience with anyone concerned about tryptophan while on anti depresssnts. I’m on 20mg escitalopram (Lexapro) which is typically max dose . I’ve took well above 2000mg and not had any sign of anything bad happening. I bought a bag containing 250g of a sports supplier. I didn’t use it every day at all as I was stable .My attempt was to improve sleep or in hopes it would make me tired before bed, this was last year before my current relapse. I can’t say that it made me sleepy either . But certainly nothing bad !
I did end up throwing half the bag away as is was a lot of powder probably a few months back. So in my attemp to get back on track from this current relapse I picked up 5htp recently as I struggled to function and needed to try something quick. 50mg from Holland and barret , don’t really like any of there products and have been taking 1 per night and I think it’s helping. You certainly can feel something happening in the brain when taking either – but again no sign of anything like seretonin syndrome.
I’d also like to share I was on Sertraline for 3 months and it wasn’t really helping that much but discontinued because of stomach issues from it, I’d only found out about 5htp at the time ( sure wish I’d found out about Julia Ross book or trudy’s then) and started dosing 50mg tablets then with lithium orotate as I tapered the last couple of doses of Sertraline. I did get remission for a week, obviously Sertraline was still in my system – but hardly anything as I tapered 25mg of it roughly. I wish I would have had some info back then . I think I was dosing 150mg 5htp – which probably isn’t a lot to counter depression and anxiety but I wish I would have held in there and gone much higher- I was desperate to get back to work and was just too ill and gave in and got another prescription from the doctor.
I thought I’d share my experience. I’m no doctor but my guess is it’s completely safe to use along side medication in moderate doses . I would love to be off these tablets but now it’s not even worth thinking about.
But anybody out there struggling and can’t cope and on medication nothing bad or anything has happened to me taking either tryptophan or 5htp.
Much love to anybody battling anxiety or depression
Billy
Glad to hear you did ok but we still have the precaution because there is the possibility of serotonin syndrome
Dear Trudy
Would it be okay to take between 12 and 18 grammes of myoinisitol (if I can get my hands on that) for really strong OCD?
I have a bottle, right now, of ‘Viridian’, myoinisitol
It’s “120 gram Powder”
The directions/dosage written on the bottle are: “2000mg twice daily”
I will try to order a large amount, if you think that it would be good
What brand do you think would be good?
The GP has just recommended, prescribed ‘Seroxat’ antidepressant to help
It would be great not to be taking this
Thank you very much
Kind regards
H
H
I can’t offer specific advice via the blog but can share that the upper limit is 18g. I have clients start with 500-1000mg and we go up from there based on their need.
I have read that tryptophan and/or GABA supplementation can be neurotoxic, which makes me fearful of continuing on them, even though I have found them immensely helpful to help me sleep due to low serotonin. Should I be concerned about neurotoxicity, especially with genetic propensity for late onset dementia?
Thank you for your response!
Mjay
Please share links to the articles you have read so I can address your concerns. It’s wonderful that tryptophan and GABA have been immensely helpful for your sleep. How much of each is helping and how long had you struggled with sleep issues?
My 11-year-old has been using pharmaGaba (100mg in the morning) for anxiety, panic attacks. The panic attacks are better, anxiety not completely gone. Is the Source Naturals Gaba Calm safe to try for someone her age?
Thank you.
Aimee
I like to capitalize on what’s already working and when 100mg pharmaGABA has great results in terms of eliminating panic attacks and hopefully anxiety is reduced too, then I increase the dose over the next few weeks observing symptoms and looking for further improvements. I do that before adding something else.
How long was she on the pharmaGABA before she saw no panic attacks? And how long had they been happening?
I’m curious what else had she had tried before the pharmaGABA and how you decided on pharmaGABA?
That said, I’ve had good results with GABA Calm with children this age. Here is one example https://www.everywomanover29.com/blog/gaba-children-adhd-focus-issues-irritability-anxiety-tantrums/
Thanks so much for your reply! We started with l-Triptophan because her counselor suspected low serotonin. It was too hard to get the small dose out of the capsule we bought, and then I read about the physical anxiety manifestations with low Gaba. That sounded more like my daughter, so we just got the Gaba that was available at our local vitamin store, which was pharmaGaba. Jess Sherman recommended starting with 100mg for kids, so I got that dose. The L-Triptophan is helpful to me and my older daughter. We just take as needed when our thoughts are getting overwhelming.
My daughter’s panic has been triggered by separation (from me) which didn’t happen at regular times during the summer. So it’s hard to tell when the panic subsided. I think she was taking the Gaba at least for a few weeks before that got better. It had been happening for about 3 months before that. She’s still very sad when I have to go, but she isn’t spinning in fear and illogic!
Yesterday, she put a Gaba in her lunch box because she’s thinking it doesn’t do anything unless she’s triggered. She did take it at lunch and when something happened a couple hours later that would normally have worried her, she noticed that she didn’t feel so anxious about it. It’s great that she’s seeing these things herself!
Aimee
That’s wonderful results with the 100mg pharmaGABA and yes, great that she is seeing these things herself. I have mom’s help their child experiment with different doses and timing to figure out is ideal for each child’s needs. Please keep us posted on her progress.
With sadness and fear we also consider low serotonin and there is a 100mg chewable tryptophan by Lidtke.
I’m thrilled to hear her counselor is recommending nutritional support. More and more psychologists are recognizing this need. And do glad you heard about this from Jess Sherman – she’s a wonderful nutritionist and good friend!
Glad to hear tryptophan helps you and your older daughter with overwhelming thoughts too. GABA can helps with some of that too and many folks need both low serotonin and low GABA support.
Hi. I’m wondering if amino acids are safe to take when tapering off a psychiatric medication. I’m currently coming off Olanzapine prescribed for anxiety and insomnia and am looking for support.
Todd
Best is to read this blog and work with and discuss with your prescribing doctor as there is the risk of serotonin syndrome with SSRIs and tryptophan https://www.everywomanover29.com/blog/taper-from-antidepressant-tryptophan-amino-acids/
If this is not possible I’ve had client’s work with a knowledgeable pharmacist (with the doctor’s monitoring) or find a new doctor or share my book with him.
If you are new to the amino acids (and other anxiety nutrition solutions like gluten/sugar/caffeine removal, blood sugar control, gut health, pyroluria etc) my book “The Antianxiety Food Solution” is a great place to start. More here https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/
We do also discuss this on the Anxiety Summit 5: Gut-Brain Axis, Nov 8-14, 2021. Look for “SSRI Impact on the Microbiome and Safe SSRI Tapering” with Dr. Achina P. Stein, DO, DFAPA, ABIHM, IFMCP. Register here https://anxietysummit5.byhealthmeans.com/?idev_id=739
Hello Trudy: Thank you for your blog. Very interesting and informative!
My teen has anxiety attacks and is electrohypersensitive as well. With high exposures, anxiety is worse ie. a dental x-ray will set him off for a week of high anxiety, pacing the house and this gradually disappears. We avoid dental x-rays (routine) and we feel there are too many of them too especially for someone who is sensitive to them. Ativan is needed and zoloft as well. He wanted to get off Zoloft which he did taperng off of it. He thinks more clearly now he says.
Our Naturopathic Doctor suggested trying a PharmaGaba 100 mg chewable tab. and unfortunately it knocked him out (very sleepy, deep sleep) I could hear him breathe from the next room. So we were going to try cutting it in half or even quarters and taking one of those. But before we could try that we had him tested for Neurotransmitters/Amino Acids and indeed the results did show:
GABA was high which our ND did state this explains why he likely overdosed with the one tab.
Serotonin is balanced.
Dopamine high
DOPAC extremely high
Creatinine high
Histamine low
Norepinephrine low
Phenethylamine (PEA) low
Tyramine and Tyrosine both borderline low
EHS – He finds taking magnesium glycinate, grounding in EMF clean area and epsom salt baths helpful for his EHS. Not to mention reducing exposures to RF EMF’s. Very difficult thing to do as wireless technology exposures are increasing in society but we know that personal exposures can indeed be reduced as a start.
What do you think about diagnostics like the neurotransmitter one above? It did confirm that GABA supplement is not the way to go but to consider other options. We would like to do a comprehensive bloodwork too. Is there anything in particular that you would want to check the levels of?
Sincerely,
Anne
Anne
Unfortunately the urine neurotransmitter test is not very reliable and I prefer to use the symptoms questionnaire and response to supplements.
Using GABA is a fine balancing act and too much can do this. We reduce the dose in this instance and would start super super low with sensitive individuals. If the root cause of the anxiety is not low GABA levels then this could happen too. In this case we assess for low serotonin and other other causes of the anxiety. With OCD I’d suspect low serotonin before low GABA.
Prior or current use of benzodiazepines can be an issue for a subset of the population too, due to downregulated GABA receptors. Electrohypersensitivity may well complicate things further or may be in part caused by the meds.
Some GABA products may be an issue too and I’ve just recently heard that some folks with histamine issues don’t do well with pharmaGABA (which is made via fermentation).
There is also something called the GABA shunt. I’m still looking into the mechanisms of this and will be doing a blog post on this topic.
Hi Trudy
Thanks so much for your informative newsletters and links. I always enjoy your personal notes and pics, such a nice touch. I live in Cape Town, grew up in Umhlanga, I think you originally hail from KZN too?
After reading your ‘Most versatile/nutrient-dense moisturizer – organic/grass-fed beef tallow!’ newsletter and clicking on the link I thought I would see if there was anyone in SA producing something similar, and yes, indeed, there is!
Please have a look at https://pureprimalskin.com/
I have been using the hair and body soap, my hair is feeling so much thicker and trust me, I have ‘thine’ hair! Thin and fine 🙂 Love the Lip Lekker lip balm and the skin lotion too. About to order the hydrolysed collagen.
Anyway, thought I would share this local is lekker with you.
Thanks
Catherine
Catherine
Thanks so much for the lovely feedback and yes I’m from KZN and also lived in Umhlanga for a few years! Love the Cape and Cape Town and did some fun climbing on Table Mtn and in the Cederberg!
I really appreciate you sharing about this product in South Africa! I took a look and it looks super. Next time I share about Primal Derma I’ll mention this one too. I’m actually going to do a blog post and will share your feedback too.
Be sure to read this before using collagen – Collagen and gelatin lower serotonin: does this increase your anxiety and depression? https://www.everywomanover29.com/blog/collagen-gelatin-lower-serotonin-increase-anxiety-depression/
Hola Trudy. I’m trying to follow your advise for taking supplements ( pyroluria and anxiety) on your book and also on your posts. On gaba, i wasn’t able to get “gaba calm”, so I got klaire labs 420 mg gaba only in capsules; is it ok to open caps for sublingual use? also, got inositol powder700 mg by “designs for health” as per your recomend. on book for ocd; how is it best taken, between meals or with food, label doesnt specify. as always, thanking you and your staff for what you do for improving health.
Francisco
I have clients open the 420mg GABA and start with about 1/3 initially and go up from there. Inositol is best used away from meals but can’t be used with food if it causes digestive upset
How long can you safely take Tryptophan. Is it risky to take it long term?
Shirley
It really depends on each person’s unique needs and how much work they also do on addressing why serotonin is low – like diet, stress, toxins, dysbiosis, gluten issues, BCP etc
Hi Trudy,
I have a 10 y.o. daughter with extreme social anxiety, GAD and obsessive thoughts and sugar cravings and many aspergers traits. (I too have anxiety, panic disorder and major hormonal issues). Should she try tryptophan or GABA or both and which ones?
Kristen
With GAD, obsessive thoughts, sugar cravings and panic disorder, I always start with addressing low serotonin with tryptophan or 5-HTP and low GABA with GABA. When someone has hormonal issues, the amino acids can start to help too.
The best way to determine if someone may have low GABA/serotonin is to look at the low GABA/serotonin symptoms, rate them on a scale of 1-10 with 10 being worst, do a trial of the respective amino acid and rate the symptoms again right afterwards (in the next 2 to 30 minutes). Here are the symptoms https://www.everywomanover29.com/blog/amino-acids-mood-questionnaire-from-the-antianxiety-food-solution/
When you are new to the amino acids (and other anxiety nutrition solutions like gluten/sugar/caffeine removal, blood sugar control, gut health, pyroluria etc) my book “The Antianxiety Food Solution” is a great place to start. More here https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/
It’s a comprehensive approach – amino acids AND diet. What is your diet and your daughter’s diet like right now – gluten-free, sugar-free, caffeine-free, eating protein at breakfast for blood sugar control, real whole foods, grass-fed red meat, wild fish, fermented foods etc?
With social anxiety we look into pyroluria. Here is the pyroluria questionnaire https://www.everywomanover29.com/blog/pyroluria-questionnaire-from-the-antianxiety-food-solution/ My book has an entire chapter on the topic and there are many blog posts on this site too
I’m sure you’re aware – low serotonin, low GABA and pyroluria is common with Aspergers.
My online GABA Quickstart group program is helpful when you have questions and need guidance. More here https://www.anxietynutritioninstitute.com/gabaquickstart/
Hello,
I made the Walsh test and I have pyrrole disorder.
I have started to take P5P and Zinc and soon Manganese for the pyrrole disorder. I know the dosage from my practitioner.
I have read now about taking Primrose oil or Borage oil, because of the fatty acid GLA (Gamma-linolenic acid).
I dont really know, if I need to take it, because probably not every person with pyrrole disorder needs it.
But I have read a bit about GLA and DGLA and all in all there are no negative side effects to take this omega 6 acids.
So I will try it. Does someone know how much GLA a person with pyrrole disorder needs to take?
Thanks
Hans
I’d discuss with your practitioner. I also cover all this in the pyroluria chapter of my book so be sure to re-read that section about dosing and testing fatty acid levels if you decide to do that. It also covers how EPO/GLA helps zinc absorption.
My book “The Antianxiety Food Solution” https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/
Hi Trudy,
I’m confused about what you mean by vitamin C negating the effects of any amino acid. In a good way or bad way negating the effects? Like if you accidentally take too much of an amino acid? Or if you have naturally high levels of a certain amino acid that you want to lower? But then would vitamin C negate the effects of all of your other amino acids? I’m obviously misunderstanding and want to make sure I’m not messing things up by taking vitamin C around the same time as any amino acids (particularly taurine). Thanks!
Christina
Christina
If someone has a bad reaction it will negate the bad reaction. But it will also remove any benefits too. I have clients take it at least an hour from the amino acids.
Thank you for clarifying. That is so interesting! I’ll start taking my vitamin C away from my taurine!
Hi, Trudy. Is it possible to need every amino acid listed here? I feel like I fall under pretty much every category. I’m a 29 year old female with diagnosed adrenal androgen PCOS & undiagnosed, but suspected (by myself) adhd. Can I tell you where I struggle & you tell me where you think I fit?
1. I’m always exhausted/lethargic
2. I have trouble focusing
3. Tend to procrastinate
4. Extremely tight/painful/spasmed muscles constantly
5. Look for mood boost from foods
6. Have trouble getting to sleep at night, stay up late even though I don’t want to & have to get up early
7. Tend to be a worry wort & over analyze
8. Tend to be disorganized
9. Wake up depressed even before I know it has rained (I will know it has rained by how I wake up feeling. Bizarre, but true)
10. Definitely have diagnosed IR & blood sugar issues
11. Definitely have the ruminating/unwanted thoughts
12. Definitely unmotivated to do things I actually want to do!
13. Have poor time management
Please help! Appreciate which categories you think I fall into. Thanks so much!
Buttercup
It’s possible to fall into all categories ie low serotonin, low GABA, low catecholamines, low endophins and low blood sugar – and it’s common.
I think you’ll be better served figuring this out yourself. I suggest looking at the questionnaire and putting each of the above into it’s respective category and then I’ll give you my feedback https://www.everywomanover29.com/blog/amino-acids-mood-questionnaire-from-the-antianxiety-food-solution/
This way you’ll be better prepared when you use my book – “The Antianxiety Food Solution” – to implement the amino acids https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/
I did do the questionnaire. I’m just confused if I fit into some categories because there is symptom overlap. I’m gonna say for sure GABA, because I have a nervous stomach & tight muscles so I have the “physical anxiety.” I do also have anxiety, unwanted bad memories & anxious thoughts & fears so idk if that goes with the GABA or would also be serotonin. I do have winter blues which makes me think I fall into serotonin too. I fit the Catecholamines very well, I have every symptom of that. I do emotionally eat to soothe myself when I’m stressed, but I don’t necessarily know if I fit low endorphins. I do cry easily when I am hurt, but I don’t necessarily know that that is a problem. What kind of feedback can you give based on that?
Hi Trudy. Can you give me your feedback if you need all of the amino acids? I think I do. Is it as simple as taking them all?
Buttercup
Many people do and we trial one at a time and some folks do find they need to take them all
I am new to your communications, so you may have answered this question before. Apologies, if so. I was diagnosed with pyroluria in the 1990’s. Because of other circumstances needing all my attention, I did not get up to speed on dealing with it, thoroughly, until recently. My question is: I know pyroluria sufferers often need more GLA (Omega 6s) than “normal” people. Unfortunately, I am also salicylate sensitive (Evening Primrose Oil and stevia, I believe, are both high in salicylates). What do you recommend as substitutes for those who should avoid those two products? I think borage oil may be an alternative to EPO (would be interested in your opinion). I know of no good substitute sweetener for stevia.
Robin
I have not been asked this question and I’m curious to hear how you react if you do use evening primrose oil? Is it the same reaction as when you consume high salicylate foods and which foods are triggers for you?
One option is to do fatty acid testing to determine if GLA is needed (although it typically is with pyoluria). If GLA is low, one option is to use the enzyme xylanase (as in a product such as No-phenol by Houston Enzymes) to help break down the phenols/salicylates or at least enable it’s ingestion.
Sorry, I forgot I already asked these questions and asked them again today.
I don’t think I ever tried EPO because I heard it contained salicylate. Other high salicylate foods that bother me are clove, cinnamin, sodium benzoate, wintergreen, curcumin, peppermint, ginger, aspirin, berries (I still eat them, but not in large quantities). I recall East Indian food being problematic. I think there are some non-food items also, but I can’t remember. I avoid salicylate containing personal products.
Reactions that I’m aware of are stomach pain (sometimes severe) and feeling wired. Perhaps also tinnitus.
I’ve kind of given up on avoiding all salicylates, because it’s impossible.
Robin
Thanks for sharing all this. I don’t have enough information yet to give a good answer but I plan to look into this further so thanks for asking the question. From what I’m reading, borage oil also contains salicylates so it’s likely not an option either.
If it was me and I had a need for GLA (based on test results and symptoms) I would consider a trial of a small amount EPO and/or borage oil, provided the reactions to salicylate foods/products were not severe and abated quickly once the offending food was removed. As mentioned above, using the enzyme xylanase may help to help break down the phenols/salicylates or at least enable it’s ingestion.
One other thing to consider is GABA and GABA levels. It seems GABA may counter some of the adverse effects of salicylates. Do you have low GABA levels and find beenfits with using GABA sublingually? And have you seen any correlation with salicylate sensitivity being reduced (no or less stomach pain, less wired, less severe or no tinnitus?
Hi– I am working with a hollistic dr. here with Gaba and tryptophan….but can I take them together at nite (for wakeful sleeping)??? Also, the Gaba chewable lozenger you recommend has some sorbitol—which is definitely not a good thing!
Alice
I have folks use both if their sleep issues are caused by low GABA and low serotonin. Best to discuss with the holistic doctor you are working with.
IF you feel like you need guidance and support, consider joining the online GABA Quickstart program so you can get help figuring it out https://www.anxietynutritioninstitute.com/gabaquickstart/
When someone is new to the amino acids (and other anxiety nutrition solutions like real whole food, quality animal protein, fermented foods, organic produce, health fats, gluten/sugar/caffeine removal, blood sugar control, gut health, pyroluria etc) my book “The Antianxiety Food Solution” is a great place to start for making changes to be nutritionally stable before starting to taper. More here https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/
There are many other options that don’t contain sorbitol.
Trudy,
Can you recommend an alternative to Evening Primrose Oil for pyroluria (perhaps Borage Oil/ GLA)? I believe I read some time ago that Evening Primrose Oil is high in salicylate (if I’m not mistaken). I am salicylate sensitive. I also think stevia is high in saliclylate. Can you comment on these?
Robin
I’ll address the EPO/borage oil question on the other thread
According to Beth O’Hara “stevia and monk fruit have unknown salicylate levels. These haven’t been tested but clinical observation shows they are likely high salicylate. Only try after salicylate levels improve.” https://mastcell360.com/salicylates-and-salicylate-foods-what-to-know-when-you-have-mast-cell-activation-syndrome-or-histamine-intolerance/ She also lists coconut sugar as being high in salicylates so other sweeteners will be better options. Ideally we want to reduce/eliminate all sweeteners
Hi Trudy:
I read your book, thank you for all you do!
I tried GABA & noticed no difference even after titrating to the max dose. Recently I read an article about pharmaGABA & how it is closer to the natural GABA our body already produces. What are your thoughts on this?
Regards,
Terri
Terri
Some folks do well with pharmaGABA and some better with GABA.
I am curious which GABA product and what starting/ending dose you used? And if it was used sublingually/opened onto tongue vs swallowed?
If you feel like you need guidance and support, consider joining the online GABA Quickstart program so you can get help figuring it out. More here about the program and purchase info https://www.anxietynutritioninstitute.com/gabaquickstart/ I had one woman person through 4 different GABA products until they found the one that worked for them
Hi,
I was reading your article on Saffron with interest.
I am just wondering if in your opinion it is safe to take both St John’s
Wort and Saffron? I know that St John’s Wort can interact with SSRIs badly,
but can’t find anything definitive about Saffron in relation to SJW.
Some products exist that combine the two (which makes me think it might be ok) but I have been taking both for some time now separately.
If you can point me to any information about this I would be most grateful.
GB
I am not aware of any research combining both – as far as benefits or issues. You are correct – there are a number of products combining these. One example by a reputable company is Mediherb Nevaton® Forte which “contains Skullcap, St John’s Wort, Schisandra and Saffron to support healthy nervous system function including mood balance.”
Sharing a link to the saffron blog for other readers https://www.everywomanover29.com/blog/saffron-antidepressant-antianxiety/
Hi there, I’ve been suffering from derealization and feeling not myself lately and I’ve been to the doctors for multiple blood test and they can’t really help me. They did say my vitamin b12 was a problem. Do you think you could help me with this issue and have you dealt with this before? Kind regards
TC
I have seen low B12 cause many psychiatric problems and when blood work indicates it’s low it’s important to address with supplementation and retest. You mention gluten in your other question and issues may lead to low B12 (and other deficiencies like low D, low iron, low zinc etc)
Hi Trudy:
I’ve read your book & most of the articles on your blog. However, I’\ve tried mega doses of GABA & I notice no difference. I recently read an article about PharmaGABA and I’m interested in what you think about it.
I’ve asked this question multiple times and sent an email and the response was that you only answer questions on Facebook. So I tried that too, with no response. I realize you must get hundreds of questions so I’m trying once again.
Kind Regards,
Terri
Terri
Many folks do very well on pharmaGABA. But if megadoses of GABA don’t work (especially if used sublingually/ or capsule opened) I’d suspect the person may not have low GABA levels and pharmaGABA would not work either.
How did you use it and how much/which product?
Apologies for the runaround
Hi Trudy. Thank you so very much for the wealth of knowledge you share. I am struggling to find Zinc Sulphate in liquid form that does not contain glycerine. Does the Zinc Challenge also work if this ingredient is included in the drops?
Thanks in advance.
Melanie
I don’t know for sure but suspect not.
Can anyone tell me if they have found a 5HTP supplement under 50 mg? Even 50 mg is too high for me, but all the brands seem to go from 50-100.
Allie
Lifelink makes a 25mg cherwable
Hi Trudy,
I wasn’t sure how to contact you so I sent you an email in July. I received a response today from someone on your support team suggesting that I send my questions to the relevant blog. I’m not sure if this is the right place but here goes…
July 30, 2022
Hi Trudy,
I know you are very busy but I thought I’d see if you have you ever heard of HSDD? (Hypoactive Sexual Desire Disorder).
There is a description below. I am 70 yrs old and think that I may have this condition, possibly for many years. I had never heard about it until I got an email from Dr Michael Greger about foods that can improve sexual dysfunction. He suggests a plant based diet which I’ve been eating for 14 years after a diagnosis of ovarian cancer. Sadly, it hasn’t seemed to help me.
I wondered if you thought any of the substances that you often recommend could be helpful for this dysfunction. I have had a complete hysterectomy as a result of my ovarian cancer. I’ve been married for 48 years to an amazingly patient man who I love very much. He has nothing to do with my lack of desire, I think it may be a brain and/or hormone related thing. I tried hormones approx a year ago but didn’t see any improvement. Maybe i wasn’t taking the right hormones or the right dosage, I don’t know but I stopped because I started having some breast achiness which made me nervous because of my earlier cancer. I take only one prescription, NP Thyroid and many supplements.
If this is not something you could help with, is there anyone that you might recommend?
I appreciate any suggestions you may have. Thank you for your time,
S
This is an Article I read that describes HSDD –
https://www.mayoclinicproceedings.org/article/S0025-6196(16)30596-1/fulltext
“Hypoactive sexual desire disorder in women is an important female sexual dysfunction that has been well-characterized for more than 3 decades. Based on contemporary research, the pathogenesis of HSDD is attributed to an imbalance in central sexual excitatory (dopamine, norepinephrine, melanocortin, and oxytocin) and sexual inhibitory (serotonin, opioid, endocannabinoid, and prolactin) pathways. Epidemiologic studies have identified multiple contributing factors, such as psychological conditions, relationship concerns, medical conditions, medications, and menopause.”
S
I’d look into low GABA and low serotonin as they are closely related to progesterone and estrogen. I’d also look into pyroluria as the nutrients are used to make hormones and brain chemicals (zinc, vitamin B6 and EPO). I’s also reconsider a plant-based diet and incorporate healthy animal proteins and fats. You can find this all on the blog and in my book The Antianxiety Food Solution https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/
Don’t worry that the title says antianxiety … just read it as if it says solution for Hypoactive Sexual Desire Disorder (there are many overlaps).
The same with this blog post https://www.everywomanover29.com/blog/tryptophan-for-pms-premenstrual-dysphoria-mood-swings-tension-irritability/
Hi Trudy! Would amino acids help with achalasia condition? I just wonder how to get these down the stomach. Thanks.
Tally
I have all my clients use them sublingually so this would work with achalasia. And here is one example where GABA is rubbed on the inside of the cheek https://www.everywomanover29.com/blog/paroxysmal-laryngospasm-with-low-gaba-physical-tension-type-anxiety-is-gaba-powder-rubbed-on-the-inside-of-the-cheek-a-solution/
I havebeen off Klonopin for 7 yrs .I was doing well for a long period of time.Now back to horrible protracted withdrawals. Derealization,mind racing,no sleep ,etc.Was taking magnesium and d3 and vitamin c.Stopped supplementation.Have been gluten free for over a year.I am afraid and really donot know what to do.All blood test are normal.Please
any suggestions?
Antoinette
I’m sorry to hear. When this happens with clients it’s sometimes related to a recent fluoroquinolone antibiotic prescription, infection or mold toxicity. Even added stress especially for pyrolurics can be a a trigger. We explore low GABA, low serotonin and address both and pyroluria if needed. When antibiotics are a factor we address the microbiome.
Low GABA/low serotonin questionnaire https://www.everywomanover29.com/blog/amino-acids-mood-questionnaire-from-the-antianxiety-food-solution/
Pyroluria questionnaire https://www.everywomanover29.com/blog/pyroluria-questionnaire-from-the-antianxiety-food-solution/
Hi Trudy,
Thanks for your work! Do you have an article on interactions between medications and amino acids/other supplements?
Many thanks!
Dean
There is a section in the amino acid chapter of my book The Antianxiety Food Solution. It is also a good resource for the amino acids, other nutrients, pyroluria, gut health and all the dietary factors too – https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/
It only covers SSRIs. I also write about gabapentin here https://www.everywomanover29.com/blog/gaba-is-not-the-same-as-gabapentin-gaba-gamma-aminobutyric-acid-is-an-amino-acid-supplement-gabapentin-is-a-prescription-medication/
Hi,
Just wanted to let you know, Natural Factors PharmaGABA chewables are NOT sweetened with cane sugar, and have not been for quite some time now (a couple years, minimum.)
They are sweetened with xylitol.
Also, it might be good to remind folks, if they have products in the house containing xylitol, they MUST be kept away from pets…xylitol is extremely toxic to dogs.
Have learned so much from you and appreciate it so much!
Lora
Thanks for sharing and the warning for dogs
I need some help. I am a 72 year old man. I recently developed an anxiety disorder. I get hand tremors possibly not related the anxiety and have had it for about a year, it also seem to be helped by drinking water. I have always had manageable anxiety however after my doctor put me on Amlodipine for blood pressure this set my anxiety off. Months after I stopped the Amlodipine I still have the anxiety. I have found many many other people with the same symptoms from Amlodipine on several other web sites, lasting weeks to months
My anxiety disorder symptoms are Brain fog, depersonalization, slight headache or lightheadedness usually when I get stressed. Symptoms seem worse in the morning. I have high cortical levels/past eye condition caused by high cortical. Can you give me any advice as far as supplements, etc. I tried Tryptophan 500mg and it made me vary sleepy. I have also had a bad experience quitting benzo drugs about 20 years ago and I think this may have caused some of my problems. Is it safe for me to try GABA? My A1c and glucose levels are good.
JP
With high cortisol I have clients use Seriphos https://www.everywomanover29.com/blog/seriphos-original-formula-anxiety-insomnia-cortisol/
With this class of medications we also look into low vitamin D and possibly Co-Enzyme Q10 as they can become depleted.
If the anxiety is low GABA type of physical anxiety then GABA will help.
My book is a great resource when you are new to the amino acids – The Antianxiety Food Solution https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/ You don’t mention diet but that is a big part of issues too.
Update; After over 8 months of experimenting with different options for my anxiety attacks, I find I find my hand tremors are completely cured by drinking 80 oz of water in the morning in the first 4 hours after waking. My anxiety attacks are less and less, only about 1 to 5 a month and are mostly in the morning. My anxiety attacks are sometimes accompanied by stomach acid or diverticulitis and could be triggered by some medications or vitamins. Cold showers in the morning seem to help. Amlodipine (a calcium channel blocker for hypertension) originally triggered this nightmare over 8 months ago. My diet is not bad and improving. Gluten triggers my acid reflex so I mostly avoid it. Any additional input you can give me would be appreciated.
JP
JP
I have clients avoid gluten 100% and use GABA/tryptophan when they have anxiety. And all the approaches covered in my book
Hi Trudy
I deal with MCAS/histamine intolerance plus high blood sugar/low blood sugar. Weight gain, extremely high needs for food (I don’t think I actually absorbed minerals and vitamins very well.) sleep disorder. Ibs.
I don’t tolerate B6 or tryptophan very well. And I don’t understand why. Or what to do about it. Vit B supplements are generally not tolerated well. Is is lack of magnesium?
Lou
With complex issues it’s best to work with an integrative practitioner. Here is some info on pyroluria and MCAS/histamine https://www.everywomanover29.com/blog/the-importance-of-addressing-pyroluria-with-chronic-lyme-disease-and-co-infections-mcas-mast-cell-activation-syndrome-and-other-chronic-illnesses/
my son and i scored very low for gaba and serotonin. is there another brand instead of the lidtke tryptophan you recommend? I just cant afford much right now. Im planning on starting the now brand gaba powder with a pixie dust dose for myself and my 21 yo son with pans/pandas who is extremely sensitive to everything and tolerates very few supplements. thank you.
Belinda
Doctor’s Best and Life Extension are options – they can be purchased via iherb (my link to save 5% https://www.iherb.com/?rcode=BAN2021)
Please give us feedback once you use one of both of them
Thank you! I’ll give feedback if i try one
Hello!
Do you have a list of practitioners in Australia that can do a full profile and understand your methods.
Regards,
ANN
I’m finding the source naturals gaba lozenge wakes me up at night. Why would that beL Should I try gaba by itself? Having.a bard time finding in a low enough dose. Ideas?
Brenda
Some of the other ingredients in GABA Calm can be an issue for some folks and many find a GABA only product works better for them. I have clients open a capsule or use a powder, measuring out 125mg to start. A mini measuring spoon set like this one https://amzn.to/3Q94nsI (my Amazon link) helps.
Hi Trudy
I posted this to one of the other blogs, but didn’t get a response..
I’ve been using Gaba and Tryptophan off and on for a while now. It helps with my anxiety, but I always try to be the hero and tell myself I can go without it. I’ve had Tinnitus in one ear for 6 months now, which really makes me anxious. I heard Tinnitus could come from anxiety, is that true? My Psychiatrist has suggested that I go on Lexapro since the anxiety is affecting my daily life. What are your thoughts on this? Is it safe? Will I have to be on it indefinitely? I really don’t want to start taking it, but I haven’t been feeling well in general for quite sometime now..
Lisa
Your question has been addressed here https://www.everywomanover29.com/blog/gaba-physical-tension-stiff-tense-muscles-type-anxiety/
I’ve started 5 htp for sleep and anxiety. I’m taking 100-200 mg per night and think it’s helping. Sleeping good, remembering my dreams which you said was a good sign. I have chronic migraines though and use triptan prn. Everyone is cautioning me about serotonin syndrome. How much and far apart do I need to use these meds? I just ordered tryptophan because I think I have high anxiety cortisol levels, (as you suggested) I assume the risk of serotonin syndrome is the same.
Also, I’m using gaba too. I was taking 300mg a couple times a day but wasn’t feeling much noticeable calm. If I up it to 500mg, I get the flush reaction for a couple minutes. I should feel different pretty immediately after I take. (I open capsule onto my tongue)
Thank you
Sharon
PS my 9year old has bad anxiety of school, outings, trips etc., and fear of vomiting. I sprinkled alittle gaba on his tongue before school yesterday and he said he felt calm! Would you agree gaba would be right for me to keep pursuing with him given his symptoms? I tried magnesium but haven’t noticed difference.
Sharon
There is a risk of serotonin syndrome with 5-HTP/tryptophan and a medication such as triptan. I have clients discuss with their prescribing doctor (for monitoring) and use the amino acids 6 hours away from the amino acids
Wonderful to hear GABA helps your son.
Re your comments on your use of GABA, I don’t recommend pushing thru the flush
Trudy, I just bought the Lidtke l-tryptophan 500mg. I have only taken it a couple times and I would like to know if I should be swallowing the capsules or opening them/slash mixing with something else. What are your suggestions?
Denise
I have clients try both ways to see what works best
Hi Trudy, I’m new to your stuff but Im finding it very helpful. I have pyroloria and am working with a naturopath. At this point I wont go into the details but regarding taking a GABA supplement at night, you mentioned one from country life that you used 15-20 years ago, but is there a different product that you use now, before bed? I don’t see something specifically for nighttime in your fullscript recommendations. I also have a BIG problem with ruminations especially in bed.
Jon
Personally I will sometimes use NOW GABA powder (carefully measuring out 125mg) and when I’m traveling or wake in the night I use GABA Calm. I recommend the same for many of my clients.
GABA can help with ruminations and I also consider low serotonin (and tryptophan or 5-HTP if cortisol isn’t high)
Thanks! One more – I have pyroloria. ive always remembered my dreams but they are always bizarre and/or nightmares. Which ive read is sometimes the case instead of not remembering dreaming at all. I am on the equivalent of 500mg b6 between the b6 and p5p and that hasn’t changed. Still always nightmares and/or totally bizarre. I was hoping that would change with the B6. Any thoughts on that?
Jon
With regards to B6 and P5P as some folks do better on one vs the other and we experiment with various combinations.
It would be ever so helpful if there was an easy way to PRINT your articles.
Thanks.
Cara
When I want to refer back to a blog I copy the contents to a word or google doc (which could be printed)
Do you know about a topical neuroplastic lotion called deBalm? I use it nightly for back pain. I want to know if there are side effects. Thank You!
hello
did anyone in the UK get anywhere with using a shipping service? Wanted to get Gaba cream for my niece, which isn’t on Herb.
Thanks
Rosemary
You can order Somnium, a GABA Cream directly from the company and they do ship internationally. You can read more about the product and find my link and discount code on this blog – Somnium Nighttime GABA Cream: insomnia, anxiety, bloated belly, muscle spasms, MS, ARFID, anorexia, Alzheimer’s and autism https://www.everywomanover29.com/blog/somnium-nighttime-gaba-cream-insomnia-anxiety-bloated-belly-muscle-spasms-ms-arfid-anorexia-alzheimers-and-autism/
Please let us know how it goes and do share why you’re considering GABA cream for your niece and her age?
Thanks Trudy. Unfortunately it comes up as unable to ship to UK. I’ve tried their detox product and it goes through to shipping no problem so it must be to do with custom rules of Gaba? I was hoping the shipping service would be a get around.
My niece is 13 years old, has autism and ADHD and not attending any school anymore as mainstream is just too upsetting for her. Authorities are being non-helpful. She’s a terrible eater, only the plainest, biege-est foods. She cannot tolerate taking any pills or capsules so I thought the body cream would be a good starting place to help her be less afraid and more calm. Her mum is getting her to take some probiotic and vitamin gummies just recently so hopefully that will help. Maybe Gaba lozenges from iHerb is easier than a shipping service.
Working full-time, with a long commute and another daughter who just doesn’t get enough attention due to Caitlin; my sister just doesn’t have the energy to research this stuff for herself and I thought I’d help.
Rosemary
Yes new rules about GABA I hear. A shipping service may get around this.
And yes a cream is a great option in a situation like this, also topical magnesium and GABA lozenges which many teens find palatable
Well done for helping – they are fortunate
Trudy,
I do have pyroluria and take supplements for that and don’t seem to have any problems with them.
I have a question about GABA. I have lots of trouble sleeping. Wake up many times and for long periods. There are numerous reasons for that. My question to you is about my trying GABA.
I tried one, 100 mg capsule of Natural Factors Stress Relax Pharma GABA and did sleep very deeply one night. But the next morning when I got up I was so dizzy and unbalanced that I thought I would have to go to the emergency room. It lasted for maybe a half hr. to an hr. I have never in my life experienced that bad a symptom. I am totally afraid to try again. It never happened before to me and hasn’t happened since. I never tried another GABA supplement. This was several months ago. It seems to me there is no other reason for that symptom but the GABA. Can you explain this? I sure would like to sleep better.
Robin
This is not a reaction I’ve heard of before and the only way to know is to try the product again. It’s possible it’s a reaction to pharma GABA or another ingredient in the product and a GABA only product is a better option
Thanks, Trudy.
I’m not sure I saw a GABA, only, product in your list of GABA’s but I’ll look again.
I talked to someone today who thought maybe my GABA reaction might be a problem in the gut and thought using a GABA cream might be a solution.
I checked the GABA cream product Somnium and saw it contains benzoic acid, whih I think is related to sodium benzoate, which I think I’m sensitive to. Do you know anything about that cream or others? If there are no GABA, only, products listed in your blog, could you mention some?
Robin
Now GABA powder is GABA only
I have been taking 5 http for a couple months now, 200mg. Have switched back and forth from this and tryptophan for serotonin support, migraine management and sleep. I think it helps me sleep better. Still have a ton of migraines. For about a month now I’ve been having abdominal pain, lots of belching and mid and pain, nausea, mild bloating, generalized gross feeling. Unaffected by food but appetite maybe little less. Poop normal, no reflux or heartburn. Don’t know the cause but wondering if it was the 5htp? Went off it for several days but pain was still there, plus I had a 6 day menstrual migraine. Tried acv, kombucha, famotidine, h2 blocker. Do you think it could be the supplement? How long do you think it would take. I know serotonin made in gut but does it affect gut lining long term? HConsidering finally going to general md for workup but they’ve never helped me. Was thinking of switching back to tryptophan for serotonin support which I think is a key to my migraines (believe I was taking 1500mg 3x/day? as you recommend) and stop 5htp long term? I’d appreciate your advise. I think awhile back when I first started htp I had stomach pains but they went away after a few days??
Sharon
5-HTP can cause digestive upset but it’s typically only an issue for about a week. Keep in mind not everyone does well with 5-HTP (outside the digestive issues)
It’s been over a month now with gi upset, belching, mild nausea and bloating. I’m continuing the 5 htp as I am thinking its doubtful that’s the cause of it. I’m now wondering if it is anxiety related. Around the time of this, I started orienting in a new area at work and I am a bit anxious about it. I hate if it is this, as it’s making me crazy that I cannot control it.